{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T00:06:41Z","timestamp":1784246801068,"version":"3.55.0"},"reference-count":67,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,5,1]],"date-time":"2020-05-01T00:00:00Z","timestamp":1588291200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,5,1]],"date-time":"2020-05-01T00:00:00Z","timestamp":1588291200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Life Sciences in Space Research"],"published-print":{"date-parts":[[2020,5]]},"DOI":"10.1016\/j.lssr.2019.10.004","type":"journal-article","created":{"date-parts":[[2019,10,16]],"date-time":"2019-10-16T20:05:58Z","timestamp":1571256358000},"page":"129-135","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"special_numbering":"C","title":["Predictions of cognitive detriments from galactic cosmic ray exposures to astronauts on exploration missions"],"prefix":"10.1016","volume":"25","author":[{"given":"Francis A.","family":"Cucinotta","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eliedonna","family":"Cacao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.lssr.2019.10.004_bib0001","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1088\/0004-637X\/765\/2\/91","article-title":"Time dependence of the proton flux measured by PAMELA during the 2006 July\u20132009 December solar minimum","volume":"765","author":"Adriani","year":"2013","journal-title":"Astrophys. J."},{"key":"10.1016\/j.lssr.2019.10.004_bib0002","first-page":"27","article-title":"Track structure model of microscopic energy deposition by protons and heavy ions in segments of neuronal cell dendrites represented by cylinders or spheres","volume":"13","author":"Alp","year":"2017","journal-title":"Life Sci. Space Res."},{"key":"10.1016\/j.lssr.2019.10.004_bib0003","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1667\/RR14923.1","article-title":"Biophysics model of heavy ion degradation of neuron morphology in mouse hippocampal granular cell layer neurons","volume":"189","author":"Alp","year":"2019","journal-title":"Radiat. Res."},{"key":"10.1016\/j.lssr.2019.10.004_bib0004","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1086\/529424","article-title":"Composition of primary cosmic-ray nuclei at high energies","volume":"678","author":"Ave","year":"2008","journal-title":"Astrophys. J."},{"key":"10.1016\/j.lssr.2019.10.004_bib0005","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1007\/s10339-011-0430-z","article-title":"The novel object recognition memory: neurobiology, test procedure, and its modifications","volume":"13","author":"Antunes","year":"2012","journal-title":"Cogn. Process."},{"key":"10.1016\/j.lssr.2019.10.004_bib0006","doi-asserted-by":"crossref","first-page":"201","DOI":"10.2307\/3578590","article-title":"An analysis of interplanetary space radiation exposure for various solar cycles","volume":"138","author":"Badhwar","year":"1994","journal-title":"Radiat. Res."},{"key":"10.1016\/j.lssr.2019.10.004_bib0007","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1016\/S0927-6505(02)00267-0","article-title":"The cosmic-ray proton and helium spectra measured with the CAPRICE98 balloon experiment","volume":"19","author":"Boezio","year":"2003","journal-title":"Astropart. Phys."},{"key":"10.1016\/j.lssr.2019.10.004_bib0008","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1667\/RR3766.1","article-title":"Exposure to mission relevant doses of 1\u00a0GeV\/nucleon 56Fe particles leads to impairment of attentional set-shifting performance in socially mature rats","volume":"182","author":"Britten","year":"2014","journal-title":"Radiat. Res."},{"issue":"4","key":"10.1016\/j.lssr.2019.10.004_bib0009","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0153998","article-title":"Relative biological effectiveness of HZE particles for chromosomal aberrations and other surrogate cancer risk endpoints","volume":"11","author":"Cacao","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.lssr.2019.10.004_bib0010","doi-asserted-by":"crossref","DOI":"10.1667\/RR15419.1","article-title":"Meta-analysis of cognitive performance by novel object recognition after proton and heavy ion exposures","volume":"192","author":"Cacao","year":"2019","journal-title":"Radiat. Res."},{"issue":"2","key":"10.1016\/j.lssr.2019.10.004_bib0011","doi-asserted-by":"crossref","first-page":"e56870","DOI":"10.1371\/journal.pone.0056870","article-title":"Pharmacological characterization of memoquin, a multi-target compound for the treatment of Alzheimer's disease","volume":"8","author":"Capurro","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.lssr.2019.10.004_bib0012","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/j.expneurol.2013.01.003","article-title":"The interaction between the dopaminergic fore-brain projections and the medial prefrontal cortex is critical for memory of objects: implications for Parkinson's disease","volume":"247","author":"Chao","year":"2013","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.lssr.2019.10.004_bib0013","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1038\/35050103","article-title":"A learning deficit related to age and beta-amyloid plaques in a mouse model of Alzheimer's disease","volume":"408","author":"Chen","year":"2000","journal-title":"Nature"},{"issue":"12","key":"10.1016\/j.lssr.2019.10.004_bib0014","doi-asserted-by":"crossref","first-page":"e53275","DOI":"10.1371\/journal.pone.0053275","article-title":"Galactic cosmic radiation leads to cognitive impairment and increased A\u03b2 plaque accumulation in a mouse model of Alzheimer's disease","volume":"7","author":"Cherry","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.lssr.2019.10.004_bib0015","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1007\/s004110050127","article-title":"Radial distributions of electron spectra from high-energy ions","volume":"37","author":"Cucinotta","year":"1998","journal-title":"Radiat. Environ. Biophys."},{"key":"10.1016\/j.lssr.2019.10.004_bib0016","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1007\/s004110050142","article-title":"Applications of amorphous track models in radiobiology","volume":"38","author":"Cucinotta","year":"1999","journal-title":"Radiat. Environ. Biophys."},{"key":"10.1016\/j.lssr.2019.10.004_bib0017","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1667\/0033-7587(2000)153[0459:MFRDOF]2.0.CO;2","article-title":"Model for radial dependence of frequency distributions for energy imparted in nanometer volumes from HZE particles","volume":"153","author":"Cucinotta","year":"2000","journal-title":"Radiat. Res."},{"key":"10.1016\/j.lssr.2019.10.004_bib0018","first-page":"54","article-title":"Space radiation risks to the central nervous system","volume":"2","author":"Cucinotta","year":"2014","journal-title":"Life Sci. Space Res."},{"key":"10.1016\/j.lssr.2019.10.004_bib0019","first-page":"1","article-title":"Predictions of space radiation fatality risk for exploration missions","volume":"13","author":"Cucinotta","year":"2017","journal-title":"Life Sci. Space Res."},{"key":"10.1016\/j.lssr.2019.10.004_bib0020","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1093\/rpd\/ncy265","article-title":"Detriments in neuron morphology following heavy ion Irradiation \u2013 what's the target?","volume":"183","author":"Cucinotta","year":"2019","journal-title":"Radiat. Prot. Dosim."},{"key":"10.1016\/j.lssr.2019.10.004_bib0021","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1080\/09553002.2019.1623427","article-title":"Risks of cognitive detriments after low dose heavy ion and proton exposures","volume":"95","author":"Cucinotta","year":"2019","journal-title":"Int. J. Radiat. Biol."},{"key":"10.1016\/j.lssr.2019.10.004_bib0022","doi-asserted-by":"crossref","first-page":"18","DOI":"10.3847\/0004-637X\/831\/1\/18","article-title":"Galactic cosmic rays in the local interstellar medium: voyager 1 observations and model results","volume":"831","author":"Cummings","year":"2016","journal-title":"Astrophys. J."},{"key":"10.1016\/j.lssr.2019.10.004_bib0023","doi-asserted-by":"crossref","first-page":"1784","DOI":"10.1038\/npp.2012.25","article-title":"Palmitoylethanolamide protects against the amyloid-beta25\u201335-induced learning and memory impairment in mice: an experimental model of Alzheimer disease","volume":"37","author":"D'Agostino","year":"2012","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.lssr.2019.10.004_bib0025","doi-asserted-by":"crossref","first-page":"3445","DOI":"10.1523\/JNEUROSCI.22-09-03445.2002","article-title":"Neuronal deficiency of presenilin 1 inhibits amyloid plaque formation and corrects hippocampal long-term potentiation but not a cognitive defect of amyloid precursor protein [V717I] transgenic mice","volume":"22","author":"Dewachter","year":"2002","journal-title":"J. Neurosci."},{"key":"10.1016\/j.lssr.2019.10.004_bib0026","doi-asserted-by":"crossref","first-page":"1508","DOI":"10.1002\/jnr.23258","article-title":"REM sleep deprivation generates cognitive and neuro-chemical disruptions in the intranigral rotenone model of Parkinson's disease","volume":"91","author":"Dos Santos","year":"2013","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.lssr.2019.10.004_bib0027","first-page":"96","article-title":"Charge composition and energy spectra of cosmic-ray nuclei for elements from Be to Ni. Results from HEAO-3-C2","volume":"233","author":"Englemann","year":"1990","journal-title":"Astron. Astrophys."},{"key":"10.1016\/j.lssr.2019.10.004_bib0028","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/0166-4328(88)90157-X","article-title":"A new one-trial test for neurobiological studies of memory in rats. 1: behavioral data","volume":"31","author":"Ennaceur","year":"1988","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.lssr.2019.10.004_bib0029","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.bbr.2012.03.008","article-title":"Repeated treatment with a low dose of reserpine as a progressive model of Parkinson's disease","volume":"231","author":"Fernandes","year":"2012","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.lssr.2019.10.004_bib0030","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1016\/j.neuint.2013.09.012","article-title":"The effect of NADPH-oxidase inhibitor apocyninon cognitive impairment induced by moderate lateral fluid percussion injury: role of inflammatory and oxidative brain damage","volume":"63","author":"Ferreira","year":"2013","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.lssr.2019.10.004_bib0031","doi-asserted-by":"crossref","first-page":"1935","DOI":"10.1007\/s00213-013-3336-x","article-title":"HOE-140: an antagonist of B2 receptor, protects against memory deficits and brain damage induced by moderate lateral fluid percussion injury in mice","volume":"231","author":"Ferreira","year":"2014","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.lssr.2019.10.004_bib0032","doi-asserted-by":"crossref","first-page":"1666","DOI":"10.1088\/0004-637X\/698\/2\/1666","article-title":"Elemental compositions and energy spectra of galactic cosmic rays during solar cycle 23","volume":"698","author":"George","year":"2009","journal-title":"Astrophys. J."},{"key":"10.1016\/j.lssr.2019.10.004_bib0033","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1086\/149822","article-title":"Solar modulation of galactic cosmic rays","volume":"154","author":"Gleesson","year":"1968","journal-title":"Astophys. J."},{"key":"10.1016\/j.lssr.2019.10.004_bib0034","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.neuroscience.2013.09.042","article-title":"Neuroprotective effects of swimming training in a mouse model of Parkinson's disease induced by 6-hydroxydopamine","volume":"256","author":"Goes","year":"2014","journal-title":"Neuroscience"},{"key":"10.1016\/j.lssr.2019.10.004_bib0035","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/j.bbr.2014.10.025","article-title":"Assessment of disease-related cognitive impairments using the novel object recognition (NOR) task in rodents","volume":"285","author":"Grayson","year":"2015","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.lssr.2019.10.004_bib0036","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.nima.2003.10.051","article-title":"Progress of the BESS superconducting spectrometer","volume":"A518","author":"Haino","year":"2004","journal-title":"Nucl. Instrum. Meth."},{"key":"10.1016\/j.lssr.2019.10.004_bib0037","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.yhbeh.2013.04.009","article-title":"A novel melatonin agonist Neu-P11 facilitates memory performance and improves cognitive impairment in a rat model of Alzheimer disease","volume":"64","author":"He","year":"2013","journal-title":"Horm. Behav."},{"key":"10.1016\/j.lssr.2019.10.004_bib0038","doi-asserted-by":"crossref","first-page":"10369","DOI":"10.1523\/JNEUROSCI.5721-09.2010","article-title":"Generation and therapeutic efficacy of highly oligomer-specificbeta-amyloid antibodies","volume":"30","author":"Hillen","year":"2010","journal-title":"J. Neurosci."},{"key":"10.1016\/j.lssr.2019.10.004_bib0039","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/j.bbr.2011.01.028","article-title":"Effects of D-cycloserine on MPTP-induced behavioral and neurological changes: potential for treatment of Parkinson's disease dementia","volume":"219","author":"Ho","year":"2011","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.lssr.2019.10.004_bib0040","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.bbr.2014.04.022","article-title":"Effects of ceftriaxone on the behavioral and neuronal changes in an MPTP-induced Parkinson's disease rat model","volume":"268","author":"Ho","year":"2014","journal-title":"Behav. Brain Res."},{"issue":"1\/2","key":"10.1016\/j.lssr.2019.10.004_bib0041","first-page":"1","article-title":"ICRP statement on tissue reactions\/early and late effects of radiation in normal tissues and organs \u2013 threshold doses for tissue reactions in a radiation protection context. ICRP publication 118","volume":"41","year":"2012","journal-title":"Ann. ICRP"},{"key":"10.1016\/j.lssr.2019.10.004_bib0042","doi-asserted-by":"crossref","first-page":"356","DOI":"10.2307\/3579113","article-title":"Survey of radiosensitivity parameters","volume":"14","author":"Katz","year":"1994","journal-title":"Radiat. Res."},{"key":"10.1016\/j.lssr.2019.10.004_bib0043","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2015.00122","article-title":"Issues in ground-based GCR simulation for space radiobiology","author":"Kim","year":"2015","journal-title":"Front. Radiat. Onc."},{"key":"10.1016\/j.lssr.2019.10.004_bib0044","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1086\/156301","article-title":"The charge composition and energy spectra of cosmic-ray nuclei from 3000 MeV PER nucleon to 50\u00a0GeV PER nucleon","volume":"223","author":"Lezniak","year":"1978","journal-title":"Astrophys. J."},{"issue":"8","key":"10.1016\/j.lssr.2019.10.004_bib0045","doi-asserted-by":"crossref","first-page":"e71341","DOI":"10.1371\/journal.pone.0071341","article-title":"Cognitive dysfunction precedes the onset of motor symptoms in the Mito Park mouse model of Parkinson's disease","volume":"8","author":"Li","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.lssr.2019.10.004_bib0046","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1667\/RR2862.1","article-title":"Executive function in rats is impaired by low (20 cGy) doses of 1\u00a0GeV\/u 56Fe particles","volume":"178","author":"Lonart","year":"2012","journal-title":"Radiat. Res."},{"key":"10.1016\/j.lssr.2019.10.004_bib0047","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.expneurol.2007.04.007","article-title":"Chronic brain cytochrome oxidase inhibition selectively alters hippocampal cholinergic innervation and impairs memory: prevention by ladostigil","volume":"206","author":"Luques","year":"2007","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.lssr.2019.10.004_bib0048","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1111\/j.1460-9568.2012.08012.x","article-title":"Cognitive deficits in a mouse model of pre-manifest Parkinson's disease","volume":"35","author":"Magen","year":"2012","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.lssr.2019.10.004_bib0049","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1086\/159210","article-title":"The Abundances and energy spectra of cosmic ray ion and nickel at energies from 1 to 10\u00a0GeV PER amu","volume":"248","author":"Minagawa","year":"1981","journal-title":"Astrophys. J."},{"key":"10.1016\/j.lssr.2019.10.004_bib0050","series-title":"HZE-Particles in Manned Space Flight","year":"1973"},{"key":"10.1016\/j.lssr.2019.10.004_bib0051","series-title":"Guidance on Radiation Received in Space Activities","year":"1989"},{"key":"10.1016\/j.lssr.2019.10.004_bib0052","series-title":"Information needed to make radiation protection recommendations for space missions beyond low-earth orbit. Report 153","year":"2006"},{"key":"10.1016\/j.lssr.2019.10.004_bib0053","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1089\/neu.2012.2399","article-title":"Repeated mild traumatic brain injury: mechanisms of cerebral vulnerability","volume":"30","author":"Prins","year":"2013","journal-title":"J. Neurotrauma"},{"key":"10.1016\/j.lssr.2019.10.004_bib0054","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1667\/RR14222.1","article-title":"Effects of proton and combined proton and 56Fe radiation on the hippocampus","volume":"185","author":"Raber","year":"2016","journal-title":"Radiat. Res."},{"key":"10.1016\/j.lssr.2019.10.004_bib0055","doi-asserted-by":"crossref","first-page":"179","DOI":"10.3389\/fphys.2019.00179","article-title":"Combined effects of three high-energy charged particle beams important for space flight on brain behavioral and cognitive endpoints in B6D2F1 female and male mice","volume":"10","author":"Raber","year":"2019","journal-title":"Front. Phys."},{"key":"10.1016\/j.lssr.2019.10.004_bib0056","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1007\/s00411-006-0071-2","article-title":"Relative effectiveness of different particles and energies in disrupting behavioral performance","volume":"46","author":"Rabin","year":"2007","journal-title":"Radiat. Environ. Biophys."},{"key":"10.1016\/j.lssr.2019.10.004_bib0057","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1016\/j.asr.2011.03.008","article-title":"Operant responding following exposure to HZE particles and its relationship to particle energy and linear energy transfer","volume":"48","author":"Rabin","year":"2011","journal-title":"Adv. Space Res."},{"key":"10.1016\/j.lssr.2019.10.004_bib0059","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.bbr.2013.06.031","article-title":"Cognitive, motor and tyrosine hydroxylase temporal impairment in a model of parkinsonism induced by reserpine","volume":"253","author":"Santos","year":"2013","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.lssr.2019.10.004_bib0060","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/S0014-2999(97)00128-3","article-title":"Effect of metrifonate on extracellular brain acetylcholine and object recognition in aged rats","volume":"325","author":"Scali","year":"1997","journal-title":"Eur. J. Pharm."},{"key":"10.1016\/j.lssr.2019.10.004_bib0061","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.neuroscience.2007.04.011","article-title":"Beta-amyloid pathology in the entorhinal cortex of rats induces memory deficits: implications for Alzheimer's disease","volume":"147","author":"Sipos","year":"2007","journal-title":"Neuroscience"},{"key":"10.1016\/j.lssr.2019.10.004_bib0062","doi-asserted-by":"crossref","first-page":"11579","DOI":"10.1038\/s41598-018-30030-7","article-title":"The discrimination ratio derived from novel object recognition tasks as a measure of recognition memory sensitivity, not bias","volume":"8","author":"Sivakumaran","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.lssr.2019.10.004_bib0063","doi-asserted-by":"crossref","first-page":"2827","DOI":"10.1093\/brain\/aww175","article-title":"Visual dysfunction in Parkinson's disease","volume":"139","author":"Weil","year":"2016","journal-title":"Brain"},{"key":"10.1016\/j.lssr.2019.10.004_bib0064","series-title":"Proceedings of the 29th International Cosmic Ray Conference","first-page":"101","article-title":"The level of solar modulation of galactic cosmic rays from 1997 to 2005 as derived from ACE measurements of elemental energy spectra","author":"Wiedenbeck","year":"2005"},{"key":"10.1016\/j.lssr.2019.10.004_bib0065","series-title":"HZETRN: Description of a Free-Space Transport and Shielding Program","author":"Wilson","year":"1995"},{"key":"10.1016\/j.lssr.2019.10.004_bib0066","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1002\/em.22018","article-title":"Individual variations in dose response to spatial memory learning among outbred Wistar rats exposed from 5 to 20 cGy of 56Fe particles","volume":"57","author":"Wyrobek","year":"2016","journal-title":"Environ. Mol. Mut."},{"key":"10.1016\/j.lssr.2019.10.004_bib0067","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.neuroscience.2013.11.051","article-title":"Nobiletin treatment improves motor and cognitive deficits seen in MPTP-induced Parkinson model mice","volume":"259","author":"Yabuki","year":"2014","journal-title":"Neuroscience"},{"key":"10.1016\/j.lssr.2019.10.004_bib0068","doi-asserted-by":"crossref","first-page":"1014","DOI":"10.1086\/158997","article-title":"The elemental and isotopic composition of cosmic rays: silicon to nickel","volume":"246","author":"Young","year":"1981","journal-title":"Astrophys. J."},{"key":"10.1016\/j.lssr.2019.10.004_bib0069","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1016\/j.bbr.2006.06.034","article-title":"Learning-memory deficit with aging in APP transgenic mice of Alzheimer's disease and intervention by using tetrahydroxystilbene glucoside","volume":"173","author":"Zhang","year":"2006","journal-title":"Behav. Brain Res."}],"container-title":["Life Sciences in Space Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2214552419301221?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2214552419301221?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T13:23:05Z","timestamp":1762003385000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2214552419301221"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,5]]},"references-count":67,"alternative-id":["S2214552419301221"],"URL":"https:\/\/doi.org\/10.1016\/j.lssr.2019.10.004","relation":{},"ISSN":["2214-5524"],"issn-type":[{"value":"2214-5524","type":"print"}],"subject":[],"published":{"date-parts":[[2020,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Predictions of cognitive detriments from galactic cosmic ray exposures to astronauts on exploration missions","name":"articletitle","label":"Article Title"},{"value":"Life Sciences in Space Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.lssr.2019.10.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 The Committee on Space Research (COSPAR). Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}