{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,31]],"date-time":"2026-01-31T12:17:53Z","timestamp":1769861873759,"version":"3.49.0"},"reference-count":12,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2005,11,1]],"date-time":"2005-11-01T00:00:00Z","timestamp":1130803200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Lung Cancer"],"published-print":{"date-parts":[[2005,11]]},"DOI":"10.1016\/j.lungcan.2005.05.022","type":"journal-article","created":{"date-parts":[[2005,7,18]],"date-time":"2005-07-18T09:51:22Z","timestamp":1121680282000},"page":"265-269","source":"Crossref","is-referenced-by-count":26,"title":["Gefitinib is also active for carcinomatous meningitis in NSCLC"],"prefix":"10.1016","volume":"50","author":[{"given":"Min Kyoung","family":"Kim","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyung Hee","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jae Kyo","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joon Hyuk","family":"Choi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Myung Soo","family":"Hyun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.lungcan.2005.05.022_bib1","series-title":"Cancer, principles and practice of oncology","first-page":"2333","article-title":"Carcinomatous meningitis","author":"Larson","year":"2005"},{"key":"10.1016\/j.lungcan.2005.05.022_bib2","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/S0169-5002(03)00189-2","article-title":"Epidermal growth factor receptor targeted therapy by ZD 1839 (Iressa) in patients with brain metastases from non-small cell lung cancer (NSCLC)","volume":"41","author":"Cappuzzo","year":"2003","journal-title":"Lung Cancer"},{"key":"10.1016\/j.lungcan.2005.05.022_bib3","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1159\/000081005","article-title":"Brain metastasis responding to gefitinib alone","volume":"67","author":"Poon","year":"2004","journal-title":"Oncology"},{"key":"10.1016\/j.lungcan.2005.05.022_bib4","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.lungcan.2004.05.014","article-title":"Gefitinib is active in patients with brain metastases from non-small cell lung cancer and response is related to skin toxicity","volume":"47","author":"Chiu","year":"2005","journal-title":"Lung Cancer"},{"key":"10.1016\/j.lungcan.2005.05.022_bib5","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1093\/annonc\/mdg153","article-title":"A case study documenting the anticancer activity of ZD1839 (Iressa) in the brain","volume":"14","author":"Villano","year":"2003","journal-title":"Ann Oncol"},{"key":"10.1016\/j.lungcan.2005.05.022_bib6","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1053\/ctrv.1999.0119","article-title":"Leptomeningeal carcinomatosis","volume":"25","author":"Grossman","year":"1999","journal-title":"Cancer Treat Rev"},{"key":"10.1016\/j.lungcan.2005.05.022_bib7","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1002\/(SICI)1097-0142(19980215)82:4<733::AID-CNCR17>3.0.CO;2-Z","article-title":"Cerebrospinal fluid cytology in patients with cancer: minimizing false-negative results","volume":"82","author":"Glantz","year":"1998","journal-title":"Cancer"},{"key":"10.1016\/j.lungcan.2005.05.022_bib8","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1002\/1097-0142(19820215)49:4<759::AID-CNCR2820490427>3.0.CO;2-7","article-title":"Diagnosis and treatment of leptomeningeal metastases from solid tumors: experience with 90 patients","volume":"49","author":"Wasserstrom","year":"1982","journal-title":"Cancer"},{"key":"10.1016\/j.lungcan.2005.05.022_bib9","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1097\/00001622-200111000-00012","article-title":"Tyrosine kinase inhibitors-ZD1839 (Iressa)","volume":"13","author":"Arteaga","year":"2001","journal-title":"Curr Opin Oncol"},{"key":"10.1016\/j.lungcan.2005.05.022_bib10","doi-asserted-by":"crossref","first-page":"1497","DOI":"10.1126\/science.1099314","article-title":"EGFR mutations in lung cancer: correlation with clinical response to gefitinib therapy","volume":"304","author":"Paez","year":"2004","journal-title":"Science"},{"key":"10.1016\/j.lungcan.2005.05.022_bib11","first-page":"3496","article-title":"Brain tumors in mice are susceptible to blockade of epidermal growth factor receptor (EGFR) with the oral, specific, EGFR-tyrosine kinase inhibitor ZD1839 (Iressa)","volume":"8","author":"Heimberger","year":"2002","journal-title":"Clin Cancer Res"},{"key":"10.1016\/j.lungcan.2005.05.022_bib12","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1200\/JCO.2005.04.057","article-title":"Practical management of patients with non-small-cell lung cancer treated with gefitinib","volume":"23","author":"Shah","year":"2005","journal-title":"J Clin Oncol"}],"container-title":["Lung Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0169500205002795?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0169500205002795?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,1,24]],"date-time":"2019-01-24T08:24:01Z","timestamp":1548318241000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0169500205002795"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,11]]},"references-count":12,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2005,11]]}},"alternative-id":["S0169500205002795"],"URL":"https:\/\/doi.org\/10.1016\/j.lungcan.2005.05.022","relation":{},"ISSN":["0169-5002"],"issn-type":[{"value":"0169-5002","type":"print"}],"subject":[],"published":{"date-parts":[[2005,11]]}}}