{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T17:46:30Z","timestamp":1791913590071,"version":"4.3.4"},"reference-count":15,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81472782"],"award-info":[{"award-number":["81472782"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2017YFC1309201"],"award-info":[{"award-number":["2017YFC1309201"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","lungcancerjournal.info","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Lung Cancer"],"published-print":{"date-parts":[[2021,12]]},"DOI":"10.1016\/j.lungcan.2021.10.015","type":"journal-article","created":{"date-parts":[[2021,11,5]],"date-time":"2021-11-05T17:49:30Z","timestamp":1636134570000},"page":"86-89","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"special_numbering":"C","title":["Coexistence of a novel NBEA-ALK, EML4-ALK double-fusion in a lung adenocarcinoma patient and response to alectinib: A case report"],"prefix":"10.1016","volume":"162","author":[{"given":"Qi","family":"Liang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huanhuan","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiqian","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiming","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chongqi","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yizhi","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shanyue","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xian","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sumeng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingxiang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.lungcan.2021.10.015_b0005","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1007\/s40265-020-01445-2","article-title":"Treatment sequencing for anaplastic lymphoma kinase-rearranged non-small-cell lung cancer","volume":"81","author":"Kauffmann-Guerrero","year":"2021","journal-title":"Drugs"},{"issue":"1","key":"10.1016\/j.lungcan.2021.10.015_b0010","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1097\/JTO.0b013e31815e8b60","article-title":"EML4-ALK fusion is linked to histological characteristics in a subset of lung cancers","volume":"3","author":"Inamura","year":"2008","journal-title":"J. Thorac. Oncol."},{"issue":"7153","key":"10.1016\/j.lungcan.2021.10.015_b0015","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1038\/nature05945","article-title":"Identification of the transforming EML4-ALK fusion gene in non-small-cell lung cancer","volume":"448","author":"Soda","year":"2007","journal-title":"Nature"},{"issue":"13","key":"10.1016\/j.lungcan.2021.10.015_b0020","doi-asserted-by":"crossref","first-page":"4275","DOI":"10.1158\/1078-0432.CCR-08-0168","article-title":"EML4-ALK fusion gene and efficacy of an ALK kinase inhibitor in lung cancer","volume":"14","author":"Koivunen","year":"2008","journal-title":"Clin. Cancer Res."},{"issue":"10","key":"10.1016\/j.lungcan.2021.10.015_b0025","doi-asserted-by":"crossref","first-page":"1773","DOI":"10.1016\/j.ejca.2010.04.002","article-title":"The biology and treatment of EML4-ALK non-small cell lung cancer","volume":"46","author":"Sasaki","year":"2010","journal-title":"Eur. J. Cancer"},{"issue":"11","key":"10.1016\/j.lungcan.2021.10.015_b0030","doi-asserted-by":"crossref","first-page":"1491","DOI":"10.1016\/j.annonc.2020.07.014","article-title":"Recommendations for the use of next-generation sequencing (NGS) for patients with metastatic cancers: a report from the ESMO Precision Medicine Working Group","volume":"31","author":"Mosele","year":"2020","journal-title":"Ann. Oncol."},{"issue":"6","key":"10.1016\/j.lungcan.2021.10.015_b0035","doi-asserted-by":"crossref","first-page":"1409","DOI":"10.1093\/annonc\/mdy121","article-title":"Alectinib versus chemotherapy in crizotinib-pretreated anaplastic lymphoma kinase (ALK)-positive non-small-cell lung cancer: results from the phase III ALUR study","volume":"29","author":"Novello","year":"2018","journal-title":"Ann. Oncol."},{"issue":"7","key":"10.1016\/j.lungcan.2021.10.015_b0040","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.1016\/j.jtho.2019.03.007","article-title":"Updated efficacy and safety data and impact of the EML4-ALK fusion variant on the efficacy of alectinib in untreated ALK-Positive advanced non-small cell lung cancer in the global phase III ALEX study","volume":"14","author":"Camidge","year":"2019","journal-title":"J. Thorac. Oncol."},{"issue":"1","key":"10.1016\/j.lungcan.2021.10.015_b0045","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.cub.2014.10.071","article-title":"Neurobeachin is required postsynaptically for electrical and chemical synapse formation","volume":"25","author":"Miller","year":"2015","journal-title":"Curr. Biol."},{"issue":"5","key":"10.1016\/j.lungcan.2021.10.015_b0050","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1002\/ana.25350","article-title":"Developmental disease gene with early generalized epilepsy phenotypes","volume":"84","author":"Mulhern","year":"2018","journal-title":"Ann. Neurol."},{"issue":"7","key":"10.1016\/j.lungcan.2021.10.015_b0055","doi-asserted-by":"crossref","first-page":"1724","DOI":"10.1158\/0008-5472.CAN-15-2443","article-title":"Distinct subtypes of gastric cancer defined by molecular characterization include novel mutational signatures with prognostic capability","volume":"76","author":"Li","year":"2016","journal-title":"Cancer Res."},{"issue":"6","key":"10.1016\/j.lungcan.2021.10.015_b0060","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1016\/j.tranon.2014.09.009","article-title":"Prognostic significance of decreased expression of six large common fragile site genes in oropharyngeal squamous cell carcinomas","volume":"7","author":"Gao","year":"2014","journal-title":"Transl. Oncol."},{"issue":"4","key":"10.1016\/j.lungcan.2021.10.015_b0065","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1002\/path.5467","article-title":"Exome sequencing identifies new somatic alterations and mutation patterns of tongue squamous cell carcinoma in a Chinese population","volume":"251","author":"Zhang","year":"2020","journal-title":"J. Pathol."},{"issue":"6","key":"10.1016\/j.lungcan.2021.10.015_b0070","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1093\/jnci\/djy156","article-title":"A prospective study of circulating tumor DNA to guide matched targeted therapy in lung cancers","volume":"111","author":"Sabari","year":"2019","journal-title":"J. Natl. Cancer Inst."},{"key":"10.1016\/j.lungcan.2021.10.015_b0075","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.lungcan.2021.06.018","article-title":"Clinical utility of next-generation sequencing-based ctDNA testing for common and novel ALK fusions","volume":"159","author":"Mondaca","year":"2021","journal-title":"Lung Cancer"}],"container-title":["Lung Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0169500221005869?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0169500221005869?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T16:57:15Z","timestamp":1791910635000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0169500221005869"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12]]},"references-count":15,"alternative-id":["S0169500221005869"],"URL":"https:\/\/doi.org\/10.1016\/j.lungcan.2021.10.015","relation":{},"ISSN":["0169-5002"],"issn-type":[{"value":"0169-5002","type":"print"}],"subject":[],"published":{"date-parts":[[2021,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Coexistence of a novel NBEA-ALK, EML4-ALK double-fusion in a lung adenocarcinoma patient and response to alectinib: A case report","name":"articletitle","label":"Article Title"},{"value":"Lung Cancer","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.lungcan.2021.10.015","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}