{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T19:03:50Z","timestamp":1791227030070,"version":"4.1.0"},"reference-count":41,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2015,6,1]],"date-time":"2015-06-01T00:00:00Z","timestamp":1433116800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","lungcancerjournal.info","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Lung Cancer"],"published-print":{"date-parts":[[2015,6]]},"DOI":"10.1016\/j.lungcan.2015.03.013","type":"journal-article","created":{"date-parts":[[2015,4,6]],"date-time":"2015-04-06T13:54:39Z","timestamp":1428328479000},"page":"332-337","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":25,"title":["Intratumoral macrophage phenotype and CD8 + T lymphocytes as potential tools to predict local tumor outgrowth at the intervention site in malignant pleural mesothelioma"],"prefix":"10.1016","volume":"88","author":[{"given":"Robin","family":"Cornelissen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lysanne A.","family":"Lievense","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan-Lukas","family":"Robertus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rudi W.","family":"Hendriks","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henk C.","family":"Hoogsteden","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joost P.J.J.","family":"Hegmans","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joachim G.J.V.","family":"Aerts","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.lungcan.2015.03.013_bib0210","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1148\/radiology.211.3.r99jn03657","article-title":"Malignant pleural mesothelioma: US-guided histologic core-needle biopsy","volume":"211","author":"Heilo","year":"1999","journal-title":"Radiology"},{"key":"10.1016\/j.lungcan.2015.03.013_bib0215","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/S0761-8425(04)71235-8","article-title":"Malignant pleural mesothelioma: radiotherapy for the prevention of seeding nodules","volume":"21","author":"Cellerin","year":"2004","journal-title":"Rev Mal Respir"},{"key":"10.1016\/j.lungcan.2015.03.013_bib0220","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.lungcan.2009.06.014","article-title":"Prophylactic radiotherapy to intervention sites in mesothelioma: a systematic review and survey of UK practice","volume":"66","author":"Lee","year":"2009","journal-title":"Lung Cancer"},{"key":"10.1016\/j.lungcan.2015.03.013_bib0225","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1378\/chest.13-3057","article-title":"Catheter tract metastasis associated with indwelling pleural catheters","volume":"146","author":"Thomas","year":"2014","journal-title":"Chest"},{"key":"10.1016\/j.lungcan.2015.03.013_bib0230","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/j.radonc.2011.08.038","article-title":"Prophylactic irradiation of intervention sites in malignant pleural mesothelioma","volume":"101","author":"Froment","year":"2011","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.lungcan.2015.03.013_bib0235","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1378\/chest.108.3.754","article-title":"Prevention of malignant seeding after invasive diagnostic procedures in patients with pleural mesothelioma. A randomized trial of local radiotherapy","volume":"108","author":"Boutin","year":"1995","journal-title":"Chest"},{"key":"10.1016\/j.lungcan.2015.03.013_bib0240","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1038\/sj.bjc.6601957","article-title":"A randomised trial of single-dose radiotherapy to prevent procedure tract metastasis by malignant mesothelioma","volume":"91","author":"Bydder","year":"2004","journal-title":"Br J Cancer"},{"key":"10.1016\/j.lungcan.2015.03.013_bib0245","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.radonc.2007.05.022","article-title":"A randomised controlled trial of intervention site radiotherapy in malignant pleural mesothelioma","volume":"84","author":"O\u2019Rourke","year":"2007","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.lungcan.2015.03.013_bib0250","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1097\/MCP.0b013e3282fcea50","article-title":"Prophylactic radiotherapy for pleural puncture sites in mesothelioma: the controversy continues","volume":"14","author":"Davies","year":"2008","journal-title":"Curr Opin Pulm Med"},{"key":"10.1016\/j.lungcan.2015.03.013_bib0255","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1016\/j.rmed.2005.09.034","article-title":"Needle-track metastases and prophylactic radiotherapy for mesothelioma","volume":"100","author":"West","year":"2006","journal-title":"Respir Med"},{"key":"10.1016\/j.lungcan.2015.03.013_bib0260","doi-asserted-by":"crossref","first-page":"2636","DOI":"10.1200\/JCO.2003.11.136","article-title":"Phase III study of pemetrexed in combination with cisplatin versus cisplatin alone in patients with malignant pleural mesothelioma","volume":"21","author":"Vogelzang","year":"2003","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.lungcan.2015.03.013_bib0265","article-title":"Radiotherapy for the treatment of pain in malignant pleural mesothelioma: a systematic review","author":"Macleod","year":"2013","journal-title":"Lung Cancer"},{"key":"10.1016\/j.lungcan.2015.03.013_bib0270","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/S0936-6555(05)80540-0","article-title":"Prevention of tumour seeding following thoracoscopy in mesothelioma by prophylactic radiotherapy","volume":"7","author":"Low","year":"1995","journal-title":"Clin Oncol (R Coll Radiol)"},{"key":"10.1016\/j.lungcan.2015.03.013_bib0275","doi-asserted-by":"crossref","first-page":"1543","DOI":"10.1007\/s00262-010-0881-6","article-title":"CD8+ tumor-infiltrating lymphocytes predict favorable prognosis in malignant pleural mesothelioma after resection","volume":"59","author":"Yamada","year":"2010","journal-title":"Cancer Immunol Immunother"},{"key":"10.1016\/j.lungcan.2015.03.013_bib0280","doi-asserted-by":"crossref","first-page":"1721","DOI":"10.1007\/s00262-011-1073-8","article-title":"Chronic inflammation in tumor stroma is an independent predictor of prolonged survival in epithelioid malignant pleural mesothelioma patients","volume":"60","author":"Suzuki","year":"2011","journal-title":"Cancer Immunol Immunother"},{"key":"10.1016\/j.lungcan.2015.03.013_bib0285","doi-asserted-by":"crossref","first-page":"5234","DOI":"10.1002\/cncr.26143","article-title":"Circulating and tumor-infiltrating myeloid cells predict survival in human pleural mesothelioma","volume":"117","author":"Burt","year":"2011","journal-title":"Cancer"},{"key":"10.1016\/j.lungcan.2015.03.013_bib0290","doi-asserted-by":"crossref","DOI":"10.1016\/j.lungcan.2013.02.017","article-title":"Tumor-associated macrophages in thoracic malignancies","author":"Lievense","year":"2013","journal-title":"Lung Cancer"},{"key":"10.1016\/j.lungcan.2015.03.013_bib0295","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1016\/S1471-4906(02)02302-5","article-title":"Macrophage polarization: tumor-associated macrophages as a paradigm for polarized M2 mononuclear phagocytes","volume":"23","author":"Mantovani","year":"2002","journal-title":"Trends Immunol"},{"key":"10.1016\/j.lungcan.2015.03.013_bib0300","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.cell.2010.03.014","article-title":"Macrophage diversity enhances tumor progression and metastasis","volume":"141","author":"Qian","year":"2010","journal-title":"Cell"},{"key":"10.1016\/j.lungcan.2015.03.013_bib0305","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1038\/35051594","article-title":"Identification of the haemoglobin scavenger receptor","volume":"409","author":"Kristiansen","year":"2001","journal-title":"Nature"},{"key":"10.1016\/j.lungcan.2015.03.013_bib0310","first-page":"794","article-title":"CD163 a specific marker of macrophages in paraffin-embedded tissue samples","volume":"122","author":"Lau","year":"2004","journal-title":"AJCP"},{"key":"10.1016\/j.lungcan.2015.03.013_bib0315","doi-asserted-by":"crossref","first-page":"3330","DOI":"10.1200\/JCO.2008.19.9919","article-title":"Macrophage markers in serum and tumor have prognostic impact in American Joint Committee on Cancer stage I\/II melanoma","volume":"27","author":"Jensen","year":"2009","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.lungcan.2015.03.013_bib0320","doi-asserted-by":"crossref","first-page":"e955356","DOI":"10.4161\/21624011.2014.955356","article-title":"Tumor-associated macrophages as therapeutic target in cancer therapy and their complex biology","author":"Cannarile","year":"2014","journal-title":"OncoImmunology"},{"key":"10.1016\/j.lungcan.2015.03.013_bib0325","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1183\/09031936.00065708","article-title":"Macrophages within NSCLC tumour islets are predominantly of a cytotoxic M1 phenotype associated with extended survival","volume":"33","author":"Ohri","year":"2009","journal-title":"Eur Respir J"},{"key":"10.1016\/j.lungcan.2015.03.013_bib0330","first-page":"1007","article-title":"Lymphocytic infiltration of pleural mesothelioma and its significance for survival","volume":"61","author":"Leigh","year":"1982","journal-title":"S Afr Med J"},{"key":"10.1016\/j.lungcan.2015.03.013_bib0335","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1016\/j.jtcvs.2007.10.026","article-title":"Impact of tumor-infiltrating T cells on survival in patients with malignant pleural mesothelioma","volume":"135","author":"Anraku","year":"2008","journal-title":"J Thorac Cardiovasc Surg"},{"key":"10.1016\/j.lungcan.2015.03.013_bib0340","doi-asserted-by":"crossref","first-page":"1086","DOI":"10.1183\/09031936.06.00135305","article-title":"Mesothelioma environment comprises cytokines and T-regulatory cells that suppress immune responses","volume":"27","author":"Hegmans","year":"2006","journal-title":"Eur Respir J"},{"key":"10.1016\/j.lungcan.2015.03.013_bib0345","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.coi.2010.01.009","article-title":"Macrophages, innate immunity and cancer: balance, tolerance, and diversity","volume":"22","author":"Mantovani","year":"2010","journal-title":"Curr Opin Immunol"},{"key":"10.1016\/j.lungcan.2015.03.013_bib0350","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1007\/s10555-006-9001-7","article-title":"Role of tumor-associated macrophages in tumor progression and invasion","volume":"25","author":"Mantovani","year":"2006","journal-title":"Cancer Metastasis Rev"},{"key":"10.1016\/j.lungcan.2015.03.013_bib0355","doi-asserted-by":"crossref","first-page":"e106742","DOI":"10.1371\/journal.pone.0106742","article-title":"Ratio of intratumoral macrophage phenotypes is a prognostic factor in epithelioid malignant pleural mesothelioma","volume":"9","author":"Cornelissen","year":"2014","journal-title":"PLOS ONE"},{"key":"10.1016\/j.lungcan.2015.03.013_bib0360","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1038\/nrc1256","article-title":"Tumour-educated macrophages promote tumour progression and metastasis","volume":"4","author":"Pollard","year":"2004","journal-title":"Nat Rev Cancer"},{"key":"10.1016\/j.lungcan.2015.03.013_bib0365","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1189\/jlb.0609385","article-title":"Tumor-associated macrophages (TAM) as major players of the cancer-related inflammation","volume":"86","author":"Solinas","year":"2009","journal-title":"J Leukoc Biol"},{"key":"10.1016\/j.lungcan.2015.03.013_bib0370","doi-asserted-by":"crossref","first-page":"884","DOI":"10.1007\/s12032-014-0884-9","article-title":"Anti-inflammatory macrophages activate invasion in pancreatic adenocarcinoma by increasing the MMP9 and ADAM8 expression","volume":"31","author":"Puolakkainen","year":"2014","journal-title":"Med Oncol"},{"key":"10.1016\/j.lungcan.2015.03.013_bib0375","article-title":"CRKL promotes lung cancer cell invasion through ERK-MMP9 pathway","author":"Lin","year":"2014","journal-title":"Mol Carcinog"},{"key":"10.1016\/j.lungcan.2015.03.013_bib0380","first-page":"1","article-title":"Intraepithelial T cells and tumor-associated macrophages in ovarian cancer patients","volume":"13","author":"Mhawech-Fauceglia","year":"2013","journal-title":"Cancer Immun"},{"key":"10.1016\/j.lungcan.2015.03.013_bib0385","doi-asserted-by":"crossref","first-page":"1913","DOI":"10.1111\/j.1349-7006.2010.01614.x","article-title":"Significance of alternatively activated macrophages in patients with intrahepatic cholangiocarcinoma","volume":"101","author":"Hasita","year":"2010","journal-title":"Cancer Sci"},{"key":"10.1016\/j.lungcan.2015.03.013_bib0390","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1002\/ijc.25113","article-title":"Anti-inflammatory M2 type macrophages characterize metastasized and tyrosine kinase inhibitor-treated gastrointestinal stromal tumors","volume":"127","author":"Van Dongen","year":"2010","journal-title":"Int J Cancer"},{"key":"10.1016\/j.lungcan.2015.03.013_bib0395","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1007\/s10555-010-9223-6","article-title":"Interactions between lymphocytes and myeloid cells regulate pro- versus anti-tumor immunity","volume":"29","author":"DeNardo","year":"2010","journal-title":"Cancer Metastasis Rev"},{"key":"10.1016\/j.lungcan.2015.03.013_bib0400","doi-asserted-by":"crossref","first-page":"2220","DOI":"10.4049\/jimmunol.181.3.2220","article-title":"Human anti-inflammatory macrophages induce Foxp3+ GITR+ CD25+ regulatory T cells, which suppress via membrane-bound TGFbeta-1","volume":"181","author":"Savage","year":"2008","journal-title":"J Immunol"},{"key":"10.1016\/j.lungcan.2015.03.013_bib0405","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1016\/j.ccr.2014.05.016","article-title":"Targeting tumor-associated macrophages with anti-CSF-1R antibody reveals a strategy for cancer therapy","volume":"25","author":"Ries","year":"2014","journal-title":"Cancer Cell"},{"key":"10.1016\/j.lungcan.2015.03.013_bib0410","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1183\/09031936.00063109","article-title":"Guidelines of the European Respiratory Society and the European Society of Thoracic Surgeons for the management of malignant pleural mesothelioma","volume":"35","author":"Scherpereel","year":"2009","journal-title":"Eur Respir J"}],"container-title":["Lung Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0169500215001658?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0169500215001658?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,6,8]],"date-time":"2024-06-08T06:54:14Z","timestamp":1717829654000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0169500215001658"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,6]]},"references-count":41,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2015,6]]}},"alternative-id":["S0169500215001658"],"URL":"https:\/\/doi.org\/10.1016\/j.lungcan.2015.03.013","relation":{},"ISSN":["0169-5002"],"issn-type":[{"value":"0169-5002","type":"print"}],"subject":[],"published":{"date-parts":[[2015,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Intratumoral macrophage phenotype and CD8+ T lymphocytes as potential tools to predict local tumor outgrowth at the intervention site in malignant pleural mesothelioma","name":"articletitle","label":"Article Title"},{"value":"Lung Cancer","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.lungcan.2015.03.013","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier Ireland Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}