{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T20:15:24Z","timestamp":1785615324918,"version":"3.56.0"},"reference-count":57,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100010574","name":"China Academy of Space Technology","doi-asserted-by":"publisher","award":["TKTSPY-2020-04-21"],"award-info":[{"award-number":["TKTSPY-2020-04-21"]}],"id":[{"id":"10.13039\/501100010574","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2022YFA1604504"],"award-info":[{"award-number":["2022YFA1604504"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100016344","name":"Qian Xuesen Laboratory for Space Technology, China Aerospace Science and Technology Corporation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100016344","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002402","name":"Sun Yat-Sen University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002402","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31871188"],"award-info":[{"award-number":["31871188"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["HYZHXM03007"],"award-info":[{"award-number":["HYZHXM03007"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Life Sciences in Space Research"],"published-print":{"date-parts":[[2024,2]]},"DOI":"10.1016\/j.lssr.2023.09.006","type":"journal-article","created":{"date-parts":[[2023,9,22]],"date-time":"2023-09-22T02:26:22Z","timestamp":1695349582000},"page":"115-125","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["Simulated space environmental factors of weightlessness, noise and low atmospheric pressure differentially affect the diurnal rhythm and the gut microbiome"],"prefix":"10.1016","volume":"40","author":[{"given":"Xihui","family":"Gan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianwei","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silin","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guanghan","family":"Kan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohong","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongni","family":"Tian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meimei","family":"Liao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dapeng","family":"Ju","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuihong","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoping","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4405-3959","authenticated-orcid":false,"given":"Jinhu","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.lssr.2023.09.006_bib0001","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.cmet.2016.09.014","article-title":"Rhythmic oxygen levels reset circadian clocks through HIF1alpha","volume":"25","author":"Adamovich","year":"2017","journal-title":"Cell Metab."},{"key":"10.1016\/j.lssr.2023.09.006_bib0002","first-page":"S145","article-title":"Studies of circadian rhythms in space flight: some results and prospects","volume":"34","author":"Alpatov","year":"1991","journal-title":"Physiologist"},{"key":"10.1016\/j.lssr.2023.09.006_bib0003","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1038\/s41574-020-00427-4","article-title":"Circadian rhythms and the gut microbiota: from the metabolic syndrome to cancer","volume":"16","author":"Bishehsari","year":"2020","journal-title":"Nat. Rev. Endocrinol."},{"key":"10.1016\/j.lssr.2023.09.006_bib0004","series-title":"The Biological Clock. Two Views","author":"Brown","year":"1970"},{"key":"10.1016\/j.lssr.2023.09.006_bib0005","doi-asserted-by":"crossref","first-page":"1492","DOI":"10.3390\/ijerph14121492","article-title":"Exposure to night-time traffic noise, melatonin-regulating gene variants and change in glycemia in adults","volume":"14","author":"Eze","year":"2017","journal-title":"Int. J. Environ. Res. Public Health"},{"key":"10.1016\/j.lssr.2023.09.006_bib0006","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1007\/s13311-017-0600-5","article-title":"Gut microbiota and the neuroendocrine system","volume":"15","author":"Farzi","year":"2018","journal-title":"Neurotherapeutics"},{"key":"10.1016\/j.lssr.2023.09.006_bib0007","doi-asserted-by":"crossref","first-page":"7958","DOI":"10.1096\/fj.201902976R","article-title":"Three months of bed rest induce a residual transcriptomic signature resilient to resistance exercise countermeasures","volume":"34","author":"Fernandez-Gonzalo","year":"2020","journal-title":"FASEB J."},{"key":"10.1016\/j.lssr.2023.09.006_bib0008","doi-asserted-by":"crossref","first-page":"15019","DOI":"10.1038\/npjmgrav.2015.19","article-title":"Circadian misalignment affects sleep and medication use before and during spaceflight","volume":"2","author":"Flynn-Evans","year":"2016","journal-title":"NPJ Microgravity"},{"key":"10.1016\/j.lssr.2023.09.006_bib0009","doi-asserted-by":"crossref","first-page":"196","DOI":"10.3390\/life10090196","article-title":"Integrated RNA-seq analysis indicates asynchrony in clock genes between tissues under spaceflight","volume":"10","author":"Fujita","year":"2020","journal-title":"Life"},{"key":"10.1016\/j.lssr.2023.09.006_bib0010","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/0273-1177(94)90431-6","article-title":"Influence of gravity on the circadian timing system","volume":"14","author":"Fuller","year":"1994","journal-title":"Adv. Space Res."},{"key":"10.1016\/j.lssr.2023.09.006_bib0011","first-page":"1","article-title":"The effects of gravity on the circadian timing system","volume":"1","author":"Fuller","year":"1994","journal-title":"J. Gravit. Physiol."},{"key":"10.1016\/j.lssr.2023.09.006_bib0012","doi-asserted-by":"crossref","DOI":"10.1126\/science.aau8650","article-title":"The NASA Twins Study: a multidimensional analysis of a year-long human space flight","volume":"364","author":"Garrett-Bakelman","year":"2019","journal-title":"Science"},{"key":"10.1016\/j.lssr.2023.09.006_bib0013","first-page":"23","article-title":"Keeping the right time in space: importance of circadian clock and sleep for physiology and performance of astronauts","volume":"1","author":"Guo","year":"2014","journal-title":"Mil. Med. Res."},{"key":"10.1016\/j.lssr.2023.09.006_bib0014","first-page":"295","article-title":"Circadian rhythms of the Macaca nemestrina monkey in Biosatellite 3","volume":"42","author":"Hahn","year":"1971","journal-title":"Aerosp. Med."},{"key":"10.1016\/j.lssr.2023.09.006_bib0015","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1016\/S0022-1910(03)00068-4","article-title":"Gravity and light effects on the circadian clock of a desert beetle, Trigonoscelis gigas","volume":"49","author":"Hoban-Higgins","year":"2003","journal-title":"J. Insect Physiol."},{"key":"10.1016\/j.lssr.2023.09.006_bib0016","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1177\/0748730410379711","article-title":"JTK_CYCLE: an efficient nonparametric algorithm for detecting rhythmic components in genome-scale data sets","volume":"25","author":"Hughes","year":"2010","journal-title":"J. Biol. Rhythms"},{"key":"10.1016\/j.lssr.2023.09.006_bib0017","doi-asserted-by":"crossref","first-page":"9","DOI":"10.4103\/sni.sni_250_17","article-title":"Space-brain: the negative effects of space exposure on the central nervous system","volume":"9","author":"Jandial","year":"2018","journal-title":"Surg. Neurol. Int."},{"key":"10.1016\/j.lssr.2023.09.006_bib0018","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1186\/s40168-019-0724-4","article-title":"Reproducible changes in the gut microbiome suggest a shift in microbial and host metabolism during spaceflight","volume":"7","author":"Jiang","year":"2019","journal-title":"Microbiome"},{"key":"10.1016\/j.lssr.2023.09.006_bib0019","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1038\/nbt.2676","article-title":"Predictive functional profiling of microbial communities using 16S rRNA marker gene sequences","volume":"31","author":"Langille","year":"2013","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.lssr.2023.09.006_bib0020","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1038\/nrgastro.2016.4","article-title":"Gut microbiota in 2015: prevotella in the gut: choose carefully","volume":"13","author":"Ley","year":"2016","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.lssr.2023.09.006_bib0021","doi-asserted-by":"crossref","first-page":"1966","DOI":"10.1093\/bioinformatics\/btp336","article-title":"SOAP2: an improved ultrafast tool for short read alignment","volume":"25","author":"Li","year":"2009","journal-title":"Bioinformatics"},{"key":"10.1016\/j.lssr.2023.09.006_bib0022","doi-asserted-by":"crossref","first-page":"e47984","DOI":"10.1371\/journal.pone.0047984","article-title":"Changes in the diurnal rhythms during a 45-day head-down bed rest","volume":"7","author":"Liang","year":"2012","journal-title":"PLoS ONE"},{"issue":"4","key":"10.1016\/j.lssr.2023.09.006_bib0023","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1080\/09291016.2014.882093","article-title":"Effects of a 45-day head-down bed rest on the diurnal rhythms of activity, sleep and heart rate","volume":"45","author":"Liang","year":"2014","journal-title":"Biol. Rhythm Res."},{"key":"10.1016\/j.lssr.2023.09.006_bib0024","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1016\/j.neuron.2019.03.028","article-title":"Morning and evening circadian pacemakers independently drive premotor centers via a specific dopamine relay","volume":"102","author":"Liang","year":"2019","journal-title":"Neuron"},{"key":"10.1016\/j.lssr.2023.09.006_bib0025","doi-asserted-by":"crossref","first-page":"1220","DOI":"10.1093\/clinids\/4.6.1220","article-title":"Infections caused by nondiphtheria corynebacterial","volume":"4","author":"Lipsky","year":"1982","journal-title":"Rev. Infect. Dis."},{"key":"10.1016\/j.lssr.2023.09.006_bib0026","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1080\/19490976.2019.1710091","article-title":"Effects of spaceflight on the composition and function of the human gut microbiota","volume":"11","author":"Liu","year":"2020","journal-title":"Gut Microbes"},{"key":"10.1016\/j.lssr.2023.09.006_bib0027","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0139758","article-title":"Effect of spaceflight on the circadian rhythm, lifespan and gene expression of Drosophila melanogaster","volume":"10","author":"Ma","year":"2015","journal-title":"PLoS ONE"},{"key":"10.1016\/j.lssr.2023.09.006_bib0028","doi-asserted-by":"crossref","first-page":"2093","DOI":"10.1007\/s00421-014-2923-9","article-title":"Circadian rhythm of peripheral perfusion during 10-day hypoxic confinement and bed rest","volume":"114","author":"McDonnell","year":"2014","journal-title":"Eur. J. Appl. Physiol."},{"key":"10.1016\/j.lssr.2023.09.006_bib0029","series-title":"Human Health and Performance Risks of Space Exploration Missions: Evidence Reviewed By the NASA Human Research Program","author":"McPhee","year":"2009"},{"key":"10.1016\/j.lssr.2023.09.006_bib0030","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1038\/s41526-017-0015-y","article-title":"Latent virus reactivation in astronauts on the international space station","volume":"3","author":"Mehta","year":"2017","journal-title":"NPJ Microgravity"},{"key":"10.1016\/j.lssr.2023.09.006_bib0031","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1080\/07420528.2016.1224241","article-title":"Circadian rhythms in bed rest: monitoring core body temperature via heat-flux approach is superior to skin surface temperature","volume":"34","author":"Mendt","year":"2017","journal-title":"Chronobiol. Int."},{"key":"10.1016\/j.lssr.2023.09.006_bib0032","first-page":"203","article-title":"The biological clock of Chlamydomonas reinhardii in space","volume":"43","author":"Mergenhagen","year":"1987","journal-title":"Eur. J. Cell. Biol."},{"key":"10.1016\/j.lssr.2023.09.006_bib0033","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1152\/japplphysiol.00969.2001","article-title":"Hindlimb unloading rodent model: technical aspects","volume":"92","author":"Morey-Holton","year":"2002","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.lssr.2023.09.006_bib0034","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1093\/ajh\/hpt026","article-title":"Day\/night variability in blood pressure: influence of posture and physical activity","volume":"26","author":"Morris","year":"2013","journal-title":"Am. J. Hypertens."},{"key":"10.1016\/j.lssr.2023.09.006_bib0035","doi-asserted-by":"crossref","first-page":"605","DOI":"10.3389\/fendo.2020.00605","article-title":"Altered gut microbiota composition is associated with back pain in overweight and obese individuals","volume":"11","author":"Nitert","year":"2020","journal-title":"Front. Endocrinol."},{"key":"10.1016\/j.lssr.2023.09.006_bib0036","doi-asserted-by":"crossref","first-page":"3123","DOI":"10.1093\/bioinformatics\/btu494","article-title":"STAMP: statistical analysis of taxonomic and functional profiles","volume":"30","author":"Parks","year":"2014","journal-title":"Bioinformatics"},{"key":"10.1016\/j.lssr.2023.09.006_bib0037","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1089\/ast.2021.0009","article-title":"Spaceflight virology: what do we know about viral threats in the spaceflight environment?","volume":"22","author":"Pavleti\u0107","year":"2022","journal-title":"Astrobiology"},{"key":"10.1016\/j.lssr.2023.09.006_bib0038","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1111\/imm.13278","article-title":"Cross talk between circadian rhythms and the microbiota","volume":"161","author":"Pearson","year":"2020","journal-title":"Immunology"},{"key":"10.1016\/j.lssr.2023.09.006_bib0039","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.cmet.2016.09.010","article-title":"Circadian clock interaction with HIF1alpha mediates oxygenic metabolism and anaerobic glycolysis in skeletal muscle","volume":"25","author":"Peek","year":"2017","journal-title":"Cell Metab"},{"key":"10.1016\/j.lssr.2023.09.006_bib0040","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0125792","article-title":"Space environmental factor impacts upon murine colon microbiota and mucosal homeostasis","volume":"10","author":"Ritchie","year":"2015","journal-title":"PLoS ONE"},{"key":"10.1016\/j.lssr.2023.09.006_bib0041","doi-asserted-by":"crossref","first-page":"16","DOI":"10.3389\/fmicb.2019.00016","article-title":"Herpes virus reactivation in astronauts during spaceflight and its application on","volume":"10","author":"Rooney","year":"2019","journal-title":"Earth. Front. Microbiol."},{"key":"10.1016\/j.lssr.2023.09.006_bib0042","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1038\/s41526-021-00133-z","article-title":"A review of alterations to the brain during spaceflight and the potential relevance to crew in long-duration space exploration","volume":"7","author":"Roy-O'Reilly","year":"2021","journal-title":"NPJ Microgravity"},{"key":"10.1016\/j.lssr.2023.09.006_bib0043","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/S0955-0674(00)00194-0","article-title":"HIF-1 and mechanisms of hypoxia sensing","volume":"13","author":"Semenza","year":"2001","journal-title":"Curr. Opin. Cell Biol."},{"key":"10.1016\/j.lssr.2023.09.006_bib0044","series-title":"Management of High Altitude Pathophysiology","first-page":"3","article-title":"Chapter 1 - High altitude and hypoxia","author":"Sharma","year":"2018"},{"key":"10.1016\/j.lssr.2023.09.006_bib0045","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1007\/s12275-018-7548-y","article-title":"Intestinal microbiota and the immune system in metabolic diseases","volume":"56","author":"Sittipo","year":"2018","journal-title":"J. Microbiol."},{"key":"10.1016\/j.lssr.2023.09.006_bib0046","doi-asserted-by":"crossref","first-page":"1699","DOI":"10.1007\/s00421-020-04404-7","article-title":"Analysis of changes in cardiac circadian rhythms of RR and QT induced by a 60-day head-down bed rest with and without nutritional countermeasure","volume":"120","author":"Solbiati","year":"2020","journal-title":"Eur. J. Appl. Physiol."},{"key":"10.1016\/j.lssr.2023.09.006_bib0047","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1002\/j.1552-4604.1994.tb04996.x","article-title":"Sleep and circadian rhythms in space","volume":"34","author":"Stampi","year":"1994","journal-title":"J. Clin. Pharmacol."},{"key":"10.1016\/j.lssr.2023.09.006_bib0048","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1126\/science.11540800","article-title":"Neurospora circadian rhythms in space: a reexamination of the endogenous-exogenous question","volume":"225","author":"Sulzman","year":"1984","journal-title":"Science"},{"key":"10.1016\/j.lssr.2023.09.006_bib0049","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1146\/annurev-pathol-020117-043559","article-title":"Microbial contribution to the human metabolome: implications for health and disease","volume":"15","author":"Van Treuren","year":"2020","journal-title":"Annu. Rev. Pathol."},{"key":"10.1016\/j.lssr.2023.09.006_bib0050","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1038\/ki.2012.345","article-title":"Chronic kidney disease alters intestinal microbial flora","volume":"83","author":"Vaziri","year":"2013","journal-title":"Kidney Int."},{"key":"10.1016\/j.lssr.2023.09.006_bib0051","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1002\/bies.950181215","article-title":"Human physiology in space","volume":"18","author":"Vernikos","year":"1996","journal-title":"Bioessays"},{"key":"10.1016\/j.lssr.2023.09.006_bib0052","unstructured":"Wang, D., et\u00a0al., 2014. Space Meets Time: impact of Gravity on Circadian\/Diurnal Rhythms, A sponsored supplement to Science: human performance in space - advancing astronautics research in China, 15\u201317."},{"key":"10.1016\/j.lssr.2023.09.006_bib0053","doi-asserted-by":"crossref","first-page":"2184","DOI":"10.1093\/bioinformatics\/bts356","article-title":"SeQC: quality control of RNA-seq experiments","volume":"28","author":"Wang","year":"2012","journal-title":"Bioinformatics"},{"key":"10.1016\/j.lssr.2023.09.006_bib0054","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1016\/j.bbrc.2016.12.078","article-title":"Activation of HIF-1\u03b1 and its downstream targets in rat hippocampus after long-term simulated microgravity exposure","volume":"485","author":"Wang","year":"2017","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.lssr.2023.09.006_bib0055","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.cmet.2016.09.009","article-title":"Reciprocal regulation between the circadian clock and hypoxia signaling at the genome level in mammals","volume":"25","author":"Wu","year":"2017","journal-title":"Cell Metab."},{"key":"10.1016\/j.lssr.2023.09.006_bib0056","doi-asserted-by":"crossref","first-page":"W316","DOI":"10.1093\/nar\/gkr483","article-title":"KOBAS 2.0: a web server for annotation and identification of enriched pathways and diseases","volume":"39","author":"Xie","year":"2011","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.lssr.2023.09.006_bib0057","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2020.619189","article-title":"The immune system can hear noise","volume":"11","author":"Zhang","year":"2021","journal-title":"Front. Immunol."}],"container-title":["Life Sciences in Space Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2214552423000706?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2214552423000706?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T13:25:39Z","timestamp":1762003539000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2214552423000706"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2]]},"references-count":57,"alternative-id":["S2214552423000706"],"URL":"https:\/\/doi.org\/10.1016\/j.lssr.2023.09.006","relation":{},"ISSN":["2214-5524"],"issn-type":[{"value":"2214-5524","type":"print"}],"subject":[],"published":{"date-parts":[[2024,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Simulated space environmental factors of weightlessness, noise and low atmospheric pressure differentially affect the diurnal rhythm and the gut microbiome","name":"articletitle","label":"Article Title"},{"value":"Life Sciences in Space Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.lssr.2023.09.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Committee on Space Research (COSPAR). Published by Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}