{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,31]],"date-time":"2026-01-31T04:10:45Z","timestamp":1769832645095,"version":"3.49.0"},"reference-count":51,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Life Sciences in Space Research"],"published-print":{"date-parts":[[2025,2]]},"DOI":"10.1016\/j.lssr.2024.09.002","type":"journal-article","created":{"date-parts":[[2024,9,19]],"date-time":"2024-09-19T06:26:24Z","timestamp":1726727184000},"page":"122-125","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["The hypercapnic environment on the International Space Station (ISS): A potential contributing factor to ocular surface symptoms in astronauts"],"prefix":"10.1016","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1241-736X","authenticated-orcid":false,"given":"Ritu","family":"Sampige","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joshua","family":"Ong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ethan","family":"Waisberg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Berdahl","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew G.","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.lssr.2024.09.002_bib0023","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jtos.2023.04.007","article-title":"TFOS lifestyle report: impact of environmental conditions on the ocular surface","volume":"29","author":"Alves","year":"2023","journal-title":"Ocul. Surf."},{"key":"10.1016\/j.lssr.2024.09.002_bib0009","first-page":"14","article-title":"Dry eye disease in astronauts: a narrative review","author":"Ax","year":"2023","journal-title":"Front. Physiol."},{"key":"10.1016\/j.lssr.2024.09.002_bib0036","series-title":"Optics for the New Millennium: An Absolute Review Textbook","first-page":"365","article-title":"Optics in Micro-Gravity and Zero-Gravity Conditions","author":"Batliwala","year":"2022"},{"issue":"4","key":"10.1016\/j.lssr.2024.09.002_bib0035","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1016\/j.jtos.2013.07.003","article-title":"Role of hyperosmolarity in the pathogenesis and management of dry eye disease: proceedings of the OCEAN group meeting","volume":"11","author":"Baudouin","year":"2013","journal-title":"Ocul. Surf."},{"key":"10.1016\/j.lssr.2024.09.002_bib0042","series-title":"Nausea and Vomiting","first-page":"43","article-title":"The stomach\u2014both a target and potential contributor in space sickness","author":"Berry","year":"2017"},{"issue":"9","key":"10.1016\/j.lssr.2024.09.002_bib0028","first-page":"1514","article-title":"Corneal acidosis during contact lens wear: effects of hypoxia and CO2","volume":"28","author":"Bonanno","year":"1987","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"issue":"2","key":"10.1016\/j.lssr.2024.09.002_bib0008","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1097\/IIO.0000000000000168","article-title":"Effects of the external environment on dry eye disease","volume":"57","author":"Calonge","year":"2017","journal-title":"Int. Ophthalmol. Clin."},{"issue":"8","key":"10.1016\/j.lssr.2024.09.002_bib0043","first-page":"9195","article-title":"Inflammation is involved in response of gastric mucosal epithelial cells under simulated microgravity by integrated transcriptomic analysis","volume":"13","author":"Chai","year":"2021","journal-title":"Am. J. Transl. Res."},{"issue":"1","key":"10.1016\/j.lssr.2024.09.002_bib0033","first-page":"134","article-title":"Stromal acidosis affects corneal hydration control","volume":"33","author":"Cohen","year":"1992","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"issue":"3","key":"10.1016\/j.lssr.2024.09.002_bib0001","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1016\/j.jtos.2017.05.008","article-title":"TFOS DEWS II definition and classification report","volume":"15","author":"Craig","year":"2017","journal-title":"Ocul. Surf."},{"issue":"2","key":"10.1016\/j.lssr.2024.09.002_bib0041","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.resp.2010.12.001","article-title":"Theory of gastric CO2 ventilation and its control during respiratory acidosis: Implications for central chemosensitivity, pH regulation, and diseases causing chronic CO2 retention","volume":"175","author":"Dean","year":"2011","journal-title":"Respir. Physiol. Neurobiol."},{"key":"10.1016\/j.lssr.2024.09.002_bib0046","series-title":"International Space Station Carbon Dioxide Removal Assembly (iss cdra) Concepts and Advancements","first-page":"0148","author":"El Sherif","year":"2005"},{"key":"10.1016\/j.lssr.2024.09.002_bib0010","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.ajo.2017.06.033","article-title":"Prevalence of diagnosed dry eye disease in the united states among adults aged 18 years and older","volume":"182","author":"Farrand","year":"2017","journal-title":"Am. J. Ophthalmol."},{"issue":"1","key":"10.1016\/j.lssr.2024.09.002_bib0034","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1111\/j.1444-0938.1993.tb03873.x","article-title":"The Effect Of Solution Tonicity On The Eye","volume":"76","author":"Fletcher","year":"1993","journal-title":"Clinical and Experimental Optometry"},{"key":"10.1016\/j.lssr.2024.09.002_bib0037","doi-asserted-by":"crossref","DOI":"10.1016\/j.buildenv.2020.107278","article-title":"Accumulation and spatial distribution of CO2 in the astronaut's crew quarters on the International Space Station","volume":"185","author":"Georgescu","year":"2020","journal-title":"Build. Environ."},{"key":"10.1016\/j.lssr.2024.09.002_bib0039","doi-asserted-by":"crossref","DOI":"10.1016\/j.buildenv.2021.108150","article-title":"Personalized ventilation solutions for reducing CO2 levels in the crew quarters of the International Space Station","volume":"204","author":"Georgescu","year":"2021","journal-title":"Build. Environ."},{"issue":"3","key":"10.1016\/j.lssr.2024.09.002_bib0031","first-page":"851","article-title":"Corneal epithelial and aqueous humor acidification during in vivo contact lens wear in rabbits","volume":"35","author":"Giasson","year":"1994","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"issue":"1","key":"10.1016\/j.lssr.2024.09.002_bib0006","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.jtos.2018.11.003","article-title":"The impact of dry eye disease treatment on patient satisfaction and quality of life: A review","volume":"17","author":"Gomes","year":"2019","journal-title":"Ocul. Surf."},{"issue":"11","key":"10.1016\/j.lssr.2024.09.002_bib0029","doi-asserted-by":"crossref","first-page":"1283","DOI":"10.3109\/02713688708997553","article-title":"Hydrogel Contact Lenses Impede Carbon Dioxide Efflux from the Human Cornea","volume":"6","author":"Holden","year":"1987","journal-title":"Curr. Eye Res."},{"issue":"8","key":"10.1016\/j.lssr.2024.09.002_bib0024","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1001\/jamaophthalmol.2020.2237","article-title":"Association of the indoor environment with dry eye metrics","volume":"138","author":"Huang","year":"2020","journal-title":"JAMa Ophthalmol."},{"issue":"2","key":"10.1016\/j.lssr.2024.09.002_bib0022","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/j.jtos.2018.03.001","article-title":"Effects of environment pollution on the ocular surface","volume":"16","author":"Jung","year":"2018","journal-title":"Ocul. Surf."},{"key":"10.1016\/j.lssr.2024.09.002_bib0047","first-page":"0148","author":"Knox","year":"2000","journal-title":"International Space Station Carbon Dioxide Removal Assembly Testing"},{"issue":"5","key":"10.1016\/j.lssr.2024.09.002_bib0027","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1097\/JOM.0000000000000158","article-title":"Relationship between carbon dioxide levels and reported headaches on the international space station","volume":"56","author":"Law","year":"2014","journal-title":"J. Occup. Environ. Med."},{"key":"10.1016\/j.lssr.2024.09.002_bib0002","series-title":"Ocular Surface Disease: Cornea, Conjunctiva and Tear Film","first-page":"3","article-title":"1 - Historical concepts of ocular surface disease","author":"Lee","year":"2013"},{"issue":"1","key":"10.1016\/j.lssr.2024.09.002_bib0038","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1038\/s41526-020-0097-9","article-title":"Spaceflight associated neuro-ocular syndrome (SANS) and the neuro-ophthalmologic effects of microgravity: a review and an update","volume":"6","author":"Lee","year":"2020","journal-title":"NPJ. Microgravity."},{"key":"10.1016\/j.lssr.2024.09.002_bib0050","article-title":"Spaceflight associated dry eye syndrome (SADES): radiation, stressors, and ocular surface health","author":"Lee","year":"2024","journal-title":"Life Sci. Space Res. (Amst)"},{"issue":"4","key":"10.1016\/j.lssr.2024.09.002_bib0025","doi-asserted-by":"crossref","DOI":"10.1016\/j.ajo.2014.01.001","article-title":"Dry eye exacerbation in patients exposed to desiccating stress under controlled environmental conditions","volume":"157","author":"L\u00f3pez-Miguel","year":"2014","journal-title":"Am. J. Ophthalmol."},{"issue":"2008-01-2127","key":"10.1016\/j.lssr.2024.09.002_bib0044","doi-asserted-by":"crossref","first-page":"420","DOI":"10.4271\/2008-01-2127","article-title":"Maintaining and monitoring the habitable environment of the international space station","volume":"1","author":"Macatangay","year":"2008","journal-title":"SAE Int. J. Aerospace"},{"issue":"3","key":"10.1016\/j.lssr.2024.09.002_bib0017","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1038\/s41433-023-02730-6","article-title":"Chorioretinal folds in astronauts: risk of chorioretinal fold-related maculopathy and terrestrial staging of disease","volume":"38","author":"Masalkhi","year":"2024","journal-title":"Eye"},{"key":"10.1016\/j.lssr.2024.09.002_bib0045","series-title":"40th International Conference on Environmental Systems","article-title":"Overview of carbon dioxide control issues during international space station\/space shuttle joint docked operations","author":"Matty","year":"2010"},{"issue":"11","key":"10.1016\/j.lssr.2024.09.002_bib0021","doi-asserted-by":"crossref","first-page":"2300","DOI":"10.1016\/j.ophtha.2016.07.028","article-title":"Matrix metalloproteinase 9 testing in dry eye disease using a commercially available point-of-care immunoassay","volume":"123","author":"Messmer","year":"2016","journal-title":"Ophthalmology."},{"issue":"7","key":"10.1016\/j.lssr.2024.09.002_bib0020","article-title":"Indoor carbon monoxide and ocular surface inflammation","volume":"61","author":"Miralles","year":"2020","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.lssr.2024.09.002_bib0014","doi-asserted-by":"crossref","DOI":"10.1038\/s41433-024-03119-9","article-title":"Sleep and optic disc edema in spaceflight associated neuro-ocular syndrome (SANS)","author":"Nguyen","year":"2024","journal-title":"Eye"},{"key":"10.1016\/j.lssr.2024.09.002_bib0040","series-title":"NASA-STD-3001 Technical Brief - Carbon Dioxide (CO2)","year":"2023"},{"key":"10.1016\/j.lssr.2024.09.002_bib0048","first-page":"502","article-title":"Performance testing of a trace contaminant control subassembly for the\u201c international space station\u201d","author":"Perry","year":"1998","journal-title":"SAE Transactions"},{"issue":"5","key":"10.1016\/j.lssr.2024.09.002_bib0004","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1097\/00003226-200009000-00009","article-title":"The diagnosis and management of dry eye: a twenty-five\u2013year review","volume":"19","author":"Pflugfelder","year":"2000","journal-title":"Cornea"},{"issue":"1","key":"10.1016\/j.lssr.2024.09.002_bib0003","article-title":"A comprehensive review on dry eye disease: diagnosis, medical management, recent developments, and future challenges","volume":"2015","author":"Phadatare","year":"2015","journal-title":"Adv. Pharmaceut."},{"issue":"8","key":"10.1016\/j.lssr.2024.09.002_bib0030","first-page":"1542","article-title":"Hypoxic effects on corneal morphology and function","volume":"31","author":"Polse","year":"1990","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"issue":"3","key":"10.1016\/j.lssr.2024.09.002_bib0032","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1097\/00006324-199603000-00009","article-title":"Effects of hypoxia and hypercapnia on contact lens- induced corneal acidosis","volume":"73","author":"Rivera","year":"1996","journal-title":"Optometry Vision Sci."},{"key":"10.1016\/j.lssr.2024.09.002_bib0005","doi-asserted-by":"crossref","DOI":"10.1038\/s41433-024-03143-9","article-title":"Accelerated aging in space and the ocular surface","author":"Sampige","year":"2024","journal-title":"Eye"},{"key":"10.1016\/j.lssr.2024.09.002_bib0015","doi-asserted-by":"crossref","DOI":"10.1038\/s41433-024-03147-5","article-title":"XR-SANS: a multi-modal framework for analyzing visual changes with extended reality (XR) in Spaceflight Associated Neuro-Ocular Syndrome (SANS)","author":"Sampige","year":"2024","journal-title":"Eye"},{"issue":"3","key":"10.1016\/j.lssr.2024.09.002_bib0051","first-page":"79","article-title":"The ocular surface\u2013gut axis in spaceflight: implications of intestinal changes in microgravity on tear film physiology","volume":"2","author":"Sampige","year":"2024","journal-title":"J. Clin.mp; Trans. Ophthalmol."},{"issue":"1","key":"10.1016\/j.lssr.2024.09.002_bib0007","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1001\/archophthalmol.2011.364","article-title":"Dry eye disease: an immune-mediated ocular surface disorder","volume":"130","author":"Stevenson","year":"2012","journal-title":"Arch. Ophthalmol."},{"key":"10.1016\/j.lssr.2024.09.002_bib0011","first-page":"37","article-title":"Neurostimulation as a technology countermeasure for dry eye syndrome in astronauts","volume":"42","author":"Suh","year":"2024","journal-title":"Life Sci. Space Res. (Amst)"},{"key":"10.1016\/j.lssr.2024.09.002_bib0013","article-title":"The evaluation and management of corneal penetrating and perforating injuries during long-duration spaceflight","author":"Suh","year":"2024","journal-title":"Eye"},{"key":"10.1016\/j.lssr.2024.09.002_bib0049","doi-asserted-by":"crossref","DOI":"10.1016\/j.survophthal.2024.08.005","article-title":"Safety protocols, precautions, and countermeasures aboard the International Space Station (ISS) to prevent ocular injury","author":"Suh","year":"2024","journal-title":"Surv. Ophthalmol."},{"key":"10.1016\/j.lssr.2024.09.002_bib0026","unstructured":"WHO. Air pollution. World Health Organization. https:\/\/www.who.int\/health-topics\/air-pollution."},{"issue":"7","key":"10.1016\/j.lssr.2024.09.002_bib0012","doi-asserted-by":"crossref","first-page":"1238","DOI":"10.1038\/s41433-023-02911-3","article-title":"Corneal abrasions in space: current therapeutics and future directions","volume":"38","author":"Waisberg","year":"2024","journal-title":"Eye"},{"issue":"8","key":"10.1016\/j.lssr.2024.09.002_bib0016","doi-asserted-by":"crossref","first-page":"1409","DOI":"10.1038\/s41433-024-02951-3","article-title":"Mitochondrial dysfunction in spaceflight associated neuro-ocular syndrome (SANS): a molecular hypothesis in pathogenesis","volume":"38","author":"Waisberg","year":"2024","journal-title":"Eye"},{"issue":"3","key":"10.1016\/j.lssr.2024.09.002_bib0018","doi-asserted-by":"crossref","first-page":"83","DOI":"10.4103\/pajo.pajo_25_24","article-title":"Climate change and eye health","volume":"6","author":"Waisberg","year":"2024","journal-title":"Pan-Am. J. Ophthalmol."},{"issue":"7","key":"10.1016\/j.lssr.2024.09.002_bib0019","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.1038\/s41433-023-02907-z","article-title":"El Ni\u00f1o and eye health: ophthalmic manifestations of changes in climate","volume":"38","author":"Waisberg","year":"2024","journal-title":"Eye"}],"container-title":["Life Sciences in Space Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2214552424000865?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2214552424000865?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,1,24]],"date-time":"2025-01-24T23:15:07Z","timestamp":1737760507000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2214552424000865"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2]]},"references-count":51,"alternative-id":["S2214552424000865"],"URL":"https:\/\/doi.org\/10.1016\/j.lssr.2024.09.002","relation":{},"ISSN":["2214-5524"],"issn-type":[{"value":"2214-5524","type":"print"}],"subject":[],"published":{"date-parts":[[2025,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The hypercapnic environment on the International Space Station (ISS): A potential contributing factor to ocular surface symptoms in astronauts","name":"articletitle","label":"Article Title"},{"value":"Life Sciences in Space Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.lssr.2024.09.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Committee on Space Research (COSPAR). Published by Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}