{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T19:08:27Z","timestamp":1786993707635,"version":"build-2736575974"},"reference-count":21,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,10,1]],"date-time":"2018-10-01T00:00:00Z","timestamp":1538352000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81202068"],"award-info":[{"award-number":["81202068"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","lungcancerjournal.info","clinicalkey.es","clinicalkey.fr","clinicalkey.com.au","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Lung Cancer"],"published-print":{"date-parts":[[2018,10]]},"DOI":"10.1016\/j.lungcan.2018.07.016","type":"journal-article","created":{"date-parts":[[2018,7,23]],"date-time":"2018-07-23T06:03:54Z","timestamp":1532325834000},"page":"1-5","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"special_numbering":"C","title":["Novel gene mutations in well-differentiated fetal adenocarcinoma of the lung in the next generation sequencing era"],"prefix":"10.1016","volume":"124","author":[{"given":"Yiyun","family":"Fu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Su","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yidan","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiya","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lili","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.lungcan.2018.07.016_bib0005","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1097\/JTO.0b013e318206a221","article-title":"International association for the study of lung cancer\/American thoracic society\/European respiratory society international multidisciplinary classification of lung adenocarcinoma","volume":"6","author":"Travis","year":"2011","journal-title":"J. Thorac. Oncol."},{"key":"10.1016\/j.lungcan.2018.07.016_bib0010","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.1097\/JTO.0000000000000630","article-title":"The 2015 World Health Organization classification of lung tumors: impact of genetic, clinical and radiologic advances since the 2004 classification","volume":"10","author":"Travis","year":"2015","journal-title":"J. Thorac. Oncol."},{"key":"10.1016\/j.lungcan.2018.07.016_bib0015","doi-asserted-by":"crossref","first-page":"2071","DOI":"10.21037\/jtd.2017.07.14","article-title":"Differences between low and high grade fetal adenocarcinoma of the lung: a clinicopathological and molecular study","volume":"9","author":"Zhang","year":"2017","journal-title":"J. Thoracic Dis."},{"key":"10.1016\/j.lungcan.2018.07.016_bib0020","doi-asserted-by":"crossref","first-page":"2368","DOI":"10.1002\/1097-0142(19910501)67:9<2368::AID-CNCR2820670926>3.0.CO;2-G","article-title":"Pulmonary blastomas","volume":"67","author":"Koss","year":"1991","journal-title":"Cancer"},{"key":"10.1016\/j.lungcan.2018.07.016_bib0025","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/0169-5002(95)00489-0","article-title":"Well-differentiated fetal adenocarcinoma of lung","volume":"13","author":"Fujino","year":"1995","journal-title":"Lung Cancer"},{"key":"10.1016\/j.lungcan.2018.07.016_bib0030","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1097\/00000478-198203000-00009","article-title":"Pulmonary blastoma with argyrophil cells and lacking sarcomatous features (pulmonary endodermal tumor resembling fetal lung)","volume":"6","author":"Kradin","year":"1982","journal-title":"Am. J. Surg. Pathol."},{"key":"10.1016\/j.lungcan.2018.07.016_bib0035","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1097\/PAS.0b013e31827e1e83","article-title":"High-grade lung adenocarcinoma with fetal lung-like morphology clinicopathologic, immunohistochemical, and molecular analyses of 17 cases","volume":"37","author":"Morita","year":"2013","journal-title":"Am. J. Surg. Pathol."},{"key":"10.1016\/j.lungcan.2018.07.016_bib0040","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1016\/j.ejmg.2014.09.008","article-title":"DICER1 mutations in a patient with an ovarian Sertoli-Leydig tumor, well-differentiated fetal adenocarcinoma of the lung, and familial multinodular goiter","volume":"57","author":"Wu","year":"2014","journal-title":"Eur. J. Med. Genet."},{"key":"10.1016\/j.lungcan.2018.07.016_bib0045","doi-asserted-by":"crossref","first-page":"e31","DOI":"10.1016\/j.jtho.2015.09.012","article-title":"Germline and somatic DICER1 mutations in a well-differentiated fetal adenocarcinoma of the lung","volume":"11","author":"de Kock","year":"2016","journal-title":"J. Thorac. Oncol."},{"key":"10.1016\/j.lungcan.2018.07.016_bib0050","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1002\/dc.23526","article-title":"Well-differentiated fetal adenocarcinoma of the lung mimicking adenoid cystic carcinoma on fine needle aspiration: a case report","volume":"44","author":"Rerkpichaisuth","year":"2016","journal-title":"Diagn. Cytopathol."},{"key":"10.1016\/j.lungcan.2018.07.016_bib0055","first-page":"838","article-title":"Well-differentiated fetal adenocarcinoma of lung: a case report with 14 cases literature review","volume":"13","author":"Zhang","year":"2010","journal-title":"Zhongguo Fei Ai Za Zhi"},{"key":"10.1016\/j.lungcan.2018.07.016_bib0060","first-page":"E13","article-title":"Aberration of the Wnt signaling pathway in pulmonary fatal adenocarcinoma: a case report","volume":"26","author":"Li","year":"2014","journal-title":"Chin J Cancer Res"},{"key":"10.1016\/j.lungcan.2018.07.016_bib0065","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1038\/modpathol.3880575","article-title":"Aberrant nuclear localization and gene mutation of beta-catenin in low-grade adenocarcinoma of fetal lung type: up-regulation of the Wnt signaling pathway may be a common denominator for the development of tumors that form morules","volume":"15","author":"Nakatani","year":"2002","journal-title":"Mod. Pathol."},{"key":"10.1016\/j.lungcan.2018.07.016_bib0070","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1002\/path.1352","article-title":"Beta-catenin mutations in pulmonary blastomas: association with morule formation","volume":"200","author":"Sekine","year":"2003","journal-title":"J. Pathol."},{"key":"10.1016\/j.lungcan.2018.07.016_bib0075","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1006236","article-title":"Interaction with PALB2 Is essential for maintenance of genomic integrity by BRCA2","volume":"12","author":"Hartford","year":"2016","journal-title":"PLos Genet."},{"key":"10.1016\/j.lungcan.2018.07.016_bib0080","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1038\/ng.3002","article-title":"Rare variants of large effect in BRCA2 and CHEK2 affect risk of lung cancer","volume":"46","author":"Wang","year":"2014","journal-title":"Nat. Genet."},{"key":"10.1016\/j.lungcan.2018.07.016_bib0085","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1136\/jmg.2004.028829","article-title":"C. Netherlands collaborative group on hereditary breast, cancer risks in BRCA2 families: estimates for sites other than breast and ovary","volume":"42","author":"van Asperen","year":"2005","journal-title":"J. Med. Genet."},{"key":"10.1016\/j.lungcan.2018.07.016_bib0090","first-page":"243","article-title":"G. International tuberous sclerosis complex consensus, tuberous sclerosis complex diagnostic criteria update: recommendations of the 2012","volume":"49","author":"Northrup","year":"2013"},{"key":"10.1016\/j.lungcan.2018.07.016_bib0095","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.jaad.2007.05.004","article-title":"Tuberous sclerosis complex: advances in diagnosis, genetics, and management","volume":"57","author":"Schwartz","year":"2007","journal-title":"J. Am. Acad. Dermatol."},{"key":"10.1016\/j.lungcan.2018.07.016_bib0100","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1007\/s11060-006-9134-0","article-title":"Hamartin and tuberin modulate gene transcription via beta-catenin","volume":"79","author":"Jozwiak","year":"2006","journal-title":"J. Neurooncol."},{"key":"10.1016\/j.lungcan.2018.07.016_bib0105","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.braindev.2006.09.009","article-title":"Upregulation of the WNT pathway in tuberous sclerosis-associated subependymal giant cell astrocytomas","volume":"29","author":"Jozwiak","year":"2007","journal-title":"Brain Dev."}],"container-title":["Lung Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S016950021830477X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S016950021830477X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,26]],"date-time":"2018-09-26T19:45:17Z","timestamp":1537991117000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S016950021830477X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,10]]},"references-count":21,"alternative-id":["S016950021830477X"],"URL":"https:\/\/doi.org\/10.1016\/j.lungcan.2018.07.016","relation":{},"ISSN":["0169-5002"],"issn-type":[{"value":"0169-5002","type":"print"}],"subject":[],"published":{"date-parts":[[2018,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Novel gene mutations in well-differentiated fetal adenocarcinoma of the lung in the next generation sequencing era","name":"articletitle","label":"Article Title"},{"value":"Lung Cancer","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.lungcan.2018.07.016","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}