{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T07:58:26Z","timestamp":1785484706874,"version":"3.56.0"},"reference-count":26,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T00:00:00Z","timestamp":1770940800000},"content-version":"vor","delay-in-days":43,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002660","name":"Islamic Azad University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002660","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Leukemia Research Reports"],"published-print":{"date-parts":[[2026]]},"DOI":"10.1016\/j.lrr.2026.100570","type":"journal-article","created":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T07:21:58Z","timestamp":1771226518000},"page":"100570","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Synergistic effects of arsenic trioxide and atorvastatin on proliferation and apoptosis in acute lymphoblastic leukemia cells"],"prefix":"10.1016","volume":"25","author":[{"given":"Sepideh","family":"Hassanpour Khodaei","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shahnaz","family":"Sabetkam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zeinab","family":"Mazloumi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Rafat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diana","family":"Hekari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0920-9583","authenticated-orcid":false,"given":"Khadijeh","family":"Dizaji Asl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.lrr.2026.100570_bib26","doi-asserted-by":"crossref","DOI":"10.34172\/ipp.2025.43799","article-title":"CD34+CD38-stem cells and CD34 + CD38 + progenitor cells as markers of chemotherapy response in acute myeloid leukemia patients","volume":"11","author":"Fergany","year":"2025","journal-title":"Immunopath. Persa"},{"issue":"13","key":"10.1016\/j.lrr.2026.100570_bib0001","doi-asserted-by":"crossref","first-page":"3346","DOI":"10.3390\/cancers15133346","article-title":"Acute lymphoblastic leukemia immunotherapy treatment: now, next, and beyond","volume":"15","author":"Aureli","year":"2023","journal-title":"Cancers"},{"key":"10.1016\/j.lrr.2026.100570_bib0002","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1182\/asheducation-2018.1.137","article-title":"Genetics and prognosis of ALL in children vs adults","volume":"2018","author":"Roberts","year":"2018","journal-title":"Hematol. Am. Soc. Hematol. Educ. Program"},{"key":"10.1016\/j.lrr.2026.100570_bib0003","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1182\/asheducation-2018.1.25","article-title":"No free rides: management of toxicities of novel immunotherapies in ALL, including financial","volume":"2018","author":"Jain","year":"2018","journal-title":"Hematol. Am. Soc. Hematol. Educ. Program"},{"key":"10.1016\/j.lrr.2026.100570_bib0004","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1182\/asheducation-2018.1.9","article-title":"Antibody-based therapies in patients with acute lymphoblastic leukemia","volume":"2018","author":"Dinner","year":"2018","journal-title":"Hematol. Am. Soc. Hematol. Educ. Program"},{"issue":"1","key":"10.1016\/j.lrr.2026.100570_bib25","article-title":"In vitro anti-cancer potentiality of quince and dandelion leaves extract against leukemia cell lines and database retrieval expression of BCR ABL and TCR genes in leukemia","volume":"12","author":"Abdulrahman","year":"2026","journal-title":"Immunopath. Persa"},{"key":"10.1016\/j.lrr.2026.100570_bib0005","doi-asserted-by":"crossref","first-page":"463","DOI":"10.3389\/fonc.2020.00463","article-title":"Combinatorial low dose arsenic trioxide and cisplatin exacerbates autophagy via AMPK\/STAT3 signaling on targeting head and neck cancer initiating cells","volume":"10","author":"Hu","year":"2020","journal-title":"Front. Oncol."},{"key":"10.1016\/j.lrr.2026.100570_bib0006","first-page":"44","article-title":"A review of arsenic trioxide and acute promyelocytic leukemia","volume":"8","author":"Alimoghaddam","year":"2014","journal-title":"Int. J. Hematol. Oncol. Stem Cell Res."},{"key":"10.1016\/j.lrr.2026.100570_bib0007","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1038\/s41420-023-01558-z","article-title":"An overview of arsenic trioxide-involved combined treatment algorithms for leukemia: basic concepts and clinical implications","volume":"9","author":"Jiang","year":"2023","journal-title":"Cell Death Discov."},{"key":"10.1016\/j.lrr.2026.100570_bib0008","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.biopha.2016.12.130","article-title":"Effect and mechanism of Sorbus pohuashanensis (Hante) Hedl. flavonoids protect against arsenic trioxide-induced cardiotoxicity","volume":"88","author":"Yu","year":"2017","journal-title":"Biomed. Pharmacother."},{"issue":"2","key":"10.1016\/j.lrr.2026.100570_bib0009","doi-asserted-by":"crossref","first-page":"43799","DOI":"10.34172\/ipp.2025.43799","article-title":"CD34+ CD38-stem cells and CD34+ CD38+ progenitor cells as markers of chemotherapy response in acute myeloid leukemia patients","volume":"11","author":"Fergany","year":"2025","journal-title":"Immunopathol. Persa."},{"key":"10.1016\/j.lrr.2026.100570_bib0010","doi-asserted-by":"crossref","first-page":"3337","DOI":"10.1080\/15384101.2019.1676581","article-title":"Cholesterol depletion sensitizes gallbladder cancer to cisplatin by impairing DNA damage response","volume":"18","author":"Zhang","year":"2019","journal-title":"Cell Cycle"},{"key":"10.1016\/j.lrr.2026.100570_bib0011","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-024-71240-6","article-title":"The molecular basis of the anticancer effect of statins","volume":"14","author":"Buccioli","year":"2024","journal-title":"Sci. Rep."},{"key":"10.1016\/j.lrr.2026.100570_bib0012","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1038\/nrcardio.2013.80","article-title":"Statins in the primary prevention of cardiovascular disease","volume":"10","author":"Reiner","year":"2013","journal-title":"Nat. Rev. Cardiol."},{"key":"10.1016\/j.lrr.2026.100570_bib0013","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1001\/jama.2022.13044","article-title":"Force UPST: statin Use for the primary prevention of cardiovascular disease in adults: US Preventive Services Task Force Recommendation Statement","volume":"328","year":"2022","journal-title":"JAMA"},{"issue":"15","key":"10.1016\/j.lrr.2026.100570_bib0014","doi-asserted-by":"crossref","first-page":"3948","DOI":"10.3390\/cancers15153948","article-title":"Statins in cancer prevention and therapy","volume":"15","author":"Ricco","year":"2023","journal-title":"Cancers"},{"key":"10.1016\/j.lrr.2026.100570_bib0015","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1111\/j.1365-2141.2011.08696.x","article-title":"Statins are active in acute lymphoblastic leukaemia (ALL): a therapy that may treat ALL and prevent avascular necrosis","volume":"155","author":"Sheen","year":"2011","journal-title":"Br. J. Haematol."},{"key":"10.1016\/j.lrr.2026.100570_bib0016","doi-asserted-by":"crossref","DOI":"10.34172\/ipp.2024.40597","article-title":"Statins and the risk of colorectal cancer; a systematic review and meta-analysis of cohort and case-control studies","volume":"11","author":"Abbaszadeh","year":"2024","journal-title":"Immunopathol. Persa"},{"key":"10.1016\/j.lrr.2026.100570_bib0017","first-page":"e2078","article-title":"Statins as anti-tumor agents: a paradigm for repurposed drugs","volume":"7","author":"Tripathi","year":"2024","journal-title":"Cancer Rep."},{"key":"10.1016\/j.lrr.2026.100570_bib0018","doi-asserted-by":"crossref","DOI":"10.34172\/jrip.2023.32192","article-title":"The association between statin administration and renal cell carcinoma; a systematic review and meta-analysis","volume":"12","author":"Ramezannezhad","year":"2023","journal-title":"J. Renal. Inj. Prev."},{"key":"10.1016\/j.lrr.2026.100570_bib0019","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1007\/s12032-022-01892-9","article-title":"Nosrati S: a review of effects of atorvastatin in cancer therapy","volume":"40","author":"Shaghaghi","year":"2022","journal-title":"Med. Oncol."},{"issue":"1","key":"10.1016\/j.lrr.2026.100570_bib0020","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.canlet.2012.04.011","article-title":"Statins and cancer: current and future prospects","volume":"324","author":"Osmak","year":"2012","journal-title":"Cancer lett."},{"key":"10.1016\/j.lrr.2026.100570_bib0021","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.3389\/fonc.2019.01032","article-title":"Atorvastatin exerts antileukemia activity via inhibiting mevalonate-YAP axis in K562 and HL60 cells","volume":"9","author":"Zhang","year":"2019","journal-title":"Front. Oncol."},{"key":"10.1016\/j.lrr.2026.100570_bib0022","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1186\/1756-8722-3-28","article-title":"Basic mechanisms of arsenic trioxide (ATO)-induced apoptosis in human leukemia (HL-60) cells","volume":"3","author":"Yedjou","year":"2010","journal-title":"J. Hematol. Oncol."},{"key":"10.1016\/j.lrr.2026.100570_bib0023","doi-asserted-by":"crossref","first-page":"2728","DOI":"10.1111\/jcmm.17286","article-title":"Combined anticancer effects of simvastatin and arsenic trioxide on prostate cancer cell lines via downregulation of the VEGF and OPN isoforms genes","volume":"26","author":"Mirzaei","year":"2022","journal-title":"J. Cell Mol. Med."},{"key":"10.1016\/j.lrr.2026.100570_bib0024","first-page":"2478","article-title":"Atorvastatin exhibits anti-tumorigenic and anti-metastatic effects in ovarian cancer in vitro","volume":"7","author":"Jones","year":"2017","journal-title":"Am. J. Cancer Res."}],"updated-by":[{"DOI":"10.1016\/j.lrr.2026.100593","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T00:00:00Z","timestamp":1778889600000}},{"DOI":"10.1016\/j.lrr.2026.100593","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000}}],"container-title":["Leukemia Research Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213048926000105?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213048926000105?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T07:12:04Z","timestamp":1785481924000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2213048926000105"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":26,"alternative-id":["S2213048926000105"],"URL":"https:\/\/doi.org\/10.1016\/j.lrr.2026.100570","relation":{},"ISSN":["2213-0489"],"issn-type":[{"value":"2213-0489","type":"print"}],"subject":[],"published":{"date-parts":[[2026]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Synergistic effects of arsenic trioxide and atorvastatin on proliferation and apoptosis in acute lymphoblastic leukemia cells","name":"articletitle","label":"Article Title"},{"value":"Leukemia Research Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.lrr.2026.100570","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"100570"}}