{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T16:02:48Z","timestamp":1787068968160,"version":"build-2736575974"},"reference-count":42,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,11,27]],"date-time":"2025-11-27T00:00:00Z","timestamp":1764201600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100009581","name":"Shaanxi Province Health Commission","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009581","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100015401","name":"Key Research and Development Projects of Shaanxi Province","doi-asserted-by":"publisher","award":["2024SF-YBXM-437"],"award-info":[{"award-number":["2024SF-YBXM-437"]}],"id":[{"id":"10.13039\/501100015401","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Life Sciences in Space Research"],"published-print":{"date-parts":[[2026,1]]},"DOI":"10.1016\/j.lssr.2025.11.011","type":"journal-article","created":{"date-parts":[[2025,11,22]],"date-time":"2025-11-22T00:46:08Z","timestamp":1763772368000},"page":"204-215","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Human umbilical cord MSC-derived exosomes attenuate radiation-induced pulmonary fibrosis via remodeling the gut-lung axis in mice"],"prefix":"10.1016","volume":"48","author":[{"given":"Yan","family":"Zhou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haonan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaodie","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xing","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengjuan","family":"Shang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kewei","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5750-6000","authenticated-orcid":false,"given":"Guirong","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.lssr.2025.11.011_bib0001","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2021.600711","article-title":"Mesenchymal stromal cell-derived extracellular vesicles in lung diseases: current status and perspectives","volume":"9","author":"Abreu","year":"2021","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.lssr.2025.11.011_bib0002","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/bs.pmbts.2022.07.003","article-title":"Structure, functions, and diversity of the healthy human microbiome","volume":"191","author":"Ahrodia","year":"2022","journal-title":"Prog. Mol. Biol. Transl. Sci."},{"key":"10.1016\/j.lssr.2025.11.011_bib0003","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1165\/rcmb.2018-0180OC","article-title":"Glutaminolysis epigenetically regulates antiapoptotic gene expression in idiopathic pulmonary fibrosis fibroblasts","volume":"60","author":"Bai","year":"2019","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"10.1016\/j.lssr.2025.11.011_bib0004","doi-asserted-by":"crossref","first-page":"5886","DOI":"10.1038\/s41467-020-19701-0","article-title":"Disease-associated gut microbiome and metabolome changes in patients with chronic obstructive pulmonary disease","volume":"11","author":"Bowerman","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.lssr.2025.11.011_bib0005","doi-asserted-by":"crossref","first-page":"65","DOI":"10.3390\/antiox11010065","article-title":"Gut microbiota-derived PGF2\u03b1 fights against radiation-induced lung toxicity through the MAPK\/NF-\u03bab pathway","volume":"11","author":"Chen","year":"2022","journal-title":"Antioxidants"},{"key":"10.1016\/j.lssr.2025.11.011_bib0006","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.tranon.2018.09.009","article-title":"Advances in molecular mechanisms and treatment of radiation-induced pulmonary fibrosis","volume":"12","author":"Chen","year":"2019","journal-title":"Transl. Oncol."},{"key":"10.1016\/j.lssr.2025.11.011_bib0007","doi-asserted-by":"crossref","DOI":"10.3389\/fcimb.2024.1258246","article-title":"The mechanism of gut-lung axis in pulmonary fibrosis","volume":"14","author":"Dong","year":"2024","journal-title":"Front. Cell Infect. Microbiol."},{"key":"10.1016\/j.lssr.2025.11.011_bib0008","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.radonc.2015.09.001","article-title":"Radiation-induced lung damage - clinical risk profiles and predictive imaging on their way to risk-adapted individualized treatment planning?","volume":"117","author":"Ebert","year":"2015","journal-title":"RadiOther Oncol."},{"key":"10.1016\/j.lssr.2025.11.011_bib0009","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1165\/rcmb.2019-0119ED","article-title":"Preventing glutaminolysis: a potential therapy for pulmonary fibrosis","volume":"61","author":"Esguerra","year":"2019","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"10.1016\/j.lssr.2025.11.011_bib0010","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1186\/s12890-021-01783-1","article-title":"Efficacy of antifibrotic drugs, nintedanib and pirfenidone, in treatment of progressive pulmonary fibrosis in both idiopathic pulmonary fibrosis (IPF) and non-IPF: a systematic review and meta-analysis","volume":"21","author":"Finnerty","year":"2021","journal-title":"BMC. Pulm. Med."},{"key":"10.1016\/j.lssr.2025.11.011_bib0011","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1165\/rcmb.2019-0008OC","article-title":"Glutamine metabolism is required for collagen protein synthesis in lung fibroblasts","volume":"61","author":"Hamanaka","year":"2019","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"10.1016\/j.lssr.2025.11.011_bib0012","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1186\/s13287-021-02378-7","article-title":"Mesenchymal stem\/stromal cell-derived exosomes in regenerative medicine and cancer; overview of development, challenges, and opportunities","volume":"12","author":"Hassanzadeh","year":"2021","journal-title":"Stem Cell Res. Ther."},{"key":"10.1016\/j.lssr.2025.11.011_bib0013","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2024.1469696","article-title":"Mesenchymal stem cell application in pulmonary disease treatment with emphasis on their interaction with lung-resident immune cells","volume":"15","author":"Hazrati","year":"2024","journal-title":"Front. Immunol."},{"key":"10.1016\/j.lssr.2025.11.011_bib0014","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-024-80023-y","article-title":"Triangle correlations of lung microbiome, host physiology and gut microbiome in a rat model of idiopathic pulmonary fibrosis","volume":"14","author":"Hou","year":"2024","journal-title":"Sci. Rep."},{"key":"10.1016\/j.lssr.2025.11.011_bib0015","doi-asserted-by":"crossref","first-page":"2212","DOI":"10.1097\/CM9.0000000000000928","article-title":"Gut-lymph-lung pathway mediates sepsis-induced acute lung injury","volume":"133","author":"Jin","year":"2020","journal-title":"Chin. Med. J."},{"key":"10.1016\/j.lssr.2025.11.011_bib0016","doi-asserted-by":"crossref","DOI":"10.36877\/pmmb.a0000396","article-title":"The role of Human gut microbe ruminococcus gnavus in inflammatory diseases","volume":"6","author":"Kandasamy","year":"2023","journal-title":"Prog. Microbes Mol. Biol."},{"key":"10.1016\/j.lssr.2025.11.011_bib0017","article-title":"The roles of glutamine in the intestine and its implication in intestinal diseases","volume":"18","author":"Kim","year":"2017","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.lssr.2025.11.011_bib0018","doi-asserted-by":"crossref","first-page":"148","DOI":"10.4103\/0253-7613.16210","article-title":"l-glutamic acid and glutamine: exciting molecules of clinical interest","volume":"37","author":"Kulkarni Chanda","year":"2005","journal-title":"Indian J. Pharmacol."},{"key":"10.1016\/j.lssr.2025.11.011_bib0019","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2022.984429","article-title":"Abscopal effects of thoracic X-ray radiation on spermatogenesis in mice","volume":"13","author":"Lai","year":"2022","journal-title":"Front. Physiol."},{"key":"10.1016\/j.lssr.2025.11.011_bib0020","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1089\/ars.2019.7965","article-title":"Mesenchymal stem cell-derived extracellular vesicles attenuate radiation-induced lung injury via miRNA-214-3p","volume":"35","author":"Lei","year":"2021","journal-title":"Antioxid. Redox. Signal."},{"issue":"1","key":"10.1016\/j.lssr.2025.11.011_bib0021","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1038\/s41392-025-02262-3","article-title":"Clinical investigation on nebulized human umbilical cord MSC-derived extracellular vesicles for pulmonary fibrosis treatment","volume":"10","author":"Li","year":"2025","journal-title":"Signal. Transduct. Target. Ther."},{"key":"10.1016\/j.lssr.2025.11.011_bib0022","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2020.110826","article-title":"Effects of phycocyanin on pulmonary and gut microbiota in a radiation-induced pulmonary fibrosis model","volume":"132","author":"Li","year":"2020","journal-title":"Biomed. PharmacOther"},{"key":"10.1016\/j.lssr.2025.11.011_bib0023","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1186\/s13046-022-02351-z","article-title":"Mouse mesenchymal stem cell-derived exosomal miR-466f-3p reverses EMT process through inhibiting AKT\/GSK3beta pathway via c-MET in radiation-induced lung injury","volume":"41","author":"Li","year":"2022","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"10.1016\/j.lssr.2025.11.011_bib0024","doi-asserted-by":"crossref","first-page":"4557","DOI":"10.1002\/ptr.7926","article-title":"Cryptotanshinone alleviates radiation-induced lung fibrosis via modulation of gut microbiota and bile acid metabolism","volume":"37","author":"Li","year":"2023","journal-title":"PhytOther Res."},{"key":"10.1016\/j.lssr.2025.11.011_bib0025","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.3390\/biomedicines9091181","article-title":"Promising biomarkers of radiation-induced lung injury: a review","volume":"9","author":"Liu","year":"2021","journal-title":"Biomedicines"},{"key":"10.1016\/j.lssr.2025.11.011_bib0026","doi-asserted-by":"crossref","DOI":"10.1016\/j.micpath.2024.107245","article-title":"Exploring the effects of lactulose on lung-intestinal tissue-associated factors and the TLR4\/NF-kappaB signaling pathway in COPD rats based on lung-gut axis theory","volume":"199","author":"Liu","year":"2025","journal-title":"Microb. Pathog."},{"key":"10.1016\/j.lssr.2025.11.011_bib0027","doi-asserted-by":"crossref","DOI":"10.3390\/ijms232214331","article-title":"Tocotrienol-rich fractions offer potential to suppress pulmonary fibrosis progression","volume":"23","author":"Lu","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.lssr.2025.11.011_bib0028","doi-asserted-by":"crossref","DOI":"10.3390\/ijms252011259","article-title":"The gut microbiome advances precision medicine and diagnostics for inflammatory bowel diseases","volume":"25","author":"Mousa","year":"2024","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.lssr.2025.11.011_bib0029","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1002\/cyto.a.23242","article-title":"Isolation, cultivation, and characterization of human mesenchymal stem cells","volume":"93","author":"Mushahary","year":"2018","journal-title":"Cytom. A"},{"key":"10.1016\/j.lssr.2025.11.011_bib0030","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2025.139962","article-title":"High-viscosity dietary fibers modulate gut microbiota and liver metabolism to prevent obesity in high-fat diet-fed mice","volume":"298","author":"Nagano","year":"2025","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.lssr.2025.11.011_bib0031","doi-asserted-by":"crossref","DOI":"10.1155\/2016\/1073140","article-title":"Extracellular vesicles: evolving factors in stem cell biology","volume":"2016","author":"Nawaz","year":"2016","journal-title":"Stem Cells Int."},{"key":"10.1016\/j.lssr.2025.11.011_bib0032","doi-asserted-by":"crossref","DOI":"10.3390\/microorganisms13051084","article-title":"Gut microbiota: an immersion in dysbiosis, associated pathologies, and probiotics","volume":"13","author":"Origuela","year":"2025","journal-title":"Microorganisms"},{"key":"10.1016\/j.lssr.2025.11.011_bib0033","article-title":"Comparative study of ectopic lymphoid aggregates in sheep and murine models of bleomycin-induced pulmonary fibrosis","volume":"2023","author":"Perera","year":"2023","journal-title":"Can. Respir. J."},{"key":"10.1016\/j.lssr.2025.11.011_bib0034","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2022.868086","article-title":"COPD and gut-lung axis: how microbiota and host inflammasome influence COPD and related therapeutics","volume":"13","author":"Qu","year":"2022","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.lssr.2025.11.011_bib0035","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2022.985223","article-title":"The gut-lung axis: gut microbiota changes associated with pulmonary fibrosis in mouse models induced by bleomycin","volume":"13","author":"Quan","year":"2022","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.lssr.2025.11.011_bib0036","doi-asserted-by":"crossref","DOI":"10.1128\/mbio.00039-24","article-title":"Ruminococcus torques is a keystone degrader of intestinal mucin glycoprotein, releasing oligosaccharides used byBacteroides thetaiotaomicron","volume":"15","author":"Schaus","year":"2024","journal-title":"mBio"},{"key":"10.1016\/j.lssr.2025.11.011_bib0037","doi-asserted-by":"crossref","first-page":"iqae008","DOI":"10.1093\/oxfimm\/iqae008","article-title":"The gut-lung axis: the impact of the gut mycobiome on pulmonary diseases and infections","volume":"5","author":"Sey","year":"2024","journal-title":"Oxf. Open. Immunol."},{"key":"10.1016\/j.lssr.2025.11.011_bib0038","doi-asserted-by":"crossref","DOI":"10.1016\/j.cellimm.2025.104933","article-title":"Nebulized mesenchymal stem cell-derived exosomes attenuate airway inflammation in a rat model of chronic obstructive pulmonary disease","volume":"409-410","author":"Wang","year":"2025","journal-title":"Cell Immunol."},{"key":"10.1016\/j.lssr.2025.11.011_bib0039","doi-asserted-by":"crossref","first-page":"3571","DOI":"10.1038\/s41598-024-53842-2","article-title":"Effects of radiofrequency field from 5G communication on fecal microbiome and metabolome profiles in mice","volume":"14","author":"Wang","year":"2024","journal-title":"Sci. Rep."},{"key":"10.1016\/j.lssr.2025.11.011_bib0040","doi-asserted-by":"crossref","DOI":"10.1080\/20013078.2017.1396823","article-title":"Updating the MISEV minimal requirements for extracellular vesicle studies: building bridges to reproducibility","volume":"6","author":"Witwer","year":"2017","journal-title":"J. ExtraCell Vesicles."},{"issue":"1","key":"10.1016\/j.lssr.2025.11.011_bib0041","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1186\/s12951-024-02830-9","article-title":"S-RBD-modified and miR-486-5p-engineered exosomes derived from mesenchymal stem cells suppress ferroptosis and alleviate radiation-induced lung injury and long-term pulmonary fibrosis","volume":"22","author":"Zhang","year":"2024","journal-title":"J. Nanobiotechn."},{"key":"10.1016\/j.lssr.2025.11.011_bib0042","article-title":"Intestinal-pulmonary axis: a 'Force for good' against respiratory viral infections","volume":"16","author":"Zhu","year":"2025","journal-title":"Front. Immunol."}],"container-title":["Life Sciences in Space Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2214552425001397?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2214552425001397?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T02:50:59Z","timestamp":1769136659000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2214552425001397"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":42,"alternative-id":["S2214552425001397"],"URL":"https:\/\/doi.org\/10.1016\/j.lssr.2025.11.011","relation":{},"ISSN":["2214-5524"],"issn-type":[{"value":"2214-5524","type":"print"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Human umbilical cord MSC-derived exosomes attenuate radiation-induced pulmonary fibrosis via remodeling the gut-lung axis in mice","name":"articletitle","label":"Article Title"},{"value":"Life Sciences in Space Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.lssr.2025.11.011","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier B.V. on behalf of Committee on Space Research (COSPAR).","name":"copyright","label":"Copyright"}]}}