{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T20:48:42Z","timestamp":1786740522852,"version":"build-2736575974"},"reference-count":19,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","lungcancerjournal.info","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Lung Cancer"],"published-print":{"date-parts":[[2023,7]]},"DOI":"10.1016\/j.lungcan.2023.107247","type":"journal-article","created":{"date-parts":[[2023,5,15]],"date-time":"2023-05-15T06:46:52Z","timestamp":1684133212000},"page":"107247","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["Germline EGFR c.2527G\u00a0&gt;\u00a0A (p.V843I) variant and familial lung cancer"],"prefix":"10.1016","volume":"181","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1511-3505","authenticated-orcid":false,"given":"Saba","family":"Alsaddah","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas I.","family":"Papadakis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nora","family":"Wong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Palma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Szlachtycz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tania","family":"Cruz Marino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre-Olivier","family":"Fiset","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William D","family":"Foulkes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.lungcan.2023.107247_b0005","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1590\/S1415-47572013000300022","article-title":"Identification of candidate genes for lung cancer somatic mutation test kits","volume":"36","author":"Chen","year":"2013","journal-title":"Genet Mol Biol"},{"issue":"21","key":"10.1016\/j.lungcan.2023.107247_b0010","doi-asserted-by":"crossref","first-page":"2129","DOI":"10.1056\/NEJMoa040938","article-title":"Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib","volume":"350","author":"Lynch","year":"2004","journal-title":"N Engl J Med"},{"issue":"12","key":"10.1016\/j.lungcan.2023.107247_b0015","doi-asserted-by":"crossref","first-page":"1315","DOI":"10.1038\/ng1671","article-title":"Inherited susceptibility to lung cancer may be associated with the T790M drug resistance mutation in EGFR","volume":"37","author":"Bell","year":"2005","journal-title":"Nat Genet"},{"issue":"8","key":"10.1016\/j.lungcan.2023.107247_b0020","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1056\/NEJMoa044238","article-title":"EGFR mutation and resistance of non-small-cell lung cancer to gefitinib","volume":"352","author":"Kobayashi","year":"2005","journal-title":"N Engl J Med"},{"issue":"1","key":"10.1016\/j.lungcan.2023.107247_b0025","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.lungcan.2012.11.013","article-title":"A dramatic lung cancer course in a patient with a rare EGFR germline mutation exon 21 V843I: Is EGFR TKI resistance predictable?","volume":"80","author":"Demierre","year":"2013","journal-title":"Lung Cancer"},{"issue":"4","key":"10.1016\/j.lungcan.2023.107247_b0030","doi-asserted-by":"crossref","first-page":"1430","DOI":"10.1016\/j.athoracsur.2007.10.012","article-title":"Novel germline mutation: EGFR V843I in patient with multiple lung adenocarcinomas and family members with lung cancer","volume":"85","author":"Ikeda","year":"2008","journal-title":"Ann Thorac Surg"},{"issue":"8","key":"10.1016\/j.lungcan.2023.107247_b0035","doi-asserted-by":"crossref","first-page":"e191","DOI":"10.1200\/JCO.2010.31.4492","article-title":"Familial lung adenocarcinoma caused by the EGFR V843I germ-line mutation","volume":"29","author":"Ohtsuka","year":"2011","journal-title":"J Clin Oncol"},{"issue":"133","key":"10.1016\/j.lungcan.2023.107247_b0040","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1183\/09059180.00009313","article-title":"Germ-line exon 21 EGFR mutations, V843I and P848L, in nonsmall cell lung cancer patients","volume":"23","author":"Prim","year":"2014","journal-title":"Eur Respir Rev"},{"issue":"3","key":"10.1016\/j.lungcan.2023.107247_b0045","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.21037\/apm-21-2653","article-title":"A non-small cell lung cancer (NSCLC) patient harboring a rare epidermal growth factor receptor (EGFR) L858R\/V843I mutation complex benefited from osimertinib: a case report. Ann","volume":"11","author":"Zhou","year":"2022","journal-title":"Palliat Med"},{"key":"10.1016\/j.lungcan.2023.107247_b0050","article-title":"Next-generation sequencing of non-small cell lung cancer at a Quebec health care cancer centre","volume":"35","author":"Sorin","year":"2023","journal-title":"Cancer Treat Res Commun"},{"issue":"2","key":"10.1016\/j.lungcan.2023.107247_b0055","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.cllc.2014.09.008","article-title":"Impact of smoking status on EGFR-TKI efficacy for advanced non-small-cell lung cancer in EGFR mutants: a meta-analysis","volume":"16","author":"Zhang","year":"2015","journal-title":"Clin Lung Cancer"},{"issue":"6","key":"10.1016\/j.lungcan.2023.107247_b0060","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1007\/s00401-016-1549-x","article-title":"Germline and somatic FGFR1 abnormalities in dysembryoplastic neuroepithelial tumors","volume":"131","author":"Rivera","year":"2016","journal-title":"Acta Neuropathol"},{"key":"10.1016\/j.lungcan.2023.107247_b0065","doi-asserted-by":"crossref","unstructured":"Sang, J., Zhang, T., Kim, J., Li, M., Pesatori, A. C., Consonni, D., Song, L., Liu, J., Zhao, W., Hoang, P. H., Campbell, D. S., Feng, J., D'Arcy, M. E., Synnott, N., Chen, Y., Wu, Z., Zhu, B., Yang, X. R., Brown, K. M., . . . Landi, M. T. (2022). Rare germline deleterious variants increase susceptibility for lung cancer. Hum Mol Genet, 31(20), 3558-3565. 10.1093\/hmg\/ddac123.","DOI":"10.1093\/hmg\/ddac123"},{"issue":"6822","key":"10.1016\/j.lungcan.2023.107247_b0070","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1038\/35057062","article-title":"Initial sequencing and analysis of the human genome","volume":"409","author":"Lander","year":"2001","journal-title":"Nature"},{"key":"10.1016\/j.lungcan.2023.107247_b0075","doi-asserted-by":"crossref","unstructured":"Li, H., Handsaker, B., Wysoker, A., Fennell, T., Ruan, J., Homer, N., Marth, G., Abecasis, G., & Durbin, R. (2009). The Sequence Alignment\/Map format and SAMtools. Bioinformatics, 25(16), 2078-2079. 10.1093\/bioinformatics\/btp352.","DOI":"10.1093\/bioinformatics\/btp352"},{"issue":"3","key":"10.1016\/j.lungcan.2023.107247_b0080","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1038\/nbt.2514","article-title":"Sensitive detection of somatic point mutations in impure and heterogeneous cancer samples","volume":"31","author":"Cibulskis","year":"2013","journal-title":"Nat Biotechnol"},{"issue":"2","key":"10.1016\/j.lungcan.2023.107247_b0085","doi-asserted-by":"crossref","first-page":"80","DOI":"10.4161\/fly.19695","article-title":"A program for annotating and predicting the effects of single nucleotide polymorphisms, SnpEff: SNPs in the genome of Drosophila melanogaster strain w1118; iso-2; iso-3","volume":"6","author":"Cingolani","year":"2012","journal-title":"Fly (Austin)"},{"key":"10.1016\/j.lungcan.2023.107247_b0090","doi-asserted-by":"crossref","unstructured":"Robinson, J. T., Thorvaldsd\u00f3ttir, H., Wenger, A. M., Zehir, A., & Mesirov, J. P. (2017). Variant Review with the Integrative Genomics Viewer. Cancer Res, 77(21), e31-e34. 10.1158\/0008-5472.Can-17-0337.","DOI":"10.1158\/0008-5472.CAN-17-0337"},{"issue":"3","key":"10.1016\/j.lungcan.2023.107247_b0095","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1101\/gr.129684.111","article-title":"VarScan 2: somatic mutation and copy number alteration discovery in cancer by exome sequencing","volume":"22","author":"Koboldt","year":"2012","journal-title":"Genome Res"}],"container-title":["Lung Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0169500223007857?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0169500223007857?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,30]],"date-time":"2025-09-30T13:04:47Z","timestamp":1759237487000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0169500223007857"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,7]]},"references-count":19,"alternative-id":["S0169500223007857"],"URL":"https:\/\/doi.org\/10.1016\/j.lungcan.2023.107247","relation":{},"ISSN":["0169-5002"],"issn-type":[{"value":"0169-5002","type":"print"}],"subject":[],"published":{"date-parts":[[2023,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Germline EGFR c.2527G\u00a0>\u00a0A (p.V843I) variant and familial lung cancer","name":"articletitle","label":"Article Title"},{"value":"Lung Cancer","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.lungcan.2023.107247","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"107247"}}