{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T21:02:54Z","timestamp":1791925374912,"version":"4.3.4"},"reference-count":33,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,6,25]],"date-time":"2025-06-25T00:00:00Z","timestamp":1750809600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000738","name":"US Department of Veterans Affairs","doi-asserted-by":"publisher","award":["CX002233-01A2"],"award-info":[{"award-number":["CX002233-01A2"]}],"id":[{"id":"10.13039\/100000738","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart Lung and Blood Institute","doi-asserted-by":"publisher","award":["R01-HL-156998-01A1"],"award-info":[{"award-number":["R01-HL-156998-01A1"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008746","name":"National Cancer Center","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008746","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","lungcancerjournal.info","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Lung Cancer"],"published-print":{"date-parts":[[2025,8]]},"DOI":"10.1016\/j.lungcan.2025.108643","type":"journal-article","created":{"date-parts":[[2025,7,3]],"date-time":"2025-07-03T17:14:06Z","timestamp":1751562846000},"page":"108643","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Cell adhesion molecule-1 is a promising target for chimeric antigen receptors in lung adenocarcinoma"],"prefix":"10.1016","volume":"206","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-0349-0929","authenticated-orcid":false,"given":"Sergey","family":"Zolov","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergei","family":"Chuikov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiva Krishna","family":"Katkam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5181-2696","authenticated-orcid":false,"given":"Peter J.","family":"Chockley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guoan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1947-791X","authenticated-orcid":false,"given":"Venkateshwar G.","family":"Keshamouni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.lungcan.2025.108643_b0005","first-page":"7","article-title":"Cancer statistics, 2020","volume":"70","author":"Siegel","year":"2020","journal-title":"CA Cancer J. Clin."},{"issue":"3","key":"10.1016\/j.lungcan.2025.108643_b0010","first-page":"209","article-title":"Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"71","author":"Sung","year":"2021","journal-title":"CA Cancer J. Clin."},{"issue":"5","key":"10.1016\/j.lungcan.2025.108643_b0015","doi-asserted-by":"crossref","first-page":"497","DOI":"10.6004\/jnccn.2022.0025","article-title":"Non-small cell lung cancer, version 3.2022, NCCN clinical practice guidelines in oncology","volume":"20","author":"Ettinger","year":"2022","journal-title":"J. Natl. Compr. Canc. Netw."},{"issue":"22","key":"10.1016\/j.lungcan.2025.108643_b0020","doi-asserted-by":"crossref","first-page":"2078","DOI":"10.1056\/NEJMoa1801005","article-title":"Pembrolizumab plus chemotherapy in metastatic non-small-cell lung cancer","volume":"378","author":"Gandhi","year":"2018","journal-title":"N. Engl. J. Med."},{"issue":"9","key":"10.1016\/j.lungcan.2025.108643_b0025","doi-asserted-by":"crossref","first-page":"1040","DOI":"10.1200\/JCO.20.03570","article-title":"Therapy for stage IV non-small-cell lung cancer with driver alterations: ASCO and OH (CCO) joint guideline update","volume":"39","author":"Hanna","year":"2021","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.lungcan.2025.108643_b0030","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1146\/annurev-med-062315-120245","article-title":"CAR T cell therapy for solid tumors","volume":"68","author":"Newick","year":"2017","journal-title":"Annu. Rev. Med."},{"issue":"1","key":"10.1016\/j.lungcan.2025.108643_b0035","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1038\/s41571-023-00832-4","article-title":"CAR T cell therapy for patients with solid tumours: key lessons to learn and unlearn","volume":"21","author":"Albelda","year":"2024","journal-title":"Nat. Rev. Clin. Oncol."},{"issue":"4","key":"10.1016\/j.lungcan.2025.108643_b0040","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1038\/s41408-021-00459-7","article-title":"CAR-T cell therapy: current limitations and potential strategies","volume":"11","author":"Sterner","year":"2021","journal-title":"Blood Cancer J."},{"issue":"9","key":"10.1016\/j.lungcan.2025.108643_b0045","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1111\/j.1349-7006.2005.00089.x","article-title":"Involvement of a cell adhesion molecule, TSLC1\/IGSF4, in human oncogenesis","volume":"96","author":"Murakami","year":"2005","journal-title":"Cancer Sci."},{"issue":"8","key":"10.1016\/j.lungcan.2025.108643_b0050","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1111\/j.1349-7006.2005.00075.x","article-title":"Loss of TSLC1 expression in lung adenocarcinoma: relationships with histological subtypes, sex and prognostic significance","volume":"96","author":"Goto","year":"2005","journal-title":"Cancer Sci."},{"issue":"4","key":"10.1016\/j.lungcan.2025.108643_b0055","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1038\/86934","article-title":"TSLC1 is a tumor-suppressor gene in human non-small-cell lung cancer","volume":"27","author":"Kuramochi","year":"2001","journal-title":"Nat. Genet."},{"issue":"4","key":"10.1016\/j.lungcan.2025.108643_b0060","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1038\/s41419-019-1515-3","article-title":"CADM1 is a TWIST1-regulated suppressor of invasion and survival","volume":"10","author":"Hartsough","year":"2019","journal-title":"Cell Death Dis."},{"issue":"4","key":"10.1016\/j.lungcan.2025.108643_b0065","doi-asserted-by":"crossref","first-page":"1384","DOI":"10.1172\/JCI97611","article-title":"Epithelial-mesenchymal transition leads to NK cell-mediated metastasis-specific immunosurveillance in lung cancer","volume":"128","author":"Chockley","year":"2018","journal-title":"J. Clin. Invest."},{"issue":"2","key":"10.1016\/j.lungcan.2025.108643_b0070","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.ccell.2017.06.009","article-title":"Control of metastasis by NK cells","volume":"32","author":"Lopez-Soto","year":"2017","journal-title":"Cancer Cell"},{"issue":"8","key":"10.1016\/j.lungcan.2025.108643_b0075","doi-asserted-by":"crossref","first-page":"4408","DOI":"10.4049\/jimmunol.1202950","article-title":"Epithelial-mesenchymal transition induces an antitumor immune response mediated by NKG2D receptor","volume":"190","author":"Lopez-Soto","year":"2013","journal-title":"J. Immunol."},{"issue":"18","key":"10.1016\/j.lungcan.2025.108643_b0080","doi-asserted-by":"crossref","first-page":"2140","DOI":"10.1101\/gad.1820209","article-title":"Contextual extracellular cues promote tumor cell EMT and metastasis by regulating miR-200 family expression","volume":"23","author":"Gibbons","year":"2009","journal-title":"Genes Dev."},{"issue":"12","key":"10.1016\/j.lungcan.2025.108643_b0085","doi-asserted-by":"crossref","first-page":"3890","DOI":"10.1182\/blood-2006-04-017061","article-title":"T lymphocytes redirected against the kappa light chain of human immunoglobulin efficiently kill mature B lymphocyte-derived malignant cells","volume":"108","author":"Vera","year":"2006","journal-title":"Blood"},{"issue":"12","key":"10.1016\/j.lungcan.2025.108643_b0090","doi-asserted-by":"crossref","DOI":"10.1136\/jitc-2021-003894","article-title":"Engineering CAR-NK cells to secrete IL-15 sustains their anti-AML functionality but is associated with systemic toxicities","volume":"9","author":"Christodoulou","year":"2021","journal-title":"J. Immunother. Cancer"},{"key":"10.1016\/j.lungcan.2025.108643_b0095","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/bs.mcb.2021.06.014","article-title":"Generation of CAR T-cells using gamma-retroviral vector","volume":"167","author":"Watanabe","year":"2022","journal-title":"Methods Cell Biol."},{"issue":"8","key":"10.1016\/j.lungcan.2025.108643_b0100","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1038\/s41389-020-00257-z","article-title":"Targeting PD-L1 in non-small cell lung cancer using CAR T cells","volume":"9","author":"Liu","year":"2020","journal-title":"Oncogenesis"},{"issue":"6","key":"10.1016\/j.lungcan.2025.108643_b0105","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1111\/j.1349-7006.2002.tb01297.x","article-title":"Promoter methylation of TSLC1 and tumor suppression by its gene product in human prostate cancer","volume":"93","author":"Fukuhara","year":"2002","journal-title":"Jpn. J. Cancer Res."},{"key":"10.1016\/j.lungcan.2025.108643_b0110","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1146\/annurev-pathmechdis-051222-122423","article-title":"Update on epithelial-mesenchymal plasticity in cancer progression","volume":"19","author":"Fontana","year":"2024","journal-title":"Annu. Rev. Pathol."},{"issue":"1","key":"10.1016\/j.lungcan.2025.108643_b0115","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1186\/s12885-023-11267-6","article-title":"Prognostic value and immunological role of PD-L1 gene in pan-cancer","volume":"24","author":"Wang","year":"2024","journal-title":"BMC Cancer"},{"issue":"18","key":"10.1016\/j.lungcan.2025.108643_b0120","doi-asserted-by":"crossref","DOI":"10.3390\/cancers13184655","article-title":"Discordance of PD-L1 expression at the protein and RNA levels in early breast cancer","volume":"13","author":"Zerdes","year":"2021","journal-title":"Cancers (Basel)"},{"issue":"10","key":"10.1016\/j.lungcan.2025.108643_b0125","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1158\/2159-8290.CD-18-0442","article-title":"Tumor antigen escape from CAR T-cell therapy","volume":"8","author":"Majzner","year":"2018","journal-title":"Cancer Discov."},{"issue":"10","key":"10.1016\/j.lungcan.2025.108643_b0130","doi-asserted-by":"crossref","first-page":"1290","DOI":"10.1038\/nm.2446","article-title":"A human memory T cell subset with stem cell-like properties","volume":"17","author":"Gattinoni","year":"2011","journal-title":"Nat. Med."},{"issue":"6","key":"10.1016\/j.lungcan.2025.108643_b0135","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1038\/s41591-018-0041-7","article-title":"CAR T cell-induced cytokine release syndrome is mediated by macrophages and abated by IL-1 blockade","volume":"24","author":"Giavridis","year":"2018","journal-title":"Nat. Med."},{"issue":"1","key":"10.1016\/j.lungcan.2025.108643_b0140","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1038\/nrclinonc.2017.148","article-title":"Chimeric antigen receptor T-cell therapy - assessment and management of toxicities","volume":"15","author":"Neelapu","year":"2018","journal-title":"Nat. Rev. Clin. Oncol."},{"issue":"4","key":"10.1016\/j.lungcan.2025.108643_b0145","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1038\/nrclinonc.2018.20","article-title":"Toxicity management after chimeric antigen receptor T cell therapy: one size does not fit 'ALL'","volume":"15","author":"Neelapu","year":"2018","journal-title":"Nat. Rev. Clin. Oncol."},{"issue":"9","key":"10.1016\/j.lungcan.2025.108643_b0150","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1158\/2326-6066.CIR-16-0365","article-title":"The Tumor microenvironment regulates sensitivity of murine lung tumors to PD-1\/PD-L1 antibody blockade","volume":"5","author":"Li","year":"2017","journal-title":"Cancer Immunol. Res."},{"issue":"5","key":"10.1016\/j.lungcan.2025.108643_b0155","doi-asserted-by":"crossref","first-page":"1544","DOI":"10.1053\/j.gastro.2008.01.081","article-title":"Cell adhesion molecule 1 is a novel pancreatic-islet cell adhesion molecule that mediates nerve-islet cell interactions","volume":"134","author":"Koma","year":"2008","journal-title":"Gastroenterology"},{"issue":"1","key":"10.1016\/j.lungcan.2025.108643_b0160","doi-asserted-by":"crossref","first-page":"49","DOI":"10.4161\/isl.18675","article-title":"Adhesion molecule CADM1 contributes to gap junctional communication among pancreatic islet alpha-cells and prevents their excessive secretion of glucagon","volume":"4","author":"Ito","year":"2012","journal-title":"Islets"},{"issue":"3","key":"10.1016\/j.lungcan.2025.108643_b0165","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1007\/s00262-020-02735-0","article-title":"Chimeric antigen receptor (CAR)-T-cell therapy in non-small-cell lung cancer (NSCLC): current status and future perspectives","volume":"70","author":"Qu","year":"2021","journal-title":"Cancer Immunol. Immunother."}],"container-title":["Lung Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0169500225005355?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0169500225005355?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T04:31:01Z","timestamp":1778473861000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0169500225005355"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8]]},"references-count":33,"alternative-id":["S0169500225005355"],"URL":"https:\/\/doi.org\/10.1016\/j.lungcan.2025.108643","relation":{},"ISSN":["0169-5002"],"issn-type":[{"value":"0169-5002","type":"print"}],"subject":[],"published":{"date-parts":[[2025,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Cell adhesion molecule-1 is a promising target for chimeric antigen receptors in lung adenocarcinoma","name":"articletitle","label":"Article Title"},{"value":"Lung Cancer","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.lungcan.2025.108643","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"108643"}}