{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T09:09:27Z","timestamp":1791882567990,"version":"4.3.4"},"reference-count":33,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,5,3]],"date-time":"2023-05-03T00:00:00Z","timestamp":1683072000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","lungcancerjournal.info","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Lung Cancer"],"published-print":{"date-parts":[[2023,7]]},"DOI":"10.1016\/j.lungcan.2023.107229","type":"journal-article","created":{"date-parts":[[2023,5,3]],"date-time":"2023-05-03T20:56:12Z","timestamp":1683147372000},"page":"107229","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"special_numbering":"C","title":["Development and validation of a simple general population lung cancer risk model including AHRR-methylation"],"prefix":"10.1016","volume":"181","author":[{"given":"Katja Kemp","family":"Jacobsen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camilla Jannie","family":"Kobylecki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sune Moeller","family":"Skov-Jeppesen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4061-4133","authenticated-orcid":false,"given":"Stig Egil","family":"Bojesen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.lungcan.2023.107229_b0005","first-page":"209","article-title":"Cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"71","author":"Sung","year":"2021","journal-title":"CA Cancer J. Clin."},{"issue":"11","key":"10.1016\/j.lungcan.2023.107229_b0010","doi-asserted-by":"crossref","first-page":"1493","DOI":"10.1016\/S1470-2045(19)30456-5","article-title":"Progress in cancer survival, mortality, and incidence in seven high-income countries 1995\u20132014 (ICBP SURVMARK-2): a population-based study","volume":"20","author":"Arnold","year":"2019","journal-title":"Lancet Oncol."},{"issue":"1","key":"10.1016\/j.lungcan.2023.107229_b0015","first-page":"7","article-title":"Cancer statistics, 2022","volume":"72","author":"Siegel","year":"2022","journal-title":"CA Cancer J. Clin."},{"issue":"6","key":"10.1016\/j.lungcan.2023.107229_b0020","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1056\/NEJMoa1911793","article-title":"Reduced lung-cancer mortality with volume CT screening in a randomized trial","volume":"382","author":"de Koning","year":"2020","journal-title":"N. Engl. J. Med."},{"issue":"4","key":"10.1016\/j.lungcan.2023.107229_b0025","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1158\/1055-9965.EPI-21-1059","article-title":"AHRR (cg05575921) methylation safely improves specificity of lung cancer screening eligibility criteria: a cohort study","volume":"31","author":"Jacobsen","year":"2022","journal-title":"Cancer Epidemiol. Biomark. Prev."},{"issue":"13","key":"10.1016\/j.lungcan.2023.107229_b0030","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.1093\/jnci\/djr173","article-title":"Lung cancer risk prediction: prostate, lung, colorectal and ovarian cancer screening trial models and validation","volume":"103","author":"Tammemagi","year":"2011","journal-title":"J. Natl Cancer Inst."},{"issue":"6","key":"10.1016\/j.lungcan.2023.107229_b0035","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1093\/jnci\/95.6.470","article-title":"Variations in lung cancer risk among smokers","volume":"95","author":"Bach","year":"2003","journal-title":"J. Natl Cancer Inst."},{"issue":"9","key":"10.1016\/j.lungcan.2023.107229_b0040","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1093\/jnci\/djk153","article-title":"A risk model for prediction of lung cancer","volume":"99","author":"Spitz","year":"2007","journal-title":"J. Natl. Cancer Inst."},{"issue":"9","key":"10.1016\/j.lungcan.2023.107229_b0045","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1158\/1940-6207.CAPR-14-0424","article-title":"Selecting high-risk individuals for lung cancer screening: a prospective evaluation of existing risk models and eligibility criteria in the German EPIC cohort","volume":"8","author":"Li","year":"2015","journal-title":"Cancer Prev. Res. (Phila.)"},{"issue":"3","key":"10.1016\/j.lungcan.2023.107229_b0050","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1183\/13993003.00359-2016","article-title":"Risk factors for lung cancer worldwide","volume":"48","author":"Malhotra","year":"2016","journal-title":"Eur. Respir. J."},{"issue":"4","key":"10.1016\/j.lungcan.2023.107229_b0055","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1615\/CritRevTherDrugCarrierSyst.2021037912","article-title":"Exploring liposomes for lung cancer therapy","volume":"39","author":"Shahid","year":"2022","journal-title":"Crit. Rev. Ther. Drug Carrier Syst."},{"issue":"5","key":"10.1016\/j.lungcan.2023.107229_b0060","doi-asserted-by":"crossref","first-page":"e63812","DOI":"10.1371\/journal.pone.0063812","article-title":"Tobacco smoking leads to extensive genome-wide changes in DNA methylation","volume":"8","author":"Zeilinger","year":"2013","journal-title":"PLoS One"},{"issue":"11","key":"10.1016\/j.lungcan.2023.107229_b0065","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.4161\/epi.22520","article-title":"Demethylation of the aryl hydrocarbon receptor repressor as a biomarker for nascent smokers","volume":"7","author":"Philibert","year":"2012","journal-title":"Epigenetics"},{"issue":"5","key":"10.1016\/j.lungcan.2023.107229_b0070","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1093\/hmg\/dds488","article-title":"Epigenome-wide association study in the European Prospective Investigation into Cancer and Nutrition (EPIC-Turin) identifies novel genetic loci associated with smoking","volume":"22","author":"Shenker","year":"2013","journal-title":"Hum. Mol. Genet."},{"issue":"1","key":"10.1016\/j.lungcan.2023.107229_b0075","doi-asserted-by":"crossref","DOI":"10.1186\/1471-2164-15-151","article-title":"The effect of smoking on DNA methylation of peripheral blood mononuclear cells from African American women","volume":"15","author":"Dogan","year":"2014","journal-title":"BMC Genomics"},{"issue":"1","key":"10.1016\/j.lungcan.2023.107229_b0080","doi-asserted-by":"crossref","DOI":"10.1186\/1868-7083-6-4","article-title":"Differences in smoking associated DNA methylation patterns in South Asians and Europeans","volume":"6","author":"Elliott","year":"2014","journal-title":"Clin. Epigenetics"},{"issue":"1","key":"10.1016\/j.lungcan.2023.107229_b0085","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms10192","article-title":"Hypomethylation of smoking-related genes is associated with future lung cancer in four prospective cohorts","volume":"6","author":"Fasanelli","year":"2015","journal-title":"Nat. Commun."},{"issue":"5","key":"10.1016\/j.lungcan.2023.107229_b0090","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1161\/CIRCGENETICS.116.001506","article-title":"Epigenetic signatures of cigarette smoking","volume":"9","author":"Joehanes","year":"2016","journal-title":"Circ. Cardiovasc. Genet."},{"issue":"11","key":"10.1016\/j.lungcan.2023.107229_b0095","doi-asserted-by":"crossref","first-page":"2482","DOI":"10.1002\/ijc.30374","article-title":"Comparison and combination of blood DNA methylation at smoking-associated genes and at lung cancer-related genes in prediction of lung cancer mortality","volume":"139","author":"Zhang","year":"2016","journal-title":"Int. J. Cancer"},{"issue":"8","key":"10.1016\/j.lungcan.2023.107229_b0100","doi-asserted-by":"crossref","first-page":"2349","DOI":"10.1093\/hmg\/ddu751","article-title":"Dynamics of smoking-induced genome-wide methylation changes with time since smoking cessation","volume":"24","author":"Guida","year":"2015","journal-title":"Hum. Mol. Genet."},{"issue":"7","key":"10.1016\/j.lungcan.2023.107229_b0105","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1136\/thoraxjnl-2016-208789","article-title":"AHRR (cg05575921) hypomethylation marks smoking behaviour, morbidity and mortality","volume":"72","author":"Bojesen","year":"2017","journal-title":"Thorax"},{"issue":"4","key":"10.1016\/j.lungcan.2023.107229_b0110","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1158\/1055-9965.EPI-22-0099","article-title":"Biomarker-based lung cancer screening eligibility: implementation considerations","volume":"31","author":"Hung","year":"2022","journal-title":"Cancer Epidemiol. Biomark. Prev."},{"issue":"21","key":"10.1016\/j.lungcan.2023.107229_b0115","doi-asserted-by":"crossref","first-page":"2875","DOI":"10.1200\/JCO.2010.32.9870","article-title":"Nicotinic acetylcholine receptor polymorphism, smoking behavior, and tobacco-related cancer and lung and cardiovascular diseases: a cohort study","volume":"29","author":"Kaur-Knudsen","year":"2011","journal-title":"J. Clin. Oncol."},{"issue":"8","key":"10.1016\/j.lungcan.2023.107229_b0120","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1056\/NEJMoa1211776","article-title":"Selection criteria for lung-cancer screening","volume":"368","author":"Tammem\u00e4gi","year":"2013","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.lungcan.2023.107229_b0125","doi-asserted-by":"crossref","unstructured":"A. Kerpel-Fronius, M. Tammem\u00e4gi, M. Cavic, et al; members of the Diagnostics Working Group; ED and Screening Committee: Screening for Lung Cancer in Individuals Who Never Smoked: An International Association for the Study of Lung Cancer Early Detection and Screening Committee Report. J. Thorac. Oncol. 17(1) 2022 56-66.","DOI":"10.1016\/j.jtho.2021.07.031"},{"issue":"1","key":"10.1016\/j.lungcan.2023.107229_b0130","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1136\/thx.2006.064196","article-title":"Impaired lung function and lung cancer incidence in a cohort of Swedish construction workers","volume":"62","author":"Purdue","year":"2007","journal-title":"Thorax"},{"issue":"1","key":"10.1016\/j.lungcan.2023.107229_b0135","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1183\/09031936.00049909","article-title":"Lung function predicts lung cancer risk in smokers: a tool for targeting screening programmes","volume":"35","author":"Calabro","year":"2010","journal-title":"Eur. Respir. J."},{"key":"10.1016\/j.lungcan.2023.107229_b0140","doi-asserted-by":"crossref","first-page":"k4981","DOI":"10.1136\/bmj.k4981","article-title":"Circulating high sensitivity C reactive protein concentrations and risk of lung cancer: nested case-control study within Lung Cancer Cohort Consortium","volume":"364","author":"Muller","year":"2019","journal-title":"BMJ"},{"issue":"11","key":"10.1016\/j.lungcan.2023.107229_b0145","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.1016\/j.ejca.2015.04.020","article-title":"Cardiorespiratory fitness, C-reactive protein and lung cancer risk: A prospective population-based cohort study","volume":"51","author":"Pletnikoff","year":"2015","journal-title":"Eur. J. Cancer"},{"issue":"13","key":"10.1016\/j.lungcan.2023.107229_b0150","doi-asserted-by":"crossref","first-page":"2096","DOI":"10.1080\/15592294.2022.2108082","article-title":"Using Cg05575921 methylation to predict lung cancer risk: a potentially bias-free precision epigenetics approach","volume":"17","author":"Philibert","year":"2022","journal-title":"Epigenetics"},{"issue":"3","key":"10.1016\/j.lungcan.2023.107229_b0155","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1016\/j.rmed.2006.06.013","article-title":"Exhaled CO, a predictor of lung function?","volume":"101","author":"Fabricius","year":"2007","journal-title":"Respir. Med."},{"issue":"6","key":"10.1016\/j.lungcan.2023.107229_b0160","doi-asserted-by":"crossref","first-page":"1607","DOI":"10.1158\/0008-5472.CAN-20-1237","article-title":"Assessing lung cancer absolute risk trajectory based on a polygenic risk model","volume":"81","author":"Hung","year":"2021","journal-title":"Cancer Res."},{"issue":"12","key":"10.1016\/j.lungcan.2023.107229_b0165","doi-asserted-by":"crossref","first-page":"e754","DOI":"10.1016\/S1470-2045(17)30861-6","article-title":"European position statement on lung cancer screening","volume":"18","author":"Oudkerk","year":"2017","journal-title":"Lancet Oncol."}],"container-title":["Lung Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0169500223007675?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0169500223007675?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,30]],"date-time":"2025-09-30T13:04:02Z","timestamp":1759237442000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0169500223007675"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,7]]},"references-count":33,"alternative-id":["S0169500223007675"],"URL":"https:\/\/doi.org\/10.1016\/j.lungcan.2023.107229","relation":{},"ISSN":["0169-5002"],"issn-type":[{"value":"0169-5002","type":"print"}],"subject":[],"published":{"date-parts":[[2023,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Development and validation of a simple general population lung cancer risk model including AHRR-methylation","name":"articletitle","label":"Article Title"},{"value":"Lung Cancer","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.lungcan.2023.107229","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Author(s). Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"107229"}}