{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,7]],"date-time":"2026-01-07T07:47:22Z","timestamp":1767772042561,"version":"build-2238731810"},"reference-count":27,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,2,1]],"date-time":"2019-02-01T00:00:00Z","timestamp":1548979200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,2,1]],"date-time":"2019-02-01T00:00:00Z","timestamp":1548979200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2018,12,5]],"date-time":"2018-12-05T00:00:00Z","timestamp":1543968000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","lungcancerjournal.info","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Lung Cancer"],"published-print":{"date-parts":[[2019,2]]},"DOI":"10.1016\/j.lungcan.2018.12.005","type":"journal-article","created":{"date-parts":[[2018,12,5]],"date-time":"2018-12-05T13:07:07Z","timestamp":1544015227000},"page":"152-157","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"special_numbering":"C","title":["Genetic alterations of driver genes as independent prognostic factors for disease-free survival in patients with resected non-small cell lung cancer"],"prefix":"10.1016","volume":"128","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5705-9423","authenticated-orcid":false,"given":"Akira","family":"Ono","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mitsuhiro","family":"Isaka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masakuni","family":"Serizawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katsuhiro","family":"Omae","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6762-8455","authenticated-orcid":false,"given":"Hideaki","family":"Kojima","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuhisa","family":"Nakashima","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shota","family":"Omori","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazushige","family":"Wakuda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0590-9259","authenticated-orcid":false,"given":"Hirotsugu","family":"Kenmotsu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4047-2929","authenticated-orcid":false,"given":"Tateaki","family":"Naito","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2416-546X","authenticated-orcid":false,"given":"Haruyasu","family":"Murakami","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenichi","family":"Urakami","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takeshi","family":"Nagashima","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Sugino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masatoshi","family":"Kusuhara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshiaki","family":"Takahashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ken","family":"Yamaguchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuhisa","family":"Ohde","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.lungcan.2018.12.005_bib0005","doi-asserted-by":"crossref","first-page":"1546","DOI":"10.1126\/science.1235122","article-title":"Cancer genome landscapes","volume":"339","author":"Vogelstein","year":"2013","journal-title":"Science"},{"issue":"959","key":"10.1016\/j.lungcan.2018.12.005_bib0010","article-title":"Targeted next generation sequencing identifies markers of response to PD-1 blockade","volume":"4","author":"Johnson","year":"2016","journal-title":"Cancer Immunol. Res."},{"issue":"519","key":"10.1016\/j.lungcan.2018.12.005_bib0015","article-title":"Comprehensive genomic characterization of squamous cell lung cancers","volume":"489","author":"Cancer Genome Atlas Research Network","year":"2012","journal-title":"Nature"},{"issue":"543","key":"10.1016\/j.lungcan.2018.12.005_bib0020","article-title":"Comprehensive molecular profiling of lung adenocarcinoma","volume":"511","author":"Cancer Genome Atlas Research Network","year":"2014","journal-title":"Nature"},{"issue":"706","key":"10.1016\/j.lungcan.2018.12.005_bib0025","volume":"2","author":"Goldstraw","year":"2007","journal-title":"J. Thorac. Oncol."},{"issue":"380","key":"10.1016\/j.lungcan.2018.12.005_bib0030","article-title":"Disease recurrence after resection for stage I lung cancer","volume":"12","author":"Al-Kattan","year":"1997","journal-title":"Eur. J. Cardiothorac. Surg."},{"issue":"479","key":"10.1016\/j.lungcan.2018.12.005_bib0035","article-title":"Lung cancer","volume":"355","author":"Hoffman","year":"2000","journal-title":"Lancet"},{"issue":"619","key":"10.1016\/j.lungcan.2018.12.005_bib0040","article-title":"Surrogate endpoints for overall survival in chemotherapy and radiotherapy trials in operable and locally advanced lung cancer: a re-analysis of meta-analyses of individual patients\u2019 data","volume":"14","author":"Mauguen","year":"2013","journal-title":"Lancet Oncol."},{"key":"10.1016\/j.lungcan.2018.12.005_bib0045","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.1016\/j.jtho.2018.04.003","article-title":"Prognostic impact of tumor mutation burden in patients with completely resected non-small cell lung Cancer: brief report","volume":"13","author":"Owada-Ozaki","year":"2018","journal-title":"J. Thorac. Oncol."},{"issue":"39","key":"10.1016\/j.lungcan.2018.12.005_bib0050","volume":"11","author":"Goldstraw","year":"2015","journal-title":"J. Thorac. Oncol."},{"key":"10.1016\/j.lungcan.2018.12.005_bib0055","doi-asserted-by":"crossref","first-page":"51","DOI":"10.2220\/biomedres.37.51","article-title":"Next generation sequencing approach for detecting 491 fusion genes from human cancer","volume":"37","author":"Urakami","year":"2016","journal-title":"Biomed. Res."},{"issue":"1713","key":"10.1016\/j.lungcan.2018.12.005_bib0060","article-title":"A randomized trial of adjuvant chemotherapy with uracil-tegafur for adenocarcinoma of the lung","volume":"350","author":"Kato","year":"2004","journal-title":"N. Engl. J. Med."},{"issue":"3552","key":"10.1016\/j.lungcan.2018.12.005_bib0065","article-title":"Lung adjuvant cisplatin evaluation: a pooled analysis by the LACE Collaborative Group","volume":"26","author":"Pignon","year":"2008","journal-title":"J. Clin. Oncol."},{"issue":"220","key":"10.1016\/j.lungcan.2018.12.005_bib0070","article-title":"Adjuvant cisplatin and vinorelbine for completely resected non-small cell lung cancer: subgroup analysis of the lung adjuvant cisplatin evaluation","volume":"5","author":"Douillard","year":"2010","journal-title":"J. Thorac. Oncol."},{"key":"10.1016\/j.lungcan.2018.12.005_bib0075","doi-asserted-by":"crossref","first-page":"1267","DOI":"10.1016\/S0140-6736(10)60059-1","article-title":"Adjuvant chemotherapy, with or without postoperative radiotherapy, in operable non-small-cell lung cancer: two meta-analyses of individual patient data","volume":"375","author":"NSCLC Meta-analyses Collaborative Group","year":"2010","journal-title":"Lancet"},{"issue":"1998","key":"10.1016\/j.lungcan.2018.12.005_bib0080","article-title":"Using multiplexed assays of oncogenic drivers in lung cancers to select targeted drugs","volume":"311","author":"Kris","year":"2014","journal-title":"JAMA"},{"issue":"1038","key":"10.1016\/j.lungcan.2018.12.005_bib0085","article-title":"The impact of smoking and TP53 mutations in lung adenocarcinoma patients with targetable mutations-the lung cancer mutation consortium (LCMC2)","volume":"24","author":"Aisner","year":"2018","journal-title":"Clin. Cancer Res."},{"issue":"2477","key":"10.1016\/j.lungcan.2018.12.005_bib0090","article-title":"Clinical application of amplicon-based next-generation sequencing to therapeutic decision making in lung cancer. Clinical application of amplicon-based next-generation sequencing to therapeutic decision making in lung cancer","volume":"26","author":"Takeda","year":"2015","journal-title":"Ann. Oncol."},{"issue":"46","key":"10.1016\/j.lungcan.2018.12.005_bib0095","article-title":"A Japanese lung cancer registry study: prognosis of 13,010 resected lung cancers","volume":"3","author":"Asamura","year":"2008","journal-title":"J. Thorac. Oncol."},{"issue":"28","key":"10.1016\/j.lungcan.2018.12.005_bib0100","article-title":"Risk factors for local recurrence after lobectomy and lymph node dissection in patients with non-small cell lung cancer: implications for adjuvant therapy","volume":"115","author":"Isaka","year":"2018","journal-title":"Lung Cancer"},{"issue":"4999","key":"10.1016\/j.lungcan.2018.12.005_bib0105","article-title":"Meta-analysis of postoperative adjuvant chemotherapy with tegafur-uracil in non-small-cell lung cancer","volume":"23","author":"Hamada","year":"2005","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.lungcan.2018.12.005_bib0110","doi-asserted-by":"crossref","first-page":"e59","DOI":"10.1093\/ejcts\/ezt195","article-title":"Recurrence of mediastinal node cancer after lobe-specific systematic nodal dissection for non-small-cell lung cancer","volume":"44","author":"Maniwa","year":"2013","journal-title":"Eur. J. Cardiothorac. Surg."},{"key":"10.1016\/j.lungcan.2018.12.005_bib0115","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1093\/jjco\/hyx170","article-title":"A randomized Phase III trial of lobe-specific vs. Systematic nodal dissection for clinical Stage I-II non-small cell lung cancer (JCOG1413)","volume":"48","author":"Hishida","year":"2018","journal-title":"Jpn. J. Clin. Oncol."},{"key":"10.1016\/j.lungcan.2018.12.005_bib0120","doi-asserted-by":"crossref","first-page":"1888","DOI":"10.1093\/bioinformatics\/btt293","article-title":"PurBayes: estimating tumor cellularity and subclonality in next-generation sequencing data","volume":"29","author":"Larson","year":"2013","journal-title":"Bioinformatics"},{"issue":"1023","key":"10.1016\/j.lungcan.2018.12.005_bib0125","article-title":"Development and validation of a clinical cancer genomic profiling test based on massively parallel DNA sequencing","volume":"31","author":"Frampton","year":"2013","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.lungcan.2018.12.005_bib0130","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0140712","article-title":"Analytical and clinical validation of a digital sequencing panel for quantitative, highly accurate evaluation of cell-free circulating tumor DNA","volume":"10","author":"Lanman","year":"2015","journal-title":"PLoS One"},{"issue":"547","key":"10.1016\/j.lungcan.2018.12.005_bib0135","article-title":"Integrated digital error suppression for improved detection of circulating tumor DNA","volume":"34","author":"Newman","year":"2016","journal-title":"Nat. Biotechnol."}],"updated-by":[{"DOI":"10.1016\/j.lungcan.2019.03.006","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2019,4,1]],"date-time":"2019-04-01T00:00:00Z","timestamp":1554076800000}}],"container-title":["Lung Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0169500218306913?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0169500218306913?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,30]],"date-time":"2025-09-30T12:25:29Z","timestamp":1759235129000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0169500218306913"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,2]]},"references-count":27,"alternative-id":["S0169500218306913"],"URL":"https:\/\/doi.org\/10.1016\/j.lungcan.2018.12.005","relation":{},"ISSN":["0169-5002"],"issn-type":[{"value":"0169-5002","type":"print"}],"subject":[],"published":{"date-parts":[[2019,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Genetic alterations of driver genes as independent prognostic factors for disease-free survival in patients with resected non-small cell lung cancer","name":"articletitle","label":"Article Title"},{"value":"Lung Cancer","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.lungcan.2018.12.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}