{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T15:22:40Z","timestamp":1761578560516,"version":"3.44.0"},"reference-count":29,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2011,12,1]],"date-time":"2011-12-01T00:00:00Z","timestamp":1322697600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2011,12,1]],"date-time":"2011-12-01T00:00:00Z","timestamp":1322697600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology, Japan","doi-asserted-by":"crossref","award":["21790793"],"award-info":[{"award-number":["21790793"]}],"id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"crossref"}]},{"name":"National Hospital Organization Policy Based Medical Services"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","lungcancerjournal.info","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Lung Cancer"],"published-print":{"date-parts":[[2011,12]]},"DOI":"10.1016\/j.lungcan.2011.04.001","type":"journal-article","created":{"date-parts":[[2011,5,10]],"date-time":"2011-05-10T02:39:26Z","timestamp":1304995166000},"page":"419-425","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":16,"title":["Expression of thymidylate synthase, orotate phosphoribosyltransferase and dihydropyrimidine dehydrogenase in thymic epithelial tumors"],"prefix":"10.1016","volume":"74","author":[{"given":"Kyoichi","family":"Kaira","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masakuni","family":"Serizawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuhiro","family":"Koh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satoru","family":"Miura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rieko","family":"Kaira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masato","family":"Abe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuo","family":"Nakagawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuhisa","family":"Ohde","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takehiro","family":"Okumura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haruyasu","family":"Murakami","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Asuka","family":"Tsuya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yukiko","family":"Nakamura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tateaki","family":"Naito","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshiaki","family":"Takahashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haruhiko","family":"Kondo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Nakajima","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masahiro","family":"Endo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nobuyuki","family":"Yamamoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.lungcan.2011.04.001_bib0005","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1002\/ijc.11099","article-title":"Malignant thymoma in the United States: demographic patterns in incidence and associations with subsequent malignancies","volume":"105","author":"Engels","year":"2003","journal-title":"Int J Cancer"},{"year":"1999","series-title":"Histological typing of tumours of the thymus, international histological classification of tumours","author":"Rosai","key":"10.1016\/j.lungcan.2011.04.001_bib0010"},{"year":"2004","series-title":"WHO classification of tumors. Pathology and genetics of tumors of the lung, pleura, thymus and heart","author":"Travis","key":"10.1016\/j.lungcan.2011.04.001_bib0015"},{"key":"10.1016\/j.lungcan.2011.04.001_bib0020","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1097\/00000421-200206000-00012","article-title":"Chemotherapy for advanced thymic carcinoma: clinical response to cisplatin, doxorubicin, vincristine, and cyclophosphamide (ADOC chemotherapy)","volume":"25","author":"Koizumi","year":"2002","journal-title":"Am J Clin Oncol"},{"key":"10.1016\/j.lungcan.2011.04.001_bib0025","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1002\/cncr.11606","article-title":"Weekly chemotherapy with cisplatin, vincristine, doxorubicin, and etoposide is an effective treatment for advanced thymic carcinoma","volume":"98","author":"Yok","year":"2003","journal-title":"Cancer"},{"key":"10.1016\/j.lungcan.2011.04.001_bib0030","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/j.lungcan.2009.03.031","article-title":"Efficacy of chemotherapy with carboplatin and paclitaxel for unresectable thymic carcinoma","volume":"67","author":"Igawa","year":"2010","journal-title":"Lung Cancer"},{"key":"10.1016\/j.lungcan.2011.04.001_bib0035","doi-asserted-by":"crossref","first-page":"1076","DOI":"10.1097\/JTO.0b013e318183af9c","article-title":"S-1 treatment for chemorefractory thymic carcinoma","volume":"3","author":"Ono","year":"2008","journal-title":"J Thorac Oncol"},{"key":"10.1016\/j.lungcan.2011.04.001_bib0040","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1097\/00001813-199607000-00010","article-title":"Development of a novel form of an oral 5-fluorouracil derivative (S-1) directed to the potentiation of the tumor selective cytotoxicity of 5-fluorouracil by two biochemical modulators","volume":"7","author":"Shirasaka","year":"1996","journal-title":"Anticancer Drugs"},{"key":"10.1016\/j.lungcan.2011.04.001_bib0045","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1054\/bjoc.2001.2031","article-title":"Phase II study of S-1, a novel oral fluorouracil, in advanced non-small-cell lung cancer","volume":"85","author":"Kawahara","year":"2001","journal-title":"Br J Cancer"},{"key":"10.1016\/j.lungcan.2011.04.001_bib0050","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1038\/sj.bjc.6603297","article-title":"Evaluation of biomarkers associated with 5-FU sensitivity for non-small-cell lung cancer patients postoperatively treated with UFT","volume":"95","author":"Nakano","year":"2006","journal-title":"Br J Cancer"},{"key":"10.1016\/j.lungcan.2011.04.001_bib0055","doi-asserted-by":"crossref","first-page":"2485","DOI":"10.1002\/1097-0142(19811201)48:11<2485::AID-CNCR2820481123>3.0.CO;2-R","article-title":"Follow-up study of thymomas with special reference to their clinical stages","volume":"48","author":"Masaoka","year":"1981","journal-title":"Cancer"},{"key":"10.1016\/j.lungcan.2011.04.001_bib0060","doi-asserted-by":"crossref","first-page":"3746","DOI":"10.1200\/JCO.2009.27.4662","article-title":"Biologic correlation of 2-[18F]-fluoro-2-deoxy-d-glucose uptake on positron emission tomography in thymic epithelial tumors","volume":"28","author":"Kaira","year":"2010","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.lungcan.2011.04.001_bib0065","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1093\/jnci\/92.3.205","article-title":"New guidelines to evaluate the response to treatment in solid tumors","volume":"92","author":"Therasse","year":"2000","journal-title":"J Natl Cancer Inst"},{"key":"10.1016\/j.lungcan.2011.04.001_bib0070","first-page":"1407","article-title":"Thymidylate synthase gene and protein expression correlate and are associated with response to 5-fluorouracil in human colorectal and gastric tumor","volume":"55","author":"Johnston","year":"1995","journal-title":"Cancer Res"},{"key":"10.1016\/j.lungcan.2011.04.001_bib0075","doi-asserted-by":"crossref","first-page":"4298","DOI":"10.1200\/JCO.2001.19.23.4298","article-title":"ERCC1 and thymidylate synthase mRNA levels predict survival for colorectal cancer patients receiving combination oxaliplatin and fluorouracil chemotherapy","volume":"19","author":"Shirota","year":"2001","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.lungcan.2011.04.001_bib0080","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1200\/JCO.1996.14.1.176","article-title":"Thymidylate synthase mRNA level in adenocarcinoma of the stomach: a predictor for primary tumor response and overall survival","volume":"14","author":"Lenz","year":"1995","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.lungcan.2011.04.001_bib0085","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1158\/1078-0432.CCR-07-1513","article-title":"Thymidylate synthase expression in gastroenteropancreatic and pulmonary neuroendocrine tumors","volume":"14","author":"Ceppi","year":"2008","journal-title":"Clin Cancer Res"},{"key":"10.1016\/j.lungcan.2011.04.001_bib0090","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1002\/jso.21576","article-title":"High-grade neuroendocrine carcinoma of the lung shows increased thymidylate synthase expression compared to other histotypes","volume":"102","author":"Ibe","year":"2010","journal-title":"J Surg Oncol"},{"key":"10.1016\/j.lungcan.2011.04.001_bib0095","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1007\/s005950300018","article-title":"Thymidylate synthase and dihydropyrimidine dehydrogenase mRNA levels in thymoma","volume":"33","author":"Sasaki","year":"2003","journal-title":"Surg Today"},{"key":"10.1016\/j.lungcan.2011.04.001_bib0100","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1002\/jso.21277","article-title":"L-type amino acid transporter 1 (LAT1) is frequently expressed in thymic carcinomas but is absent in thymomas","volume":"99","author":"Kaira","year":"2009","journal-title":"J Surg Oncol"},{"key":"10.1016\/j.lungcan.2011.04.001_bib0105","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1038\/sj.bjc.6603639","article-title":"Changes in the status of p53 affect drug sensitivity to thymidylate synthase (TS) inhibitors by altering TS levels","volume":"96","author":"Giovannetti","year":"2007","journal-title":"Br J Cancer"},{"key":"10.1016\/j.lungcan.2011.04.001_bib0110","doi-asserted-by":"crossref","first-page":"4999","DOI":"10.1200\/JCO.2005.09.017","article-title":"Meta-analysis of postoperative adjuvant chemotherapy with tegafur\u2013uracil in non-small-cell lung cancer","volume":"23","author":"Hamada","year":"2005","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.lungcan.2011.04.001_bib0115","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1093\/jjco\/hyn121","article-title":"Comparison of 5-fluorouracil-related gene expression levels between adenocarcinomas and squamous cell carcinomas of the lung","volume":"39","author":"Ishihama","year":"2009","journal-title":"Jpn J Clin Oncol"},{"key":"10.1016\/j.lungcan.2011.04.001_bib0120","first-page":"1417","article-title":"Thymidylate synthase expression in oral squamous cell carcinoma predicts response to S-1","volume":"15","author":"Harada","year":"2006","journal-title":"Oncol Rep"},{"key":"10.1016\/j.lungcan.2011.04.001_bib0125","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1038\/sj.bjc.6605831","article-title":"Thymidylate synthase, thymidine phosphorylase, and excision repair-complementation group 1 expression as predictive markers of capecitabine plus cisplatin chemotherapy as first-line treatment for patients with advanced oesophageal squamous cell carcinoma","volume":"7","author":"Lee","year":"2010","journal-title":"Br J Cancer"},{"key":"10.1016\/j.lungcan.2011.04.001_bib0130","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1016\/j.oraloncology.2005.12.009","article-title":"Orotate phosphoribosyl transferase mRNA expression in oral squamous cell carcinoma and its relationship with the duhydropyrimidine dehydrogenase expression and the clinical effect of 5-fluorouracil","volume":"42","author":"Yoshitomi","year":"2006","journal-title":"Oral Oncol"},{"key":"10.1016\/j.lungcan.2011.04.001_bib0135","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1002\/cncr.11955","article-title":"Prognostic significance of orotate phosphoribosyl transferase activity in bladder carcinoma","volume":"100","author":"Mizutani","year":"2004","journal-title":"Cancer"},{"key":"10.1016\/j.lungcan.2011.04.001_bib0140","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1097\/JTO.0b013e3181d0a4a7","article-title":"S-1 plus cisplatin chemotherapy with concurrent radiation for thymic basaloid carcinoma","volume":"5","author":"Tagawa","year":"2010","journal-title":"J Thorac Oncol"},{"key":"10.1016\/j.lungcan.2011.04.001_bib0145","first-page":"709","article-title":"Thymidylate synthase, dihydropyrimidine dehydrogenase, orotate phosphoribosyltransferase mRNA and protein expression levels in solid tumors in large scale population analysis","volume":"22","author":"Fukui","year":"2008","journal-title":"Int J Mol Med"}],"container-title":["Lung Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0169500211002169?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0169500211002169?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,30]],"date-time":"2025-09-30T12:21:02Z","timestamp":1759234862000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0169500211002169"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,12]]},"references-count":29,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2011,12]]}},"alternative-id":["S0169500211002169"],"URL":"https:\/\/doi.org\/10.1016\/j.lungcan.2011.04.001","relation":{},"ISSN":["0169-5002"],"issn-type":[{"type":"print","value":"0169-5002"}],"subject":[],"published":{"date-parts":[[2011,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Expression of thymidylate synthase, orotate phosphoribosyltransferase and dihydropyrimidine dehydrogenase in thymic epithelial tumors","name":"articletitle","label":"Article Title"},{"value":"Lung Cancer","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.lungcan.2011.04.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2011 Elsevier Ireland Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}