{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T19:47:53Z","timestamp":1773344873707,"version":"3.50.1"},"reference-count":54,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,10,4]],"date-time":"2024-10-04T00:00:00Z","timestamp":1728000000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004735","name":"Natural Science Foundation of Hunan Province","doi-asserted-by":"publisher","award":["2021JJ70103"],"award-info":[{"award-number":["2021JJ70103"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100017699","name":"Henan Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["279367"],"award-info":[{"award-number":["279367"]}],"id":[{"id":"10.13039\/501100017699","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004608","name":"Natural Science Foundation of Jiangsu Province","doi-asserted-by":"publisher","award":["BK20241139"],"award-info":[{"award-number":["BK20241139"]}],"id":[{"id":"10.13039\/501100004608","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004361","name":"Swiss Cancer League","doi-asserted-by":"publisher","award":["KFS - 4851-273 08-2019"],"award-info":[{"award-number":["KFS - 4851-273 08-2019"]}],"id":[{"id":"10.13039\/501100004361","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001711","name":"Swiss National Science Foundation","doi-asserted-by":"publisher","award":["310030_192648"],"award-info":[{"award-number":["310030_192648"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004543","name":"China Scholarship Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004543","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013362","name":"Swiss Cancer Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013362","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82173012"],"award-info":[{"award-number":["82173012"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82404066"],"award-info":[{"award-number":["82404066"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","lungcancerjournal.info","clinicalkey.es","clinicalkey.com.au","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Lung Cancer"],"published-print":{"date-parts":[[2024,11]]},"DOI":"10.1016\/j.lungcan.2024.107986","type":"journal-article","created":{"date-parts":[[2024,10,5]],"date-time":"2024-10-05T00:52:03Z","timestamp":1728089523000},"page":"107986","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["Crispr-mediated genome editing reveals a preponderance of non-oncogene addictions as targetable vulnerabilities in pleural mesothelioma"],"prefix":"10.1016","volume":"197","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4691-1761","authenticated-orcid":false,"given":"Duo","family":"Xu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shun-Qing","family":"Liang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min","family":"Su","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haitang","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R\u00e9my","family":"Bruggmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simone","family":"Oberhaensli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhang","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanyun","family":"Gao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas M.","family":"Marti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1199-6520","authenticated-orcid":false,"given":"Wenxiang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ralph A.","family":"Schmid","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yongqian","family":"Shu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrick","family":"Dorn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ren-Wang","family":"Peng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.lungcan.2024.107986_b0005","doi-asserted-by":"crossref","first-page":"e161","DOI":"10.1016\/S1470-2045(18)30100-1","article-title":"Novel therapies for malignant pleural mesothelioma","volume":"19","author":"Scherpereel","year":"2018","journal-title":"Lancet Oncol."},{"issue":"5","key":"10.1016\/j.lungcan.2024.107986_b0010","doi-asserted-by":"crossref","first-page":"402","DOI":"10.3322\/caac.21572","article-title":"Mesothelioma: Scientific clues for prevention, diagnosis, and therapy","volume":"69","author":"Carbone","year":"2019","journal-title":"CA Cancer J Clin."},{"issue":"14","key":"10.1016\/j.lungcan.2024.107986_b0015","doi-asserted-by":"crossref","first-page":"2636","DOI":"10.1200\/JCO.2003.11.136","article-title":"Phase III study of pemetrexed in combination with cisplatin versus cisplatin alone in patients with malignant pleural mesothelioma","volume":"21","author":"Vogelzang","year":"2003","journal-title":"J. Clin. Oncol."},{"issue":"4","key":"10.1016\/j.lungcan.2024.107986_b0020","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1038\/ng.3520","article-title":"Comprehensive genomic analysis of malignant pleural mesothelioma identifies recurrent mutations, gene fusions and splicing alterations","volume":"48","author":"Bueno","year":"2016","journal-title":"Nat. Genet."},{"issue":"12","key":"10.1016\/j.lungcan.2024.107986_b0025","doi-asserted-by":"crossref","first-page":"1548","DOI":"10.1158\/2159-8290.CD-18-0804","article-title":"Integrative molecular characterization of malignant pleural mesothelioma","volume":"8","author":"Hmeljak","year":"2018","journal-title":"Cancer Discov."},{"issue":"11","key":"10.1016\/j.lungcan.2024.107986_b0030","doi-asserted-by":"crossref","first-page":"1516","DOI":"10.15252\/embr.201643030","article-title":"Drugging the addict: non-oncogene addiction as a target for cancer therapy","volume":"17","author":"Nagel","year":"2016","journal-title":"EMBO Rep."},{"issue":"5","key":"10.1016\/j.lungcan.2024.107986_b0035","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1016\/j.cell.2009.02.024","article-title":"Principles of cancer therapy: oncogene and non-oncogene addiction","volume":"136","author":"Luo","year":"2009","journal-title":"Cell"},{"issue":"8","key":"10.1016\/j.lungcan.2024.107986_b0040","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1038\/nrc3299","article-title":"From cancer genomes to oncogenic drivers, tumour dependencies and therapeutic targets","volume":"12","author":"Eifert","year":"2012","journal-title":"Nat Rev Cancer."},{"issue":"3","key":"10.1016\/j.lungcan.2024.107986_b0045","doi-asserted-by":"crossref","first-page":"280","DOI":"10.15252\/embr.201439949","article-title":"Oncogene addiction: pathways of therapeutic response, resistance, and road maps toward a cure","volume":"16","author":"Pagliarini","year":"2015","journal-title":"EMBO Rep."},{"issue":"1","key":"10.1016\/j.lungcan.2024.107986_b0050","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1038\/s41573-019-0046-z","article-title":"Synthetic lethality as an engine for cancer drug target discovery","volume":"19","author":"Huang","year":"2020","journal-title":"Nat. Rev. Drug Discov."},{"issue":"5","key":"10.1016\/j.lungcan.2024.107986_b0055","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1038\/s41568-021-00435-0","article-title":"The role of ROS in tumour development and progression","volume":"22","author":"Cheung","year":"2022","journal-title":"Nat. Rev. Cancer."},{"issue":"6","key":"10.1016\/j.lungcan.2024.107986_b0060","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1289\/ehp.1104287","article-title":"Mitochondria-derived reactive intermediate species mediate asbestos-induced genotoxicity and oxidative stress-responsive signaling pathways","volume":"120","author":"Huang","year":"2012","journal-title":"Environ. Health Perspect."},{"issue":"135","key":"10.1016\/j.lungcan.2024.107986_b0065","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1183\/09059180.00007014","article-title":"Malignant pleural mesothelioma: history, controversy and future of a manmade epidemic","volume":"24","author":"R\u00f8e","year":"2015","journal-title":"Eur. Respir. Rev."},{"issue":"3","key":"10.1016\/j.lungcan.2024.107986_b0070","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1158\/1078-0432.CCR-11-2259","article-title":"Molecular pathways: targeting mechanisms of asbestos and erionite carcinogenesis in mesothelioma","volume":"18","author":"Carbone","year":"2012","journal-title":"Clin. Cancer Res."},{"issue":"13","key":"10.1016\/j.lungcan.2024.107986_b0075","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.1056\/NEJMra1912719","article-title":"Perspectives on the treatment of malignant pleural mesothelioma","volume":"385","author":"Janes","year":"2021","journal-title":"N Engl J Med."},{"key":"10.1016\/j.lungcan.2024.107986_b0080","article-title":"Therapeutic landscape of malignant pleural mesothelioma: collateral vulnerabilities and evolutionary dependencies in the spotlight","volume":"10","author":"Xu","year":"2020","journal-title":"Front Oncol."},{"key":"10.1016\/j.lungcan.2024.107986_b0085","doi-asserted-by":"crossref","DOI":"10.1177\/1758835920971421","article-title":"Biomarker-guided targeted and immunotherapies in malignant pleural mesothelioma","volume":"12","author":"Yang","year":"2020","journal-title":"Ther. Adv. Med. Oncol."},{"issue":"6","key":"10.1016\/j.lungcan.2024.107986_b0090","doi-asserted-by":"crossref","first-page":"1515","DOI":"10.1016\/j.cell.2015.11.015","article-title":"High-resolution CRISPR screens reveal fitness genes and genotype-specific cancer liabilities","volume":"163","author":"Hart","year":"2015","journal-title":"Cell"},{"issue":"6","key":"10.1016\/j.lungcan.2024.107986_b0095","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1016\/j.cmet.2016.08.017","article-title":"A genome-wide CRISPR death screen identifies genes essential for oxidative phosphorylation","volume":"24","author":"Arroyo","year":"2016","journal-title":"Cell Metab."},{"issue":"2","key":"10.1016\/j.lungcan.2024.107986_b0100","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/j.molcel.2016.03.006","article-title":"A genome-wide CRISPR screen identifies CDC25A as a determinant of sensitivity to ATR inhibitors","volume":"62","author":"Ruiz","year":"2016","journal-title":"Mol. Cell."},{"issue":"11","key":"10.1016\/j.lungcan.2024.107986_b0105","doi-asserted-by":"crossref","first-page":"2281","DOI":"10.1038\/nprot.2013.143","article-title":"Genome engineering using the CRISPR-Cas9 system","volume":"8","author":"Ran","year":"2013","journal-title":"Nat Protoc."},{"issue":"6166","key":"10.1016\/j.lungcan.2024.107986_b0110","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1126\/science.1247005","article-title":"Genome-scale CRISPR-Cas9 knockout screening in human cells","volume":"343","author":"Shalem","year":"2014","journal-title":"Science"},{"issue":"2","key":"10.1016\/j.lungcan.2024.107986_b0115","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1158\/1535-7163.MCT-19-0724","article-title":"CRISPR screening identifies WEE1 as a combination target for standard chemotherapy in malignant pleural mesothelioma","volume":"19","author":"Xu","year":"2020","journal-title":"Mol. Cancer Ther."},{"issue":"1","key":"10.1016\/j.lungcan.2024.107986_b0120","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1038\/s41416-018-0145-3","article-title":"Increased sensitivity to apoptosis upon endoplasmic reticulum stress-induced activation of the unfolded protein response in chemotherapy-resistant malignant pleural mesothelioma","volume":"119","author":"Xu","year":"2018","journal-title":"Br. J. Cancer."},{"issue":"2","key":"10.1016\/j.lungcan.2024.107986_b0125","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1038\/nbt.3437","article-title":"Optimized sgRNA design to maximize activity and minimize off-target effects of CRISPR-Cas9","volume":"34","author":"Doench","year":"2016","journal-title":"Nat. Biotechnol."},{"issue":"12","key":"10.1016\/j.lungcan.2024.107986_b0130","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1186\/s13059-014-0554-4","article-title":"MAGeCK enables robust identification of essential genes from genome-scale CRISPR\/Cas9 knockout screens","volume":"15","author":"Li","year":"2014","journal-title":"Genome Biol."},{"issue":"10","key":"10.1016\/j.lungcan.2024.107986_b0135","doi-asserted-by":"crossref","first-page":"1704","DOI":"10.1016\/j.jtho.2019.06.020","article-title":"Pathologic considerations and standardization in mesothelioma clinical trials","volume":"14","author":"Tsao","year":"2019","journal-title":"J Thorac Oncol."},{"key":"10.1016\/j.lungcan.2024.107986_b0140","doi-asserted-by":"crossref","DOI":"10.5858\/arpa.2023-0304-RA","article-title":"Guidelines for pathologic diagnosis of mesothelioma: 2023 update of the consensus statement from the international mesothelioma interest group","author":"Husain","year":"2024","journal-title":"Arch. Pathol. Lab. Med."},{"key":"10.1016\/j.lungcan.2024.107986_b0145","unstructured":"[Chinese guideline for clinical diagnosis and treatment of malignant pleural mesothelioma (2021 Edition)]. Zhonghua Zhong Liu Za Zhi. 2021;43(4):383-94."},{"issue":"9","key":"10.1016\/j.lungcan.2024.107986_b0150","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1038\/s41389-019-0158-7","article-title":"HSP90\/AXL\/eIF4E-regulated unfolded protein response as an acquired vulnerability in drug-resistant KRAS-mutant lung cancer","volume":"8","author":"Yang","year":"2019","journal-title":"Oncogenesis."},{"issue":"5","key":"10.1016\/j.lungcan.2024.107986_b0155","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1158\/2159-8290.CD-12-0095","article-title":"The cBio cancer genomics portal: an open platform for exploring multidimensional cancer genomics data","volume":"2","author":"Cerami","year":"2012","journal-title":"Cancer Discov."},{"issue":"D1","key":"10.1016\/j.lungcan.2024.107986_b0160","doi-asserted-by":"crossref","first-page":"D991","DOI":"10.1093\/nar\/gks1193","article-title":"NCBI GEO: archive for functional genomics data sets\u2014update","volume":"41","author":"Barrett","year":"2012","journal-title":"Nucleic Acids Res."},{"issue":"D1","key":"10.1016\/j.lungcan.2024.107986_b0165","doi-asserted-by":"crossref","first-page":"D941","DOI":"10.1093\/nar\/gky1015","article-title":"COSMIC: the catalogue of somatic mutations in cancer","volume":"47","author":"Tate","year":"2019","journal-title":"Nucleic Acids Res."},{"issue":"D1","key":"10.1016\/j.lungcan.2024.107986_b0170","doi-asserted-by":"crossref","first-page":"D1068","DOI":"10.1093\/nar\/gkx1143","article-title":"DGIdb 3.0: a redesign and expansion of the drug-gene interaction database","volume":"46","author":"Cotto","year":"2018","journal-title":"Nucleic Acids Res."},{"issue":"1","key":"10.1016\/j.lungcan.2024.107986_b0175","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1038\/nprot.2008.211","article-title":"Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources","volume":"4","author":"Huang da","year":"2009","journal-title":"Nat Protoc."},{"issue":"1","key":"10.1016\/j.lungcan.2024.107986_b0180","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/nar\/gkn923","article-title":"Bioinformatics enrichment tools: paths toward the comprehensive functional analysis of large gene lists","volume":"37","author":"Huang da","year":"2009","journal-title":"Nucleic Acids Res."},{"issue":"Database issue","key":"10.1016\/j.lungcan.2024.107986_b0185","doi-asserted-by":"crossref","first-page":"D433","DOI":"10.1093\/nar\/gki005","article-title":"STRING: known and predicted protein-protein associations, integrated and transferred across organisms","volume":"33","author":"von Mering","year":"2005","journal-title":"Nucleic Acids Res."},{"issue":"12","key":"10.1016\/j.lungcan.2024.107986_b0190","doi-asserted-by":"crossref","first-page":"3191","DOI":"10.1158\/1078-0432.CCR-16-1971","article-title":"Co-occurring mutations of tumor suppressor genes, LATS2 and NF2, in malignant pleural mesothelioma","volume":"23","author":"Tranchant","year":"2017","journal-title":"Clin. Cancer Res."},{"issue":"11","key":"10.1016\/j.lungcan.2024.107986_b0195","doi-asserted-by":"crossref","first-page":"1997","DOI":"10.1038\/s41416-022-01979-0","article-title":"Genomic landscape of pleural and peritoneal mesothelioma tumours","volume":"127","author":"Hiltbrunner","year":"2022","journal-title":"Br. J. Cancer"},{"issue":"1","key":"10.1016\/j.lungcan.2024.107986_b0200","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.cell.2015.08.063","article-title":"CDK7-dependent transcriptional addiction in triple-negative breast cancer","volume":"163","author":"Wang","year":"2015","journal-title":"Cell"},{"issue":"6","key":"10.1016\/j.lungcan.2024.107986_b0205","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1038\/s41422-018-0020-z","article-title":"A CRISPR screen identifies CDK7 as a therapeutic target in hepatocellular carcinoma","volume":"28","author":"Wang","year":"2018","journal-title":"Cell Res."},{"key":"10.1016\/j.lungcan.2024.107986_b0210","doi-asserted-by":"crossref","DOI":"10.3322\/caac.21572","article-title":"Mesothelioma: Scientific clues for prevention, diagnosis, and therapy","author":"Carbone","year":"2019","journal-title":"CA Cancer J. Clin."},{"issue":"2","key":"10.1016\/j.lungcan.2024.107986_b0215","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1158\/1535-7163.MCT-19-0356","article-title":"Functional Genomic Screen in Mesothelioma Reveals that Loss of Function of BRCA1-Associated Protein 1 Induces Chemoresistance to Ribonucleotide Reductase Inhibition","volume":"19","author":"Okonska","year":"2020","journal-title":"Mol. Cancer Ther."},{"issue":"10","key":"10.1016\/j.lungcan.2024.107986_b0220","doi-asserted-by":"crossref","DOI":"10.3390\/cancers11101502","article-title":"Endoplasmic reticulum stress signaling as a therapeutic target in malignant pleural mesothelioma","volume":"11","author":"Xu","year":"2019","journal-title":"Cancers (Basel)"},{"issue":"4","key":"10.1016\/j.lungcan.2024.107986_b0225","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1038\/s41419-021-03668-x","article-title":"Malignant pleural mesothelioma co-opts BCL-XL and autophagy to escape apoptosis","volume":"12","author":"Xu","year":"2021","journal-title":"Cell Death Dis."},{"issue":"41","key":"10.1016\/j.lungcan.2024.107986_b0230","doi-asserted-by":"crossref","first-page":"25543","DOI":"10.1073\/pnas.2007622117","article-title":"Asbestos induces mesothelial cell transformation via HMGB1-driven autophagy","volume":"117","author":"Xue","year":"2020","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"1","key":"10.1016\/j.lungcan.2024.107986_b0235","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1038\/s41420-023-01307-2","article-title":"MEK1 drives oncogenic signaling and interacts with PARP1 for genomic and metabolic homeostasis in malignant pleural mesothelioma","volume":"9","author":"Yang","year":"2023","journal-title":"Cell Death Discov."},{"issue":"28","key":"10.1016\/j.lungcan.2024.107986_b0240","doi-asserted-by":"crossref","first-page":"2863","DOI":"10.1200\/JCO.2018.78.5204","article-title":"Frequency of germline mutations in cancer susceptibility genes in malignant mesothelioma","volume":"36","author":"Panou","year":"2018","journal-title":"J. Clin. Oncol."},{"issue":"8","key":"10.1016\/j.lungcan.2024.107986_b0245","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1016\/j.neo.2017.05.003","article-title":"Combined inhibition of CDK4\/6 and PI3K\/AKT\/mTOR pathways induces a synergistic anti-tumor effect in malignant pleural mesothelioma cells","volume":"19","author":"Bonelli","year":"2017","journal-title":"Neoplasia"},{"issue":"8","key":"10.1016\/j.lungcan.2024.107986_b0250","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1158\/2159-8290.CD-19-1220","article-title":"Biological mechanisms and clinical significance of BAP1 mutations in human cancer","volume":"10","author":"Carbone","year":"2020","journal-title":"Cancer Discov."},{"issue":"7769","key":"10.1016\/j.lungcan.2024.107986_b0255","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1038\/s41586-019-1426-6","article-title":"Intercellular interaction dictates cancer cell ferroptosis via NF2-YAP signalling","volume":"572","author":"Wu","year":"2019","journal-title":"Nature"},{"issue":"11","key":"10.1016\/j.lungcan.2024.107986_b0260","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2019.05.043","article-title":"Systematic analysis of drug vulnerabilities conferred by tumor suppressor loss","volume":"27","author":"Ding","year":"2019","journal-title":"Cell Rep."},{"issue":"8","key":"10.1016\/j.lungcan.2024.107986_b0265","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1038\/nrc.2017.42","article-title":"Novel insights into mesothelioma biology and implications for therapy","volume":"17","author":"Yap","year":"2017","journal-title":"Nat. Rev. Cancer."},{"issue":"3","key":"10.1016\/j.lungcan.2024.107986_b0270","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1016\/j.cell.2017.06.010","article-title":"Defining a cancer dependency map","volume":"170","author":"Tsherniak","year":"2017","journal-title":"Cell"}],"container-title":["Lung Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0169500224005208?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0169500224005208?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,11,19]],"date-time":"2024-11-19T07:05:46Z","timestamp":1731999946000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0169500224005208"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11]]},"references-count":54,"alternative-id":["S0169500224005208"],"URL":"https:\/\/doi.org\/10.1016\/j.lungcan.2024.107986","relation":{},"ISSN":["0169-5002"],"issn-type":[{"value":"0169-5002","type":"print"}],"subject":[],"published":{"date-parts":[[2024,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Crispr-mediated genome editing reveals a preponderance of non-oncogene addictions as targetable vulnerabilities in pleural mesothelioma","name":"articletitle","label":"Article Title"},{"value":"Lung Cancer","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.lungcan.2024.107986","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Author(s). Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"107986"}}