{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T05:43:19Z","timestamp":1781588599176,"version":"3.54.5"},"reference-count":21,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,9,22]],"date-time":"2023-09-22T00:00:00Z","timestamp":1695340800000},"content-version":"am","delay-in-days":325,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","lungcancerjournal.info","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Lung Cancer"],"published-print":{"date-parts":[[2022,11]]},"DOI":"10.1016\/j.lungcan.2022.09.002","type":"journal-article","created":{"date-parts":[[2022,9,6]],"date-time":"2022-09-06T11:47:54Z","timestamp":1662464874000},"page":"67-70","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"special_numbering":"C","title":["Characterization of lung cancers in patients with BRCA germline variants: A multicenter series"],"prefix":"10.1016","volume":"173","author":[{"given":"Mateo","family":"Sanchis-Borja","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent","family":"Fallet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabeth","family":"Fabre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie","family":"Wislez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"St\u00e9phane","family":"Culine","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00e9rard","family":"Zalcman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Philippe","family":"Spano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathalie Chabbert","family":"Buffet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florence","family":"Coulet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick R.","family":"Benusiglio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacques","family":"Cadranel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.lungcan.2022.09.002_b0005","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1007\/s00439-003-0968-7","article-title":"Lung cancer risk in germline p53 mutation carriers: association between an inherited cancer predisposition, cigarette smoking, and cancer risk","volume":"113","author":"Hwang","year":"2003","journal-title":"Hum. Genet."},{"key":"10.1016\/j.lungcan.2022.09.002_b0010","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1097\/JTO.0000000000000130","article-title":"Hereditary lung cancer syndrome targets never smokers with germline EGFR gene T790M mutations","volume":"9","author":"Gazdar","year":"2014","journal-title":"J. Thorac. Oncol."},{"key":"10.1016\/j.lungcan.2022.09.002_b0015","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1097\/PPO.0b013e3181cf0204","article-title":"BRCA gene structure and function in tumor suppression: a repair-centric perspective","volume":"16","author":"Murphy","year":"2010","journal-title":"Cancer J."},{"key":"10.1016\/j.lungcan.2022.09.002_b0020","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/S0092-8674(02)00615-3","article-title":"Cancer susceptibility and the functions of BRCA1 and BRCA2","volume":"108","author":"Venkitaraman","year":"2002","journal-title":"Cell"},{"issue":"23","key":"10.1016\/j.lungcan.2022.09.002_b0025","doi-asserted-by":"crossref","first-page":"2402","DOI":"10.1001\/jama.2017.7112","article-title":"Risks of breast, ovarian, and contralateral breast cancer for BRCA1 and BRCA2 mutation carriers","volume":"317","author":"Kuchenbaecker","year":"2017","journal-title":"JAMA"},{"key":"10.1016\/j.lungcan.2022.09.002_b0030","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1002\/cncr.29041","article-title":"Cancers associated with BRCA1 and BRCA2 mutations other than breast and ovarian","volume":"121","author":"Mersch","year":"2015","journal-title":"Cancer"},{"key":"10.1016\/j.lungcan.2022.09.002_b0035","doi-asserted-by":"crossref","first-page":"1268","DOI":"10.1038\/s41467-022-28840-5","article-title":"Clinical and genomic features of Chinese lung cancer patients with germline mutations","volume":"13","author":"Peng","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.lungcan.2022.09.002_b0040","doi-asserted-by":"crossref","first-page":"2801","DOI":"10.1002\/cncr.33573","article-title":"Germline mutations and age at onset of lung adenocarcinoma","volume":"127","author":"Reckamp","year":"2021","journal-title":"Cancer"},{"key":"10.1016\/j.lungcan.2022.09.002_b0045","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1038\/gim.2015.30","article-title":"Standards and guidelines for the interpretation of sequence variants: a joint consensus recommendation of the American College of Medical Genetics and Genomics and the Association for Molecular Pathology","volume":"17","author":"Richards","year":"2015","journal-title":"Genet. Med."},{"key":"10.1016\/j.lungcan.2022.09.002_b0050","doi-asserted-by":"crossref","unstructured":"X. Hu, D. Yang, Y. Li, L. Li, Y. Wang, P. Chen, S. Xu, X. Pu, W. Zhu, P. Deng, J. Ye, H. Zhang, A. Lizaso, H. Liu, X. Mao, H. Huang, Q. Chu, C. Hu, Prevalence and clinical significance of pathogenic germline BRCA1\/2 mutations in Chinese non-small cell lung cancer patients, Cancer Biol Med. 16 (2019) 556\u2013564. doi: 10.20892\/j.issn.2095-3941.2018.0506.","DOI":"10.20892\/j.issn.2095-3941.2018.0506"},{"key":"10.1016\/j.lungcan.2022.09.002_b0055","doi-asserted-by":"crossref","first-page":"4183","DOI":"10.1200\/JCO.2016.67.0554","article-title":"Population frequency of germline BRCA1\/2 mutations","volume":"34","author":"Maxwell","year":"2016","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.lungcan.2022.09.002_b0060","doi-asserted-by":"crossref","first-page":"e2213070","DOI":"10.1001\/jamanetworkopen.2022.13070","article-title":"Prevalence of germline findings among tumors from cancer types lacking hereditary testing guidelines","volume":"5","author":"Yap","year":"2022","journal-title":"JAMA Network Open"},{"key":"10.1016\/j.lungcan.2022.09.002_b0065","article-title":"Somatic and germline BRCA 1&2 mutations in advanced non-small cell lung cancer from the SAFIR02-Lung Trial","author":"Remon","year":"2020","journal-title":"JTO Clin. Res. Rep."},{"key":"10.1016\/j.lungcan.2022.09.002_b0070","first-page":"ddac123","article-title":"Rare germline deleterious variants increase susceptibility for lung cancer","author":"Sang","year":"2022","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.lungcan.2022.09.002_b0075","doi-asserted-by":"crossref","unstructured":"S. Li, V. Silvestri, G. Leslie, T.R. Rebbeck, S.L. Neuhausen, J.L. Hopper, H.R. Nielsen, A. Lee, X. Yang, L. McGuffog, M.T. Parsons, I.L. Andrulis, N. Arnold, M. Belotti, \u00c5. Borg, B. Buecher, S.S. Buys, S.M. Caputo, W.K. Chung, C. Colas, S.V. Colonna, J. Cook, M.B. Daly, M. de la Hoya, A. de Pauw, H. Delhomelle, J. Eason, C. Engel, D.G. Evans, U. Faust, T.N. Fehm, F. Fostira, G. Fountzilas, M. Frone, V. Garcia-Barberan, P. Garre, M. Gauthier-Villars, A. Gehrig, G. Glendon, D.E. Goldgar, L. Golmard, M.H. Greene, E. Hahnen, U. Hamann, H. Hanson, T. Hassan, J. Hentschel, J. Horvath, L. Izatt, R. Janavicius, Y. Jiao, E.M. John, B.Y. Karlan, S.-W. Kim, I. Konstantopoulou, A. Kwong, A. Laug\u00e9, J.W. Lee, F. Lesueur, N. Mebirouk, A. Meindl, E. Mouret-Fourme, H. Musgrave, J. Ngeow Yuen Yie, D. Niederacher, S.K. Park, I.S. Pedersen, J. Ramser, S.J. Ramus, J. Rantala, M.U. Rashid, F. Reichl, J. Ritter, A. Rump, M. Santamari\u00f1a, C. Saule, G. Schmidt, R.K. Schmutzler, L. Senter, S. Shariff, C.F. Singer, M.C. Southey, D. Stoppa-Lyonnet, C. Sutter, Y. Tan, S.H. Teo, M.B. Terry, M. Thomassen, M. Tischkowitz, A.E. Toland, D. Torres, A. Vega, S.A. Wagner, S. Wang-Gohrke, B. Wappenschmidt, B.H.F. Weber, D. Yannoukakos, A.B. Spurdle, D.F. Easton, G. Chenevix-Trench, L. Ottini, A.C. Antoniou, Cancer Risks Associated With BRCA1 and BRCA2 Pathogenic Variants, JCO. (2022) JCO.21.02112. 10.1200\/JCO.21.02112.","DOI":"10.1200\/JCO.21.02112"},{"key":"10.1016\/j.lungcan.2022.09.002_b0080","article-title":"BRCA1 and BRCA2 gene mutations and lung cancer sisk: a meta-analysis","volume":"56","author":"Lee","year":"2020","journal-title":"Medicina (Kaunas)."},{"issue":"11","key":"10.1016\/j.lungcan.2022.09.002_b0085","doi-asserted-by":"crossref","first-page":"2263","DOI":"10.1002\/ijc.31257","article-title":"The association between smoking and cancer incidence in BRCA1 and BRCA2 mutation carriers","volume":"142","author":"Ko","year":"2018","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.lungcan.2022.09.002_b0090","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1038\/gim.2014.82","article-title":"Cigarette smoking in women after BRCA1\/2 genetic test disclosure: a 5-year follow-up study of the GENEPSO PS cohort","volume":"17","author":"Julian-Reynier","year":"2015","journal-title":"Genet. Med."},{"key":"10.1016\/j.lungcan.2022.09.002_b0095","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.lungcan.2019.09.008","article-title":"Homologous recombination in lung cancer, germline and somatic mutations, clinical and phenotype characterization","volume":"137","author":"Kadouri","year":"2019","journal-title":"Lung Cancer."},{"key":"10.1016\/j.lungcan.2022.09.002_b0100","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1038\/s41698-021-00199-8","article-title":"A subset of lung cancer cases shows robust signs of homologous recombination deficiency associated genomic mutational signatures","volume":"5","author":"Diossy","year":"2021","journal-title":"NPJ Precis. Oncol."},{"key":"10.1016\/j.lungcan.2022.09.002_b0105","doi-asserted-by":"crossref","DOI":"10.1183\/16000617.0045-2021","article-title":"Lung cancer is also a hereditary disease","volume":"30","author":"Benusiglio","year":"2021","journal-title":"Eur. Respir. Rev."}],"container-title":["Lung Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S016950022200616X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S016950022200616X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,30]],"date-time":"2025-09-30T13:01:53Z","timestamp":1759237313000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S016950022200616X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11]]},"references-count":21,"alternative-id":["S016950022200616X"],"URL":"https:\/\/doi.org\/10.1016\/j.lungcan.2022.09.002","relation":{},"ISSN":["0169-5002"],"issn-type":[{"value":"0169-5002","type":"print"}],"subject":[],"published":{"date-parts":[[2022,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Characterization of lung cancers in patients with BRCA germline variants: A multicenter series","name":"articletitle","label":"Article Title"},{"value":"Lung Cancer","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.lungcan.2022.09.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}