{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T20:07:00Z","timestamp":1747166820894,"version":"3.40.5"},"reference-count":70,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","lungcancerjournal.info","clinicalkey.es","clinicalkey.com.au","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Lung Cancer"],"published-print":{"date-parts":[[2024,8]]},"DOI":"10.1016\/j.lungcan.2024.107868","type":"journal-article","created":{"date-parts":[[2024,7,11]],"date-time":"2024-07-11T21:28:29Z","timestamp":1720733309000},"page":"107868","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["A prospective analysis of the management practices for patients with Stage-III-N2Non-Small-Cell lung cancer (OBSERVE IIIA\u2013B GFPC 04-2020Study)"],"prefix":"10.1016","volume":"194","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-4975-5426","authenticated-orcid":false,"given":"Mathilde","family":"Jacob","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pierre","family":"Fournel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claire","family":"Tissot","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacques","family":"Cadranel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8683-0969","authenticated-orcid":false,"given":"Olivier","family":"Bylicki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isabelle","family":"Monnet","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gr\u00e9goire","family":"Justeau","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6160-2732","authenticated-orcid":false,"given":"Charles","family":"Ricordel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pascal","family":"Thomas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3459-2767","authenticated-orcid":false,"given":"Lionel","family":"Falchero","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chrystel","family":"Locher","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marie","family":"Wislez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alain","family":"Vergnenegre","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samir","family":"Abdiche","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Floran","family":"Guisier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8467-7876","authenticated-orcid":false,"given":"Acya","family":"Bizieux","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Regine","family":"Lamy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Geraldine","family":"Fran\u00e7ois","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gonzagues","family":"De Chabot","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4297-7413","authenticated-orcid":false,"given":"Thomas","family":"Pierret","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1116-0360","authenticated-orcid":false,"given":"Marie","family":"Sabatini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marion","family":"Abeillera","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sabine","family":"Vieillot","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephanie","family":"Martinez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5209-3032","authenticated-orcid":false,"given":"Hugues","family":"Morel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H\u00e9l\u00e8ne","family":"Doubre","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6479-7210","authenticated-orcid":false,"given":"Anne","family":"Madroszyk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Margaux","family":"Geier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean","family":"LucLabourey","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christos","family":"Choua\u00efd","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laurent","family":"Greillier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.lungcan.2024.107868_b0005","doi-asserted-by":"crossref","first-page":"506","DOI":"10.21037\/tlcr.2020.03.40","article-title":"Epidemiology of Stage III Lung Cancer: frequency, Diagnostic Characteristics, and Survival","volume":"10","author":"Casal-Mouri\u00f1o","year":"2021","journal-title":"Transl Lung Cancer Res."},{"key":"10.1016\/j.lungcan.2024.107868_b0010","doi-asserted-by":"crossref","first-page":"709","DOI":"10.21037\/qims.2018.08.02","article-title":"The 8th Lung Cancer TNM Classification and clinical Staging System: Review of the Changes andClinical Implications","volume":"8","author":"Lim","year":"2018","journal-title":"Quant Imaging Med Surg."},{"key":"10.1016\/j.lungcan.2024.107868_b0015","article-title":"Early and locally Advanced Non-Small-Cell Lung Cancer (NSCLC): ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up","author":"Postmus","year":"2017281","journal-title":"AnnOncol."},{"key":"10.1016\/j.lungcan.2024.107868_b0020","first-page":"54","article-title":"Local treatment of Stage IIIA-N2 Non-Small Cell Lung Cancer: surgery and\/or radiotherapy","volume":"32","author":"Van Meerbeeck","year":"2020","journal-title":"CurrOpinOncol."},{"key":"10.1016\/j.lungcan.2024.107868_b0025","doi-asserted-by":"crossref","first-page":"00159","DOI":"10.1183\/23120541.00159-2019","article-title":"International Guidelines on Stage III N2 Non-Small Cell Lung Cancer: surgery or radiotherapy?","volume":"6","author":"Putora","year":"2020","journal-title":"ERJ Open Res."},{"key":"10.1016\/j.lungcan.2024.107868_b0030","article-title":"An Observational Study on Treatment Outcomes in Patients with Stage III NSCLC in Taiwan: the KINDLE study","volume":"3","author":"Su","year":"2022","journal-title":"JTO ClinResRep."},{"key":"10.1016\/j.lungcan.2024.107868_b0035","doi-asserted-by":"crossref","first-page":"13","DOI":"10.21037\/ccts-20-97","article-title":"Heterogeneity of Stage IIIA Non-Small Cell Lung Cancer\u2014different tumours, different nodal status, different treatment, different prognosis: a narrative review","volume":"4","author":"Flury","year":"2022","journal-title":"Curr Chall Thorac Surg."},{"key":"10.1016\/j.lungcan.2024.107868_b0040","first-page":"e203","article-title":"Prognostic Significance of the Number of Metastatic pN2 Lymph Nodes in Stage IIIA-N2 Non\u2013Small-Cell Lung Cancer after Curative Resection","volume":"16","author":"Yoo","year":"2015","journal-title":"ClinLung Cancer."},{"key":"10.1016\/j.lungcan.2024.107868_b0045","doi-asserted-by":"crossref","first-page":"1960","DOI":"10.21037\/tlcr-20-1210","article-title":"Stage III N2 Non-Small Cell Lung Cancer Treatment: Decision-Making Among Surgeons And Radiation Oncologists","volume":"10","author":"Glatzer","year":"2021","journal-title":"Transl Lung Cancer Res."},{"key":"10.1016\/j.lungcan.2024.107868_b0050","doi-asserted-by":"crossref","first-page":"113","DOI":"10.3892\/ol.2023.13699","article-title":"Diagnosis and Management of Patients with Stage III Non\u2013Small-Cell Lung Cancer: A Joint Statement by the Lebanese Society of Medical Oncology and the Lebanese Pulmonary Society (Review)","volume":"25","author":"\u0391oun-Bacha","year":"2023","journal-title":"Oncol Lett."},{"key":"10.1016\/j.lungcan.2024.107868_b0055","doi-asserted-by":"crossref","first-page":"1656","DOI":"10.3390\/cancers14071656","article-title":"Multimodality Treatment Including Surgeryrelated to the Type of N2 Involvement In Locally Advanced Non-Small Cell Lung Cancer","volume":"14","author":"Allaeys","year":"2022","journal-title":"Cancers"},{"key":"10.1016\/j.lungcan.2024.107868_b0060","first-page":"3160","article-title":"Stage III Non-Small-Cell Lung Cancer: an Overview of Treatment Options","volume":"30","author":"Petrella","year":"2023","journal-title":"CurrOncol."},{"key":"10.1016\/j.lungcan.2024.107868_b0065","doi-asserted-by":"crossref","first-page":"1613","DOI":"10.1093\/ejcts\/ezv457","article-title":"Stage IIIA-N2 Non Non\u2013Small-Cell Lung Cancer: from \u2018surprise\u2019 involvement to surgical nightmare","volume":"49","author":"Van Schil","year":"2016","journal-title":"Eur J Cardiothorac Surg."},{"key":"10.1016\/j.lungcan.2024.107868_b0070","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.lungcan.2023.01.008","article-title":"Reaching Multidisciplinary Consensus On The Management Of Non-Bulky\/Non-Infiltrative Stage IIIA N2 Non-Small Cell Lung Cancer","volume":"177","author":"Scherpereel","year":"2023","journal-title":"Lung Cancer"},{"key":"10.1016\/j.lungcan.2024.107868_b0075","doi-asserted-by":"crossref","first-page":"e0126547","DOI":"10.1371\/journal.pone.0126547","article-title":"Effects Of Multidisciplinary Team Care On The Survival Of Patients With Different Stages Of Non-Small Cell Lung Cancer: A National Cohort Study","volume":"10","author":"Pan","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.lungcan.2024.107868_b0080","article-title":"European Cancer Organisation Essential Requirements for Quality Cancer Care (ERQCC): Lung cancer","author":"Lievens","year":"2020","journal-title":"Lung Cancer"},{"key":"10.1016\/j.lungcan.2024.107868_b0085","doi-asserted-by":"crossref","first-page":"2589","DOI":"10.12659\/MSM.898675","article-title":"Five-Year Survival among Stage IIIA Lung Cancer Patients Receiving Two Different Treatment Modalities","volume":"22","author":"Bilfinger","year":"2016","journal-title":"Med Sci Monit."},{"key":"10.1016\/j.lungcan.2024.107868_b0090","first-page":"615","article-title":"Population-Based Treatment Patterns and Outcomes for Stage III Non-Small Cell Lung Cancer Patients","volume":"43","author":"Yusuf","year":"2020","journal-title":"A Real-World Evidence Study.AmJClinOncol."},{"key":"10.1016\/j.lungcan.2024.107868_b0095","first-page":"433","article-title":"Surgical Multimodality Treatment For Baseline Resectable Stage IIIA-N2 Non-Small Cell Lung Cancer. Degree Of Mediastinal Lymph Node Involvement And Impact On Survival","volume":"36","author":"Decaluw\u00e9","year":"2009","journal-title":"EurJCardiothoracSurg."},{"key":"10.1016\/j.lungcan.2024.107868_b0100","article-title":"Adjuvant Treatment Following Irradical Resection of Stage I-IIINon-Small Cell Lung Cancer: A Population-Based Study","volume":"46","author":"Rasing","year":"2022","journal-title":"CurrProblCancer."},{"key":"10.1016\/j.lungcan.2024.107868_b0105","first-page":"1052","article-title":"Predicting Incomplete Resection In Non-Small Cell Lung Cancer Preoperatively: A Validated Nomogram","volume":"111","author":"Rasing","year":"2021","journal-title":"AnnThoracSurg."},{"key":"10.1016\/j.lungcan.2024.107868_b0110","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1080\/14737140.2017.1319766","article-title":"Advances in the use of Surgery And Multimodality Treatment for N2 Non-Small Cell Lung Cancer","volume":"17","author":"Van Schil","year":"2017","journal-title":"Exp RevAnticancer Ther."},{"key":"10.1016\/j.lungcan.2024.107868_b0115","first-page":"267","article-title":"Combined Modality Therapy in Stage IIIA Non-Small Cell Lung Cancer: Clarity or Confusion Despite The Highest Level of Evidence?","volume":"58","author":"Jeremic","year":"2017","journal-title":"JRadiatRes."},{"year":"2017","series-title":"Berzenji L, Yogeswaran SK, Hendriks JM","author":"Van Schil","key":"10.1016\/j.lungcan.2024.107868_b0120"},{"key":"10.1016\/j.lungcan.2024.107868_b0125","doi-asserted-by":"crossref","first-page":"2050","DOI":"10.3390\/cancers12082050","article-title":"Resectable IIIA-N2 Non-Small-Cell Lung Cancer (NSCLC): in search for the proper treatment","volume":"12","author":"Brascia","year":"2020","journal-title":"Cancers"},{"key":"10.1016\/j.lungcan.2024.107868_b0130","article-title":"Identification of resectable N2 in NSCLC: a single center experience and review of the SEER database. Front","author":"QingWY","year":"2021","journal-title":"Oncol."},{"key":"10.1016\/j.lungcan.2024.107868_b0135","first-page":"2319","article-title":"Indications for invasive mediastinal staging for Non-Small Cell Lung Cancer","volume":"156","author":"Lin","year":"2018","journal-title":"JThoracCardiovascSurg."},{"key":"10.1016\/j.lungcan.2024.107868_b0140","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1111\/crj.13267","article-title":"Predictors of mediastinal staging and usefulness of PET in patients with stage IIIA (N2) or IIIB (N3) Lung Cancer","volume":"15","author":"Gull\u00f3n","year":"2021","journal-title":"Clin Respir J."},{"key":"10.1016\/j.lungcan.2024.107868_b0145","first-page":"787","article-title":"Revised ESTS Guidelines for Preoperative Mediastinal Lymph Node Staging for Non-Small-Cell Lung Cancer","volume":"45","author":"De Leyn","year":"2014","journal-title":"EurJCardiothoracSurg."},{"key":"10.1016\/j.lungcan.2024.107868_b0150","first-page":"1464","article-title":"NCCN Guidelines Insights: Non-Small Cell Lung Cancer","volume":"17","author":"Ettinger","year":"2019","journal-title":"Version 1.2020. Jnatlcomprcancnetw."},{"key":"10.1016\/j.lungcan.2024.107868_b0155","doi-asserted-by":"crossref","first-page":"e211S","DOI":"10.1378\/chest.12-2355","article-title":"Methods for staging Non-Small Cell Lung Cancer","volume":"143","author":"Silvestri","year":"2013","journal-title":"Chest"},{"key":"10.1016\/j.lungcan.2024.107868_b0160","first-page":"1573","article-title":"2nd ESMO Consensus Conference in Lung Cancer: Locally Advanced Stage III Non-Small-Cell Lung Cancer","volume":"26","author":"Eberhardt","year":"2015","journal-title":"AnnOncol"},{"key":"10.1016\/j.lungcan.2024.107868_b0165","doi-asserted-by":"crossref","DOI":"10.1016\/j.lungcan.2021.12.004","article-title":"Surgical or Medical Strategy for Locally-Advanced, Stage IIIA\/B-N2 Non-Small Cell Lung Cancer: reproducibility of decision-making at a Multidisciplinary Tumor Board","author":"Mainguen\u00e9","year":"2022","journal-title":"Lung Cancer"},{"key":"10.1016\/j.lungcan.2024.107868_b0170","first-page":"229","article-title":"Association between treatment facility volume, therapy types, and Overall Survival in patients with Stage IIIA Non-Small Cell Lung Cancer","volume":"17","author":"Kommalapati","year":"2019","journal-title":"JNatlComprCancNetw."},{"key":"10.1016\/j.lungcan.2024.107868_b0175","first-page":"346","article-title":"Survival Outcomes among lung Cancer Patients treated using a Multidisciplinary Team Approach","volume":"19","author":"Bilfinger","year":"2018","journal-title":"ClinLung Cancer."},{"key":"10.1016\/j.lungcan.2024.107868_b0180","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1186\/s12913-020-4930-3","article-title":"The impact of Tumor Board on cancer care: evidence from an umbrella review","volume":"20","author":"Specchia","year":"2020","journal-title":"BMC Health Serv Res."},{"key":"10.1016\/j.lungcan.2024.107868_b0185","doi-asserted-by":"crossref","first-page":"507","DOI":"10.21037\/tlcr.2020.04.11","article-title":"Artificial Intelligence and Lung Cancer Treatment Decision: agreement with recommendation of Multidisciplinary Tumor Board","volume":"9","author":"Kim","year":"2020","journal-title":"Transl Lung Cancer Res."},{"key":"10.1016\/j.lungcan.2024.107868_b0190","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1007\/s12149-015-1038-7","article-title":"FDG PET\/CT for assessing the resectability of NSCLC patients with N2 disease after neoadjuvant therapy","volume":"30","author":"Kremer","year":"2016","journal-title":"Ann Nucl Med."},{"key":"10.1016\/j.lungcan.2024.107868_b0195","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1186\/s12890-022-02159-9","article-title":"Systematic Endoscopic Staging of mediastinum to determine impact on radiotherapy for Locally Advanced Lung Cancer (SEISMIC): protocol for a Prospective Single Arm Multicentre Interventional Study","volume":"22","author":"Steinfort","year":"2022","journal-title":"BMC Pulm Med."},{"key":"10.1016\/j.lungcan.2024.107868_b0200","doi-asserted-by":"crossref","first-page":"e2488","DOI":"10.1097\/MD.0000000000002488","article-title":"Systematic Endobronchial Ultrasound-guided mediastinal staging versus Positron Emission Tomography for comprehensive mediastinal staging in NSCLC before radical radiotherapy of Non-Small Cell Lung Cancer: a pilot study","volume":"95","author":"Steinfort","year":"2016","journal-title":"Medicine"},{"key":"10.1016\/j.lungcan.2024.107868_b0205","doi-asserted-by":"crossref","first-page":"1452","DOI":"10.1093\/jnci\/djr325","article-title":"Sequential vs Concurrent Chemoradiation for Stage III Non-Small Cell Lung Cancer: randomized phase III trial RTOG 9410","volume":"103","author":"Curran","year":"2011","journal-title":"Jnatl Cancer Inst."},{"key":"10.1016\/j.lungcan.2024.107868_b0210","doi-asserted-by":"crossref","first-page":"2181","DOI":"10.1200\/JCO.2009.26.2543","article-title":"Meta-Analysis of Concomitant versus Sequential Radiochemotherapy in Locally AdvancedNon\u2013Small-Cell Lung Cancer","volume":"28","author":"Aup\u00e9rin","year":"2010","journal-title":"J Clin Oncol."},{"key":"10.1016\/j.lungcan.2024.107868_b0215","doi-asserted-by":"crossref","first-page":"1356","DOI":"10.1200\/JCO.21.02528","article-title":"Management of Stage III Non\u2013Small-Cell Lung Cancer: ASCO guideline","volume":"40","author":"Daly","year":"2022","journal-title":"J Clin Oncol."},{"key":"10.1016\/j.lungcan.2024.107868_b0220","first-page":"860","article-title":"Four-Year Survival With Durvalumab After Chemoradiotherapy in Stage III NSCLC\u2014an update from the PACIFIC trial","volume":"16","author":"Faivre-Finn","year":"2021","journal-title":"JThoracOncol."},{"key":"10.1016\/j.lungcan.2024.107868_b0225","doi-asserted-by":"crossref","first-page":"2342","DOI":"10.1056\/NEJMoa1809697","article-title":"Overall Survival with Durvalumab after Chemoradiotherapy In Stage III NSCLC","volume":"379","author":"Antonia","year":"2018","journal-title":"NEnglJMed."},{"key":"10.1016\/j.lungcan.2024.107868_b0230","first-page":"1415","article-title":"Durvalumab after sequential chemoradiotherapy in stage III, unresectable NSCLC: the phase 2 PACIFIC-6 trial","volume":"17","author":"Garassino","year":"2022","journal-title":"JThoracOncol."},{"key":"10.1016\/j.lungcan.2024.107868_b0235","first-page":"1994","article-title":"Consolidation Durvalumab should not be administered to patients with Stage III EGFR-mutant NSCLC","volume":"16","author":"Aredo","year":"2021","journal-title":"JThoracOncol."},{"key":"10.1016\/j.lungcan.2024.107868_b0240","doi-asserted-by":"crossref","first-page":"1919","DOI":"10.1056\/NEJMoa1709937","article-title":"Durvalumab after Chemoradiotherapy in Stage III Non\u2013Small-Cell Lung Cancer","volume":"377","author":"Antonia","year":"2017","journal-title":"NEnglJMed."},{"key":"10.1016\/j.lungcan.2024.107868_b0245","first-page":"371","article-title":"Osimertinib maintenance after definitive chemoradiation in patients with unresectable EGFRmutation Positive Stage III Non\u2013Small-Cell Lung Cancer: LAURA trial in progress","volume":"22","author":"Lu","year":"2021","journal-title":"ClinLung Cancer."},{"key":"10.1016\/j.lungcan.2024.107868_b0250","doi-asserted-by":"crossref","first-page":"539","DOI":"10.21037\/tlcr-20-420","article-title":"Induction treatment in patients with Stage III Non-Small Cell Lung Cancer","volume":"10","author":"Palmero","year":"2021","journal-title":"Transl Lung Cancer Res."},{"key":"10.1016\/j.lungcan.2024.107868_b0255","doi-asserted-by":"crossref","first-page":"1561","DOI":"10.1016\/S0140-6736(13)62159-5","article-title":"Preoperative chemotherapy for Non-Small-Cell Lung Cancer: a Systematic Review and Meta-Analysis of individual participant data","volume":"383","author":"NSCLC Meta-analysis Collaborative Group","year":"2014","journal-title":"Lancet"},{"issue":"11","key":"10.1016\/j.lungcan.2024.107868_b0260","first-page":"1380","article-title":"Preoperative versus Postoperative Chemotherapy in patients with resectable Non-Small Cell Lung Cancer: systematic review and Indirect Comparison Meta-Analysis of Randomized Trials","volume":"4","author":"Lim","year":"2009","journal-title":"JThoracOncol."},{"key":"10.1016\/j.lungcan.2024.107868_b0265","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1200\/JCO.21.01589","article-title":"Preoperative and Postoperative systemic therapy for operable Non\u2013Small-Cell Lung Cancer","volume":"40","author":"Chaft","year":"2022","journal-title":"J Clin Oncol."},{"key":"10.1016\/j.lungcan.2024.107868_b0270","article-title":"Persistent N2 after induction is not a contraindication to surgery for Lung Cancer","author":"Andrews","year":"2022","journal-title":"AnnThoracSurg."},{"key":"10.1016\/j.lungcan.2024.107868_b0275","article-title":"Treatment sequencing in Resectable Lung Cancer: the good and the bad of Adjuvant versus Neoadjuvant Therapy","author":"Provencio","year":"2022","journal-title":"Am SocClinOncoL."},{"key":"10.1016\/j.lungcan.2024.107868_b0280","doi-asserted-by":"crossref","DOI":"10.1200\/JCO.2022.40.17_suppl.LBA8511","article-title":"Neoadjuvant Nivolumab (NIVO) + Platinum-Doublet Chemotherapy (Chemo) Versus Chemo For Resectable (IB\u2013IIIA) Non-Small Cell Lung Cancer (NSCLC): association of Pathological Regression with Event-Free Survival (EFS) in CheckMate 816","author":"Provencio","year":"2022","journal-title":"J Clin Oncol."},{"key":"10.1016\/j.lungcan.2024.107868_b0285","doi-asserted-by":"crossref","first-page":"2872","DOI":"10.1200\/JCO.21.00276","article-title":"SAKK 16\/14: Durvalumab in addition to Neoadjuvant Chemotherapy in patients with Stage IIIA (N2) Non-Small Cell Lung Cancer\u2014A Multicentre Single-Arm Phase II Trial","volume":"39","author":"Rothschild","year":"2021","journal-title":"J Clin Oncol."},{"key":"10.1016\/j.lungcan.2024.107868_b0290","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1016\/S1470-2045(20)30140-6","article-title":"Neoadjuvant Atezolizumab And Chemotherapy in patients with resectable Non-Small-Cell Lung Cancer: an Open-Label, Multicentre, Single-Arm, Phase 2 Trial","volume":"21","author":"Shu","year":"2020","journal-title":"Lancet Oncol."},{"key":"10.1016\/j.lungcan.2024.107868_b0295","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1038\/s41591-020-01224-2","article-title":"Neoadjuvant Nivolumab Or Nivolumab Plus Ipilimumab In Operable Non-Small Cell Lung Cancer: the Phase 2 Randomized NEOSTAR trial","volume":"27","author":"Cascone","year":"2021","journal-title":"Nat Med."},{"key":"10.1016\/j.lungcan.2024.107868_b0300","first-page":"e533","article-title":"ADAURA: Phase III, Double-Blind, Randomized Study Of Osimertinib Versus Placebo in EGFRmutation-positive Early-Stage NSCLC after Complete Surgical Resection","volume":"19","author":"Wu","year":"2018","journal-title":"ClinLung Cancer."},{"key":"10.1016\/j.lungcan.2024.107868_b0305","doi-asserted-by":"crossref","first-page":"4045","DOI":"10.2217\/fon-2021-0549","article-title":"Neoadjuvant Osimertinib with\/without chemotherapy versus Chemotherapy alone for EGFR-mutated Resectable Non-Small-Cell Lung Cancer: NeoADAURA","volume":"17","author":"Tsuboi","year":"2021","journal-title":"Future Oncol."},{"key":"10.1016\/j.lungcan.2024.107868_b0310","first-page":"423","article-title":"Postoperative Chemotherapy use and outcomes from ADAURA: Osimertinib as Adjuvant therapy for Resected EGFR-mutated NSCLC","volume":"17","author":"Wu","year":"2022","journal-title":"JThoracOncol."},{"key":"10.1016\/j.lungcan.2024.107868_b0315","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.lungcan.2023.02.011","article-title":"Osimertinib as Neoadjuvant Therapy in patients with EGFR-mutant Resectable Stage II-IIIB Lung Adenocarcinoma (NEOS): A Multicenter, Single-Arm, Open-Label Phase 2B Trial","volume":"178","author":"Lv","year":"2023","journal-title":"Lung Cancer"},{"key":"10.1016\/j.lungcan.2024.107868_b0320","doi-asserted-by":"crossref","DOI":"10.1056\/NEJMoa2304594","article-title":"Overall Survival with Osimertinib in Resected EGFR-mutated NSCLC","author":"Tsuboi","year":"2023","journal-title":"N Engl J Med."},{"key":"10.1016\/j.lungcan.2024.107868_b0325","doi-asserted-by":"crossref","first-page":"7222","DOI":"10.3390\/ijms23137222","article-title":"Targeted Therapy and Immunotherapy in Early-Stage Non-Small Cell Lung Cancer: current evidence and ongoing trials","volume":"23","author":"De Scordilli","year":"2022","journal-title":"Int J Mol Sci."},{"key":"10.1016\/j.lungcan.2024.107868_b0330","doi-asserted-by":"crossref","DOI":"10.1177\/11795549221109487","article-title":"Therapeutic strategies for resectable Stage-IIIA N2 Non-Small Cell Lung Cancer Patients: A Network Meta-Analysis","volume":"16","author":"Shen","year":"2022","journal-title":"Clin Med Insights Oncol."},{"key":"10.1016\/j.lungcan.2024.107868_b0335","first-page":"106","article-title":"Surgical Treatment of Stage III Non-Small Cell Lung Cancer","volume":"45","author":"Van Schil","year":"2009","journal-title":"EurJCancer."},{"key":"10.1016\/j.lungcan.2024.107868_b0340","doi-asserted-by":"crossref","first-page":"892","DOI":"10.21037\/jtd-21-1597","article-title":"Clinical Significance of Tumor Necrosis and Viability In Non-Small Cell Lung Cancer","volume":"14","author":"Moon","year":"2022","journal-title":"J Thorac Dis."},{"key":"10.1016\/j.lungcan.2024.107868_b0345","first-page":"1668","article-title":"Tumor Necrosis as a Prognostic Factor for Stage IA Non-Small Cell Lung Cancer","volume":"91","author":"Park","year":"2011","journal-title":"AnnThoracSurg."},{"issue":"6","key":"10.1016\/j.lungcan.2024.107868_b0350","first-page":"1866","article-title":"The Optimal Treatment for Stage IIIA-N2 Non-Small Cell Lung Cancer: A Network Meta-Analysis","volume":"107","author":"Zhao","year":"2019","journal-title":"AnnThoracSurg."}],"container-title":["Lung Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0169500224004021?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0169500224004021?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,8,13]],"date-time":"2024-08-13T22:18:01Z","timestamp":1723587481000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0169500224004021"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8]]},"references-count":70,"alternative-id":["S0169500224004021"],"URL":"https:\/\/doi.org\/10.1016\/j.lungcan.2024.107868","relation":{},"ISSN":["0169-5002"],"issn-type":[{"type":"print","value":"0169-5002"}],"subject":[],"published":{"date-parts":[[2024,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A prospective analysis of the management practices for patients with Stage-III-N2Non-Small-Cell lung cancer (OBSERVE IIIA\u2013B GFPC 04-2020Study)","name":"articletitle","label":"Article Title"},{"value":"Lung Cancer","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.lungcan.2024.107868","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Author(s). Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"107868"}}