{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T04:51:01Z","timestamp":1792731061139,"version":"4.5.0"},"reference-count":36,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,6,19]],"date-time":"2025-06-19T00:00:00Z","timestamp":1750291200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100009938","name":"Knud H\u00f8jgaard's Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009938","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Life Sciences in Space Research"],"published-print":{"date-parts":[[2025,11]]},"DOI":"10.1016\/j.lssr.2025.06.008","type":"journal-article","created":{"date-parts":[[2025,6,19]],"date-time":"2025-06-19T11:49:07Z","timestamp":1750333747000},"page":"134-139","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Exploring microgravity-induced changes to the coagulation system using thrombelastograph - a topical review"],"prefix":"10.1016","volume":"47","author":[{"given":"Ivy","family":"Mayor","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karsten","family":"Lindgaard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bijan","family":"Harandi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jakob","family":"Stensballe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2062-9570","authenticated-orcid":false,"given":"Jesper","family":"M\u00f8lgaard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.lssr.2025.06.008_bib37","unstructured":"Astronaut\/Cosmonaut Statistics [webpage document], n.d. . World Space Flight. URL https:\/\/www.worldspaceflight.com\/bios\/stats.php (accessed 1.10.25)."},{"key":"10.1016\/j.lssr.2025.06.008_bib0002","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1056\/NEJMc1905875","article-title":"Venous thrombosis during spaceflight","volume":"382","author":"Au\u00f1\u00f3n-Chancellor","year":"2020","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.lssr.2025.06.008_bib0003","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1097\/BOT.0000000000001714","article-title":"Ability of thromboelastography to detect hypercoagulability: a systematic review and meta-analysis","volume":"34","author":"Brown","year":"2020","journal-title":"J. Orthop. Trauma"},{"key":"10.1016\/j.lssr.2025.06.008_bib0004","doi-asserted-by":"crossref","first-page":"1795","DOI":"10.1182\/blood-2017-03-745349","article-title":"Red blood cells in thrombosis","volume":"130","author":"Byrnes","year":"2017","journal-title":"Blood"},{"key":"10.1016\/j.lssr.2025.06.008_bib0005","series-title":"StatPearls","article-title":"Physiology, coagulation pathways","author":"Chaudhry","year":"2024"},{"key":"10.1016\/j.lssr.2025.06.008_bib0006","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1111\/eci.12383","article-title":"Bed rest does not induce hypercoagulability","volume":"45","author":"Cvirn","year":"2015","journal-title":"Eur. J. Clin. Invest."},{"key":"10.1016\/j.lssr.2025.06.008_bib0007","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1053\/ajkd.2001.27765","article-title":"Water and sodium balance in space","volume":"38","author":"Drummer","year":"2001","journal-title":"Am. J. Kidney Dis."},{"key":"10.1016\/j.lssr.2025.06.008_bib0008","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1152\/jappl.1996.81.1.408","article-title":"Central venous pressure in humans during microgravity","volume":"81","author":"Foldager","year":"1996","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.lssr.2025.06.008_bib0009","doi-asserted-by":"crossref","first-page":"1593","DOI":"10.1161\/CIRCULATIONAHA.119.044203","article-title":"Natriuretic peptide resetting in astronauts","volume":"141","author":"Frings-Meuthen","year":"2020","journal-title":"Circulation"},{"key":"10.1016\/j.lssr.2025.06.008_bib0010","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1051\/ject\/201749026","article-title":"The TEG\u00ae6s on shaky ground? A novel assessment of the TEG\u00ae6s performance under a challenging condition","volume":"49","author":"Gill","year":"2017","journal-title":"J. Extra Corpor. Technol."},{"key":"10.1016\/j.lssr.2025.06.008_bib0011","doi-asserted-by":"crossref","DOI":"10.1002\/phy2.135","article-title":"Effects of long-term head-down-tilt bed rest and different training regimes on the coagulation system of healthy men","volume":"1","author":"Haider","year":"2013","journal-title":"Physiol Rep"},{"key":"10.1016\/j.lssr.2025.06.008_bib0012","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1002\/bjs.1800680308","article-title":"The PO2 in venous valve pockets: its possible bearing on thrombogenesis","volume":"68","author":"Hamer","year":"1981","journal-title":"Br. J. Surg."},{"key":"10.1016\/j.lssr.2025.06.008_bib0013","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1186\/1757-7241-20-47","article-title":"Current management of massive hemorrhage in trauma","volume":"20","author":"Johansson","year":"2012","journal-title":"Scand. J. Trauma Resusc. Emerg. Med."},{"key":"10.1016\/j.lssr.2025.06.008_bib0014","doi-asserted-by":"crossref","first-page":"1086","DOI":"10.1038\/s41598-020-57822-0","article-title":"Sodium-induced population shift drives activation of thrombin","volume":"10","author":"Kahler","year":"2020","journal-title":"Sci. Rep."},{"key":"10.1016\/j.lssr.2025.06.008_bib0015","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1186\/s12920-019-0490-y","article-title":"The molecular mechanisms driving physiological changes after long duration space flights revealed by quantitative analysis of human blood proteins","volume":"12","author":"Kashirina","year":"2019","journal-title":"BMC Med. Genomics"},{"key":"10.1016\/j.lssr.2025.06.008_bib0016","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1113\/EP089409","article-title":"The effect of microgravity on the human venous system and blood coagulation: a systematic review","volume":"106","author":"Kim","year":"2021","journal-title":"Exp. Physiol."},{"key":"10.1016\/j.lssr.2025.06.008_bib0017","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1186\/s12878-017-0083-y","article-title":"Alterations in hematologic indices during long-duration spaceflight","volume":"17","author":"Kunz","year":"2017","journal-title":"BMC Hematol"},{"key":"10.1016\/j.lssr.2025.06.008_bib0018","first-page":"125","article-title":"Hemostasis system indices after short-term space flights and during 7-day \u201cdry\u201d immersion experiment","volume":"36","author":"Kuzichkin","year":"2010","journal-title":"Fiziol. Cheloveka"},{"key":"10.1016\/j.lssr.2025.06.008_bib0019","doi-asserted-by":"crossref","first-page":"8142","DOI":"10.1038\/s41598-017-08432-w","article-title":"Protein expression changes caused by spaceflight as measured for 18 Russian cosmonauts","volume":"7","author":"Larina","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.lssr.2025.06.008_bib0020","unstructured":"Leach-Huntoon, C., n.d. Fluid-Electrolyte Regulation during Space Flight."},{"key":"10.1016\/j.lssr.2025.06.008_bib0021","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.120.016479","article-title":"Simulated hypergravity activates hemostasis in healthy volunteers","volume":"9","author":"Limper","year":"2020","journal-title":"J. Am. Heart Assoc."},{"key":"10.1016\/j.lssr.2025.06.008_bib0022","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1093\/eurheartj\/ehaa359","article-title":"The thrombotic risk of spaceflight: has a serious problem been overlooked for more than half of a century?","volume":"42","author":"Limper","year":"2021","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.lssr.2025.06.008_bib0023","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/s12959-015-0038-0","article-title":"Global assays of hemostasis in the diagnostics of hypercoagulation and evaluation of thrombosis risk","volume":"13","author":"Lipets","year":"2015","journal-title":"Thromb. J."},{"key":"10.1016\/j.lssr.2025.06.008_bib0024","doi-asserted-by":"crossref","DOI":"10.3389\/fbioe.2021.716184","article-title":"Platelets in wound healing: what happens in space?","volume":"9","author":"Locatelli","year":"2021","journal-title":"Front. Bioeng. Biotechnol."},{"key":"10.1016\/j.lssr.2025.06.008_bib0025","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1160\/TH12-01-0004","article-title":"Reduced coagulation at high altitude identified by thromboelastography","volume":"107","author":"Martin","year":"2012","journal-title":"Thromb. Haemost."},{"key":"10.1016\/j.lssr.2025.06.008_bib0026","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1097\/TA.0000000000001892","article-title":"Excess sodium is deleterious on endothelial and glycocalyx barrier function: a microfluidic study","volume":"85","author":"Martin","year":"2018","journal-title":"J. Trauma Acute Care Surg."},{"key":"10.1016\/j.lssr.2025.06.008_bib0027","unstructured":"Nasa astronaut medical standards, selection and annual recertification, 2021. Office of the chief health and Medical officer."},{"key":"10.1016\/j.lssr.2025.06.008_bib0028","first-page":"125","article-title":"Effect of microgravity, temperature, and concentration on fibrin and collagen assembly","volume":"8","author":"Nunes","year":"1995","journal-title":"Microgravity Sci. Technol."},{"key":"10.1016\/j.lssr.2025.06.008_bib0030","doi-asserted-by":"crossref","first-page":"6","DOI":"10.32473\/space.1.1.138044","article-title":"The physiology of recreational space travel","volume":"1","author":"Reid","year":"2024","journal-title":"SPACE"},{"key":"10.1016\/j.lssr.2025.06.008_bib0031","doi-asserted-by":"crossref","first-page":"S119","DOI":"10.1097\/TA.0000000000002224","article-title":"Thromboelastography on-the-go: evaluation of the TEG 6s device during ground and high-altitude aeromedical evacuation with extracorporeal life support","volume":"87","author":"Roberts","year":"2019","journal-title":"J. Trauma Acute Care Surg."},{"key":"10.1016\/j.lssr.2025.06.008_bib0032","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1177\/1358863X21996825","article-title":"Relevance of immobility as a risk factor for symptomatic proximal and isolated distal deep vein thrombosis in acutely ill medical inpatients","volume":"26","author":"Sartori","year":"2021","journal-title":"Vasc. Med."},{"key":"10.1016\/j.lssr.2025.06.008_bib0033","doi-asserted-by":"crossref","first-page":"2439","DOI":"10.1093\/eurheartj\/ehab309","article-title":"SCORE2 risk prediction algorithms: new models to estimate 10-year risk of cardiovascular disease in Europe","volume":"42","year":"2021","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.lssr.2025.06.008_bib0001","first-page":"3153","article-title":"Use of risk assessment tools to guide decision-making in the primary prevention of atherosclerotic cardiovascular disease: a special report from the American Heart Association and American College of Cardiology","volume":"73","year":"2019","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.lssr.2025.06.008_bib0034","doi-asserted-by":"crossref","first-page":"H1591","DOI":"10.1152\/ajpheart.00435.2015","article-title":"Coagulation changes during lower body negative pressure and blood loss in humans","volume":"309","author":"van Helmond","year":"2015","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.lssr.2025.06.008_bib0035","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1093\/pcmedi\/pbaa022","article-title":"Long-term spaceflight and the cardiovascular system","volume":"3","author":"Vernice","year":"2020","journal-title":"Precis. Clin. Med."},{"key":"10.1016\/j.lssr.2025.06.008_bib0036","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1093\/labmed\/lmx050","article-title":"Coagulation testing in the core laboratory","volume":"48","author":"Winter","year":"2017","journal-title":"Lab. Med."}],"container-title":["Life Sciences in Space Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S221455242500077X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S221455242500077X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T02:48:20Z","timestamp":1761187700000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S221455242500077X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11]]},"references-count":36,"alternative-id":["S221455242500077X"],"URL":"https:\/\/doi.org\/10.1016\/j.lssr.2025.06.008","relation":{},"ISSN":["2214-5524"],"issn-type":[{"value":"2214-5524","type":"print"}],"subject":[],"published":{"date-parts":[[2025,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Exploring microgravity-induced changes to the coagulation system using thrombelastograph - a topical review","name":"articletitle","label":"Article Title"},{"value":"Life Sciences in Space Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.lssr.2025.06.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier B.V. on behalf of The Committee on Space Research (COSPAR).","name":"copyright","label":"Copyright"}]}}