{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T16:20:08Z","timestamp":1770826808556,"version":"3.50.1"},"reference-count":12,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2010,11,1]],"date-time":"2010-11-01T00:00:00Z","timestamp":1288569600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Lung Cancer"],"published-print":{"date-parts":[[2010,11]]},"DOI":"10.1016\/j.lungcan.2010.08.012","type":"journal-article","created":{"date-parts":[[2010,9,4]],"date-time":"2010-09-04T10:51:09Z","timestamp":1283597469000},"page":"223-225","source":"Crossref","is-referenced-by-count":21,"title":["Successful treatment of two lung cancer patients with erlotinib following gefitinib-induced hepatotoxicity"],"prefix":"10.1016","volume":"70","author":[{"given":"Geoffrey Y.","family":"Ku","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akhil","family":"Chopra","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"Jr.","given":"Gilberto de Lima","family":"Lopes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.lungcan.2010.08.012_bib0005","doi-asserted-by":"crossref","first-page":"2237","DOI":"10.1200\/JCO.2003.10.038","article-title":"Multi-institutional randomized phase II trial of gefitinib for previously treated patients with advanced non-small-cell lung cancer (the IDEAL 1 Trial) [corrected]","volume":"21","author":"Fukuoka","year":"2003","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.lungcan.2010.08.012_bib0010","doi-asserted-by":"crossref","first-page":"2149","DOI":"10.1001\/jama.290.16.2149","article-title":"Efficacy of gefitinib, an inhibitor of the epidermal growth factor receptor tyrosine kinase, in symptomatic patients with non-small cell lung cancer: a randomized trial","volume":"290","author":"Kris","year":"2003","journal-title":"Jama"},{"key":"10.1016\/j.lungcan.2010.08.012_bib0015","doi-asserted-by":"crossref","first-page":"1527","DOI":"10.1016\/S0140-6736(05)67625-8","article-title":"Gefitinib plus best supportive care in previously treated patients with refractory advanced non-small-cell lung cancer: results from a randomised, placebo-controlled, multicentre study (Iressa Survival Evaluation in Lung Cancer)","volume":"366","author":"Thatcher","year":"2005","journal-title":"Lancet"},{"key":"10.1016\/j.lungcan.2010.08.012_bib0020","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1056\/NEJMoa0810699","article-title":"Gefitinib or carboplatin-paclitaxel in pulmonary adenocarcinoma","volume":"361","author":"Mok","year":"2009","journal-title":"N Engl J Med"},{"key":"10.1016\/j.lungcan.2010.08.012_bib0025","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1200\/JCO.2006.07.5754","article-title":"Phase II clinical trial of chemotherapy-naive patients > or = 70 years of age treated with erlotinib for advanced non-small-cell lung cancer","volume":"25","author":"Jackman","year":"2007","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.lungcan.2010.08.012_bib0030","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1016\/j.cgh.2007.04.014","article-title":"Fulminant hepatic failure secondary to erlotinib","volume":"5","author":"Liu","year":"2007","journal-title":"Clin Gastroenterol Hepatol"},{"key":"10.1016\/j.lungcan.2010.08.012_bib0035","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1345\/aph.1L468","article-title":"Erlotinib-induced hepatitis complicated by fatal lactic acidosis in an elderly man with lung cancer","volume":"43","author":"Pellegrinotti","year":"2009","journal-title":"Ann Pharmacother"},{"key":"10.1016\/j.lungcan.2010.08.012_bib0040","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1111\/j.1365-2125.2009.03459.x","article-title":"Three cases of severe hepatic impairment caused by erlotinib","volume":"68","author":"Huang","year":"2009","journal-title":"Br J Clin Pharmacol"},{"key":"10.1016\/j.lungcan.2010.08.012_bib0065","doi-asserted-by":"crossref","first-page":"e273","DOI":"10.1200\/JCO.2009.26.5496","article-title":"Successful treatment with erlotinib after gefitinib-related severe hepatotoxicity","volume":"28","author":"Takeda","year":"2010","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.lungcan.2010.08.012_bib0050","doi-asserted-by":"crossref","first-page":"8531","DOI":"10.1200\/JCO.2004.00.6650","article-title":"Side effects related to cancer treatment. CASE 1. Hepatitis following treatment with gefitinib","volume":"23","author":"Ho","year":"2005","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.lungcan.2010.08.012_bib0055","doi-asserted-by":"crossref","first-page":"e60","DOI":"10.1200\/JCO.2006.07.8261","article-title":"Liver toxicity after treatment with gefitinib and anastrozole: drug-drug interactions through cytochrome p450?","volume":"24","author":"Carlini","year":"2006","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.lungcan.2010.08.012_bib0060","doi-asserted-by":"crossref","first-page":"3213","DOI":"10.1200\/JCO.2006.05.7109","article-title":"Promising new treatment schedule for gefitinib responders after severe hepatotoxicity with daily administration","volume":"24","author":"Seki","year":"2006","journal-title":"J Clin Oncol"}],"container-title":["Lung Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0169500210003910?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0169500210003910?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,12,8]],"date-time":"2018-12-08T07:52:59Z","timestamp":1544255579000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0169500210003910"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,11]]},"references-count":12,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2010,11]]}},"alternative-id":["S0169500210003910"],"URL":"https:\/\/doi.org\/10.1016\/j.lungcan.2010.08.012","relation":{},"ISSN":["0169-5002"],"issn-type":[{"value":"0169-5002","type":"print"}],"subject":[],"published":{"date-parts":[[2010,11]]}}}