{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T10:02:51Z","timestamp":1789725771084,"version":"4.0.1"},"reference-count":61,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100002852","name":"China Astronaut Research and Training Center State Key Laboratory of Space Medicine Fundamentals and Application","doi-asserted-by":"publisher","award":["HYZ1XK02003"],"award-info":[{"award-number":["HYZ1XK02003"]}],"id":[{"id":"10.13039\/501100002852","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100018206","name":"Experiment","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100018206","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82274056"],"award-info":[{"award-number":["82274056"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Life Sciences in Space Research"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.lssr.2026.02.007","type":"journal-article","created":{"date-parts":[[2026,2,14]],"date-time":"2026-02-14T16:32:45Z","timestamp":1771086765000},"page":"154-169","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Gastrodia elata Blume (Tianma) extract mitigates simulated microgravity\u2013induced oxidative stress and enhance learning and memory in Caenorhabditis elegans"],"prefix":"10.1016","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-1955-9455","authenticated-orcid":false,"given":"Muhammad Zulqarnain","family":"Shakir","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inam","family":"Ullah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad Wasim","family":"Usmani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiang","family":"Ning","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jixian","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuchen","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yufen","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guanghua","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiaobei","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huabiao","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad","family":"Imran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad","family":"Ashraf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ning","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinmin","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.lssr.2026.02.007_bib0001","first-page":"1","article-title":"The NASA Twins Study: a multidimensional analysis of a year-long human spaceflight","volume":"144","author":"Al","year":"2019","journal-title":"Science (80-.)"},{"key":"10.1016\/j.lssr.2026.02.007_bib0002","unstructured":"Ali, M., 1969. Life Sciences in Space Research insights into neurobiology and neurophysiology of C. Elegans: A review of real spaceflight and stimulated microgravity effects on the nervous system title page review article real spaceflight and simulated microgravity ef."},{"key":"10.1016\/j.lssr.2026.02.007_bib0003","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41526-024-00418-z","article-title":"Advancing insights into microgravity induced muscle changes using Caenorhabditis elegans as a model organism","volume":"10","author":"Beckett","year":"2024","journal-title":"NPJ. Microgravity."},{"key":"10.1016\/j.lssr.2026.02.007_bib0004","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1146\/annurev.pharmtox.43.100901.135934","article-title":"The caenorhabditis elegans dopaminergic system: opportunities for insights into dopamine transport and neurodegeneration","volume":"43","author":"Blakely","year":"2003","journal-title":"Annu. Rev. Pharmacol. Toxicol"},{"key":"10.1016\/j.lssr.2026.02.007_bib0005","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1038\/nn.2526","article-title":"Neuropeptide feedback modifies odor-evoked dynamics in C . Elegans olfactory neurons","volume":"13","author":"Chalasani","year":"2010","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.lssr.2026.02.007_bib0006","article-title":"Chemosensation in C","author":"Chemosensation","year":"2006","journal-title":"Elegans"},{"key":"10.1016\/j.lssr.2026.02.007_bib0007","first-page":"51","article-title":"Protective effects of compound Gastrodia elata formula on the cognitive impairment induced by simulated weightlessness in mice","volume":"48","author":"Chen","year":"2026","journal-title":"Life Sci. Sp. Res."},{"key":"10.1016\/j.lssr.2026.02.007_bib0008","first-page":"1","article-title":"Protective effect of Gastrodia elata blume ameliorates simulated weightlessness-induced cognitive impairment in mice","volume":"36","author":"Chen","year":"2023","journal-title":"Life Sci. Sp. Res."},{"key":"10.1016\/j.lssr.2026.02.007_bib0009","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.3390\/cells12071043","article-title":"Current knowledge about the impact of microgravity on gene regulation","volume":"12","author":"Corydon","year":"2023","journal-title":"Cells"},{"key":"10.1016\/j.lssr.2026.02.007_bib0010","first-page":"1071","article-title":"Bradscholars Caenorhabditis elegans in microgravity : an omics perspective Caenorhabditis elegans in microgravity : an omics perspective","volume":"2","author":"Craig","year":"2023","journal-title":"iScience"},{"key":"10.1016\/j.lssr.2026.02.007_bib0011","first-page":"1","article-title":"Immune system dysregulation during spaceflight : potential countermeasures for deep space exploration missions","volume":"9","author":"Crucian","year":"2018","journal-title":"Front. Physiol."},{"key":"10.1016\/j.lssr.2026.02.007_bib0012","article-title":"Mitochondrial oxidative stress impairs energy metabolism and reduces stress resistance and longevity of C","volume":"2019","author":"Dilberger","year":"2019","journal-title":"Elegans. Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.lssr.2026.02.007_bib0014","doi-asserted-by":"crossref","first-page":"2037","DOI":"10.1016\/j.cub.2016.06.002","article-title":"The transcription factor ATF5 mediates a mammalian mitochondrial UPR","volume":"26","author":"Fiorese","year":"2016","journal-title":"Curr. Biol."},{"key":"10.1016\/j.lssr.2026.02.007_bib0015","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1111\/j.1474-9726.2005.00153.x","article-title":"In vivo spectrofluorimetry reveals endogenous biomarkers that report healthspan and dietary restriction in Caenorhabditis elegans","volume":"4","author":"Gerstbrein","year":"2005","journal-title":"Aging Cell"},{"key":"10.1016\/j.lssr.2026.02.007_bib0016","first-page":"629","article-title":"Behavioral analysis of learning and memory in C","author":"Giles","year":"2007","journal-title":"Elegans. Learn. Mem. A Compr. Ref."},{"key":"10.1016\/j.lssr.2026.02.007_bib0017","doi-asserted-by":"crossref","first-page":"816","DOI":"10.3390\/stresses4040054","article-title":"Improving cognitive and chemosensory function in Caenorhabditis elegans through polyphenol-rich sugarcane extract","volume":"4","author":"Heydarian","year":"2024","journal-title":"Stresses"},{"key":"10.1016\/j.lssr.2026.02.007_bib0018","doi-asserted-by":"crossref","first-page":"7266","DOI":"10.3390\/molecules15107266","article-title":"The Nrf2 system as a potential target for the development of indirect antioxidants","volume":"15","author":"Jung","year":"2010","journal-title":"Molecules."},{"key":"10.1016\/j.lssr.2026.02.007_bib0019","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1146\/annurev.pharmtox.46.120604.141046","article-title":"Cell survival responses to environmental stresses via the Keap1-Nrf2-ARE pathway","volume":"47","author":"Kensler","year":"2007","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"10.1016\/j.lssr.2026.02.007_bib0020","article-title":"Comparative analysis of muscle atrophy during spaceflight, nutritional deficiency and disuse in the nematode Caenorhabditis elegans","volume":"24","author":"Kim","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.lssr.2026.02.007_bib0021","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2018.101065","article-title":"Redox biology strategies to detect mitochondrial oxidants","volume":"21","author":"Kowaltowski","year":"2019","journal-title":"Redox. Biol."},{"key":"10.1016\/j.lssr.2026.02.007_bib0022","doi-asserted-by":"crossref","DOI":"10.3390\/antiox11020268","article-title":"A potential probiotic Lactobacillus plantarum JBC5 improves longevity and healthy aging by modulating antioxidative, innate immunity and serotonin-signaling pathways in Caenorhabditis elegans","volume":"11","author":"Kumar","year":"2022","journal-title":"Antioxidants"},{"key":"10.1016\/j.lssr.2026.02.007_bib0023","doi-asserted-by":"crossref","unstructured":"Laranjeiro, R., Harinath, G., Pollard, A.K., Gaffney, C.J., Deane, C.S., Vanapalli, S.A., Etheridge, T., Szewczyk, N.J., Driscoll, M., 2020. Spaceflight affects neuronal morphology and alters transcellular degradation of neuronal debris in adult Caenorhabditis elegans 1\u201340.","DOI":"10.1101\/2020.11.10.377143"},{"key":"10.1016\/j.lssr.2026.02.007_bib0024","doi-asserted-by":"crossref","DOI":"10.1016\/j.fitote.2025.106921","article-title":"Investigation of Kai-Xin-San in alleviating cognitive impairment in a\u03b2 transgenic Caenorhabditis elegans through mitochondrial function regulation","volume":"187","author":"Li","year":"2025","journal-title":"Fitoterapia"},{"key":"10.1016\/j.lssr.2026.02.007_bib0025","first-page":"1","article-title":"Mitochondrial unfolded protein response to microgravity stress in nematode Caenorhabditis elegans","volume":"9","author":"Liu","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.lssr.2026.02.007_bib0026","first-page":"1","article-title":"Mitochondrial unfolded protein response to microgravity stress in nematode Caenorhabditis elegans","volume":"6","author":"Liu","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.lssr.2026.02.007_bib0027","doi-asserted-by":"crossref","DOI":"10.1155\/2020\/1293935","article-title":"Secoisolariciresinol diglucoside delays the progression of aging-related diseases and extends the lifespan of Caenorhabditis elegans via DAF-16 and HSF-1","volume":"2020","author":"Lu","year":"2020","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.lssr.2026.02.007_bib0028","doi-asserted-by":"crossref","DOI":"10.3390\/molecules28052235","article-title":"Polygonati rhizoma polysaccharide prolongs lifespan and healthspan in Caenorhabditis elegans","volume":"28","author":"Luan","year":"2023","journal-title":"Molecules."},{"key":"10.1016\/j.lssr.2026.02.007_bib0029","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s40360-020-00455-w","article-title":"Lipopolysaccharide exposure induces oxidative damage in Caenorhabditis elegans: protective effects of carnosine","volume":"21","author":"Ma","year":"2020","journal-title":"BMC Pharmacol. Toxicol."},{"key":"10.1016\/j.lssr.2026.02.007_bib0030","doi-asserted-by":"crossref","unstructured":"Meng, F., Li, J., Rao, Y., Wang, W., Fu, Y., 2017. A Chinese Herbal formula, Gengnianchun, ameliorates ? -amyloid peptide toxicity in a Caenorhabditis elegans model of Alzheimer \u2019 s Disease 2017. https:\/\/doi.org\/10.1155\/2017\/7480980.","DOI":"10.1155\/2017\/7480980"},{"key":"10.1016\/j.lssr.2026.02.007_bib0031","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1016\/j.devcel.2008.03.002","article-title":"Article sensory signaling-dependent remodeling of olfactory cilia architecture in C","volume":"1","author":"Mukhopadhyay","year":"2008","journal-title":"Elegans. Dev. Cell"},{"key":"10.1016\/j.lssr.2026.02.007_bib0032","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41526-021-00171-7","article-title":"The effects of real and simulated microgravity on cellular mitochondrial function","volume":"7","author":"Nguyen","year":"2021","journal-title":"NPJ. Microgravity."},{"key":"10.1016\/j.lssr.2026.02.007_bib0033","first-page":"288","article-title":"Mitohormesis: promoting health and lifespan by increased levels of reactive oxygen species (ros)","volume":"12","author":"Of","year":"2014","journal-title":"Nonlinearity Biol. Toxicol. Med."},{"key":"10.1016\/j.lssr.2026.02.007_bib0034","article-title":"Spaceflight affects neuronal morphology and alters transcellular degradation of neuronal debris in adult Caenorhabditis elegans","volume":"24","author":"Pollard","year":"2021","journal-title":"iScience"},{"key":"10.1016\/j.lssr.2026.02.007_bib0035","doi-asserted-by":"crossref","first-page":"1445","DOI":"10.1007\/s11064-010-0205-4","article-title":"Protective effects of flavonoids against oxidative stress induced by simulated microgravity in SH-SY5Y cells","volume":"35","author":"Qu","year":"2010","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.lssr.2026.02.007_bib0036","unstructured":"Rhizoma, P., Prolongs, P., 2023. Polygonati rhizoma polysaccharide prolongs lifespan and healthspan in Caenorhabditis elegans."},{"key":"10.1016\/j.lssr.2026.02.007_bib0037","doi-asserted-by":"crossref","first-page":"12395","DOI":"10.1039\/D1FO02823E","article-title":"Ginkgo seed extract promotes longevity and stress resistance of: caenorhabditis elegans","volume":"12","author":"Shen","year":"2021","journal-title":"Food Funct."},{"key":"10.1016\/j.lssr.2026.02.007_bib0038","doi-asserted-by":"crossref","DOI":"10.3892\/br.2023.1620","article-title":"Protective effect of Gastrodia elata Blume in a Caenorhabditis elegans model of Alzheimer\u2019s disease based on network pharmacology","volume":"18","author":"Shi","year":"2023","journal-title":"Biomed. Reports"},{"key":"10.1016\/j.lssr.2026.02.007_bib0039","first-page":"1","article-title":"The protective effects of gastrodin on neurological disorders : an update and future perspectives","volume":"2024","author":"Shi","year":"2024","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.lssr.2026.02.007_bib0040","first-page":"1","article-title":"Paving the way to better understand the effects of prolonged space fl ight on operational performance and its neural bases","volume":"9","author":"Stahn","year":"2021","journal-title":"NPJ. Microgravity."},{"key":"10.1016\/j.lssr.2026.02.007_bib0041","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1007\/s10339-021-01050-5","article-title":"Brains in space : the importance of understanding the impact of long \u2011 duration spaceflight on spatial cognition and its neural circuitry","volume":"22","author":"Stahn","year":"2021","journal-title":"Cogn. Process."},{"key":"10.1016\/j.lssr.2026.02.007_bib0042","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1007\/s00198-012-2028-4","article-title":"Treatment of hydrogen molecule abates oxidative stress and alleviates bone loss induced by modeled microgravity in rats","volume":"24","author":"Sun","year":"2013","journal-title":"Osteoporos. Int."},{"key":"10.1016\/j.lssr.2026.02.007_bib0043","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.1016\/j.asr.2008.03.017","article-title":"Description of International Caenorhabditis elegans Experiment first flight (ICE-FIRST)","volume":"42","author":"Szewczyk","year":"2008","journal-title":"Adv. Sp. Res."},{"key":"10.1016\/j.lssr.2026.02.007_bib0044","doi-asserted-by":"crossref","first-page":"5769","DOI":"10.1111\/jcmm.16600","article-title":"Gastrodin induces lysosomal biogenesis and autophagy to prevent the formation of foam cells via AMPK- \u00ad TFEB signalling axis","volume":"25","author":"Tao","year":"2021","journal-title":"J. Cell. Mol. Med."},{"key":"10.1016\/j.lssr.2026.02.007_bib0045","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1007\/s00221-023-06765-9","article-title":"Autophagy and UPS pathway contribute to nicotine-induced protection effect in Parkinson\u2019s disease","volume":"242","author":"Ullah","year":"2024","journal-title":"Exp. Brain Res"},{"key":"10.1016\/j.lssr.2026.02.007_bib0046","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1191\/0960327102ht218oa","article-title":"Defining hormesis: comments on Calabrese and Baldwin (2002)","volume":"21","author":"Vancouver","year":"2002","journal-title":"Hum. Exp. Toxicol."},{"key":"10.1016\/j.lssr.2026.02.007_bib0047","first-page":"1","article-title":"Neuropharmacological effects of Gastrodia elata Blume and its active ingredients","volume":"16","author":"Wang","year":"2025","journal-title":"Front. Neurol."},{"key":"10.1016\/j.lssr.2026.02.007_bib0048","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13578-022-00747-0","article-title":"Insight into the mitochondrial unfolded protein response and cancer: opportunities and challenges","volume":"12","author":"Wang","year":"2022","journal-title":"Cell Biosci."},{"key":"10.1016\/j.lssr.2026.02.007_bib0049","first-page":"1","article-title":"Effects of orange extracts on longevity, healthspan, and stress resistance in Caenorhabditis elegans","volume":"25","author":"Wang","year":"2020","journal-title":"Molecules."},{"key":"10.1016\/j.lssr.2026.02.007_bib0050","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbi.2024.111036","article-title":"Gelsenicine disrupted the intestinal barrier of Caenorhabditis elegans","volume":"395","author":"Wu","year":"2024","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.lssr.2026.02.007_bib0051","doi-asserted-by":"crossref","DOI":"10.3390\/ijms25179655","article-title":"Clerodendranthus spicatus (Thunb.) water extracts reduce lipid accumulation and oxidative stress in the Caenorhabditis elegans","volume":"25","author":"Xiao","year":"2024","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.lssr.2026.02.007_bib0052","unstructured":"Xiao, Y., Hong, C., Liu, F., Shi, D., Zhu, X., Yu, C., Jiang, N., Li, S., Liu, Y., 2024. Infection in Caenorhabditis elegans via the transcription 1\u201310."},{"key":"10.1016\/j.lssr.2026.02.007_bib0053","article-title":"Mitochondrial protective effects of black goji berry anthocyanins in Caenorhabditis elegans: defenses against oxidative stress","volume":"63","author":"Xu","year":"2025","journal-title":"Food Biosci."},{"key":"10.1016\/j.lssr.2026.02.007_bib0054","doi-asserted-by":"crossref","first-page":"2608","DOI":"10.3390\/ijms19092608","article-title":"Effects of iron overload and oxidative damage on the musculoskeletal system in the space environment : data from spaceflights and Ground-based Simulation Models","volume":"19","author":"Yang","year":"2018","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.lssr.2026.02.007_bib0055","first-page":"1","article-title":"Magnolol extends lifespan and improves age-related neurodegeneration in Caenorhabditis elegans via increase of stress resistance","volume":"14","author":"Yu","year":"2024","journal-title":"Sci. Rep."},{"key":"10.1016\/j.lssr.2026.02.007_bib0056","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fnagi.2024.1414956","article-title":"P-hydroxybenzaldehyde protects Caenorhabditis elegans from oxidative stress and \u03b2-amyloid toxicity","volume":"16","author":"Yu","year":"2024","journal-title":"Front. Aging Neurosci."},{"key":"10.1016\/j.lssr.2026.02.007_bib0057","doi-asserted-by":"crossref","DOI":"10.1007\/s10522-025-10322-y","article-title":"Hyperoside extends lifespan in Caenorhabditis elegans through SEK-1\/PMK-1\/SKN-1 pathway","volume":"26","author":"Yu","year":"2025","journal-title":"Biogerontology."},{"key":"10.1016\/j.lssr.2026.02.007_bib0058","first-page":"1","article-title":"Mitochondrial regulation of NADPH oxidase in hindlimb unweighting rat cerebral arteries","volume":"9","author":"Zhang","year":"2014","journal-title":"PLoS. One"},{"key":"10.1016\/j.lssr.2026.02.007_bib0059","doi-asserted-by":"crossref","DOI":"10.1016\/j.exger.2021.111388","article-title":"Immunomodulatory effect of pentagalloyl glucose in LPS-stimulated RAW264.7 macrophages and PAO1-induced Caenorhabditis elegans","volume":"150","author":"Zhang","year":"2021","journal-title":"Exp. Gerontol."},{"key":"10.1016\/j.lssr.2026.02.007_bib0060","first-page":"1","article-title":"Oxidative stress on the ground and in the microgravity environment: pathophysiological effects and treatment","volume":"14","author":"Zhang","year":"2025","journal-title":"Antioxidants"},{"key":"10.1016\/j.lssr.2026.02.007_bib0061","first-page":"1","article-title":"Fresh Gastrodia elata Blume alleviates simulated weightlessness-induced cognitive impairment by regulating in fl ammatory and apoptosis-related pathways","author":"Zhang","year":"2023","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.lssr.2026.02.007_bib0062","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2019.135623","article-title":"Toxicity induction of nanopolystyrene under microgravity stress condition in Caenorhabditis elegans","volume":"703","author":"Zhao","year":"2020","journal-title":"Sci. Total Environ."}],"container-title":["Life Sciences in Space Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2214552426000428?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2214552426000428?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T09:09:56Z","timestamp":1789722596000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2214552426000428"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":61,"alternative-id":["S2214552426000428"],"URL":"https:\/\/doi.org\/10.1016\/j.lssr.2026.02.007","relation":{},"ISSN":["2214-5524"],"issn-type":[{"value":"2214-5524","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Gastrodia elata Blume (Tianma) extract mitigates simulated microgravity\u2013induced oxidative stress and enhance learning and memory in Caenorhabditis elegans","name":"articletitle","label":"Article Title"},{"value":"Life Sciences in Space Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.lssr.2026.02.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Committee on Space Research (COSPAR). Published by Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}