{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T12:12:53Z","timestamp":1783599173245,"version":"3.55.0"},"reference-count":40,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","lungcancerjournal.info","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Lung Cancer"],"published-print":{"date-parts":[[2021,6]]},"DOI":"10.1016\/j.lungcan.2021.04.025","type":"journal-article","created":{"date-parts":[[2021,5,3]],"date-time":"2021-05-03T12:37:22Z","timestamp":1620045442000},"page":"151-156","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"special_numbering":"C","title":["Malignant pleural mesothelioma: Comparison of surgery-based trimodality therapy to medical therapy at two tertiary academic institutions"],"prefix":"10.1016","volume":"156","author":[{"given":"Fr\u00e9d\u00e9ric","family":"Larose","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9177-7947","authenticated-orcid":false,"given":"Nicholas","family":"Quigley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yves","family":"Lacasse","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon","family":"Martel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lo\u00efc","family":"Lang-Lazdunski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.lungcan.2021.04.025_bib0005","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1093\/oxfordjournals.aje.a009093","article-title":"Analysis of current trends in United States mesothelioma incidence","volume":"145","author":"Price","year":"1997","journal-title":"Am. J. Epidemiol."},{"key":"10.1016\/j.lungcan.2021.04.025_bib0010","doi-asserted-by":"crossref","first-page":"1405","DOI":"10.1016\/S0140-6736(15)01238-6","article-title":"Bevacizumab for newly diagnosed pleural mesothelioma in the Mesothelioma Avastin Cisplatin Pemetrexed Study (MAPS): a randomised, controlled, open-label, phase 3 trial","volume":"387","author":"Zalcman","year":"2016","journal-title":"Lancet"},{"key":"10.1016\/j.lungcan.2021.04.025_bib0015","doi-asserted-by":"crossref","first-page":"2636","DOI":"10.1200\/JCO.2003.11.136","article-title":"Phase III study of pemetrexed in combination with cisplatin versus cisplatin alone in patients with malignant pleural mesothelioma","volume":"21","author":"Vogelzang","year":"2003","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.lungcan.2021.04.025_bib0020","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1016\/j.jtcvs.2014.10.041","article-title":"Pleurectomy\/decortication, hyperthermic pleural lavage with povidone-iodine, prophylactic radiotherapy, and systemic chemotherapy in patients with malignant pleural mesothelioma: a 10-year experience","volume":"149","author":"Lang-Lazdunski","year":"2015","journal-title":"J. Thorac. Cardiovasc. Surg."},{"key":"10.1016\/j.lungcan.2021.04.025_bib0025","doi-asserted-by":"crossref","first-page":"e901","DOI":"10.1016\/j.cllc.2018.08.007","article-title":"Survival by histologic subtype of malignant pleural mesothelioma and the impact of surgical resection on overall survival","volume":"19","author":"Verma","year":"2018","journal-title":"Clin. Lung Cancer"},{"key":"10.1016\/j.lungcan.2021.04.025_bib0030","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/S0140-6736(20)32714-8","article-title":"First-line nivolumab plus ipilimumab in unresectable malignant pleural mesothelioma (CheckMate 743): a multicentre, randomised, open-label, phase 3 trial","volume":"397","author":"Baas","year":"2021","journal-title":"Lancet"},{"key":"10.1016\/j.lungcan.2021.04.025_bib0035","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1200\/JCO.2017.76.6394","article-title":"Treatment of malignant pleural mesothelioma: american society of clinical oncology clinical practice guideline","volume":"36","author":"Kindler","year":"2018","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.lungcan.2021.04.025_bib0040","doi-asserted-by":"crossref","first-page":"i1","DOI":"10.1136\/thoraxjnl-2017-211321","article-title":"British Thoracic Society Guideline for the investigation and management of malignant pleural mesothelioma","volume":"73","author":"Woolhouse","year":"2018","journal-title":"Thorax"},{"key":"10.1016\/j.lungcan.2021.04.025_bib0045","first-page":"55","article-title":"ERS\/ESTS\/EACTS\/ESTRO guidelines for the management of malignant pleural mesothelioma","author":"Scherpereel","year":"2020","journal-title":"Eur. Respir. J."},{"key":"10.1016\/j.lungcan.2021.04.025_bib0050","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1016\/S1470-2045(11)70149-8","article-title":"Extra-pleural pneumonectomy versus no extra-pleural pneumonectomy for patients with malignant pleural mesothelioma: clinical outcomes of the Mesothelioma and Radical Surgery (MARS) randomised feasibility study","volume":"12","author":"Treasure","year":"2011","journal-title":"Lancet Oncol."},{"key":"10.1016\/j.lungcan.2021.04.025_bib0055","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1097\/JTO.0000000000000064","article-title":"Does surgery improve survival of patients with malignant pleural mesothelioma? A multicenter retrospective analysis of 1365 consecutive patients","volume":"9","author":"Bovolato","year":"2014","journal-title":"J. Thorac. Oncol."},{"key":"10.1016\/j.lungcan.2021.04.025_bib0060","first-page":"164","article-title":"Clinical characteristics, treatment and survival outcomes in malignant pleural mesothelioma: an institutional experience in Turkey","volume":"19","author":"Kucukoner","year":"2014","journal-title":"J. BUON"},{"key":"10.1016\/j.lungcan.2021.04.025_bib0065","doi-asserted-by":"crossref","first-page":"3354","DOI":"10.1200\/JCO.2017.73.8401","article-title":"Long-term survival outcomes of cancer-directed surgery for malignant pleural mesothelioma: propensity score matching analysis","volume":"35","author":"Nelson","year":"2017","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.lungcan.2021.04.025_bib0070","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1097\/00000421-198212000-00014","article-title":"Toxicity and response criteria of the eastern cooperative oncology group","volume":"5","author":"Oken","year":"1982","journal-title":"Am. J. Clin. Oncol."},{"key":"10.1016\/j.lungcan.2021.04.025_bib0075","doi-asserted-by":"crossref","first-page":"S757","DOI":"10.1016\/j.jtho.2019.08.1623","article-title":"Multimodality therapy using total pleurectomy in malignant pleural mesothelioma: long-term outcomes in 150 consecutive cases","volume":"14","author":"Lang-Lazdunski","year":"2019","journal-title":"J. Thorac. Oncol."},{"key":"10.1016\/j.lungcan.2021.04.025_bib0080","doi-asserted-by":"crossref","first-page":"1200","DOI":"10.1200\/JCO.18.01678","article-title":"Prophylactic irradiation of tracts in patients with malignant pleural mesothelioma: an open-label, multicenter, phase III randomized trial","volume":"37","author":"Bayman","year":"2019","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.lungcan.2021.04.025_bib0085","first-page":"38","article-title":"Prophylactic procedure tract radiotherapy for malignant pleural mesothelioma: a systematic review and meta-analysis","volume":"13","author":"Bergamin","year":"2018","journal-title":"Clin. Transl. Radiat. Oncol."},{"key":"10.1016\/j.lungcan.2021.04.025_bib0090","doi-asserted-by":"crossref","first-page":"543","DOI":"10.21037\/tlcr.2018.07.05","article-title":"The eighth TNM classification for malignant pleural mesothelioma","volume":"7","author":"Berzenji","year":"2018","journal-title":"Transl. Lung Cancer Res."},{"key":"10.1016\/j.lungcan.2021.04.025_bib0095","doi-asserted-by":"crossref","first-page":"1637","DOI":"10.1001\/jama.2015.13480","article-title":"The propensity score","volume":"314","author":"Haukoos","year":"2015","journal-title":"JAMA"},{"key":"10.1016\/j.lungcan.2021.04.025_bib0100","series-title":"ASCO 2018 54th Annual Meeting of the American Society of Clinical Oncology","article-title":"Long-term survival following trimodality therapy vs medical management of malignant pleural mesothelioma","author":"Larose","year":"2018"},{"key":"10.1016\/j.lungcan.2021.04.025_bib0105","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/S0003-4975(10)62906-2","article-title":"Surgical management of malignant mesothelioma","volume":"26","author":"DeLaria","year":"1978","journal-title":"Ann. Thorac. Surg."},{"key":"10.1016\/j.lungcan.2021.04.025_bib0110","first-page":"277","article-title":"Role of the pleura in intra and extra-pleural pneumonectomy; follow-up of 77 consecutive cases","volume":"9","author":"Tchertkoff","year":"1947","journal-title":"Q. Bull. Sea View Hosp."},{"key":"10.1016\/j.lungcan.2021.04.025_bib0115","doi-asserted-by":"crossref","first-page":"S390","DOI":"10.21037\/jtd.2018.01.116","article-title":"Pleurectomy\/decortication versus extrapleural pneumonectomy: a critical choice","volume":"10","author":"Filosso","year":"2018","journal-title":"J. Thorac. Dis."},{"key":"10.1016\/j.lungcan.2021.04.025_bib0120","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1016\/j.thorsurg.2020.08.004","article-title":"The role of extrapleural pneumonectomy in malignant pleural mesothelioma","volume":"30","author":"Donahoe","year":"2020","journal-title":"Thorac. Surg. Clin."},{"key":"10.1016\/j.lungcan.2021.04.025_bib0125","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1016\/j.lungcan.2013.11.026","article-title":"A systematic review and meta-analysis of surgical treatments for malignant pleural mesothelioma","volume":"83","author":"Cao","year":"2014","journal-title":"Lung Cancer"},{"key":"10.1016\/j.lungcan.2021.04.025_bib0130","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1016\/j.athoracsur.2014.09.056","article-title":"Meta-analysis of survival after pleurectomy decortication versus extrapleural pneumonectomy in mesothelioma","volume":"99","author":"Taioli","year":"2015","journal-title":"Ann. Thorac. Surg."},{"key":"10.1016\/j.lungcan.2021.04.025_bib0135","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.jtcvs.2014.03.011","article-title":"Malignant pleural mesothelioma and the Society of Thoracic Surgeons Database: an analysis of surgical morbidity and mortality","volume":"148","author":"Burt","year":"2014","journal-title":"J. Thorac. Cardiovasc. Surg."},{"key":"10.1016\/j.lungcan.2021.04.025_bib0140","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1016\/j.jtcvs.2015.09.129","article-title":"Accelerated hemithoracic radiation followed by extrapleural pneumonectomy for malignant pleural mesothelioma","volume":"151","author":"de Perrot","year":"2016","journal-title":"J. Thorac. Cardiovasc. Surg."},{"key":"10.1016\/j.lungcan.2021.04.025_bib0145","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1016\/j.ejcts.2009.07.032","article-title":"Three decades of experience in the surgical multi-modality management of pleural mesothelioma","volume":"37","author":"Luckraz","year":"2010","journal-title":"Eur. J. Cardiothorac. Surg."},{"key":"10.1016\/j.lungcan.2021.04.025_bib0150","series-title":"11th International Conference of the International Mesothelioma Interest Group","article-title":"Long-term outcome after radical pleurectomy followed by chemoradiation for malignant pleural mesothelioma: a 10-year single center experience","author":"Bolukbas","year":"2012"},{"key":"10.1016\/j.lungcan.2021.04.025_bib0155","series-title":"11th International Conference of the International Mesothelioma Interest Group","article-title":"The timing of chemotherapy in the multimodality therapy of pleural mesothelioma","author":"Cameron","year":"2012"},{"key":"10.1016\/j.lungcan.2021.04.025_bib0160","series-title":"11th International Conference of the International Mesothelioma Interest Group","article-title":"Radical pleurectomy and intraoperative porfimer sodium photodynamic therapy for malignant pleural mesothelioma","author":"Friedberg","year":"2012"},{"key":"10.1016\/j.lungcan.2021.04.025_bib0165","doi-asserted-by":"crossref","first-page":"1184","DOI":"10.12688\/f1000research.15512.2","article-title":"Factors influencing malignant mesothelioma survival: a retrospective review of the National Mesothelioma Virtual Bank cohort","volume":"7","author":"Amin","year":"2018","journal-title":"F1000Res"},{"key":"10.1016\/j.lungcan.2021.04.025_bib0170","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.lungcan.2013.04.019","article-title":"Radical pleurectomy and chemoradiation for malignant pleural mesothelioma: the outcome of incomplete resections","volume":"81","author":"Bolukbas","year":"2013","journal-title":"Lung Cancer"},{"key":"10.1016\/j.lungcan.2021.04.025_bib0175","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.jss.2015.01.043","article-title":"Impact of mesothelioma histologic subtype on outcomes in the Surveillance, Epidemiology, and End Results database","volume":"196","author":"Meyerhoff","year":"2015","journal-title":"J. Surg. Res."},{"key":"10.1016\/j.lungcan.2021.04.025_bib0180","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.ejcts.2010.02.028","article-title":"Obtaining an upper estimate of the survival benefit associated with surgery for mesothelioma","volume":"38","author":"Utley","year":"2010","journal-title":"Eur. J. Cardiothorac. Surg."},{"key":"10.1016\/j.lungcan.2021.04.025_bib0185","article-title":"A phase II trial of nivolumab with chemotherapy followed by maintenance nivolumab in patients with pleural mesothelioma after surgery: The NICITA study protocol","author":"Shah","year":"2020","journal-title":"Clin. Lung Cancer"},{"key":"10.1016\/j.lungcan.2021.04.025_bib0190","article-title":"Neoadjuvant immune checkpoint blockade in resectable malignant pleural mesothelioma","author":"Forde","year":"2020","journal-title":"Clin. Trials gov."},{"key":"10.1016\/j.lungcan.2021.04.025_bib0195","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2020-038892","article-title":"Mesothelioma and Radical Surgery 2 (MARS 2): protocol for a multicentre randomised trial comparing (extended) pleurectomy decortication versus no (extended) pleurectomy decortication for patients with malignant pleural mesothelioma","volume":"10","author":"Lim","year":"2020","journal-title":"BMJ Open"},{"key":"10.1016\/j.lungcan.2021.04.025_bib0200","doi-asserted-by":"crossref","first-page":"593","DOI":"10.21037\/tlcr.2018.05.07","article-title":"A randomized phase II study of pleurectomy\/decortication preceded or followed by (neo-)adjuvant chemotherapy in patients with early stage malignant pleural mesothelioma (EORTC 1205)","volume":"7","author":"Raskin","year":"2018","journal-title":"Transl. Lung Cancer Res."}],"container-title":["Lung Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0169500221001677?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0169500221001677?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,30]],"date-time":"2025-09-30T12:53:19Z","timestamp":1759236799000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0169500221001677"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6]]},"references-count":40,"alternative-id":["S0169500221001677"],"URL":"https:\/\/doi.org\/10.1016\/j.lungcan.2021.04.025","relation":{},"ISSN":["0169-5002"],"issn-type":[{"value":"0169-5002","type":"print"}],"subject":[],"published":{"date-parts":[[2021,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Malignant pleural mesothelioma: Comparison of surgery-based trimodality therapy to medical therapy at two tertiary academic institutions","name":"articletitle","label":"Article Title"},{"value":"Lung Cancer","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.lungcan.2021.04.025","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}