{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T19:24:36Z","timestamp":1780514676517,"version":"3.54.1"},"reference-count":20,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,7,3]],"date-time":"2025-07-03T00:00:00Z","timestamp":1751500800000},"content-version":"vor","delay-in-days":183,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Leukemia Research Reports"],"published-print":{"date-parts":[[2025]]},"DOI":"10.1016\/j.lrr.2025.100526","type":"journal-article","created":{"date-parts":[[2025,7,3]],"date-time":"2025-07-03T22:41:21Z","timestamp":1751582481000},"page":"100526","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Catastrophic asparaginase-induced cerebral and systemic thrombosis in a young female with T-cell lymphoblastic lymphoma: A case report & literature review"],"prefix":"10.1016","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-7552-8948","authenticated-orcid":false,"given":"Shihab Ahmed Ibrahim","family":"Ahmed","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amr Suliman","family":"AlHanbali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"16","key":"10.1016\/j.lrr.2025.100526_bib0001","doi-asserted-by":"crossref","first-page":"1541","DOI":"10.1056\/NEJMra1400972","article-title":"Acute lymphoblastic leukemia in children","volume":"373","author":"Hunger","year":"2015","journal-title":"N. Engl. J. Med."},{"issue":"5","key":"10.1016\/j.lrr.2025.100526_bib0002","doi-asserted-by":"crossref","first-page":"1646","DOI":"10.1182\/blood-2008-01-130237","volume":"112","author":"Stock","year":"2008","journal-title":"Blood"},{"issue":"19","key":"10.1016\/j.lrr.2025.100526_bib0003","doi-asserted-by":"crossref","first-page":"4419","DOI":"10.3390\/jcm10194419","article-title":"L-asparaginase toxicity in the treatment of children and adolescents with acute lymphoblastic leukemia","volume":"10","author":"Schmidt","year":"2021","journal-title":"J. Clin. Med."},{"issue":"1","key":"10.1016\/j.lrr.2025.100526_bib0004","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1038\/s41408-024-01178-5","article-title":"Venous thromboembolism in adolescents and young adults with acute lymphoblastic leukemia treated on a pediatric-inspired regimen","volume":"14","author":"Shimony","year":"2024","journal-title":"Blood Cancer J."},{"issue":"1","key":"10.1016\/j.lrr.2025.100526_bib0005","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1111\/ejh.13867","article-title":"The association of age and adverse events of PEG-asparaginase in a pediatric tertiary care hospital; a retrospective review","volume":"110","author":"Abbott","year":"2023","journal-title":"Eur. J. Haematol."},{"issue":"31","key":"10.1016\/j.lrr.2025.100526_bib0006","doi-asserted-by":"crossref","first-page":"9607","DOI":"10.12998\/wjcc.v9.i31.9607","article-title":"T-cell lymphoblastic lymphoma with extensive thrombi and cardiac thrombosis: a case report and review of literature","volume":"9","author":"Ma","year":"2021","journal-title":"World J. Clin. Cases."},{"issue":"4","key":"10.1016\/j.lrr.2025.100526_bib0007","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1111\/j.1365-2141.2010.08524.x","article-title":"The frequency and management of asparaginase-related thrombosis in paediatric and adult patients with acute lymphoblastic leukaemia treated on Dana-Farber Cancer Institute consortium protocols","volume":"152","author":"Grace","year":"2011","journal-title":"Br. J. Haematol."},{"issue":"4","key":"10.1016\/j.lrr.2025.100526_bib0008","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1111\/bjh.18683","article-title":"Venous thromboembolism incidence associated with pegylated asparaginase (ASP) compared to the native L-ASP: a retrospective analysis with an ASP-based protocol in adult patients with acute lymphoblastic leukaemia","volume":"201","author":"Chen","year":"2023","journal-title":"Br. J. Haematol."},{"issue":"4","key":"10.1016\/j.lrr.2025.100526_bib0009","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1002\/ajh.20230","article-title":"Thrombosis associated with l-asparaginase therapy and low fibrinogen levels in adult acute lymphoblastic leukemia","volume":"77","author":"Beinart","year":"2004","journal-title":"Am. J. Hematol."},{"issue":"2","key":"10.1016\/j.lrr.2025.100526_bib0010","first-page":"127","article-title":"Influence of two different Escherichia coli asparaginase preparations on fibrinolytic proteins in childhood ALL","volume":"81","author":"Nowak-G\u00f6ttl","year":"1996","journal-title":"Haematologica"},{"issue":"10","key":"10.1016\/j.lrr.2025.100526_bib0011","doi-asserted-by":"crossref","first-page":"1488","DOI":"10.3324\/haematol.12948","article-title":"Changes in antithrombin and fibrinogen levels during induction chemotherapy with l-asparaginase in adult patients with acute lymphoblastic leukemia or lymphoblastic lymphoma. Use of supportive coagulation therapy and clinical outcome: the CAPELAL study","volume":"93","author":"Hunault-Berger","year":"2008","journal-title":"Haematologica"},{"issue":"1","key":"10.1016\/j.lrr.2025.100526_bib0012","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1186\/s40164-024-00555-x","article-title":"Genetic factors, risk prediction and AI application of thrombotic diseases","volume":"13","author":"Wang","year":"2024","journal-title":"Exp. Hematol. Oncol."},{"issue":"2","key":"10.1016\/j.lrr.2025.100526_bib0013","first-page":"330","article-title":"L-asparaginase and the effect of age on coagulation and fibrinolysis in childhood acute lymphoblastic leukemia","volume":"100","author":"Appel","year":"2008","journal-title":"Thromb. Haemost."},{"issue":"2","key":"10.1016\/j.lrr.2025.100526_bib0014","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1002\/rth2.12182","article-title":"Venous thromboembolism in a large cohort of children with acute lymphoblastic leukemia: risk factors and effect on prognosis","volume":"3","author":"Klaassen","year":"2019","journal-title":"Res Pr. Thromb. Haemost."},{"issue":"3","key":"10.1016\/j.lrr.2025.100526_bib0015","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1016\/j.jvs.2011.10.005","article-title":"Peripherally inserted central catheter usage patterns and associated symptomatic upper extremity venous thrombosis","volume":"55","author":"Liem","year":"2012","journal-title":"J. Vasc. Surg."},{"issue":"17","key":"10.1016\/j.lrr.2025.100526_bib0016","doi-asserted-by":"crossref","first-page":"2101","DOI":"10.1182\/blood-2015-09-670729","article-title":"Dexamethasone vs prednisone in induction treatment of pediatric ALL: results of the randomized trial AIEOP-BFM ALL 2000","volume":"127","author":"M\u00f6ricke","year":"2016","journal-title":"Blood"},{"issue":"3","key":"10.1016\/j.lrr.2025.100526_bib0017","doi-asserted-by":"crossref","first-page":"285","DOI":"10.4103\/0976-500X.99449","article-title":"L-asparaginase induced thrombosis in acute lymphoblastic leukemia","volume":"3","author":"Kulkarni","year":"2012","journal-title":"J. Pharmacol. PharmacOther"},{"issue":"11","key":"10.1016\/j.lrr.2025.100526_bib0018","doi-asserted-by":"crossref","first-page":"2568","DOI":"10.3109\/10428194.2016.1165815","article-title":"An antithrombin replacement strategy during asparaginase therapy for acute lymphoblastic leukemia is associated with a reduction in thrombotic events","volume":"57","author":"Farrell","year":"2016","journal-title":"Leuk. Lymphoma"},{"issue":"5","key":"10.1016\/j.lrr.2025.100526_bib0019","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1097\/00001721-200107000-00005","article-title":"Prophylactic therapy with enoxaparin during l-asparaginase treatment in children with acute lymphoblastic leukemia","volume":"12","author":"Elhasid","year":"2001","journal-title":"Blood Coagul. Fibrinolysis"},{"issue":"9","key":"10.1016\/j.lrr.2025.100526_bib0020","doi-asserted-by":"crossref","first-page":"2599","DOI":"10.1007\/s00277-023-05369-1","article-title":"Antithrombotic secondary prophylaxis with low dose of apixaban or rivaroxaban in the onco-hematologic patients: comparison with non-neoplastic patients","volume":"102","author":"Chistolini","year":"2023","journal-title":"Ann. Hematol."}],"container-title":["Leukemia Research Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213048925000287?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213048925000287?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,12,4]],"date-time":"2025-12-04T12:47:10Z","timestamp":1764852430000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2213048925000287"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025]]},"references-count":20,"alternative-id":["S2213048925000287"],"URL":"https:\/\/doi.org\/10.1016\/j.lrr.2025.100526","relation":{},"ISSN":["2213-0489"],"issn-type":[{"value":"2213-0489","type":"print"}],"subject":[],"published":{"date-parts":[[2025]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Catastrophic asparaginase-induced cerebral and systemic thrombosis in a young female with T-cell lymphoblastic lymphoma: A case report & literature review","name":"articletitle","label":"Article Title"},{"value":"Leukemia Research Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.lrr.2025.100526","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"100526"}}