{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T04:26:42Z","timestamp":1768278402274,"version":"3.49.0"},"reference-count":14,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2013,6,1]],"date-time":"2013-06-01T00:00:00Z","timestamp":1370044800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Lung Cancer"],"published-print":{"date-parts":[[2013,6]]},"DOI":"10.1016\/j.lungcan.2013.02.019","type":"journal-article","created":{"date-parts":[[2013,3,20]],"date-time":"2013-03-20T00:31:17Z","timestamp":1363739477000},"page":"347-349","source":"Crossref","is-referenced-by-count":11,"title":["Pemetrexed-induced neutropenic enteritis and severe cutaneous hyperpigmentation in a patient with malignant pleural mesothelioma"],"prefix":"10.1016","volume":"80","author":[{"given":"Katharina","family":"Buchinger","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rolf","family":"Stahel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Verena","family":"Niggemeier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christoph","family":"Gubler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Franzen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.lungcan.2013.02.019_bib0005","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1517\/14740338.2011.553281","article-title":"Pemetrexed in advanced non-small cell lung cancer","volume":"10","author":"Gridelli","year":"2011","journal-title":"Expert Opin Drug Saf"},{"key":"10.1016\/j.lungcan.2013.02.019_bib0010","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1517\/14728210903074563","article-title":"Malignant pleural mesothelioma: current treatments and emerging drugs","volume":"14","author":"Belli","year":"2009","journal-title":"Expert Opin Emerg Drugs"},{"key":"10.1016\/j.lungcan.2013.02.019_bib0015","doi-asserted-by":"crossref","first-page":"1589","DOI":"10.1200\/JCO.2004.08.163","article-title":"Randomized phase III trial of pemetrexed versus docetaxel in patients with non-small-cell lung cancer previously treated with chemotherapy","volume":"22","author":"Hanna","year":"2004","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.lungcan.2013.02.019_bib0020","doi-asserted-by":"crossref","first-page":"1188","DOI":"10.1097\/JTO.0b013e318187490c","article-title":"Pemetrexed-induced typhlitis in non-small cell lung cancer","volume":"3","author":"Shvartsbeyn","year":"2008","journal-title":"J Thorac Oncol"},{"key":"10.1016\/j.lungcan.2013.02.019_bib0025","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/j.lungcan.2009.02.021","article-title":"Typhlitis during second-line chemotherapy with pemetrexed in non-small cell lung cancer (NSCLC): a case report","volume":"65","author":"Tiseo","year":"2009","journal-title":"Lung Cancer"},{"key":"10.1016\/j.lungcan.2013.02.019_bib0030","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1600-0609.2005.00442.x","article-title":"Neutropenic enterocolitis in adults: systematic analysis of evidence quality","volume":"75","author":"Gorschluter","year":"2005","journal-title":"Eur J Haematol"},{"key":"10.1016\/j.lungcan.2013.02.019_bib0035","first-page":"1753","article-title":"Pemetrexed-induced hyperpigmentation of the skin","volume":"31","author":"Schallier","year":"2011","journal-title":"Anticancer Res"},{"key":"10.1016\/j.lungcan.2013.02.019_bib0040","first-page":"769","article-title":"Revisiting cutaneous adverse reactions to pemetrexed","volume":"2","author":"Pi\u00e9rard-Franchimont","year":"2011","journal-title":"Oncol Lett"},{"key":"10.1016\/j.lungcan.2013.02.019_bib0045","first-page":"44","article-title":"Neutropenic enterocolitis","volume":"22","author":"Davila","year":"2006","journal-title":"Curr Opin Gastroenterol"},{"key":"10.1016\/j.lungcan.2013.02.019_bib0050","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1200\/JCO.1997.15.2.750","article-title":"Phase I trial of docetaxel and cisplatin in previously untreated patients with advanced non-small-cell lung cancer","volume":"15","author":"Millward","year":"1997","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.lungcan.2013.02.019_bib0055","first-page":"524","article-title":"Neutropenic enterocolitis. Two unusual cases with review of the literature","volume":"117","author":"Lev","year":"1993","journal-title":"Arch Pathol Lab Med"},{"key":"10.1016\/j.lungcan.2013.02.019_bib0060","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1097\/01243894-200601000-00007","article-title":"Pemetrexed maintenance therapy in patients with malignant pleural mesothelioma","volume":"1","author":"Van den Bogaert","year":"2006","journal-title":"J Thorac Oncol"},{"key":"10.1016\/j.lungcan.2013.02.019_bib0065","doi-asserted-by":"crossref","first-page":"2083","DOI":"10.1097\/JTO.0b013e31822e722f","article-title":"Skin toxicities compromise prolonged pemetrexed treatment","volume":"6","author":"Eguia","year":"2011","journal-title":"J Thorac Oncol"},{"key":"10.1016\/j.lungcan.2013.02.019_bib0070","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1136\/gutjnl-2011-300563","article-title":"Practice guidance on the management of acute and chronic gastrointestinal problems arising as a result of treatment for cancer","volume":"61","author":"Andreyev","year":"2012","journal-title":"Gut"}],"container-title":["Lung Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0169500213001049?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0169500213001049?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,10,17]],"date-time":"2018-10-17T22:24:28Z","timestamp":1539815068000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0169500213001049"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,6]]},"references-count":14,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2013,6]]}},"alternative-id":["S0169500213001049"],"URL":"https:\/\/doi.org\/10.1016\/j.lungcan.2013.02.019","relation":{},"ISSN":["0169-5002"],"issn-type":[{"value":"0169-5002","type":"print"}],"subject":[],"published":{"date-parts":[[2013,6]]}}}