{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T19:45:23Z","timestamp":1790797523778,"version":"4.1.0"},"reference-count":34,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,5,1]],"date-time":"2020-05-01T00:00:00Z","timestamp":1588291200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,5,1]],"date-time":"2020-05-01T00:00:00Z","timestamp":1588291200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Life Sciences in Space Research"],"published-print":{"date-parts":[[2020,5]]},"DOI":"10.1016\/j.lssr.2019.10.001","type":"journal-article","created":{"date-parts":[[2019,10,14]],"date-time":"2019-10-14T12:40:49Z","timestamp":1571056849000},"page":"119-128","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"special_numbering":"C","title":["Zoster patients on earth and astronauts in space share similar immunologic profiles"],"prefix":"10.1016","volume":"25","author":[{"given":"Hawley E.","family":"Kunz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George","family":"Makedonas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satish K.","family":"Mehta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen K.","family":"Tyring","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramya","family":"Vangipuram","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6860-0828","authenticated-orcid":false,"given":"Heather","family":"Quiriarte","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mayra","family":"Nelman-Gonzalez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Duane L.","family":"Pierson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian E.","family":"Crucian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.lssr.2019.10.001_bib0001","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.4049\/jimmunol.138.4.1229","article-title":"Analysis of immune function in herpes zoster patients: demonstration and characterization of suppressor cells","volume":"138","author":"Cauda","year":"1987","journal-title":"J. Immunol."},{"issue":"2","key":"10.1016\/j.lssr.2019.10.001_bib0002","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1089\/vim.1987.1.145","article-title":"T-cell imbalances and NK activity in varicella-zoster virus infections","volume":"1","author":"Cauda","year":"1987","journal-title":"Viral Immunol."},{"issue":"2","key":"10.1016\/j.lssr.2019.10.001_bib0003","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1007\/s15010-013-0550-8","article-title":"Incidence of herpes zoster in patients with altered immune function","volume":"42","author":"Chen","year":"2014","journal-title":"Infection"},{"issue":"6","key":"10.1016\/j.lssr.2019.10.001_bib0004","doi-asserted-by":"crossref","first-page":"1116","DOI":"10.1002\/jmv.21173","article-title":"Asymptomatic reactivation and shed of infectious varicella zoster virus in astronauts","volume":"80","author":"Cohrs","year":"2008","journal-title":"J. Med. Virol."},{"key":"10.1016\/j.lssr.2019.10.001_bib0005","doi-asserted-by":"crossref","first-page":"383","DOI":"10.2147\/IJGM.S114188","article-title":"Incidence of clinical symptoms during long-duration orbital spaceflight","volume":"9","author":"Crucian","year":"2016","journal-title":"Int. J. Gen. Med."},{"issue":"4","key":"10.1016\/j.lssr.2019.10.001_bib0006","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1016\/j.jaip.2015.12.021","article-title":"A case of persistent skin rash and rhinitis with immune system dysregulation onboard the international space station","volume":"4","author":"Crucian","year":"2016","journal-title":"J. Allergy Clin. Immunol. Pract."},{"issue":"1","key":"10.1016\/j.lssr.2019.10.001_bib0007","doi-asserted-by":"crossref","DOI":"10.1038\/npjmgrav.2015.13","article-title":"Alterations in adaptive immunity persist during long-duration spaceflight","volume":"1","author":"Crucian","year":"2015","journal-title":"npj Microgravity"},{"issue":"9","key":"10.1016\/j.lssr.2019.10.001_bib0008","doi-asserted-by":"crossref","first-page":"835","DOI":"10.3357\/ASEM.2276.2008","article-title":"Immune system dysregulation following short- vs. long-duration spaceflight","volume":"79","author":"Crucian","year":"2008","journal-title":"Aviat. Space Environ. Med."},{"issue":"10","key":"10.1016\/j.lssr.2019.10.001_bib0009","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1089\/jir.2013.0129","article-title":"Plasma cytokine concentrations indicate that in vivo hormonal regulation of immunity is altered during long-duration spaceflight","volume":"34","author":"Crucian","year":"2014","journal-title":"J. Interferon. Cytokine. Res."},{"issue":"Suppl 1","key":"10.1016\/j.lssr.2019.10.001_bib0010","doi-asserted-by":"crossref","first-page":"S47","DOI":"10.1016\/j.jinf.2015.04.015","article-title":"Varicella zoster virus immunity: a primer","volume":"71","author":"Duncan","year":"2015","journal-title":"J. Infect."},{"issue":"4\u20135","key":"10.1016\/j.lssr.2019.10.001_bib0011","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/0166-0934(82)90073-8","article-title":"Extraction of cell-associated varicella-zoster virus DNA with triton X-100-NaCl","volume":"4","author":"Gilden","year":"1982","journal-title":"J. Virol. Methods"},{"issue":"5","key":"10.1016\/j.lssr.2019.10.001_bib0012","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1189\/jlb.0309167","article-title":"Could spaceflight-associated immune system weakening preclude the expansion of human presence beyond Earth's orbit?","volume":"86","author":"Gueguinou","year":"2009","journal-title":"J. Leukoc. Biol."},{"issue":"14","key":"10.1016\/j.lssr.2019.10.001_bib0013","first-page":"2071","article-title":"T cell activation responses are differentially regulated during clinorotation and in spaceflight","volume":"13","author":"Hashemi","year":"1999","journal-title":"FASEB J. Off. Publ. Feder. Am. Soc. Exper. Biol."},{"issue":"15","key":"10.1016\/j.lssr.2019.10.001_bib0014","first-page":"2032","article-title":"Determination and clinical correlation of markers of inflammation in unvaccinated patients with varicella-zoster infection","volume":"17","author":"Karadag Oncel","year":"2013","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"issue":"Suppl 1","key":"10.1016\/j.lssr.2019.10.001_bib0015","doi-asserted-by":"crossref","first-page":"S111","DOI":"10.1002\/jmv.10364","article-title":"Varicella in Americans from NHANES III: implications for control through routine immunization","volume":"70","author":"Kilgore","year":"2003","journal-title":"J. Med. Virol."},{"issue":"1","key":"10.1016\/j.lssr.2019.10.001_bib0016","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1002\/jmv.10555","article-title":"Stress-induced subclinical reactivation of varicella zoster virus in astronauts","volume":"72","author":"Mehta","year":"2004","journal-title":"J. Med. Virol."},{"issue":"1","key":"10.1016\/j.lssr.2019.10.001_bib0017","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.cyto.2012.09.019","article-title":"Reactivation of latent viruses is associated with increased plasma cytokines in astronauts","volume":"61","author":"Mehta","year":"2013","journal-title":"Cytokine"},{"key":"10.1016\/j.lssr.2019.10.001_bib0018","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1038\/s41526-017-0015-y","article-title":"Latent virus reactivation in astronauts on the international space station","volume":"3","author":"Mehta","year":"2017","journal-title":"NPJ Microgravity"},{"key":"10.1016\/j.lssr.2019.10.001_bib0019","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1038\/s41526-017-0015-y","article-title":"Latent virus reactivation in astronauts on the international space station","volume":"3","author":"Mehta","year":"2017","journal-title":"npj Microgravity"},{"key":"10.1016\/j.lssr.2019.10.001_bib0020","article-title":"Latent virus reactivation in astronauts on the international space station","volume":"11","author":"Mehta","year":"2017","journal-title":"npj Microgravity."},{"key":"10.1016\/j.lssr.2019.10.001_bib0021","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/j.bbi.2014.05.014","article-title":"Multiple latent viruses reactivate in astronauts during space shuttle missions","volume":"41","author":"Mehta","year":"2014","journal-title":"Brain Behav. Immun."},{"issue":"5","key":"10.1016\/j.lssr.2019.10.001_bib0022","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1086\/527420","article-title":"Varicella-zoster virus in the saliva of patients with herpes zoster","volume":"197","author":"Mehta","year":"2008","journal-title":"J. Infect. Dis."},{"issue":"3","key":"10.1016\/j.lssr.2019.10.001_bib0023","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1097\/WCO.0000000000000092","article-title":"Neurological complications of varicella zoster virus reactivation","volume":"27","author":"Nagel","year":"2014","journal-title":"Curr. Opin. Neurol."},{"issue":"1","key":"10.1016\/j.lssr.2019.10.001_bib0024","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1093\/infdis\/jix508","article-title":"Diagnostic usefulness of varicella-zoster virus real-time polymerase chain reaction analysis of dna in saliva and plasma specimens from patients with herpes zoster","volume":"217","author":"Park","year":"2017","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.lssr.2019.10.001_bib0025","series-title":"Psychoneuroimmunology. II","first-page":"851","article-title":"Reactivation of latent herpes viruses in astronauts","author":"Pierson","year":"2007"},{"issue":"3","key":"10.1016\/j.lssr.2019.10.001_bib0026","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.bbi.2004.08.001","article-title":"Epstein-Barr virus shedding by astronauts during space flight","volume":"19","author":"Pierson","year":"2005","journal-title":"Brain Behav. Immun."},{"issue":"4","key":"10.1016\/j.lssr.2019.10.001_bib0027","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1093\/infdis\/jiu500","article-title":"Altered phenotype and functionality of varicella zoster virus-specific cellular immunity in individuals with active infection","volume":"211","author":"Schub","year":"2015","journal-title":"J. Infect. Dis."},{"issue":"3","key":"10.1016\/j.lssr.2019.10.001_bib0028","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1016\/j.clindermatol.2013.11.010","article-title":"Herpes zoster as a systemic disease","volume":"32","author":"Staikov","year":"2014","journal-title":"Clin. Dermatol."},{"issue":"5","key":"10.1016\/j.lssr.2019.10.001_bib0029","doi-asserted-by":"crossref","first-page":"2704","DOI":"10.1128\/JVI.03445-13","article-title":"Analysis of T cell responses during active varicella-zoster virus reactivation in human ganglia","volume":"88","author":"Steain","year":"2014","journal-title":"J. Virol."},{"issue":"12","key":"10.1016\/j.lssr.2019.10.001_bib0030","first-page":"1281","article-title":"Effects of mission duration on neuroimmune responses in astronauts","volume":"74","author":"Stowe","year":"2003","journal-title":"Aviat. Space Environ. Med."},{"issue":"6","key":"10.1016\/j.lssr.2019.10.001_bib0031","doi-asserted-by":"crossref","first-page":"627","DOI":"10.3357\/ASEM.2980.2011","article-title":"Adrenocortical and immune responses following short- and long-duration spaceflight","volume":"82","author":"Stowe","year":"2011","journal-title":"Aviat. Space Environ. Med."},{"key":"10.1016\/j.lssr.2019.10.001_bib0032","first-page":"341","article-title":"VZV t cell-mediated immunity","volume":"342","author":"Weinberg","year":"2010","journal-title":"Curr. Top. Microbiol. Immunol."},{"issue":"3","key":"10.1016\/j.lssr.2019.10.001_bib0033","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0150301","article-title":"Evaluation of chosen cytokine levels among patients with herpes zoster as ability to provide immune response","volume":"11","author":"Zajkowska","year":"2016","journal-title":"PLoS ONE"},{"issue":"12","key":"10.1016\/j.lssr.2019.10.001_bib0034","doi-asserted-by":"crossref","first-page":"1158","DOI":"10.1111\/j.1346-8138.2011.01289.x","article-title":"Study on the T-helper cell 1\/2 cytokine profile in blister fluid of patients with herpes zoster and its clinical significance","volume":"38","author":"Zhang","year":"2011","journal-title":"J Dermatol"}],"container-title":["Life Sciences in Space Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2214552419301191?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2214552419301191?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T13:23:10Z","timestamp":1762003390000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2214552419301191"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,5]]},"references-count":34,"alternative-id":["S2214552419301191"],"URL":"https:\/\/doi.org\/10.1016\/j.lssr.2019.10.001","relation":{},"ISSN":["2214-5524"],"issn-type":[{"value":"2214-5524","type":"print"}],"subject":[],"published":{"date-parts":[[2020,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Zoster patients on earth and astronauts in space share similar immunologic profiles","name":"articletitle","label":"Article Title"},{"value":"Life Sciences in Space Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.lssr.2019.10.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 The Committee on Space Research (COSPAR). Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}