{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T06:05:49Z","timestamp":1791353149610,"version":"4.3.1"},"reference-count":33,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2011,9,1]],"date-time":"2011-09-01T00:00:00Z","timestamp":1314835200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Cancer Institute NSW Early Career Development Award"},{"name":"Cancer Council NSW Program Grant"},{"name":"Intramural Research Program of the NIH"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Lung Cancer"],"published-print":{"date-parts":[[2011,9]]},"DOI":"10.1016\/j.lungcan.2010.12.023","type":"journal-article","created":{"date-parts":[[2011,2,1]],"date-time":"2011-02-01T09:17:10Z","timestamp":1296551830000},"page":"283-288","source":"Crossref","is-referenced-by-count":23,"title":["Telomerase activity in pleural malignant mesotheliomas"],"prefix":"10.1016","volume":"73","author":[{"given":"Amy Y.M.","family":"Au","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Torben","family":"Hackl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas R.","family":"Yeager","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott B.","family":"Cohen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harvey I.","family":"Pass","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Curtis C.","family":"Harris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roger R.","family":"Reddel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.lungcan.2010.12.023_bib0005","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1093\/carcin\/21.3.477","article-title":"The role of senescence and immortalization in carcinogenesis","volume":"21","author":"Reddel","year":"2000","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.lungcan.2010.12.023_bib0010","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1038\/sj.onc.1205080","article-title":"Protection of mammalian telomeres","volume":"21","author":"de Lange","year":"2002","journal-title":"Oncogene"},{"key":"10.1016\/j.lungcan.2010.12.023_bib0015","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/S0092-8674(00)81683-9","article-title":"The hallmarks of cancer","volume":"100","author":"Hanahan","year":"2000","journal-title":"Cell"},{"key":"10.1016\/j.lungcan.2010.12.023_bib0020","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1146\/annurev.bi.61.070192.000553","volume":"61","author":"Blackburn","year":"1992","journal-title":"Annu. Rev. Biochem"},{"key":"10.1016\/j.lungcan.2010.12.023_bib0025","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1016\/S0959-8049(97)00062-2","article-title":"A survey of telomerase activity in human cancer","volume":"33","author":"Shay","year":"1997","journal-title":"Eur. J. Cancer"},{"key":"10.1016\/j.lungcan.2010.12.023_bib0030","doi-asserted-by":"crossref","first-page":"3800","DOI":"10.1016\/j.febslet.2010.06.009","article-title":"Assaying and investigating Alternative Lengthening of Telomeres activity in human cells and cancers","volume":"584","author":"Henson","year":"2010","journal-title":"FEBS Lett."},{"key":"10.1016\/j.lungcan.2010.12.023_bib0035","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1038\/nrg2763","article-title":"Alternative lengthening of telomeres: models, mechanisms and implications","volume":"11","author":"Cesare","year":"2010","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/j.lungcan.2010.12.023_bib0040","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1038\/nbt.1587","article-title":"DNA C-circles are specific and quantifable markers of alternative-lengthening-of-telomeres activity","volume":"27","author":"Henson","year":"2009","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.lungcan.2010.12.023_bib0045","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.5858\/133.8.1317","article-title":"Guidelines for pathologic diagnosis of malignant mesothelioma: a consensus statement from the International Mesothelioma Interest Group","volume":"133","author":"Husain","year":"2009","journal-title":"Arch. Pathol. Lab. Med."},{"key":"10.1016\/j.lungcan.2010.12.023_bib0050","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1007\/s11864-008-0067-z","article-title":"Mesothelioma epidemiology, carcinogenesis, and pathogenesis","volume":"9","author":"Yang","year":"2008","journal-title":"Curr. Treat. Options Oncol."},{"key":"10.1016\/j.lungcan.2010.12.023_bib0055","doi-asserted-by":"crossref","first-page":"10214","DOI":"10.1073\/pnas.170207097","article-title":"Human mesothelial cells are unusually susceptible to simian virus 40-mediated transformation and asbestos cocarcinogenicity","volume":"97","author":"Bocchetta","year":"2000","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.lungcan.2010.12.023_bib0060","doi-asserted-by":"crossref","first-page":"14128","DOI":"10.1073\/pnas.0604544103","article-title":"Crocidolite asbestos and SV40 are cocarcinogens in human mesothelial cells and in causing mesothelioma in hamsters","volume":"103","author":"Kroczynska","year":"2006","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.lungcan.2010.12.023_bib0065","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1038\/sj.bjc.6602307","article-title":"The expected burden of mesothelioma mortality in Great Britain from 2002\u20132050","volume":"92","author":"Hodgson","year":"2005","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.lungcan.2010.12.023_bib0070","doi-asserted-by":"crossref","first-page":"3451","DOI":"10.1200\/JCO.2004.10.071","article-title":"Neoadjuvant chemotherapy followed by extrapleural pneumonectomy in malignant pleural mesothelioma","volume":"22","author":"Weder","year":"2004","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.lungcan.2010.12.023_bib0075","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1038\/sj.bjc.6604209","article-title":"Targeting telomerase for cancer therapeutics","volume":"98","author":"Shay","year":"2008","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.lungcan.2010.12.023_bib0080","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1016\/j.ejca.2004.12.002","article-title":"Antisense oligonucleotide-mediated inhibition of hTERT, but not hTERC, induces rapid cell growth decline and apoptosis in the absence of telomere shortening in human prostate cancer cells","volume":"41","author":"Folini","year":"2005","journal-title":"Eur. J. Cancer"},{"key":"10.1016\/j.lungcan.2010.12.023_bib0085","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1038\/nrd2081","article-title":"Telomerase therapeutics for cancer: challenges and new directions","volume":"5","author":"Shay","year":"2006","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.lungcan.2010.12.023_bib0090","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1016\/j.lungcan.2009.07.010","article-title":"Nanoparticle mediated delivery of 2\u2032-O-methyl-RNA leads to efficient telomerase inhibition and telomere shortening in human lung cancer cells","volume":"68","author":"Beisner","year":"2010","journal-title":"Lung Cancer"},{"key":"10.1016\/j.lungcan.2010.12.023_bib0095","doi-asserted-by":"crossref","first-page":"4134","DOI":"10.1158\/1078-0432.CCR-08-0099","article-title":"Multiple mechanisms of telomere maintenance exist and differentially affect clinical outcome in diffuse malignant peritoneal mesothelioma","volume":"14","author":"Villa","year":"2008","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.lungcan.2010.12.023_bib0100","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1136\/thx.53.11.915","article-title":"Telomerase activity in human pleural mesothelioma","volume":"53","author":"Dhaene","year":"1998","journal-title":"Thorax"},{"key":"10.1016\/j.lungcan.2010.12.023_bib0105","doi-asserted-by":"crossref","first-page":"1434","DOI":"10.1038\/sj.onc.1205203","article-title":"SV40 infection induces telomerase activity in human mesothelial cells","volume":"21","author":"Foddis","year":"2002","journal-title":"Oncogene"},{"key":"10.1016\/j.lungcan.2010.12.023_bib0110","first-page":"979","article-title":"Establishment of a human in vitro mesothelial cell model system for investigating mechanisms of asbestos-induced mesothelioma","volume":"134","author":"Ke","year":"1989","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.lungcan.2010.12.023_bib0115","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1038\/nmeth.f.209","article-title":"A sensitive direct human telomerase activity assay","volume":"5","author":"Cohen","year":"2008","journal-title":"Nat. Methods"},{"key":"10.1016\/j.lungcan.2010.12.023_bib0120","doi-asserted-by":"crossref","first-page":"2011","DOI":"10.1126\/science.7605428","article-title":"Specific association of human telomerase activity with immortal cells and cancer","volume":"266","author":"Kim","year":"1994","journal-title":"Science"},{"key":"10.1016\/j.lungcan.2010.12.023_bib0125","doi-asserted-by":"crossref","first-page":"3862","DOI":"10.1128\/MCB.21.12.3862-3875.2001","article-title":"Coexistence of alternative lengthening of telomeres and telomerase in hTERT-transfected GM847 cells","volume":"21","author":"Perrem","year":"2001","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.lungcan.2010.12.023_bib0130","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1038\/345458a0","article-title":"Telomeres shorten during ageing of human fibroblasts","volume":"345","author":"Harley","year":"1990","journal-title":"Nature"},{"key":"10.1016\/j.lungcan.2010.12.023_bib0135","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1038\/modpathol.3800067","article-title":"Diffuse malignant mesothelioma of the peritoneum and pleura, analysis of markers","volume":"17","author":"Trupiano","year":"2004","journal-title":"Mod. Pathol."},{"key":"10.1016\/j.lungcan.2010.12.023_bib0140","doi-asserted-by":"crossref","first-page":"3765","DOI":"10.1038\/onc.2009.238","article-title":"A gene expression signature classifying telomerase and ALT immortalization reveals an hTERT regulatory network and suggests a mesenchymal stem cell origin for ALT","volume":"28","author":"Lafferty-Whyte","year":"2009","journal-title":"Oncogene"},{"key":"10.1016\/j.lungcan.2010.12.023_bib0145","doi-asserted-by":"crossref","first-page":"4240","DOI":"10.1002\/j.1460-2075.1995.tb00098.x","article-title":"Telomere elongation in immortal human cells without detectable telomerase activity","volume":"14","author":"Bryan","year":"1995","journal-title":"EMBO J."},{"key":"10.1016\/j.lungcan.2010.12.023_bib0150","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1006\/excr.1994.1218","article-title":"HPV-16 E6 and E7 genes, like SV40 early region genes, are insufficient for immortalization of human mesothelial and bronchial epithelial cells","volume":"213","author":"De Silva","year":"1994","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.lungcan.2010.12.023_bib0155","doi-asserted-by":"crossref","first-page":"8918","DOI":"10.1158\/0008-5472.CAN-06-0273","article-title":"Telomere maintenance mechanisms in liposarcomas: association with histologic subtypes and disease progression","volume":"66","author":"Costa","year":"2006","journal-title":"Cancer Res."},{"key":"10.1016\/j.lungcan.2010.12.023_bib0160","doi-asserted-by":"crossref","first-page":"8146","DOI":"10.1158\/0008-5472.CAN-08-0945","article-title":"Pericentromeric instability and spontaneous emergence of human neoacrocentric and minute chromosomes in the alternative pathway of telomere lengthening","volume":"68","author":"Gagos","year":"2008","journal-title":"Cancer Res."},{"key":"10.1016\/j.lungcan.2010.12.023_bib0165","doi-asserted-by":"crossref","first-page":"3383","DOI":"10.1038\/sj.onc.1202752","article-title":"Repression of an alternative mechanism for lengthening of telomeres in somatic cell hybrids","volume":"18","author":"Perrem","year":"1999","journal-title":"Oncogene"}],"container-title":["Lung Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0169500211000171?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0169500211000171?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,11,18]],"date-time":"2021-11-18T09:44:45Z","timestamp":1637228685000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0169500211000171"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,9]]},"references-count":33,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2011,9]]}},"alternative-id":["S0169500211000171"],"URL":"https:\/\/doi.org\/10.1016\/j.lungcan.2010.12.023","relation":{},"ISSN":["0169-5002"],"issn-type":[{"value":"0169-5002","type":"print"}],"subject":[],"published":{"date-parts":[[2011,9]]}}}