{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T18:46:36Z","timestamp":1793645196999,"version":"4.5.1"},"reference-count":33,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,12,2]],"date-time":"2022-12-02T00:00:00Z","timestamp":1669939200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","lungcancerjournal.info","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Lung Cancer"],"published-print":{"date-parts":[[2023,1]]},"DOI":"10.1016\/j.lungcan.2022.11.022","type":"journal-article","created":{"date-parts":[[2022,12,5]],"date-time":"2022-12-05T16:39:21Z","timestamp":1670258361000},"page":"79-87","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"special_numbering":"C","title":["Validation of the novel International Association for the Study of Lung Cancer grading system and prognostic value of filigree micropapillary and discohesive growth pattern in invasive pulmonary adenocarcinoma"],"prefix":"10.1016","volume":"175","author":[{"given":"Yuan","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanjun","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shu","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaojuan","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuhui","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"5","key":"10.1016\/j.lungcan.2022.11.022_b0005","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1097\/CM9.0000000000002108","article-title":"Cancer statistics in China and United States, 2022: profiles, trends, and determinants","volume":"135","author":"Xia","year":"2022","journal-title":"Chin. Med. J. (Engl)"},{"issue":"1","key":"10.1016\/j.lungcan.2022.11.022_b0010","first-page":"7","article-title":"Cancer statistics, 2022","volume":"72","author":"Siegel","year":"2022","journal-title":"CA A Cancer J. Clinicians"},{"issue":"3","key":"10.1016\/j.lungcan.2022.11.022_b0015","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1016\/j.jtho.2021.11.003","article-title":"The 2021 who classification of lung tumors: impact of advances since 2015","volume":"17","author":"Nicholson","year":"2022","journal-title":"J. Thorac. Oncol."},{"issue":"2","key":"10.1016\/j.lungcan.2022.11.022_b0020","first-page":"93","article-title":"The eighth edition ajcc cancer staging manual: continuing to build a bridge from a population-based to a more \u201cpersonalized\u201d approach to cancer staging: the eighth edition ajcc cancer staging manual","volume":"67","author":"Amin","year":"2017","journal-title":"CA Cancer J. Clin."},{"issue":"9","key":"10.1016\/j.lungcan.2022.11.022_b0025","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.1097\/JTO.0000000000000630","article-title":"The 2015 world health organization classification of lung tumors: impact of genetic, clinical and radiologic advances since the 2004 classification","volume":"10","author":"Travis","year":"2015","journal-title":"J. Thorac. Oncol."},{"issue":"10","key":"10.1016\/j.lungcan.2022.11.022_b0030","doi-asserted-by":"crossref","first-page":"1599","DOI":"10.1016\/j.jtho.2020.06.001","article-title":"A grading system for invasive pulmonary adenocarcinoma: a proposal from the international association for the study of lung cancer pathology committee","volume":"15","author":"Moreira","year":"2020","journal-title":"J. Thorac. Oncol."},{"issue":"10","key":"10.1016\/j.lungcan.2022.11.022_b0035","doi-asserted-by":"crossref","first-page":"1753","DOI":"10.1016\/j.jtho.2021.04.008","article-title":"Validation study of the international association for the study of lung cancer histologic grading system of invasive lung adenocarcinoma","volume":"16","author":"Rokutan-Kurata","year":"2021","journal-title":"J. Thorac. Oncol."},{"issue":"10","key":"10.1016\/j.lungcan.2022.11.022_b0040","doi-asserted-by":"crossref","first-page":"1684","DOI":"10.1016\/j.jtho.2021.07.006","article-title":"Validation of the novel international association for the study of lung cancer grading system for invasive pulmonary adenocarcinoma and association with common driver mutations","volume":"16","author":"Deng","year":"2021","journal-title":"J. Thorac. Oncol."},{"issue":"9","key":"10.1016\/j.lungcan.2022.11.022_b0045","doi-asserted-by":"crossref","first-page":"1722","DOI":"10.1038\/s41379-020-0537-9","article-title":"Discohesive growth pattern (Disco-p) as an unfavorable prognostic factor in lung adenocarcinoma: an analysis of 1062 Japanese patients with resected lung adenocarcinoma","volume":"33","author":"Rokutan-Kurata","year":"2020","journal-title":"Mod. Pathol."},{"issue":"2","key":"10.1016\/j.lungcan.2022.11.022_b0050","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.humpath.2013.10.011","article-title":"Cribriform and fused glands are patterns of high-grade pulmonary adenocarcinoma","volume":"45","author":"Moreira","year":"2014","journal-title":"Hum. Pathol."},{"issue":"1","key":"10.1016\/j.lungcan.2022.11.022_b0055","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1093\/ajcp\/aqy032","article-title":"Clinical significance of complex glandular patterns in lung adenocarcinoma: clinicopathologic and molecular study in a large series of cases","volume":"150","author":"Kuang","year":"2018","journal-title":"Am. J. Clin. Pathol."},{"issue":"11","key":"10.1016\/j.lungcan.2022.11.022_b0060","doi-asserted-by":"crossref","first-page":"1948","DOI":"10.1016\/j.jtho.2019.07.008","article-title":"Expansion of the concept of micropapillary adenocarcinoma to include a newly recognized filigree pattern as well as the classical pattern based on 1468 stage i lung adenocarcinomas","volume":"14","author":"Emoto","year":"2019","journal-title":"J. Thorac. Oncol."},{"issue":"5","key":"10.1016\/j.lungcan.2022.11.022_b0065","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1038\/s41379-020-00711-8","article-title":"Recognition of filigree pattern expands the concept of micropapillary subtype in patients with surgically resected lung adenocarcinoma","volume":"34","author":"Zhu","year":"2021","journal-title":"Mod. Pathol."},{"issue":"1","key":"10.1016\/j.lungcan.2022.11.022_b0070","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1111\/his.14672","article-title":"Identification of filigree pattern increases the diagnostic accuracy of micropapillary pattern on frozen section for lung adenocarcinoma","volume":"81","author":"Zhao","year":"2022","journal-title":"Histopathology"},{"issue":"7","key":"10.1016\/j.lungcan.2022.11.022_b0075","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1097\/JTO.0b013e31824cbad8","article-title":"Predictors of death, local recurrence, and distant metastasis in completely resected pathological stage-I non-small-cell lung cancer","volume":"7","author":"Hung","year":"2012","journal-title":"J. Thorac. Oncol."},{"issue":"6","key":"10.1016\/j.lungcan.2022.11.022_b0080","doi-asserted-by":"crossref","first-page":"1624","DOI":"10.1093\/ejcts\/ezv462","article-title":"Postoperative follow-up strategy based on recurrence dynamics for non-small-cell lung cancer","volume":"49","author":"Watanabe","year":"2016","journal-title":"Eur. J. Cardiothorac. Surg."},{"issue":"8","key":"10.1016\/j.lungcan.2022.11.022_b0085","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1016\/S1470-2045(12)70242-5","article-title":"Patterns of disease recurrence after stereotactic ablative radiotherapy for early stage non-small-cell lung cancer: a retrospective analysis","volume":"13","author":"Senthi","year":"2012","journal-title":"Lancet Oncol."},{"key":"10.1016\/j.lungcan.2022.11.022_b0090","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.lungcan.2022.03.013","article-title":"EGFR mutation is not a prognostic factor for CNS metastasis in curatively resected lung adenocarcinoma patients","volume":"167","author":"Liu","year":"2022","journal-title":"Lung Cancer"},{"issue":"5","key":"10.1016\/j.lungcan.2022.11.022_b0095","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1038\/modpathol.2010.232","article-title":"Impact of proposed IASLC\/ATS\/ERS classification of lung adenocarcinoma: prognostic subgroups and implications for further revision of staging based on analysis of 514 stage I cases","volume":"24","author":"Yoshizawa","year":"2011","journal-title":"Mod. Pathol."},{"issue":"13","key":"10.1016\/j.lungcan.2022.11.022_b0100","doi-asserted-by":"crossref","first-page":"1438","DOI":"10.1200\/JCO.2011.37.2185","article-title":"The novel histologic international association for the study of lung cancer\/american thoracic society\/european respiratory society classification system of lung adenocarcinoma is a stage-independent predictor of survival","volume":"30","author":"Warth","year":"2012","journal-title":"J. Clin. Oncol."},{"issue":"8","key":"10.1016\/j.lungcan.2022.11.022_b0105","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1097\/PAS.0b013e3181e4ee32","article-title":"A grading system of lung adenocarcinomas based on histologic pattern is predictive of disease recurrence in stage I tumors","volume":"34","author":"Sica","year":"2010","journal-title":"Am. J. Surg. Pathol."},{"key":"10.1016\/j.lungcan.2022.11.022_b0110","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.lungcan.2016.01.009","article-title":"Factors influencing the concordance of histological subtype diagnosis from biopsy and resected specimens of lung adenocarcinoma","volume":"94","author":"Matsuzawa","year":"2016","journal-title":"Lung Cancer"},{"issue":"2","key":"10.1016\/j.lungcan.2022.11.022_b0115","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1111\/1759-7714.13754","article-title":"Clinical implication of minimal presence of solid or micropapillary subtype in early-stage lung adenocarcinoma","volume":"12","author":"Choi","year":"2021","journal-title":"Thorac Cancer"},{"issue":"12","key":"10.1016\/j.lungcan.2022.11.022_b0120","doi-asserted-by":"crossref","first-page":"1772","DOI":"10.1097\/JTO.0000000000000341","article-title":"A comprehensive investigation of molecular features and prognosis of lung adenocarcinoma with micropapillary component","volume":"9","author":"Zhang","year":"2014","journal-title":"J. Thorac. Oncol."},{"issue":"4","key":"10.1016\/j.lungcan.2022.11.022_b0125","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1007\/s00432-018-2588-6","article-title":"A comprehensive evaluation of clinicopathologic characteristics, molecular features and prognosis in lung adenocarcinoma with solid component","volume":"144","author":"Li","year":"2018","journal-title":"J. Cancer Res. Clin. Oncol."},{"issue":"5","key":"10.1016\/j.lungcan.2022.11.022_b0130","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1038\/modpathol.2013.188","article-title":"The cribriform pattern identifies a subset of acinar predominant tumors with poor prognosis in patients with stage I lung adenocarcinoma: a conceptual proposal to classify cribriform predominant tumors as a distinct histologic subtype","volume":"27","author":"Kadota","year":"2014","journal-title":"Mod. Pathol."},{"issue":"5","key":"10.1016\/j.lungcan.2022.11.022_b0135","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1007\/s11748-021-01758-3","article-title":"High-grade tumor classified by new system is a prognostic predictor in resected lung adenocarcinoma","volume":"70","author":"Yoshida","year":"2022","journal-title":"Gen. Thorac. Cardiovasc. Surg."},{"issue":"5","key":"10.1016\/j.lungcan.2022.11.022_b0140","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1016\/j.jtho.2022.02.005","article-title":"Clinicopathologic and genotypic features of lung adenocarcinoma characterized by the international association for the study of lung cancer grading system","volume":"17","author":"Fujikawa","year":"2022","journal-title":"J. Thorac. Oncol."},{"key":"10.1016\/j.lungcan.2022.11.022_b0145","doi-asserted-by":"crossref","first-page":"1952","DOI":"10.1111\/1759-7714.13984","article-title":"Significant difference in recurrence according to the proportion of high grade patterns in stage IA lung adenocarcinoma","volume":"12","author":"Jeon","year":"2021","journal-title":"Thorac Cancer"},{"issue":"5","key":"10.1016\/j.lungcan.2022.11.022_b0150","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1016\/j.jtho.2021.01.1621","article-title":"A validation study of the recommended change in residual tumor descriptors proposed by the international association for the study of lung cancer for patients with pn2 nscLC","volume":"16","author":"Yun","year":"2021","journal-title":"J. Thorac. Oncol."},{"issue":"10","key":"10.1016\/j.lungcan.2022.11.022_b0155","doi-asserted-by":"crossref","first-page":"e76999","DOI":"10.1371\/journal.pone.0076999","article-title":"A comprehensive comparative analysis of the histomorphological features of ALK-rearranged lung adenocarcinoma based on driver oncogene mutations: frequent expression of epithelial-mesenchymal transition markers than other genotype","volume":"8","author":"Kim","year":"2013","journal-title":"PLoS One"},{"issue":"3","key":"10.1016\/j.lungcan.2022.11.022_b0160","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1111\/1759-7714.12961","article-title":"Validation of stage groupings in the eighth edition of the tumor node metastasis classification for lung adenocarcinoma","volume":"10","author":"Yu","year":"2019","journal-title":"Thorac Cancer"},{"key":"10.1016\/j.lungcan.2022.11.022_b0165","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.lungcan.2018.12.001","article-title":"Prognostic impact of microscopic vessel invasion and visceral pleural invasion and their correlations with epithelial-mesenchymal transition, cancer stemness, and treatment failure in lung adenocarcinoma","volume":"128","author":"Neri","year":"2019","journal-title":"Lung Cancer"}],"container-title":["Lung Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0169500222007061?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0169500222007061?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,30]],"date-time":"2025-09-30T13:03:07Z","timestamp":1759237387000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0169500222007061"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1]]},"references-count":33,"alternative-id":["S0169500222007061"],"URL":"https:\/\/doi.org\/10.1016\/j.lungcan.2022.11.022","relation":{},"ISSN":["0169-5002"],"issn-type":[{"value":"0169-5002","type":"print"}],"subject":[],"published":{"date-parts":[[2023,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Validation of the novel International Association for the Study of Lung Cancer grading system and prognostic value of filigree micropapillary and discohesive growth pattern in invasive pulmonary adenocarcinoma","name":"articletitle","label":"Article Title"},{"value":"Lung Cancer","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.lungcan.2022.11.022","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Author(s). Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}