{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T21:59:09Z","timestamp":1783461549673,"version":"3.55.0"},"reference-count":39,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,10,1]],"date-time":"2017-10-01T00:00:00Z","timestamp":1506816000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","lungcancerjournal.info","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Lung Cancer"],"published-print":{"date-parts":[[2017,10]]},"DOI":"10.1016\/j.lungcan.2017.07.023","type":"journal-article","created":{"date-parts":[[2017,7,27]],"date-time":"2017-07-27T15:46:18Z","timestamp":1501170378000},"page":"25-34","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":48,"special_numbering":"C","title":["Anamorelin for advanced non-small-cell lung cancer with cachexia: Systematic review and meta-analysis"],"prefix":"10.1016","volume":"112","author":[{"given":"Kenichi","family":"Nishie","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuhei","family":"Yamamoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chie","family":"Nagata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomonobu","family":"Koizumi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masayuki","family":"Hanaoka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.lungcan.2017.07.023_bib0005","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/S0149-2918(05)80001-3","article-title":"Prognostic effect of weight loss prior to chemotherapy in cancer patients. Eastern Cooperative Oncology Group","volume":"69","author":"Dewys","year":"1980","journal-title":"Am. J. Med."},{"issue":"7","key":"10.1016\/j.lungcan.2017.07.023_bib0010","doi-asserted-by":"crossref","first-page":"1586","DOI":"10.1001\/archinte.1988.00380070082020","article-title":"Clinical symptoms and length of survival in patients with terminal cancer","volume":"148","author":"Reuben","year":"1988","journal-title":"Arch. Intern. Med."},{"issue":"7","key":"10.1016\/j.lungcan.2017.07.023_bib0015","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1007\/s11605-008-0505-z","article-title":"Cachexia worsens prognosis in patients with resectable pancreatic cancer","volume":"12","author":"Bachmann","year":"2008","journal-title":"J. Gastrointest. Surg."},{"issue":"5","key":"10.1016\/j.lungcan.2017.07.023_bib0020","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1016\/S1470-2045(10)70218-7","article-title":"Definition and classification of cancer cachexia: an international consensus","volume":"12","author":"Fearon","year":"2011","journal-title":"Lancet Oncol."},{"issue":"1","key":"10.1016\/j.lungcan.2017.07.023_bib0025","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s13539-010-0002-6","article-title":"Cachexia as a major underestimated and unmet medical need: facts and numbers","volume":"1","author":"von Haehling","year":"2010","journal-title":"J. Cachexia Sarcopenia Muscle"},{"issue":"4","key":"10.1016\/j.lungcan.2017.07.023_bib0030","doi-asserted-by":"crossref","first-page":"1133S","DOI":"10.3945\/ajcn.2010.28608C","article-title":"Body composition in patients with non-small cell lung cancer: a contemporary view of cancer cachexia with the use of computed tomography image analysis","volume":"91","author":"Baracos","year":"2010","journal-title":"Am. J. Clin. Nutr."},{"issue":"1","key":"10.1016\/j.lungcan.2017.07.023_bib0035","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1200\/JCO.2014.56.1894","article-title":"Diagnostic criteria for the classification of cancer-associated weight loss","volume":"33","author":"Martin","year":"2015","journal-title":"J. Clin. Oncol."},{"issue":"4","key":"10.1016\/j.lungcan.2017.07.023_bib0040","doi-asserted-by":"crossref","first-page":"225","DOI":"10.3322\/caac.20006","article-title":"Cancer statistics, 2009","volume":"59","author":"Jemal","year":"2009","journal-title":"CA Cancer J. Clin."},{"issue":"14","key":"10.1016\/j.lungcan.2017.07.023_bib0045","doi-asserted-by":"crossref","first-page":"1509","DOI":"10.1056\/NEJMsb0707912","article-title":"Options for slowing the growth of health care costs","volume":"358","author":"Mongan","year":"2008","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.lungcan.2017.07.023_bib0050","doi-asserted-by":"crossref","first-page":"601434","DOI":"10.1155\/2011\/601434","article-title":"Cancer cachexia: mechanisms and clinical implications","volume":"2011","author":"Donohoe","year":"2011","journal-title":"Gastroenterol. Res. Pract."},{"issue":"8","key":"10.1016\/j.lungcan.2017.07.023_bib0055","doi-asserted-by":"crossref","first-page":"1492","DOI":"10.1093\/annonc\/mdu085","article-title":"Early recognition of malnutrition and cachexia in the cancer patient: a position paper of a European School of Oncology Task Force","volume":"25","author":"Aapro","year":"2014","journal-title":"Ann. Oncol."},{"issue":"1","key":"10.1016\/j.lungcan.2017.07.023_bib0060","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/S1470-2045(14)71154-4","article-title":"Anamorelin for patients with cancer cachexia: an integrated analysis of two phase 2, randomised, placebo-controlled, double-blind trials","volume":"16","author":"Garcia","year":"2015","journal-title":"Lancet Oncol."},{"issue":"6762","key":"10.1016\/j.lungcan.2017.07.023_bib0065","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1038\/45230","article-title":"Ghrelin is a growth-hormone-releasing acylated peptide from stomach","volume":"402","author":"Kojima","year":"1999","journal-title":"Nature"},{"issue":"2","key":"10.1016\/j.lungcan.2017.07.023_bib0070","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1152\/physrev.00012.2004","article-title":"Ghrelin: structure and function","volume":"85","author":"Kojima","year":"2005","journal-title":"Physiol. Rev."},{"issue":"2","key":"10.1016\/j.lungcan.2017.07.023_bib0075","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1016\/S0003-4975(01)02847-8","article-title":"Do patients with nonmetastatic non-small cell lung cancer demonstrate altered resting energy expenditure?","volume":"72","author":"Jatoi","year":"2001","journal-title":"Ann. Thorac. Surg."},{"issue":"1","key":"10.1016\/j.lungcan.2017.07.023_bib0080","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1186\/s12937-016-0214-5","article-title":"Two ghrelin receptor agonists for adults with malnutrition: a systematic review and meta-analysis","volume":"15","author":"Su","year":"2016","journal-title":"Nutr. J."},{"issue":"9","key":"10.1016\/j.lungcan.2017.07.023_bib0085","doi-asserted-by":"crossref","first-page":"R393","DOI":"10.1530\/ERC-16-0130","article-title":"Is there an effect of ghrelin\/ghrelin analogs on cancer? A systematic review","volume":"23","author":"Sever","year":"2016","journal-title":"Endocr. Relat. Cancer"},{"issue":"9","key":"10.1016\/j.lungcan.2017.07.023_bib0090","doi-asserted-by":"crossref","first-page":"3118","DOI":"10.1210\/en.2013-1179","article-title":"Inhibition of cisplatin-induced lipid catabolism and weight loss by ghrelin in male mice","volume":"154","author":"Garcia","year":"2013","journal-title":"Endocrinology"},{"issue":"4","key":"10.1016\/j.lungcan.2017.07.023_bib0095","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1007\/s13539-014-0159-5","article-title":"Anamorelin HCl (ONO-7643), a novel ghrelin receptor agonist, for the treatment of cancer anorexia-cachexia syndrome: preclinical profile","volume":"5","author":"Pietra","year":"2014","journal-title":"J. Cachexia Sarcopenia Muscle"},{"issue":"4","key":"10.1016\/j.lungcan.2017.07.023_bib0100","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1016\/S1470-2045(15)00558-6","article-title":"Anamorelin in patients with non-small-cell lung cancer and cachexia (ROMANA 1 and ROMANA 2): results from two randomised, double-blind, phase 3 trials","volume":"17","author":"Temel","year":"2016","journal-title":"Lancet Oncol."},{"issue":"8","key":"10.1016\/j.lungcan.2017.07.023_bib0105","doi-asserted-by":"crossref","first-page":"3495","DOI":"10.1007\/s00520-016-3144-z","article-title":"Anamorelin (ONO-7643) in Japanese patients with non-small cell lung cancer and cachexia: results of a randomized phase 2 trial","volume":"24","author":"Takayama","year":"2016","journal-title":"Support. Care Cancer"},{"issue":"10","key":"10.1016\/j.lungcan.2017.07.023_bib0110","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1016\/j.jclinepi.2009.06.005","article-title":"Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement","volume":"62","author":"Moher","year":"2009","journal-title":"J. Clin. Epidemiol."},{"key":"10.1016\/j.lungcan.2017.07.023_bib0115","series-title":"Cochrane Handbook for Systematic Reviews of Interventions","author":"Green","year":"2011"},{"key":"10.1016\/j.lungcan.2017.07.023_bib0120","series-title":"Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0","article-title":"Analysing data and undertaking meta-analyses","author":"Deeks","year":"2011"},{"key":"10.1016\/j.lungcan.2017.07.023_bib0125","series-title":"Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0","article-title":"Assessing risk of bias in included studies","author":"Green","year":"2011"},{"issue":"4","key":"10.1016\/j.lungcan.2017.07.023_bib0130","doi-asserted-by":"crossref","first-page":"264","DOI":"10.7326\/0003-4819-151-4-200908180-00135","article-title":"Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement","volume":"151","author":"Moher","year":"2009","journal-title":"Ann. Intern. Med."},{"issue":"6","key":"10.1016\/j.lungcan.2017.07.023_bib0135","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1093\/annonc\/mdw390.02","article-title":"ONO-7643\/anamorelin for the treatment of patients with non-small cell lung cancer and cachexia: results from phase 2 study with Japanese patients, ESMO","volume":"27","author":"Uchino","year":"2016","journal-title":"Ann Oncol ."},{"key":"10.1016\/j.lungcan.2017.07.023_bib0140","unstructured":"S.A.B. Jennifer, S. Temel, Minish Mahendra Jain, Ying Yan, Elizabeth Manning Duus, Suzan Allen, William Mann; Massachusetts General Hospital Cancer Center, Boston, MA; Shatabdi Super Specialty Hospital, Nashik, India; Ruby Hall Clinic, Pune, India; Helsinn Therapeutics (US), Inc., Bridgewater, NJ,E valuation of quality of life from a phase II study of anamorelin HCl in NSCLC patients., ASCO, 2013."},{"issue":"1","key":"10.1016\/j.lungcan.2017.07.023_bib0145","doi-asserted-by":"crossref","first-page":"6","DOI":"10.3109\/0284186X.2012.724536","article-title":"Non-steroidal anti-inflammatory treatment in cancer cachexia: a systematic literature review","volume":"52","author":"Solheim","year":"2013","journal-title":"Acta Oncol."},{"issue":"1","key":"10.1016\/j.lungcan.2017.07.023_bib0150","first-page":"61","article-title":"Causes of death in cancer patients","volume":"6","author":"Ambrus","year":"1975","journal-title":"J. Med."},{"issue":"4","key":"10.1016\/j.lungcan.2017.07.023_bib0155","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1097\/MCO.0b013e3281a30594","article-title":"Risk factor paradox in wasting diseases","volume":"10","author":"Kalantar-Zadeh","year":"2007","journal-title":"Curr. Opin. Clin. Nutr. Metab. Care"},{"issue":"24","key":"10.1016\/j.lungcan.2017.07.023_bib0160","doi-asserted-by":"crossref","first-page":"1848","DOI":"10.1093\/jnci\/djt348","article-title":"Obesity that makes kidney cancer more likely but helps fight it more strongly","volume":"105","author":"Li","year":"2013","journal-title":"J. Natl. Cancer Inst."},{"issue":"21","key":"10.1016\/j.lungcan.2017.07.023_bib0165","doi-asserted-by":"crossref","first-page":"3401","DOI":"10.1200\/JCO.2005.04.5724","article-title":"Double-blind, placebo-controlled, randomized study of eicosapentaenoic acid diester in patients with cancer cachexia","volume":"24","author":"Fearon","year":"2006","journal-title":"J. Clin. Oncol."},{"issue":"6","key":"10.1016\/j.lungcan.2017.07.023_bib0170","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.1038\/sj.bjc.6601242","article-title":"Evaluation of cumulative prognostic scores based on the systemic inflammatory response in patients with inoperable non-small-cell lung cancer","volume":"89","author":"Forrest","year":"2003","journal-title":"Br. J. Cancer"},{"issue":"1","key":"10.1016\/j.lungcan.2017.07.023_bib0175","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.clnu.2016.07.015","article-title":"ESPEN guidelines on nutrition in cancer patients","volume":"36","author":"Arends","year":"2017","journal-title":"Clin. Nutr."},{"issue":"8","key":"10.1016\/j.lungcan.2017.07.023_bib0180","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1056\/NEJMoa1000678","article-title":"Early palliative care for patients with metastatic non-small-cell lung cancer","volume":"363","author":"Temel","year":"2010","journal-title":"N. Engl. J. Med."},{"issue":"5","key":"10.1016\/j.lungcan.2017.07.023_bib0185","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1007\/s00520-008-0486-1","article-title":"A questionnaire study of the approach to the anorexia-cachexia syndrome in patients with cancer by staff in a district general hospital","volume":"17","author":"Churm","year":"2009","journal-title":"Support. Care Cancer"},{"key":"10.1016\/j.lungcan.2017.07.023_bib0190","doi-asserted-by":"crossref","DOI":"10.1093\/annonc\/mdx192","article-title":"ROMANA 3: a phase 3 safety extension study of anamorelin in advanced non-small cell lung cancer (NSCLC) patients with cachexia","author":"Currow","year":"2017","journal-title":"Ann. Oncol."},{"issue":"8","key":"10.1016\/j.lungcan.2017.07.023_bib0195","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1016\/S1470-2045(01)00453-3","article-title":"Meta-analyses of randomised clinical trials in oncology","volume":"2","author":"Pignon","year":"2001","journal-title":"Lancet Oncol."}],"container-title":["Lung Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0169500217304026?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0169500217304026?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,10,13]],"date-time":"2020-10-13T14:09:29Z","timestamp":1602598169000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0169500217304026"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,10]]},"references-count":39,"alternative-id":["S0169500217304026"],"URL":"https:\/\/doi.org\/10.1016\/j.lungcan.2017.07.023","relation":{},"ISSN":["0169-5002"],"issn-type":[{"value":"0169-5002","type":"print"}],"subject":[],"published":{"date-parts":[[2017,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Anamorelin for advanced non-small-cell lung cancer with cachexia: Systematic review and meta-analysis","name":"articletitle","label":"Article Title"},{"value":"Lung Cancer","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.lungcan.2017.07.023","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}