{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T02:53:20Z","timestamp":1789872800221,"version":"4.0.1"},"reference-count":36,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2009,5,1]],"date-time":"2009-05-01T00:00:00Z","timestamp":1241136000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Lung Cancer"],"published-print":{"date-parts":[[2009,5]]},"DOI":"10.1016\/j.lungcan.2008.07.015","type":"journal-article","created":{"date-parts":[[2008,9,8]],"date-time":"2008-09-08T08:08:50Z","timestamp":1220861330000},"page":"155-159","source":"Crossref","is-referenced-by-count":29,"title":["Aberrant methylation of tumour-related genes in thymic epithelial tumours"],"prefix":"10.1016","volume":"64","author":[{"given":"Yukiko","family":"Hirose","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuya","family":"Kondo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiromitsu","family":"Takizawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taeko","family":"Nagao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasushi","family":"Nakagawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haruhiko","family":"Fujino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroaki","family":"Toba","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koichiro","family":"Kenzaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shoji","family":"Sakiyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akira","family":"Tangoku","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.lungcan.2008.07.015_bib1","article-title":"Tumor of the thymus","volume":"fascicle 13","author":"Rosai","year":"1976"},{"key":"10.1016\/j.lungcan.2008.07.015_bib2","article-title":"Tumors of the mediastinum","volume":"fascicle 21","author":"Shimosato","year":"1997"},{"key":"10.1016\/j.lungcan.2008.07.015_bib3","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1002\/1097-0142(19940715)74:2<542::AID-CNCR2820740203>3.0.CO;2-1","article-title":"Controversies surrounding the subclassification of thymoma","volume":"74","author":"Shimosato","year":"1994","journal-title":"Cancer"},{"key":"10.1016\/j.lungcan.2008.07.015_bib4","series-title":"WHO International histological classification of tumours","article-title":"Histological typing of tumours of the thymus","author":"Rosai","year":"1999"},{"key":"10.1016\/j.lungcan.2008.07.015_bib5","series-title":"WHO classification of tumours","article-title":"Pathology and genetics of tumours of the lung, pleura, thymus and heart","author":"Travis","year":"2004"},{"key":"10.1016\/j.lungcan.2008.07.015_bib6","doi-asserted-by":"crossref","first-page":"982","DOI":"10.1002\/1097-0142(19880301)61:5<982::AID-CNCR2820610521>3.0.CO;2-1","article-title":"Evaluation of malignant grade of thymoma by morphometric analysis","volume":"61","author":"Nomori","year":"1998","journal-title":"Cancer"},{"key":"10.1016\/j.lungcan.2008.07.015_bib7","first-page":"615","article-title":"Degree of malignancy of thymic epithelial tumors in terms of nuclear DNA content and nuclear area. An analysis of 39 cases","volume":"133","author":"Asamura","year":"1988","journal-title":"Am J Pathol"},{"key":"10.1016\/j.lungcan.2008.07.015_bib8","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/S0046-8177(96)90140-9","article-title":"Cell kinetic study of thymic epithelial tumors using PCNA (PC10) and Ki-67 (MIB-1) antibodies","volume":"27","author":"Yang","year":"1996","journal-title":"Hum Pathol"},{"key":"10.1016\/j.lungcan.2008.07.015_bib9","doi-asserted-by":"crossref","first-page":"1568","DOI":"10.1002\/1097-0142(19940901)74:5<1568::AID-CNCR2820740512>3.0.CO;2-R","article-title":"Argyrophilic nucleolar organizer region counts predict survival in thymoma","volume":"74","author":"Pich","year":"1994","journal-title":"Cancer"},{"key":"10.1016\/j.lungcan.2008.07.015_bib10","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.1038\/bjc.1997.561","article-title":"High frequency of p53 protein expression in thymic carcinoma but not in thymoma","volume":"76","author":"Hino","year":"1997","journal-title":"Br J Cancer"},{"key":"10.1016\/j.lungcan.2008.07.015_bib11","doi-asserted-by":"crossref","first-page":"1822","DOI":"10.1002\/cncr.11725","article-title":"Increased expression of matrix metalloproteinase 2 and tissue inhibitor of metalloproteinase 2 correlate with poor prognostic variables in thymic epithelial tumors","volume":"98","author":"Sogawa","year":"2003","journal-title":"Cancer"},{"key":"10.1016\/j.lungcan.2008.07.015_bib12","first-page":"1621","article-title":"Aberrant methylation in thymic carcinomas, rare in thymomas","volume":"14","author":"Suzuki","year":"2005","journal-title":"Oncol. Rep."},{"key":"10.1016\/j.lungcan.2008.07.015_bib13","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1002\/(SICI)1097-0215(19971127)73:5<639::AID-IJC5>3.0.CO;2-Y","article-title":"p16 INK4, pRB, p53 and cyclin D1 expression and hypermethylation of CDKN2 gene in thymoma and thymic carcinoma","volume":"73","author":"Hirabayashi","year":"1997","journal-title":"Int J Cancer"},{"key":"10.1016\/j.lungcan.2008.07.015_bib14","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/S0002-9440(10)64536-1","article-title":"Recurrent genetic aberrations in thymoma and thymic carcinoma","volume":"157","author":"Zettl","year":"2000","journal-title":"Am J Pathol"},{"key":"10.1016\/j.lungcan.2008.07.015_bib15","doi-asserted-by":"crossref","first-page":"1853","DOI":"10.1016\/S0002-9440(10)63031-3","article-title":"Thymic epithelial tumors can develop along two different pathogenetic pathways","volume":"159","author":"Zhou","year":"2001","journal-title":"Am J Pathol"},{"key":"10.1016\/j.lungcan.2008.07.015_bib16","first-page":"3708","article-title":"Correlating genetic aberrations with World Health Organization-defined histology and stage across the spectrum of thymomas","volume":"63","author":"Inoue","year":"2003","journal-title":"Cancer Res"},{"key":"10.1016\/j.lungcan.2008.07.015_bib17","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1615\/CritRevOncog.v12.i3-4.50","article-title":"Colorectal cancer: a multipathway disease","volume":"12","author":"Jass","year":"2006","journal-title":"Crit Rev Oncog"},{"key":"10.1016\/j.lungcan.2008.07.015_bib18","first-page":"823","article-title":"p53 alteration, proliferating cell nuclear antigen, and nucleolar organizer regions in thymic epithelial tumors","volume":"1","author":"Oyama","year":"1998","journal-title":"Int J Mol Med"},{"key":"10.1016\/j.lungcan.2008.07.015_bib19","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1007\/s004280050064","article-title":"p53 alterations in thymic epithelial tumours","volume":"431","author":"Weirich","year":"1997","journal-title":"Virchows Arch"},{"key":"10.1016\/j.lungcan.2008.07.015_bib20","doi-asserted-by":"crossref","first-page":"2485","DOI":"10.1002\/1097-0142(19811201)48:11<2485::AID-CNCR2820481123>3.0.CO;2-R","article-title":"Follow-up study of thymomas with special reference to their clinical stages","volume":"48","author":"Masaoka","year":"1981","journal-title":"Cancer"},{"key":"10.1016\/j.lungcan.2008.07.015_bib21","doi-asserted-by":"crossref","first-page":"9821","DOI":"10.1073\/pnas.93.18.9821","article-title":"Methylation-specific PCR: a novel PCR assay for methylation status of CpG islands","volume":"93","author":"Herman","year":"1996","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.lungcan.2008.07.015_bib22","first-page":"249","article-title":"Aberrant promoter methylation of multiple genes in non-small cell lung cancers","volume":"61","author":"Z\u00f6chbauer-M\u00fcller","year":"2001","journal-title":"Cancer Res"},{"key":"10.1016\/j.lungcan.2008.07.015_bib23","doi-asserted-by":"crossref","first-page":"5450","DOI":"10.1038\/sj.onc.1205605","article-title":"DNA methylation analysis: a powerful new tool for lung cancer diagnosis","volume":"21","author":"Tsou","year":"2002","journal-title":"Oncogene"},{"key":"10.1016\/j.lungcan.2008.07.015_bib24","first-page":"2370","article-title":"Aberrant promoter methylation in bronchial epithelium and sputum from current and former smokers","volume":"62","author":"Belinsky","year":"2002","journal-title":"Cancer Res"},{"key":"10.1016\/j.lungcan.2008.07.015_bib25","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.1016\/j.athoracsur.2003.07.042","article-title":"WHO histologic classification is a prognostic indicator in thymoma","volume":"77","author":"Kondo","year":"2004","journal-title":"Ann Thorac Surg"},{"key":"10.1016\/j.lungcan.2008.07.015_bib26","doi-asserted-by":"crossref","first-page":"2328","DOI":"10.1016\/j.athoracsur.2005.11.067","article-title":"Clinical value of the WHO classification system of thymoma","volume":"81","author":"Detterbeck","year":"2006","journal-title":"Ann Thorac Surg"},{"key":"10.1016\/j.lungcan.2008.07.015_bib27","first-page":"6119","article-title":"Mammalian O6-alkylguanine-DNA alkyltransferase: regulation and importance in response to alkylating carcinogenic and therapeutic agents","volume":"50","author":"Pegg","year":"1990","journal-title":"Cancer Res"},{"key":"10.1016\/j.lungcan.2008.07.015_bib28","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1016\/j.dnarep.2007.03.013","article-title":"MGMT hypermethylation: a prognostic foe, a predictive friend","volume":"6","author":"Jacinto","year":"2007","journal-title":"DNA Repair"},{"key":"10.1016\/j.lungcan.2008.07.015_bib29","first-page":"223","article-title":"Quantitative O(6)-methylguanine DNA methyltransferase methylation analysis in curatively resected non-small cell lung cancer: associations with clinical outcome","volume":"9","author":"Brabender","year":"2003","journal-title":"Clin Cancer Res"},{"key":"10.1016\/j.lungcan.2008.07.015_bib30","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1111\/j.1750-3639.2003.tb00017.x","article-title":"Promoter hypermethylation of the DNA repair gene O6-methylguanine-DNA methyltransferase is an independent predictor of shortened progression free survival in patients with low-grade diffuse astrocytomas","volume":"13","author":"Komine","year":"2003","journal-title":"Brain Pathol"},{"key":"10.1016\/j.lungcan.2008.07.015_bib31","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1245\/ASO.2005.07.020","article-title":"Tumor progression through epigenetic gene silencing of O(6)-methylguanine-DNA methyltransferase in human biliary tract cancers","volume":"12","author":"Koga","year":"2005","journal-title":"Ann Surg Oncol"},{"key":"10.1016\/j.lungcan.2008.07.015_bib32","doi-asserted-by":"crossref","first-page":"1350","DOI":"10.1056\/NEJM200011093431901","article-title":"Inactivation of the DNA-repair gene MGMT and the clinical response of gliomas to alkylating agents","volume":"343","author":"Esteller","year":"2000","journal-title":"N Engl J Med"},{"key":"10.1016\/j.lungcan.2008.07.015_bib33","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1093\/jnci\/94.1.26","article-title":"Hypermethylation of the DNA repair gene O(6)-methylguanine DNA methyltransferase and survival of patients with diffuse large B-cell lymphoma","volume":"94","author":"Esteller","year":"2002","journal-title":"J Natl Cancer Inst"},{"key":"10.1016\/j.lungcan.2008.07.015_bib34","doi-asserted-by":"crossref","first-page":"1164","DOI":"10.1200\/JCO.1994.12.6.1164","article-title":"Cisplatin plus doxorubicin plus cyclophosphamide in metastatic or recurrent thymoma: final results of an intergroup trial","volume":"12","author":"Loehrer","year":"1994","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.lungcan.2008.07.015_bib35","doi-asserted-by":"crossref","first-page":"2010","DOI":"10.1002\/1097-0142(20010601)91:11<2010::AID-CNCR1226>3.0.CO;2-2","article-title":"Combined etoposide, ifosfamide, and cisplatin in the treatment of patients with advanced thymoma and thymic carcinoma an intergroup trial","volume":"91","author":"Loehrer","year":"2001","journal-title":"Cancer"},{"key":"10.1016\/j.lungcan.2008.07.015_bib36","doi-asserted-by":"crossref","first-page":"6505","DOI":"10.1158\/1078-0432.CCR-05-0625","article-title":"Gene promoter methylation in plasma and sputum increases with lung cancer risk","volume":"11","author":"Belinsky","year":"2005","journal-title":"Clin Cancer Res"}],"container-title":["Lung Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0169500208004169?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0169500208004169?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,5,13]],"date-time":"2019-05-13T21:36:16Z","timestamp":1557783376000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0169500208004169"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,5]]},"references-count":36,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2009,5]]}},"alternative-id":["S0169500208004169"],"URL":"https:\/\/doi.org\/10.1016\/j.lungcan.2008.07.015","relation":{},"ISSN":["0169-5002"],"issn-type":[{"value":"0169-5002","type":"print"}],"subject":[],"published":{"date-parts":[[2009,5]]}}}