{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T02:46:02Z","timestamp":1778121962778,"version":"3.51.4"},"reference-count":53,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2011,2,1]],"date-time":"2011-02-01T00:00:00Z","timestamp":1296518400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Lung Cancer"],"published-print":{"date-parts":[[2011,2]]},"DOI":"10.1016\/j.lungcan.2010.04.016","type":"journal-article","created":{"date-parts":[[2010,5,18]],"date-time":"2010-05-18T03:20:15Z","timestamp":1274152815000},"page":"123-129","source":"Crossref","is-referenced-by-count":56,"title":["A combination of functional polymorphisms in the CASP8, MMP1, IL10 and SEPS1 genes affects risk of non-small cell lung cancer"],"prefix":"10.1016","volume":"71","author":[{"given":"Kent","family":"Hart","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nina E.","family":"Landvik","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helge","family":"Lind","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vidar","family":"Skaug","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aage","family":"Haugen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shanbeh","family":"Zienolddiny","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.lungcan.2010.04.016_bib1","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1093\/carcin\/bgl253","article-title":"The molecular epidemiology of lung cancer","volume":"28","author":"Schwartz","year":"2007","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.lungcan.2010.04.016_bib2","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1186\/1471-2407-8-229","article-title":"Cigarette smoke induces endoplasmic reticulum stress and the unfolded protein response in normal and malignant human lung cells","volume":"8","author":"Jorgensen","year":"2008","journal-title":"BMC Cancer"},{"issue":"5","key":"10.1016\/j.lungcan.2010.04.016_bib3","doi-asserted-by":"crossref","first-page":"1584","DOI":"10.1016\/S0022-5347(05)67683-5","article-title":"Frequent genotype changes at -308, and 488 regions of the tumor necrosis factor-alpha (TNF-alpha) gene in patients with prostate cancer","volume":"163","author":"Oh","year":"2000","journal-title":"J Urol"},{"issue":"2","key":"10.1016\/j.lungcan.2010.04.016_bib4","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.cancergencyto.2009.01.017","article-title":"A functional insertion\/deletion polymorphism in the promoter region of the NFKB1 gene increases susceptibility for prostate cancer","volume":"191","author":"Zhang","year":"2009","journal-title":"Cancer Genet Cytogenet"},{"issue":"1","key":"10.1016\/j.lungcan.2010.04.016_bib5","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.lungcan.2005.11.011","article-title":"Association of TNF-alpha polymorphism with susceptibility to and severity of non-small cell lung cancer","volume":"52","author":"Shih","year":"2006","journal-title":"Lung Cancer"},{"issue":"4","key":"10.1016\/j.lungcan.2010.04.016_bib6","doi-asserted-by":"crossref","first-page":"R395","DOI":"10.1186\/bcr802","article-title":"Role of tumour necrosis factor gene polymorphisms (-308 and -238) in breast cancer susceptibility and severity","volume":"6","author":"Azmy","year":"2004","journal-title":"Breast Cancer Res"},{"issue":"7","key":"10.1016\/j.lungcan.2010.04.016_bib7","doi-asserted-by":"crossref","first-page":"1186","DOI":"10.1093\/carcin\/bgp122","article-title":"A specific interleukin-1B haplotype correlates with high levels of IL1B mRNA in the lung and increased risk of non-small cell lung cancer","volume":"30","author":"Landvik","year":"2009","journal-title":"Carcinogenesis"},{"issue":"1\u20132","key":"10.1016\/j.lungcan.2010.04.016_bib8","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.mrgentox.2008.06.013","article-title":"Allele-specific induction of IL1B-31T\/C promoter polymorphism by lung carcinogens","volume":"656","author":"Hart","year":"2008","journal-title":"Mutat Res"},{"issue":"11","key":"10.1016\/j.lungcan.2010.04.016_bib9","doi-asserted-by":"crossref","first-page":"1234","DOI":"10.1038\/ng1655","article-title":"Genetic variation in selenoprotein S influences inflammatory response","volume":"37","author":"Curran","year":"2005","journal-title":"Nat Genet"},{"key":"10.1016\/j.lungcan.2010.04.016_bib10","article-title":"Evidence of epistasis between Interleukin-1 and Selenoprotein-S with susceptibility to RA","author":"Marinou","year":"2008","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.lungcan.2010.04.016_bib11","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1007\/978-1-4020-6554-5_2","article-title":"Caspase mechanisms","volume":"615","author":"Salvesen","year":"2008","journal-title":"Adv Exp Med Biol"},{"issue":"11","key":"10.1016\/j.lungcan.2010.04.016_bib12","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.1016\/j.bcp.2008.07.034","article-title":"Non-apoptotic functions of caspase-8","volume":"76","author":"Maelfait","year":"2008","journal-title":"Biochem Pharmacol"},{"issue":"9","key":"10.1016\/j.lungcan.2010.04.016_bib13","doi-asserted-by":"crossref","first-page":"1967","DOI":"10.1084\/jem.20071632","article-title":"Stimulation of Toll-like receptor 3 and 4 induces interleukin-1beta maturation by caspase-8","volume":"205","author":"Maelfait","year":"2008","journal-title":"J Exp Med"},{"issue":"5","key":"10.1016\/j.lungcan.2010.04.016_bib14","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1038\/ng2030","article-title":"A six-nucleotide insertion-deletion polymorphism in the CASP8 promoter is associated with susceptibility to multiple cancers","volume":"39","author":"Sun","year":"2007","journal-title":"Nat Genet"},{"issue":"1","key":"10.1016\/j.lungcan.2010.04.016_bib15","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1038\/sj.cdd.4402038","article-title":"Inflammatory caspases and inflammasomes: master switches of inflammation","volume":"14","author":"Martinon","year":"2007","journal-title":"Cell Death Differ"},{"issue":"10","key":"10.1016\/j.lungcan.2010.04.016_bib16","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1097\/01.fpc.0000220572.28585.5e","article-title":"Inflammation and apoptosis genes and the risk of restenosis after percutaneous coronary intervention","volume":"16","author":"Monraats","year":"2006","journal-title":"Pharmacogenet Genom"},{"issue":"21","key":"10.1016\/j.lungcan.2010.04.016_bib17","first-page":"7825","article-title":"A single nucleotide polymorphism in the matrix metalloproteinase-1 promoter enhances lung cancer susceptibility","volume":"61","author":"Zhu","year":"2001","journal-title":"Cancer Res"},{"issue":"23","key":"10.1016\/j.lungcan.2010.04.016_bib18","first-page":"5321","article-title":"A single nucleotide polymorphism in the matrix metalloproteinase-1 promoter creates an Ets binding site and augments transcription","volume":"58","author":"Rutter","year":"1998","journal-title":"Cancer Res"},{"key":"10.1016\/j.lungcan.2010.04.016_bib19","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1111\/j.1600-065X.2008.00706.x","article-title":"Interleukin-10: new perspectives on an old cytokine","volume":"226","author":"Mosser","year":"2008","journal-title":"Immunol Rev"},{"issue":"9","key":"10.1016\/j.lungcan.2010.04.016_bib20","doi-asserted-by":"crossref","first-page":"5771","DOI":"10.4049\/jimmunol.180.9.5771","article-title":"IL-10: the master regulator of immunity to infection","volume":"180","author":"Couper","year":"2008","journal-title":"J Immunol"},{"issue":"4","key":"10.1016\/j.lungcan.2010.04.016_bib21","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1183\/09031936.00091707","article-title":"Tumour-associated macrophages in nonsmall cell lung cancer: the role of interleukin-10","volume":"30","author":"Montuenga","year":"2007","journal-title":"Eur Respir J"},{"issue":"3","key":"10.1016\/j.lungcan.2010.04.016_bib22","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/j.lungcan.2005.07.007","article-title":"The involvement of genetic polymorphism of IL-10 promoter in non-small cell lung cancer","volume":"50","author":"Shih","year":"2005","journal-title":"Lung Cancer"},{"issue":"6","key":"10.1016\/j.lungcan.2010.04.016_bib23","doi-asserted-by":"crossref","first-page":"3915","DOI":"10.4049\/jimmunol.166.6.3915","article-title":"Novel single nucleotide polymorphisms in the distal IL-10 promoter affect IL-10 production and enhance the risk of systemic lupus erythematosus","volume":"166","author":"Gibson","year":"2001","journal-title":"J Immunol"},{"issue":"9\u201310","key":"10.1016\/j.lungcan.2010.04.016_bib24","doi-asserted-by":"crossref","first-page":"645","DOI":"10.2119\/2008-00035.Gribar","article-title":"No longer an innocent bystander: epithelial toll-like receptor signaling in the development of mucosal inflammation","volume":"14","author":"Gribar","year":"2008","journal-title":"Mol Med"},{"issue":"24","key":"10.1016\/j.lungcan.2010.04.016_bib25","doi-asserted-by":"crossref","first-page":"11771","DOI":"10.1158\/0008-5472.CAN-05-2078","article-title":"Sequence variants of Toll-like receptor 4 and susceptibility to prostate cancer","volume":"65","author":"Chen","year":"2005","journal-title":"Cancer Res"},{"issue":"10","key":"10.1016\/j.lungcan.2010.04.016_bib26","doi-asserted-by":"crossref","first-page":"4453","DOI":"10.1167\/iovs.07-1575","article-title":"Association of Toll-like receptor 4 gene polymorphisms with normal tension glaucoma","volume":"49","author":"Shibuya","year":"2008","journal-title":"Investig Ophthalmol Vis Sci"},{"issue":"6","key":"10.1016\/j.lungcan.2010.04.016_bib27","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1111\/j.1365-2613.2007.00566.x","article-title":"Toll-like receptor and tumour necrosis factor dependent endotoxin-induced acute lung injury","volume":"88","author":"Togbe","year":"2007","journal-title":"Int J Exp Pathol"},{"issue":"3","key":"10.1016\/j.lungcan.2010.04.016_bib28","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1513\/pats.200702-035AW","article-title":"CD14, endotoxin, and asthma risk: actions and interactions","volume":"4","author":"Martinez","year":"2007","journal-title":"Proc Am Thorac Soc"},{"issue":"25","key":"10.1016\/j.lungcan.2010.04.016_bib29","doi-asserted-by":"crossref","first-page":"3218","DOI":"10.1161\/01.CIR.99.25.3218","article-title":"C(-260)-->T polymorphism in the promoter of the CD14 monocyte receptor gene as a risk factor for myocardial infarction","volume":"99","author":"Hubacek","year":"1999","journal-title":"Circulation"},{"issue":"6","key":"10.1016\/j.lungcan.2010.04.016_bib30","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1093\/jnci\/djh075","article-title":"Assessing the probability that a positive report is false: an approach for molecular epidemiology studies","volume":"96","author":"Wacholder","year":"2004","journal-title":"J Natl Cancer Inst"},{"issue":"2","key":"10.1016\/j.lungcan.2010.04.016_bib31","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1086\/519024","article-title":"A Bayesian measure of the probability of false discovery in genetic epidemiology studies","volume":"81","author":"Wakefield","year":"2007","journal-title":"Am J Hum Genet"},{"issue":"7","key":"10.1016\/j.lungcan.2010.04.016_bib32","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.1038\/nprot.2008.79","article-title":"Analysis of mutational spectra by denaturing capillary electrophoresis","volume":"3","author":"Ekstrom","year":"2008","journal-title":"Nat Protoc"},{"issue":"3","key":"10.1016\/j.lungcan.2010.04.016_bib33","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/j.lungcan.2004.02.014","article-title":"Role of estrogen receptor in regulation of polycyclic aromatic hydrocarbon metabolic activation in lung","volume":"45","author":"Berge","year":"2004","journal-title":"Lung Cancer"},{"issue":"2","key":"10.1016\/j.lungcan.2010.04.016_bib34","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1093\/bioinformatics\/18.2.333","article-title":"PROMO: detection of known transcription regulatory elements using species-tailored searches","volume":"18","author":"Messeguer","year":"2002","journal-title":"Bioinformatics"},{"issue":"13","key":"10.1016\/j.lungcan.2010.04.016_bib35","doi-asserted-by":"crossref","first-page":"3651","DOI":"10.1093\/nar\/gkg605","article-title":"Identification of patterns in biological sequences at the ALGGEN server: PROMO and MALGEN","volume":"31","author":"Farre","year":"2003","journal-title":"Nucleic Acids Res"},{"issue":"6","key":"10.1016\/j.lungcan.2010.04.016_bib36","doi-asserted-by":"crossref","first-page":"1164","DOI":"10.1093\/carcin\/bgn020","article-title":"A comprehensive analysis of phase I and phase II metabolism gene polymorphisms and risk of non-small cell lung cancer in smokers","volume":"29","author":"Zienolddiny","year":"2008","journal-title":"Carcinogenesis"},{"issue":"1","key":"10.1016\/j.lungcan.2010.04.016_bib37","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1093\/hmg\/ddh008","article-title":"Functional annotation of a novel NFKB1 promoter polymorphism that increases risk for ulcerative colitis","volume":"13","author":"Karban","year":"2004","journal-title":"Hum Mol Genet"},{"issue":"5","key":"10.1016\/j.lungcan.2010.04.016_bib38","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/S0161-5890(97)00052-7","article-title":"The -308 tumor necrosis factor-alpha promoter polymorphism effects transcription","volume":"34","author":"Kroeger","year":"1997","journal-title":"Mol Immunol"},{"issue":"4","key":"10.1016\/j.lungcan.2010.04.016_bib39","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/j.cyto.2005.01.006","article-title":"IL-12 and IL-10 polymorphisms and their effects on cytokine production","volume":"30","author":"Yilmaz","year":"2005","journal-title":"Cytokine"},{"issue":"6","key":"10.1016\/j.lungcan.2010.04.016_bib40","doi-asserted-by":"crossref","first-page":"1565","DOI":"10.1189\/jlb.0308184","article-title":"The broad effects of the functional IL-10 promoter-592 polymorphism: modulation of IL-10, TIMP-3, and OPG expression and their association with periodontal disease outcome","volume":"84","author":"Claudino","year":"2008","journal-title":"J Leukoc Biol"},{"issue":"36","key":"10.1016\/j.lungcan.2010.04.016_bib41","doi-asserted-by":"crossref","first-page":"26041","DOI":"10.1074\/jbc.M602222200","article-title":"NF-kappaB1 (p50) homodimers differentially regulate pro- and anti-inflammatory cytokines in macrophages","volume":"281","author":"Cao","year":"2006","journal-title":"J Biol Chem"},{"issue":"5","key":"10.1016\/j.lungcan.2010.04.016_bib42","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1158\/1055-9965.EPI-07-2840","article-title":"Matrix metalloproteinase 1 (MMP1) is associated with early-onset lung cancer","volume":"17","author":"Sauter","year":"2008","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"issue":"1","key":"10.1016\/j.lungcan.2010.04.016_bib43","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1165\/rcmb.2007-0310OC","article-title":"Identification of a cigarette smoke-responsive region in the distal MMP-1 promoter","volume":"40","author":"Mercer","year":"2009","journal-title":"Am J Respir Cell Mol Biol"},{"issue":"5","key":"10.1016\/j.lungcan.2010.04.016_bib44","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1016\/j.febslet.2009.02.008","article-title":"Matrix metalloproteinase-1 expression induced by IL-1beta requires acid sphingomyelinase","volume":"583","author":"Bauer","year":"2009","journal-title":"FEBS Lett"},{"issue":"2","key":"10.1016\/j.lungcan.2010.04.016_bib45","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/S0968-0004(96)10073-6","article-title":"The ER-overload response: activation of NF-kappa B","volume":"22","author":"Pahl","year":"1997","journal-title":"Trends Biochem Sci"},{"issue":"5","key":"10.1016\/j.lungcan.2010.04.016_bib46","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1016\/j.cyto.2006.02.005","article-title":"Activation of the selenoprotein SEPS1 gene expression by pro-inflammatory cytokines in HepG2 cells","volume":"33","author":"Gao","year":"2006","journal-title":"Cytokine"},{"issue":"3","key":"10.1016\/j.lungcan.2010.04.016_bib47","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1111\/j.1399-0039.2007.00888.x","article-title":"The role of the selenoprotein S (SELS) gene -105G>A promoter polymorphism in inflammatory bowel disease and regulation of SELS gene expression in intestinal inflammation","volume":"70","author":"Seiderer","year":"2007","journal-title":"Tissue Antigens"},{"issue":"2","key":"10.1016\/j.lungcan.2010.04.016_bib48","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.4049\/jimmunol.180.2.1169","article-title":"Cigarette smoke-induced pulmonary inflammation is TLR4\/MyD88 and IL-1R1\/MyD88 signaling dependent","volume":"180","author":"Doz","year":"2008","journal-title":"J Immunol"},{"issue":"1","key":"10.1016\/j.lungcan.2010.04.016_bib49","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/S0006-2952(99)00296-8","article-title":"Oxidative stress and nuclear factor-kappaB activation: a reassessment of the evidence in the light of recent discoveries","volume":"59","author":"Bowie","year":"2000","journal-title":"Biochem Pharmacol"},{"issue":"3","key":"10.1016\/j.lungcan.2010.04.016_bib50","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1002\/ijc.21872","article-title":"Association of a functional polymorphism in the promoter of the MDM2 gene with risk of nonsmall cell lung cancer","volume":"119","author":"Lind","year":"2006","journal-title":"Int J Cancer"},{"issue":"23","key":"10.1016\/j.lungcan.2010.04.016_bib51","doi-asserted-by":"crossref","first-page":"12770","DOI":"10.1073\/pnas.220416097","article-title":"Increased p53 mutation load in nontumorous human liver of wilson disease and hemochromatosis: oxyradical overload diseases","volume":"97","author":"Hussain","year":"2000","journal-title":"Proc Natl Acad Sci USA"},{"issue":"3","key":"10.1016\/j.lungcan.2010.04.016_bib52","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1002\/ijc.11695","article-title":"Polymorphisms of the interleukin-1 beta gene are associated with increased risk of non-small cell lung cancer","volume":"109","author":"Zienolddiny","year":"2004","journal-title":"Int J Cancer"},{"issue":"1","key":"10.1016\/j.lungcan.2010.04.016_bib53","first-page":"184","article-title":"Inflammatory cytokines induce DNA damage and inhibit DNA repair in cholangiocarcinoma cells by a nitric oxide-dependent mechanism","volume":"60","author":"Jaiswal","year":"2000","journal-title":"Cancer Res"}],"container-title":["Lung Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0169500210002035?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0169500210002035?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,5,29]],"date-time":"2019-05-29T03:56:40Z","timestamp":1559102200000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0169500210002035"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,2]]},"references-count":53,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2011,2]]}},"alternative-id":["S0169500210002035"],"URL":"https:\/\/doi.org\/10.1016\/j.lungcan.2010.04.016","relation":{},"ISSN":["0169-5002"],"issn-type":[{"value":"0169-5002","type":"print"}],"subject":[],"published":{"date-parts":[[2011,2]]}}}