{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T20:58:31Z","timestamp":1761512311301},"reference-count":27,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2006,12,1]],"date-time":"2006-12-01T00:00:00Z","timestamp":1164931200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Lung Cancer"],"published-print":{"date-parts":[[2006,12]]},"DOI":"10.1016\/j.lungcan.2006.08.013","type":"journal-article","created":{"date-parts":[[2006,10,18]],"date-time":"2006-10-18T20:21:50Z","timestamp":1161202910000},"page":"353-357","source":"Crossref","is-referenced-by-count":7,"title":["Fractionated dose of cisplatin (CDDP) and vinorelbine (VNB) chemotherapy for elderly patients with advanced non-small cell lung cancer: Phase II trial"],"prefix":"10.1016","volume":"54","author":[{"given":"Lucio","family":"Buffoni","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diego","family":"Dongiovanni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carla","family":"Barone","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Camilla","family":"Fissore","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Davide","family":"Ottaviani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vincenzo","family":"Dongiovanni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raffaella","family":"Grillo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angelica","family":"Salvadori","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nadia","family":"Birocco","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marina","family":"Schena","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oscar","family":"Bertetto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"Suppl. 3","key":"10.1016\/j.lungcan.2006.08.013_bib1","first-page":"55","article-title":"Cancer in elderly patients: the population-based indexes in Europe (incidence, mortality, survival and prevalence)","volume":"9","author":"Vercelli","year":"1998","journal-title":"Ann Oncol"},{"key":"10.1016\/j.lungcan.2006.08.013_bib2","unstructured":"World Health Organization. WHO handbook for reporting results of cancer treatment, Geneva; 1997."},{"key":"10.1016\/j.lungcan.2006.08.013_bib3","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.1002\/(SICI)1097-0142(19971001)80:7<1273::AID-CNCR13>3.0.CO;2-4","article-title":"Cancer burne in the aged. An epidemiologic and demographic overview","volume":"80","author":"Yancik","year":"1997","journal-title":"Cancer"},{"key":"10.1016\/j.lungcan.2006.08.013_bib4","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1016\/S0272-5231(21)00909-6","article-title":"Lung cancer in the elderly patient","volume":"14","author":"Lee-Chiong","year":"1993","journal-title":"Clin Chest Med"},{"key":"10.1016\/j.lungcan.2006.08.013_bib5","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.1378\/chest.117.5.1239","article-title":"Who gets chemotherapy for metastatic lung cancer?","volume":"117","author":"Earle","year":"2000","journal-title":"Chest"},{"key":"10.1016\/j.lungcan.2006.08.013_bib6","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1634\/theoncologist.5-3-224","article-title":"Management of cancer in the older person: a practical approach","volume":"5","author":"Balducci","year":"2000","journal-title":"Oncologist"},{"key":"10.1016\/j.lungcan.2006.08.013_bib7","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/S1040-8428(99)00064-5","article-title":"Chemotherapy of advanced non-small cell lung cancer in the elderly: an update","volume":"35","author":"Gridelli","year":"2000","journal-title":"Crit Rev Oncol Hematol"},{"key":"10.1016\/j.lungcan.2006.08.013_bib8","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1080\/02841860151116402","article-title":"A systematic overview of chemotherapy effects in non-small cell lung cancer","volume":"40","author":"Sorenson","year":"2001","journal-title":"Acta Oncol"},{"key":"10.1016\/j.lungcan.2006.08.013_bib9","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1136\/bmj.311.7010.899","article-title":"Chemotherapy in non-small cell lung cancer: a meta-analysis using updated data on individual patients from 52 randomized clinical trials","volume":"311","year":"1995","journal-title":"BMJ"},{"key":"10.1016\/j.lungcan.2006.08.013_bib10","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1002\/1097-0142(20000715)89:2<328::AID-CNCR17>3.0.CO;2-F","article-title":"Weekly docetaxel in the treatment of elderly patients with advanced non-small cell lung carcinoma. A Minnie Pearl Cancer Research Network phase II trial","volume":"89","author":"Hainsworth","year":"2000","journal-title":"Cancer"},{"issue":"Suppl. 7","key":"10.1016\/j.lungcan.2006.08.013_bib11","first-page":"50","article-title":"Gemcitabine in the treatment of elderly patients with advanced non-small cell lung cancer","volume":"24","author":"Shepherd","year":"1997","journal-title":"Semin Oncol"},{"key":"10.1016\/j.lungcan.2006.08.013_bib12","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1093\/jnci\/91.1.66","article-title":"Effects of vinorelbine on quality of life and survival of elderly patients with advanced non-small cell lung cancer","volume":"91","year":"1999","journal-title":"J Natl Cancer Inst"},{"key":"10.1016\/j.lungcan.2006.08.013_bib13","doi-asserted-by":"crossref","first-page":"1463","DOI":"10.1002\/(SICI)1097-0142(19991015)86:8<1463::AID-CNCR12>3.0.CO;2-N","article-title":"Gemcitabine plus vinorelbine in non-small cell lung carcinoma patients age 70 or older or patients who cannot receive cisplatin","volume":"86","author":"Feliu","year":"1999","journal-title":"Cancer"},{"key":"10.1016\/j.lungcan.2006.08.013_bib14","doi-asserted-by":"crossref","first-page":"2529","DOI":"10.1200\/JCO.2000.18.13.2529","article-title":"Gemcitabine plus vinorelbine versus vinorelbine alone in elderly patients with advanced non-small cell lung cancer","volume":"18","author":"Frasci","year":"2000","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.lungcan.2006.08.013_bib15","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1097\/00000421-200104000-00018","article-title":"Renal tolerance to cisplatin in patients 70 years and older","volume":"24","author":"Cubillo","year":"2001","journal-title":"Am J Oncol"},{"key":"10.1016\/j.lungcan.2006.08.013_bib16","first-page":"329a","article-title":"Should older patients receive combination chemotherapy for advanced stage non-small cell lung cancer? An analysis of Southwest Oncology Trials 9509 and 9308","volume":"20","author":"Kelly","year":"2001","journal-title":"Proc Am Soc Clin Oncol"},{"key":"10.1016\/j.lungcan.2006.08.013_bib17","first-page":"53","article-title":"Advanced non-small cell lung cancer in the elderly: effective well tolerated weekly gemcitabine and cisplatin regimen. A pilot study","volume":"91","author":"Lippe","year":"2000","journal-title":"Minerva Med"},{"key":"10.1016\/j.lungcan.2006.08.013_bib18","doi-asserted-by":"crossref","first-page":"2121","DOI":"10.1200\/JCO.1994.12.10.2121","article-title":"Renal tolerance of cisplatin in patients more than 80 years old","volume":"12","author":"Thyss","year":"1994","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.lungcan.2006.08.013_bib19","first-page":"3942","article-title":"A phase II study of weekly paclitaxel in elderly patients with advanced non-small cell lung cancer","volume":"7","author":"Fidias","year":"2001","journal-title":"Clin Cancer Res"},{"issue":"Suppl. 7","key":"10.1016\/j.lungcan.2006.08.013_bib20","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/S0959-8049(01)80028-9","article-title":"Medical oncology","author":"Monfardini","year":"2001","journal-title":"Eur J Cancer"},{"key":"10.1016\/j.lungcan.2006.08.013_bib21","first-page":"308","article-title":"The MILES (Multicenter Italian Lung Cancer in the Elderly Study). Phase 3 trial: gemcitabine and vinorelbine vs. vinorelbine and vs. gemcitabine in elderly advanced non-small cell lung cancer","volume":"20","author":"Gridelli","year":"2001","journal-title":"Proc Am Soc Clin Oncol"},{"key":"10.1016\/j.lungcan.2006.08.013_bib22","first-page":"160","article-title":"Does older age ethnic group influence survival or response in patients in clinical trials for non-small cell lung cancer?","volume":"14","author":"Bizette","year":"1995","journal-title":"Proc Am Soc Clin Oncol"},{"key":"10.1016\/j.lungcan.2006.08.013_bib23","first-page":"315","article-title":"A phase III randomized trial comparing three platinum-based doublets in advanced non-small cell lung cancer: impact of PS=2 vs. 0 or 1 and age \u226570 vs. <70 on chemotherapy outcome","volume":"21","author":"Crino","year":"2002","journal-title":"Proc Am Soc Clin Oncol"},{"key":"10.1016\/j.lungcan.2006.08.013_bib24","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1007\/s002800050689","article-title":"Cisplatin-based combination chemotherapy for elderly patients with non-small cell lung cancer","volume":"40","author":"Kubota","year":"1997","journal-title":"Cancer Chemother Pharmacol"},{"key":"10.1016\/j.lungcan.2006.08.013_bib25","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1093\/jnci\/94.3.173","article-title":"Cisplatin-based therapy for elderly patients with non-small cell lung cancer: implications of Eastern Cooperative Oncology Group 5592, a randomized trial","volume":"94","author":"Langer","year":"2002","journal-title":"J Natl Cancer Inst"},{"key":"10.1016\/j.lungcan.2006.08.013_bib26","first-page":"471a","article-title":"The safety and efficacy of gemcitabine plus cisplatin in elderly chemonaive patients (age >70 years) as compared to those with age <70 years","volume":"18","author":"Nguyen","year":"1999","journal-title":"Proc Am Soc Clin Oncol"},{"issue":"Suppl. 8","key":"10.1016\/j.lungcan.2006.08.013_bib27","first-page":"58","article-title":"Correlation between age and prognosis in patients with advanced non-small cell lung cancer prognosis with cisplatin containing chemotherapy: a retrospective multicenter study","volume":"5","author":"Rinaldi","year":"1994","journal-title":"Ann Oncol"}],"container-title":["Lung Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0169500206004569?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0169500206004569?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,8,3]],"date-time":"2021-08-03T17:21:56Z","timestamp":1628011316000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0169500206004569"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,12]]},"references-count":27,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2006,12]]}},"alternative-id":["S0169500206004569"],"URL":"https:\/\/doi.org\/10.1016\/j.lungcan.2006.08.013","relation":{},"ISSN":["0169-5002"],"issn-type":[{"value":"0169-5002","type":"print"}],"subject":[],"published":{"date-parts":[[2006,12]]}}}