{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T22:02:51Z","timestamp":1781128971795,"version":"3.54.1"},"reference-count":34,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,12,1]],"date-time":"2019-12-01T00:00:00Z","timestamp":1575158400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,12,1]],"date-time":"2019-12-01T00:00:00Z","timestamp":1575158400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","lungcancerjournal.info","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Lung Cancer"],"published-print":{"date-parts":[[2019,12]]},"DOI":"10.1016\/j.lungcan.2019.10.018","type":"journal-article","created":{"date-parts":[[2019,10,20]],"date-time":"2019-10-20T09:55:16Z","timestamp":1571565316000},"page":"95-101","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"special_numbering":"C","title":["Prognostic relevance of regional lymph-node distribution in patients with N1-positive non-small cell lung cancer: A retrospective single-center analysis"],"prefix":"10.1016","volume":"138","author":[{"given":"F.","family":"Eichhorn","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.V.","family":"Klotz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Muley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Kobinger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Winter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.E.","family":"Eichhorn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"6","key":"10.1016\/j.lungcan.2019.10.018_bib0005","first-page":"394","article-title":"Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"68","author":"Bray","year":"2018","journal-title":"CA Cancer J. Clin."},{"issue":"3","key":"10.1016\/j.lungcan.2019.10.018_bib0010","doi-asserted-by":"crossref","first-page":"e0121323","DOI":"10.1371\/journal.pone.0121323","article-title":"Lung cancer incidence trends by gender, race and histology in the United States, 1973-2010","volume":"10","author":"Meza","year":"2015","journal-title":"PLoS One"},{"issue":"1","key":"10.1016\/j.lungcan.2019.10.018_bib0015","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.jtho.2015.09.009","article-title":"The IASLC lung cancer staging project: proposals for revision of the TNM stage groupings in the forthcoming (eighth) edition of the TNM classification for lung Cancer","volume":"11","author":"Goldstraw","year":"2016","journal-title":"J. Thorac. Oncol."},{"issue":"1","key":"10.1016\/j.lungcan.2019.10.018_bib0020","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/S0022-5223(99)70153-4","article-title":"The prognosis of surgically resected N2 non-small cell lung cancer: the importance of clinical N status","volume":"118","author":"Suzuki","year":"1999","journal-title":"J. Thorac. Cardiovasc. Surg."},{"issue":"7","key":"10.1016\/j.lungcan.2019.10.018_bib0025","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1097\/JTO.0b013e31807ec803","article-title":"The IASLC Lung Cancer Staging Project: proposals for the revision of the N descriptors in the forthcoming seventh edition of the TNM classification for lung cancer","volume":"2","author":"Rusch","year":"2007","journal-title":"J. Thorac. Oncol."},{"issue":"suppl_4","key":"10.1016\/j.lungcan.2019.10.018_bib0030","doi-asserted-by":"crossref","first-page":"iv1","DOI":"10.1093\/annonc\/mdx222","article-title":"Early and locally advanced non-small-cell lung cancer (NSCLC): ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up","volume":"28","author":"Postmus","year":"2017","journal-title":"Ann. Oncol."},{"issue":"5 Suppl","key":"10.1016\/j.lungcan.2019.10.018_bib0035","doi-asserted-by":"crossref","first-page":"e278S","DOI":"10.1378\/chest.12-2359","article-title":"Treatment of stage I and II non-small cell lung cancer: diagnosis and management of lung cancer, 3rd ed: American College of Chest Physicians evidence-based clinical practice guidelines","volume":"143","author":"Howington","year":"2013","journal-title":"Chest"},{"issue":"1","key":"10.1016\/j.lungcan.2019.10.018_bib0040","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1055\/s-0030-1255961","article-title":"Prevention, diagnosis, therapy, and follow-up of lung cancer: interdisciplinary guideline of the German Respiratory Society and the German Cancer society","volume":"65","author":"Goeckenjan","year":"2011","journal-title":"Pneumologie"},{"issue":"1","key":"10.1016\/j.lungcan.2019.10.018_bib0045","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1183\/09031936.00184308","article-title":"ERS\/ESTS clinical guidelines on fitness for radical therapy in lung cancer patients (surgery and chemo-radiotherapy)","volume":"34","author":"Brunelli","year":"2009","journal-title":"Eur. Respir. J."},{"issue":"3","key":"10.1016\/j.lungcan.2019.10.018_bib0050","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1510\/icvts.2011.268979","article-title":"In patients undergoing lung resection for non-small cell lung cancer, is lymph node dissection or sampling superior?","volume":"13","author":"Hughes","year":"2011","journal-title":"Interact. Cardiovasc. Thorac. Surg."},{"issue":"5","key":"10.1016\/j.lungcan.2019.10.018_bib0055","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1016\/j.ejcts.2006.08.008","article-title":"ESTS guidelines for intraoperative lymph node staging in non-small cell lung cancer","volume":"30","author":"Lardinois","year":"2006","journal-title":"Eur. J. Cardiothorac. Surg."},{"issue":"6","key":"10.1016\/j.lungcan.2019.10.018_bib0060","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1093\/ejcts\/ezw439","article-title":"Systematic lymphadenectomy versus sampling of ipsilateral mediastinal lymph-nodes during lobectomy for non-small-cell lung cancer: a systematic review of randomized trials and a meta-analysis","volume":"51","author":"Mokhles","year":"2017","journal-title":"Eur. J. Cardiothorac. Surg."},{"issue":"6","key":"10.1016\/j.lungcan.2019.10.018_bib0065","doi-asserted-by":"crossref","first-page":"1718","DOI":"10.1378\/chest.111.6.1718","article-title":"Regional lymph node classification for lung cancer staging","volume":"111","author":"Mountain","year":"1997","journal-title":"Chest"},{"issue":"5","key":"10.1016\/j.lungcan.2019.10.018_bib0070","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1097\/JTO.0b013e3181a0d82e","article-title":"The IASLC lung cancer staging project: a proposal for a new international lymph node map in the forthcoming seventh edition of the TNM classification for lung cancer","volume":"4","author":"Rusch","year":"2009","journal-title":"J. Thorac. Oncol."},{"issue":"18","key":"10.1016\/j.lungcan.2019.10.018_bib0075","doi-asserted-by":"crossref","first-page":"4512","DOI":"10.1002\/cncr.27424","article-title":"Prognostic implication of metastasis limited to segmental (level 13) and\/or subsegmental (level 14) lymph nodes in patients with surgically resected nonsmall cell lung carcinoma and pathologic N1 lymph node status","volume":"118","author":"Maeshima","year":"2012","journal-title":"Cancer"},{"issue":"3","key":"10.1016\/j.lungcan.2019.10.018_bib0080","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1016\/j.athoracsur.2013.11.051","article-title":"Metastasis to subsegmental and segmental lymph nodes in patients resected for non-small cell lung cancer: prognostic impact","volume":"97","author":"Rena","year":"2014","journal-title":"Ann. Thorac. Surg."},{"issue":"12","key":"10.1016\/j.lungcan.2019.10.018_bib0085","doi-asserted-by":"crossref","first-page":"1675","DOI":"10.1097\/JTO.0000000000000678","article-title":"The international association for the study of lung cancer lung cancer staging project: proposals for the revision of the N descriptors in the forthcoming 8th edition of the TNM classification for lung cancer","volume":"10","author":"Asamura","year":"2015","journal-title":"J. Thorac. Oncol."},{"issue":"2","key":"10.1016\/j.lungcan.2019.10.018_bib0090","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1097\/JTO.0b013e3181ff9b45","article-title":"Which is the better prognostic factor for resected non-small cell lung cancer: the number of metastatic lymph nodes or the currently used nodal stage classification?","volume":"6","author":"Wei","year":"2011","journal-title":"J. Thorac. Oncol."},{"issue":"6","key":"10.1016\/j.lungcan.2019.10.018_bib0095","doi-asserted-by":"crossref","first-page":"1618","DOI":"10.1378\/chest.12-0750","article-title":"A proposal for combination of total number and anatomical location of involved lymph nodes for nodal classification in non-small cell lung cancer","volume":"143","author":"Saji","year":"2013","journal-title":"Chest"},{"issue":"6","key":"10.1016\/j.lungcan.2019.10.018_bib0100","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1016\/S0022-5223(19)39559-5","article-title":"Lymph node mapping and curability at various levels of metastasis in resected lung cancer","volume":"76","author":"Naruke","year":"1978","journal-title":"J. Thorac. Cardiovasc. Surg."},{"issue":"1","key":"10.1016\/j.lungcan.2019.10.018_bib0105","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/S0003-4975(01)03177-0","article-title":"Inter-observer variability in systematic nodal dissection: comparison of European and Japanese nodal designation","volume":"73","author":"Watanabe","year":"2002","journal-title":"Ann. Thorac. Surg."},{"issue":"4","key":"10.1016\/j.lungcan.2019.10.018_bib0110","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1093\/ejcts\/ezw083","article-title":"Lymphadenectomy for clinical early-stage non-small-cell lung cancer: a systematic review and meta-analysis","volume":"50","author":"Meng","year":"2016","journal-title":"Eur. J. Cardiothorac. Surg."},{"issue":"3","key":"10.1016\/j.lungcan.2019.10.018_bib0115","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1016\/S1010-7940(02)00004-0","article-title":"Mediastinal lymphadenectomy in non-small cell lung cancer: effectiveness in patients with or without nodal micrometastases - results of a preliminary study","volume":"21","author":"Passlick","year":"2002","journal-title":"Eur. J. Cardiothorac. Surg."},{"issue":"2","key":"10.1016\/j.lungcan.2019.10.018_bib0120","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.lungcan.2003.08.020","article-title":"Survival and characteristics of lymph node involvement in patients with N1 non-small cell lung cancer","volume":"43","author":"Osaki","year":"2004","journal-title":"Lung Cancer"},{"issue":"4","key":"10.1016\/j.lungcan.2019.10.018_bib0125","doi-asserted-by":"crossref","first-page":"1014","DOI":"10.1016\/j.athoracsur.2008.12.053","article-title":"Prognostic significance of surgical-pathologic N1 lymph node involvement in non-small cell lung cancer","volume":"87","author":"Demir","year":"2009","journal-title":"Ann. Thorac. Surg."},{"issue":"3","key":"10.1016\/j.lungcan.2019.10.018_bib0130","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1093\/jjco\/hyr188","article-title":"Differences between squamous cell carcinoma and adenocarcinoma of the lung: are adenocarcinoma and squamous cell carcinoma prognostically equal?","volume":"42","author":"Kawase","year":"2012","journal-title":"Jpn. J. Clin. Oncol."},{"issue":"7","key":"10.1016\/j.lungcan.2019.10.018_bib0135","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.1097\/JTO.0b013e318219aae2","article-title":"Japanese lung cancer registry study of 11,663 surgical cases in 2004: demographic and prognosis changes over decade","volume":"6","author":"Sawabata","year":"2011","journal-title":"J. Thorac. Oncol."},{"issue":"1","key":"10.1016\/j.lungcan.2019.10.018_bib0140","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1097\/JTO.0b013e31815e8577","article-title":"A Japanese Lung Cancer Registry study: prognosis of 13,010 resected lung cancers","volume":"3","author":"Asamura","year":"2008","journal-title":"J. Thorac. Oncol."},{"issue":"1","key":"10.1016\/j.lungcan.2019.10.018_bib0145","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/S0022-5223(99)70467-8","article-title":"Factors influencing ten-year survival in resected stages I to IIIa non-small cell lung cancer","volume":"117","author":"Martini","year":"1999","journal-title":"J. Thorac. Cardiovasc. Surg."},{"issue":"6","key":"10.1016\/j.lungcan.2019.10.018_bib0150","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/j.resinv.2014.04.002","article-title":"Prognosis of lung cancer patients in Japan according to data from the Japanese Joint Committee of Lung Cancer registry","volume":"52","author":"Sawabata","year":"2014","journal-title":"Respir. Investig."},{"issue":"10","key":"10.1016\/j.lungcan.2019.10.018_bib0155","doi-asserted-by":"crossref","first-page":"1653","DOI":"10.1016\/j.jtho.2016.05.021","article-title":"The international epidemiology of lung Cancer: latest trends, disparities, and tumor characteristics","volume":"11","author":"Cheng","year":"2016","journal-title":"J. Thorac. Oncol."},{"issue":"3\u20134","key":"10.1016\/j.lungcan.2019.10.018_bib0160","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1177\/0218492311407904","article-title":"N1 non-small-cell lung cancer. A 20-year surgical experience","volume":"19","author":"Casali","year":"2011","journal-title":"Asian Cardiovasc. Thorac. Ann."},{"issue":"3","key":"10.1016\/j.lungcan.2019.10.018_bib0165","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1067\/mtc.2003.322","article-title":"Pathologic N1 non-small cell lung cancer: correlation between pattern of lymphatic spread and prognosis","volume":"125","author":"Marra","year":"2003","journal-title":"J. Thorac. Cardiovasc. Surg."},{"issue":"5","key":"10.1016\/j.lungcan.2019.10.018_bib0170","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1016\/j.ejso.2014.10.003","article-title":"Prognostic factors after surgical resection of N1 non-small cell lung cancer","volume":"41","author":"Mordant","year":"2015","journal-title":"Eur. J. Surg. Oncol."}],"container-title":["Lung Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0169500219306993?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0169500219306993?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,30]],"date-time":"2025-09-30T12:33:27Z","timestamp":1759235607000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0169500219306993"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,12]]},"references-count":34,"alternative-id":["S0169500219306993"],"URL":"https:\/\/doi.org\/10.1016\/j.lungcan.2019.10.018","relation":{},"ISSN":["0169-5002"],"issn-type":[{"value":"0169-5002","type":"print"}],"subject":[],"published":{"date-parts":[[2019,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Prognostic relevance of regional lymph-node distribution in patients with N1-positive non-small cell lung cancer: A retrospective single-center analysis","name":"articletitle","label":"Article Title"},{"value":"Lung Cancer","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.lungcan.2019.10.018","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}