{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T19:08:13Z","timestamp":1786993693555,"version":"build-2736575974"},"reference-count":46,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,8,1]],"date-time":"2020-08-01T00:00:00Z","timestamp":1596240000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,8,1]],"date-time":"2020-08-01T00:00:00Z","timestamp":1596240000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100005758","name":"Universit\u00e0 Politecnica delle Marche","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005758","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","lungcancerjournal.info","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Lung Cancer"],"published-print":{"date-parts":[[2020,8]]},"DOI":"10.1016\/j.lungcan.2020.06.024","type":"journal-article","created":{"date-parts":[[2020,6,21]],"date-time":"2020-06-21T10:20:47Z","timestamp":1592734847000},"page":"318-326","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":17,"special_numbering":"C","title":["Questioning the prognostic role of BAP-1 immunohistochemistry in malignant pleural mesothelioma: A single center experience with systematic review and meta-analysis"],"prefix":"10.1016","volume":"146","author":[{"given":"Luca","family":"Cantini","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federica","family":"Pecci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto","family":"Murrone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Tomasetti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cecilia","family":"Copparoni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilaria","family":"Fiordoliva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Morgese","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Rinaldi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola","family":"Mazzanti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Corrado","family":"Rubini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessia","family":"Cimadamore","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Barbisan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Riccardo","family":"Giampieri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina","family":"Scarpelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lory","family":"Santarelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9529-2960","authenticated-orcid":false,"given":"Rossana","family":"Berardi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.lungcan.2020.06.024_bib0005","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.lungcan.2018.12.004","article-title":"Retrospective response analysis of BAP1 expression to predict the clinical activity of systemic cytotoxic chemotherapy in mesothelioma","volume":"127","author":"Kumar","year":"2019","journal-title":"Lung Cancer"},{"key":"10.1016\/j.lungcan.2020.06.024_bib0010","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.jtho.2019.08.2506","article-title":"EURACAN\/IASLC proposals for updating the histologic classification of pleural mesothelioma: towards a more multidisciplinary approach","volume":"15","author":"Nicholson","year":"2020","journal-title":"J. Thorac. Oncol."},{"key":"10.1016\/j.lungcan.2020.06.024_bib0015","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2018.00091","article-title":"New perspectives on diagnosis and therapy of malignant pleural mesothelioma","author":"Rossini","year":"2018","journal-title":"Front. Oncol."},{"key":"10.1016\/j.lungcan.2020.06.024_bib0020","doi-asserted-by":"crossref","first-page":"2636","DOI":"10.1200\/JCO.2003.11.136","article-title":"Phase III study of pemetrexed in combination with cisplatin versus cisplatin alone in patients with malignant pleural mesothelioma","volume":"21","author":"Vogelzang","year":"2003","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.lungcan.2020.06.024_bib0025","doi-asserted-by":"crossref","first-page":"343","DOI":"10.3389\/fonc.2020.00343","article-title":"Emerging treatments for malignant pleural mesothelioma: where are we heading?","volume":"10","author":"Cantini","year":"2020","journal-title":"Front. Oncol."},{"key":"10.1016\/j.lungcan.2020.06.024_bib0030","first-page":"621","article-title":"Hyponatraemia is a predictor of clinical outcome for malignant pleural mesothelioma","volume":"23","author":"Berardi","year":"2015","journal-title":"Support. Care Cancer"},{"key":"10.1016\/j.lungcan.2020.06.024_bib0035","doi-asserted-by":"crossref","DOI":"10.1183\/13993003.00953-2019","article-title":"ERS\/ESTS\/EACTS\/ESTRO guidelines for the management of malignant pleural mesothelioma","author":"Scherpereel","year":"2020","journal-title":"Eur. Respir. J."},{"key":"10.1016\/j.lungcan.2020.06.024_bib0040","doi-asserted-by":"crossref","DOI":"10.1038\/s41419-018-1206-5","article-title":"BAP1 regulates different mechanisms of cell death","author":"Affar","year":"2018","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.lungcan.2020.06.024_bib0045","doi-asserted-by":"crossref","DOI":"10.1002\/gcc.22381","article-title":"Different prognostic roles of tumor suppressor gene BAP1 in cancer: a systematic review with meta-analysis","author":"Luchini","year":"2016","journal-title":"Genes Chromosom. Cancer"},{"key":"10.1016\/j.lungcan.2020.06.024_bib0050","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1038\/ng.855","article-title":"The nuclear deubiquitinase BAP1 is commonly inactivated by somatic mutations and 3p21.1 losses in malignant pleural mesothelioma","author":"Bott","year":"2011","journal-title":"Nat. Genet."},{"key":"10.1016\/j.lungcan.2020.06.024_bib0055","doi-asserted-by":"crossref","DOI":"10.1016\/j.humpath.2015.06.024","article-title":"BAP1 facilitates diagnostic objectivity, classification, and prognostication in malignant pleural mesothelioma","author":"McGregor","year":"2015","journal-title":"Hum. Pathol."},{"key":"10.1016\/j.lungcan.2020.06.024_bib0060","doi-asserted-by":"crossref","DOI":"10.1097\/PAT.0000000000000250","article-title":"Loss of expression of BAP1 predicts longer survival in mesothelioma","author":"Farzin","year":"2015","journal-title":"Pathology"},{"key":"10.1016\/j.lungcan.2020.06.024_bib0065","doi-asserted-by":"crossref","first-page":"34179","DOI":"10.1074\/jbc.M109.046755","article-title":"The deubiquitinating enzyme BAP1 regulates cell growth via interaction with HCF-1","volume":"284","author":"Machida","year":"2009","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.lungcan.2020.06.024_bib0070","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms10292","article-title":"BAP1\/ASXL1 recruitment and activation for H2A deubiquitination","volume":"7","author":"Sahtoe","year":"2016","journal-title":"Nat. Commun."},{"key":"10.1016\/j.lungcan.2020.06.024_bib0075","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1016\/j.cmet.2012.07.006","article-title":"O-GlcNAc transferase\/host cell factor C1 complex regulates gluconeogenesis by modulating PGC-1\u03b1 stability","volume":"16","author":"Bin Ruan","year":"2012","journal-title":"Cell Metab."},{"key":"10.1016\/j.lungcan.2020.06.024_bib0080","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.1309085110","article-title":"Tumor suppressor and deubiquitinase BAP1 promotes DNA double-strand break repair","author":"Yu","year":"2014","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.lungcan.2020.06.024_bib0085","doi-asserted-by":"crossref","DOI":"10.1038\/nature22798","article-title":"BAP1 regulates IP3R3-mediated Ca 2+ flux to mitochondria suppressing cell transformation","author":"Bononi","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.lungcan.2020.06.024_bib0090","doi-asserted-by":"crossref","DOI":"10.1155\/2017\/1310478","article-title":"Malignant mesothelioma, BAP1 immunohistochemistry, and VEGFA: does BAP1 have potential for early diagnosis and assessment of prognosis?","volume":"2017","author":"Pulford","year":"2017","journal-title":"Dis. Markers"},{"key":"10.1016\/j.lungcan.2020.06.024_bib0095","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.jtho.2015.11.005","article-title":"The 2015 world health organization classification of tumors of the pleura: advances since the 2004 classification","volume":"11","author":"Galateau-Salle","year":"2016","journal-title":"J. Thorac. Oncol."},{"key":"10.1016\/j.lungcan.2020.06.024_bib0100","series-title":"TNM Classification of Malignant Tumours","author":"Brierley","year":"2016"},{"key":"10.1016\/j.lungcan.2020.06.024_bib0105","article-title":"A practical guide of the southwest oncology group to measure malignant pleural mesothelioma tumors by RECIST and modified RECIST criteria","author":"Tsao","year":"2011","journal-title":"J. Thorac. Oncol."},{"key":"10.1016\/j.lungcan.2020.06.024_bib0110","doi-asserted-by":"crossref","DOI":"10.1200\/JCO.2018.79.0352","article-title":"A subset of mesotheliomas with improved survival occurring in carriers of BAP1 and other germline mutations","author":"Pastorino","year":"2018","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.lungcan.2020.06.024_bib0115","doi-asserted-by":"crossref","first-page":"9008","DOI":"10.1073\/pnas.1821510116","article-title":"Inherited predisposition to malignant mesothelioma and overall survival following platinum chemotherapy","volume":"116","author":"Hassan","year":"2019","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.lungcan.2020.06.024_bib0120","doi-asserted-by":"crossref","DOI":"10.1158\/1078-0432.CCR-13-2429","article-title":"Molecular classification of malignant pleural mesothelioma: identification of a poor prognosis subgroup linked to the epithelial-to-mesenchymal transition","author":"De Reynies","year":"2014","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.lungcan.2020.06.024_bib0125","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1158\/0008-5472.CAN-14-1008","article-title":"Whole-exome sequencing reveals frequent genetic alterations in BAP1, NF2, CDKN2A, and CUL1 in malignant pleural mesothelioma","volume":"75","author":"Guo","year":"2015","journal-title":"Cancer Res."},{"key":"10.1016\/j.lungcan.2020.06.024_bib0130","doi-asserted-by":"crossref","DOI":"10.1158\/0008-5472.CAN-15-0751","article-title":"Gender-specific molecular and clinical features underlie malignant pleural mesothelioma","author":"De Rienzo","year":"2016","journal-title":"Cancer Res."},{"key":"10.1016\/j.lungcan.2020.06.024_bib0135","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1038\/ng.3520","article-title":"Comprehensive genomic analysis of malignant pleural mesothelioma identifies recurrent mutations, gene fusions and splicing alterations","volume":"48","author":"Bueno","year":"2016","journal-title":"Nat. Genet."},{"key":"10.1016\/j.lungcan.2020.06.024_bib0140","doi-asserted-by":"crossref","DOI":"10.1038\/modpathol.2017.108","article-title":"Clinicopathologic and genetic characteristics of young patients with pleural diffuse malignant mesothelioma","author":"Vivero","year":"2018","journal-title":"Mod. Pathol."},{"key":"10.1016\/j.lungcan.2020.06.024_bib0145","doi-asserted-by":"crossref","DOI":"10.1007\/s12253-013-9677-2","article-title":"BAP1 protein is a progression factor in malignant pleural mesothelioma","author":"Arzt","year":"2014","journal-title":"Pathol. Oncol. Res."},{"key":"10.1016\/j.lungcan.2020.06.024_bib0150","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.cancergen.2018.10.001","article-title":"BAP1 gene mutations in Egyptian patients with advanced sporadic malignant pleural mesothelioma (MPM): relation with clinical outcomes and survival","volume":"228\u2013229","author":"Bahnasy","year":"2018","journal-title":"Cancer Genet."},{"key":"10.1016\/j.lungcan.2020.06.024_bib0155","doi-asserted-by":"crossref","DOI":"10.1093\/annonc\/mdx762","article-title":"Validation of the diagnosis of mesothelioma and BAP1 protein expression in a cohort of asbestos textile workers from Northern Italy","author":"Boffetta","year":"2018","journal-title":"Ann. Oncol."},{"key":"10.1016\/j.lungcan.2020.06.024_bib0160","doi-asserted-by":"crossref","DOI":"10.1016\/j.it.2016.01.004","article-title":"The nature of myeloid-derived suppressor cells in the tumor microenvironment","author":"Kumar","year":"2016","journal-title":"Trends Immunol."},{"key":"10.1016\/j.lungcan.2020.06.024_bib0165","doi-asserted-by":"crossref","DOI":"10.1016\/j.humpath.2016.09.026","article-title":"BAP1 immunohistochemistry has limited prognostic utility as a complement of CDKN2A (p16) fluorescence in situ hybridization in malignant pleural mesothelioma","author":"McGregor","year":"2017","journal-title":"Hum. Pathol."},{"key":"10.1016\/j.lungcan.2020.06.024_bib0170","doi-asserted-by":"crossref","DOI":"10.1111\/his.13392","article-title":"The epithelioid BAP1-negative and p16-positive phenotype predicts prolonged survival in pleural mesothelioma","author":"Chou","year":"2018","journal-title":"Histopathology"},{"key":"10.1016\/j.lungcan.2020.06.024_bib0175","doi-asserted-by":"crossref","DOI":"10.1016\/j.pathol.2018.05.002","article-title":"Nuclear grading, BAP1, mesothelin and PD-L1 expression in malignant pleural mesothelioma: prognostic implications","author":"Forest","year":"2018","journal-title":"Pathology"},{"key":"10.1016\/j.lungcan.2020.06.024_bib0180","doi-asserted-by":"crossref","DOI":"10.1097\/JTO.0000000000000471","article-title":"High incidence of somatic BAP1 alterations in sporadic malignant mesothelioma","author":"Nasu","year":"2015","journal-title":"J. Thorac. Oncol."},{"key":"10.1016\/j.lungcan.2020.06.024_bib0185","doi-asserted-by":"crossref","DOI":"10.1089\/gtmb.2017.0176","article-title":"Prognostic and clinicopathological significance of BAP1 protein expression in different types of Cancer - a meta-analysis","author":"Wang","year":"2018","journal-title":"Genet. Test. Mol. Biomarkers"},{"key":"10.1016\/j.lungcan.2020.06.024_bib0190","article-title":"Tissue-specific significance of BAP1 gene mutation in prognostic prediction and molecular taxonomy among different types of cancer","author":"Wang","year":"2017","journal-title":"J. Immunother. Emphasis Tumor Immunol."},{"key":"10.1016\/j.lungcan.2020.06.024_bib0195","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1183\/09031936.00207213","article-title":"Multimodal management of malignant pleural mesothelioma: where are we today?","volume":"44","author":"Van Schil","year":"2014","journal-title":"Eur. Respir. J."},{"key":"10.1016\/j.lungcan.2020.06.024_bib0200","doi-asserted-by":"crossref","DOI":"10.1093\/annonc\/mdv199","article-title":"Malignant pleural mesothelioma: ESMO clinical practice guidelines for diagnosis, treatment and follow-up","volume":"26","author":"Baas","year":"2015","journal-title":"Ann. Oncol."},{"key":"10.1016\/j.lungcan.2020.06.024_bib0205","doi-asserted-by":"crossref","DOI":"10.1097\/JTO.0b013e31829e7ef9","article-title":"Clinical characteristics of patients with malignant pleural mesothelioma harboring somatic BAP1 mutations","author":"Zauderer","year":"2013","journal-title":"J. Thorac. Oncol."},{"key":"10.1016\/j.lungcan.2020.06.024_bib0210","doi-asserted-by":"crossref","DOI":"10.1186\/s13073-019-0620-3","article-title":"BAP1 haploinsufficiency predicts a distinct immunogenic class of malignant peritoneal mesothelioma","author":"Shrestha","year":"2019","journal-title":"Genome Med."},{"key":"10.1016\/j.lungcan.2020.06.024_bib0215","doi-asserted-by":"crossref","DOI":"10.1186\/s13073-019-0631-0","article-title":"Loss of BAP1 as a candidate predictive biomarker for immunotherapy of mesothelioma","author":"Ladanyi","year":"2019","journal-title":"Genome Med."},{"key":"10.1016\/j.lungcan.2020.06.024_bib0220","doi-asserted-by":"crossref","first-page":"5438","DOI":"10.1158\/1078-0432.CCR-19-1836","article-title":"Nivo-lution in mesothelioma","volume":"25","author":"Mansfield","year":"2019","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.lungcan.2020.06.024_bib0225","article-title":"A major chromatin regulator determines resistance of tumor cells to T cell-mediated killing","author":"Pan","year":"2018","journal-title":"Science (80-)"},{"key":"10.1016\/j.lungcan.2020.06.024_bib0230","doi-asserted-by":"crossref","DOI":"10.1126\/science.aan5951","article-title":"Genomic correlates of response to immune checkpoint therapies in clear cell renal cell carcinoma","author":"Miao","year":"2018","journal-title":"Science (80-)"}],"container-title":["Lung Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0169500220304980?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0169500220304980?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,30]],"date-time":"2025-09-30T12:54:43Z","timestamp":1759236883000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0169500220304980"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8]]},"references-count":46,"alternative-id":["S0169500220304980"],"URL":"https:\/\/doi.org\/10.1016\/j.lungcan.2020.06.024","relation":{},"ISSN":["0169-5002"],"issn-type":[{"value":"0169-5002","type":"print"}],"subject":[],"published":{"date-parts":[[2020,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Questioning the prognostic role of BAP-1 immunohistochemistry in malignant pleural mesothelioma: A single center experience with systematic review and meta-analysis","name":"articletitle","label":"Article Title"},{"value":"Lung Cancer","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.lungcan.2020.06.024","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}