{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T22:52:36Z","timestamp":1790895156761,"version":"4.1.0"},"reference-count":37,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2004,5,1]],"date-time":"2004-05-01T00:00:00Z","timestamp":1083369600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Lung Cancer"],"published-print":{"date-parts":[[2004,5]]},"DOI":"10.1016\/j.lungcan.2003.10.008","type":"journal-article","created":{"date-parts":[[2003,12,30]],"date-time":"2003-12-30T12:05:34Z","timestamp":1072785934000},"page":"149-157","source":"Crossref","is-referenced-by-count":75,"title":["The utility and limitation of thyroid transcription factor-1 protein in primary and metastatic pulmonary neoplasms"],"prefix":"10.1016","volume":"44","author":[{"given":"Yih-Leong","family":"Chang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yung-Chie","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei-Yu","family":"Liao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen-Tu","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.lungcan.2003.10.008_BIB1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1242\/dev.101.1.1","article-title":"The molecular basis for metameric pattern in the drosophila embryo","volume":"101","author":"Akam","year":"1987","journal-title":"Development"},{"key":"10.1016\/j.lungcan.2003.10.008_BIB2","first-page":"445","article-title":"Surfactant proteins and thyroid transcription factor-1 in pulmonary and breast carcinomas","volume":"9","author":"Bejarano","year":"1996","journal-title":"Mod. Pathol."},{"key":"10.1016\/j.lungcan.2003.10.008_BIB3","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1023\/A:1006102607697","article-title":"Determination of lung as the primary site of cerebral metastatic adenocarcinomas using monoclonal antibody to thyroid transcription factor-1","volume":"40","author":"Bohinski","year":"1998","journal-title":"J. Neuro-Oncol."},{"key":"10.1016\/j.lungcan.2003.10.008_BIB4","doi-asserted-by":"crossref","first-page":"11160","DOI":"10.1016\/S0021-9258(18)82105-6","article-title":"Cis-active elements controlling lung cell-specific expression of human pulmonary surfactant protein B gene","volume":"268","author":"Bohinski","year":"1993","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.lungcan.2003.10.008_BIB5","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1046\/j.1365-2559.2001.01224.x","article-title":"Primary signet ring cell adenocarcinomas of the lung: a clinicopathological study of 15 cases","volume":"39","author":"Castro","year":"2001","journal-title":"Histopathol."},{"key":"10.1016\/j.lungcan.2003.10.008_BIB6","doi-asserted-by":"crossref","first-page":"1531","DOI":"10.1097\/00000478-200011000-00009","article-title":"Pulmonary sclerosing hemangioma consistently expresses thyroid transcription factor-1 (TTF-1). A new clue to its histogenesis","volume":"24","author":"Chan","year":"2000","journal-title":"Am. J. Surg. Pathol."},{"key":"10.1016\/j.lungcan.2003.10.008_BIB7","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/S0169-5002(01)00224-0","article-title":"Pulmonary pleomorphic (spindle) cell carcinoma: peculiar clinicopathologic manifestations different from ordinary non-small cell carcinoma","volume":"34","author":"Chang","year":"2001","journal-title":"Lung Cancer"},{"key":"10.1016\/j.lungcan.2003.10.008_BIB8","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1097\/00000478-200206000-00004","article-title":"New aspects in clinicopathologic and oncogene studies of 23 pulmonary lymphoepithelioma-like carcinomas","volume":"26","author":"Chang","year":"2002","journal-title":"Am. J. Surg. Pathol."},{"key":"10.1016\/j.lungcan.2003.10.008_BIB9","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1097\/00000478-200007000-00002","article-title":"A clinicopathologic study or 100 cases of pulmonary sclerosing hemangioma with immunohistochemical studies. TTF-1 is expressed in both round and surface cells, suggesting an origin from primitive respiratory epithelium","volume":"24","author":"Devouassoux-Shisheboran","year":"2000","journal-title":"Am. J. Surg. Pathol."},{"key":"10.1016\/j.lungcan.2003.10.008_BIB10","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1136\/jcp.50.1.30","article-title":"Immunocytochemical expression of tissue specific transcription factor-1 in lung carcinoma","volume":"50","author":"Di Loreto","year":"1997","journal-title":"J. Clin. Pathol."},{"key":"10.1016\/j.lungcan.2003.10.008_BIB11","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/S0304-3835(97)00466-7","article-title":"TTF-1 protein expression in pleural malignant mesotheliomas and adenocarcinomas of the lung","volume":"124","author":"Di Loreto","year":"1998","journal-title":"Cancer Lett."},{"key":"10.1016\/j.lungcan.2003.10.008_BIB12","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1111\/j.1365-2559.1986.tb02498.x","article-title":"Cellular heterogeneity in lung cancer","volume":"10","author":"Dunill","year":"1986","journal-title":"Histopathology"},{"key":"10.1016\/j.lungcan.2003.10.008_BIB13","first-page":"4744","article-title":"Expression of thyroid-specific transcription factors TTF-1 and PAX-8 in human thyroid neoplasm","volume":"54","author":"Fabbro","year":"1994","journal-title":"Cancer Res."},{"key":"10.1016\/j.lungcan.2003.10.008_BIB14","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1016\/0959-8049(95)00560-9","article-title":"TTF-1 gene expression in human lung tumors","volume":"32A","author":"Fabbro","year":"1996","journal-title":"Eur. J. Cancer"},{"key":"10.1016\/j.lungcan.2003.10.008_BIB15","first-page":"5","article-title":"Thyroid transcription factor-1: Immunohistochemical evaluation in pulmonary neuroendocrine tumors","volume":"12","author":"Folpe","year":"1999","journal-title":"Mod. Pathol."},{"key":"10.1016\/j.lungcan.2003.10.008_BIB16","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1126\/science.2884726","article-title":"Homeo boxes in the study of development","volume":"236","author":"Gehring","year":"1987","journal-title":"Science"},{"key":"10.1016\/j.lungcan.2003.10.008_BIB17","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1309\/550P-QLJX-D84W-F6DN","article-title":"Mucinous and nonmucinous bronchioloalveolar adenocarcinomas have distinct staining patterns with thyroid transcription factor and cytokeratin 20 antibodies","volume":"16","author":"Goldstein","year":"2001","journal-title":"Am. J. Clin. Pathol."},{"key":"10.1016\/j.lungcan.2003.10.008_BIB18","doi-asserted-by":"crossref","first-page":"1382","DOI":"10.1159\/000332172","article-title":"Thyroid transcription factor-1 and cytokeratin 7 and 20 in pulmonary and breast carcinoma","volume":"42","author":"Harlamert","year":"1998","journal-title":"Acta. Cytol."},{"key":"10.1016\/j.lungcan.2003.10.008_BIB19","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1089\/hyb.1996.15.49","article-title":"Monoclonal antibody to thyroid transcription factor-1: production, characterization and usefulness in tumor diagnosis","volume":"15","author":"Holzinger","year":"1996","journal-title":"Hybridoma"},{"key":"10.1016\/j.lungcan.2003.10.008_BIB20","first-page":"519","article-title":"A tissue-specific transcription factor containing a homeodomin specifies a pituitary phenotype","volume":"61","author":"Ingraham","year":"1998","journal-title":"Cell"},{"key":"10.1016\/j.lungcan.2003.10.008_BIB21","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1016\/0092-8674(90)90658-2","article-title":"A new homeobox gene contributes the DNA binding domain of the t(1;19) translocation in pre-B ALL","volume":"60","author":"Kamps","year":"1990","journal-title":"Cell"},{"key":"10.1016\/j.lungcan.2003.10.008_BIB22","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1046\/j.1365-2559.2000.00801.x","article-title":"Thyroid transcription factor-1 is the superior immunohistochemical marker for pulmonary adenocarcinomas and large cell carcinomas compared to surfactant proteins A and B","volume":"36","author":"Kaufmann","year":"2000","journal-title":"Histopathology"},{"key":"10.1016\/j.lungcan.2003.10.008_BIB23","doi-asserted-by":"crossref","first-page":"6881","DOI":"10.1074\/jbc.271.12.6881","article-title":"Transcription of the lung-specific surfactant protein C gene is mediated by thyroid transcription factor 1","volume":"271","author":"Kelly","year":"1996","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.lungcan.2003.10.008_BIB24","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1016\/S0046-8177(99)90096-5","article-title":"Utility of surfactant protein B precursor and thyroid transcription factor 1 in differentiating adenocarcinoma of the lung from malignant mesothelioma","volume":"30","author":"Khoor","year":"1999","journal-title":"Hum. Pathol."},{"key":"10.1016\/j.lungcan.2003.10.008_BIB25","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1101\/gad.10.1.60","article-title":"The T\/ebp null mouse: thyroid-specific enhancer-binding protein is essential for the organogenesis of the thyroid, lung, ventral forebrain, and pituitary","volume":"10","author":"Kimura","year":"1996","journal-title":"Genes Dev."},{"key":"10.1016\/j.lungcan.2003.10.008_BIB26","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1242\/dev.113.4.1093","article-title":"The transcription factor TTF-1 is expressed at the onset of thyroid and lung morphogenesis and in restricted regions of the fetal brain","volume":"113","author":"Lazzaro","year":"1991","journal-title":"Development"},{"key":"10.1016\/j.lungcan.2003.10.008_BIB27","doi-asserted-by":"crossref","first-page":"1515","DOI":"10.1097\/00000478-200112000-00007","article-title":"Primary signet-ring cell carcinoma of lung. Immunohistochemical study and comparison with non-pulmonary signet-ring cell carcinomas","volume":"25","author":"Merchant","year":"2001","journal-title":"Am. J. Surg. Pathol."},{"key":"10.1016\/j.lungcan.2003.10.008_BIB28","doi-asserted-by":"crossref","first-page":"135S","DOI":"10.1378\/chest.111.6_Supplement.135S","article-title":"TTF-1 is an epithelial morphoregulatory transcriptional factor","volume":"111","author":"Minoo","year":"1997","journal-title":"Chest"},{"key":"10.1016\/j.lungcan.2003.10.008_BIB29","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.1097\/00000478-200009000-00004","article-title":"Value of thyroid transcription factor-1 immunostaining in distinguishing small cell lung carcinomas form other small cell carcinomas","volume":"24","author":"Ordonez","year":"2000","journal-title":"Am. J. Surg. Pathol."},{"key":"10.1016\/j.lungcan.2003.10.008_BIB30","first-page":"318","article-title":"Prognostic value of thyroid transcription factor-1 in primary, resected, non-small cell lung carcinoma","volume":"12","author":"Puglisi","year":"1999","journal-title":"Mod. Pathol."},{"key":"10.1016\/j.lungcan.2003.10.008_BIB31","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1097\/00000478-200303000-00004","article-title":"Pulmonary carcinomas with pleomorphic, sarcomatoid, or sarcomatous elements","volume":"27","author":"Rossi","year":"2003","journal-title":"Am. J. Surg. Pathol."},{"key":"10.1016\/j.lungcan.2003.10.008_BIB32","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1177\/44.7.8675988","article-title":"Expression of thyroid transcription factor-1 (TTF-1) in fetal and neonatal human lung","volume":"44","author":"Stahlman","year":"1996","journal-title":"J. Histochem. Cytochem."},{"issue":"Pt 1","key":"10.1016\/j.lungcan.2003.10.008_BIB33","first-page":"129","article-title":"The biochemical and Immunohistochemical profile of thyroid neoplasia","volume":"23","author":"Stanta","year":"1988","journal-title":"Pathol. Annu."},{"key":"10.1016\/j.lungcan.2003.10.008_BIB34","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1053\/hupa.2002.31299","article-title":"Expression of thyroid transcription factor-1 in the spectrum of neuroendocrine cell lung proliferations with special interest in carcinoids","volume":"33","author":"Sturm","year":"2002","journal-title":"Hum. Pathol."},{"key":"10.1016\/j.lungcan.2003.10.008_BIB35","first-page":"330","article-title":"Helix-loop-helix genes translocated in lymphoid leukemia","volume":"16","author":"Visvader","year":"1991","journal-title":"TIBS"},{"key":"10.1016\/j.lungcan.2003.10.008_BIB36","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1042\/bj2730249","article-title":"Function and regulation of expression of pulmonary surfactant-associated proteins","volume":"273","author":"Weaver","year":"1991","journal-title":"Biochem. J."},{"key":"10.1016\/j.lungcan.2003.10.008_BIB37","first-page":"359","article-title":"Regulation of Clara cell secretory protein gene transcription by thyroid transcription factor-1","volume":"1350","author":"Zhang","year":"1997","journal-title":"Biochem. Biophys. Acta"}],"container-title":["Lung Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0169500203005579?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0169500203005579?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,6,13]],"date-time":"2021-06-13T18:03:33Z","timestamp":1623607413000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0169500203005579"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,5]]},"references-count":37,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2004,5]]}},"alternative-id":["S0169500203005579"],"URL":"https:\/\/doi.org\/10.1016\/j.lungcan.2003.10.008","relation":{},"ISSN":["0169-5002"],"issn-type":[{"value":"0169-5002","type":"print"}],"subject":[],"published":{"date-parts":[[2004,5]]}}}