{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T13:30:46Z","timestamp":1766064646616,"version":"3.48.0"},"reference-count":28,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100009043","name":"University of Patras","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009043","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","lungcancerjournal.info","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Lung Cancer"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1016\/j.lungcan.2025.108814","type":"journal-article","created":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T00:12:26Z","timestamp":1762215146000},"page":"108814","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["A novel agent, p-toluenesulfonamide, in the management of malignant pleural effusions"],"prefix":"10.1016","volume":"210","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4194-162X","authenticated-orcid":false,"given":"Yung-Hung","family":"Luo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chuan-Ching","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shun-Chi","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hsiao-Wen","family":"Su","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi-Chin","family":"Hsing","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shih-Yuan","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yun-Chi","family":"Lo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mao-Yuan","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shi-yue","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianxing","family":"He","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuenn-Wen","family":"Kuo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.lungcan.2025.108814_b0005","doi-asserted-by":"crossref","unstructured":"\u201cMalignant pleural effusion: from bench to bedside.\u201d Ioannis Psallidas, Ioannis Kalomenidis, Jose M. Porcel, Bruce W. Robinson and Georgios T. Stathopoulos. Eur Respir Rev 2016; 25: 189-198, European respiratory review 25(141) (2016) 360-360.","DOI":"10.1183\/16000617.5019-2016"},{"issue":"19","key":"10.1016\/j.lungcan.2025.108814_b0010","doi-asserted-by":"crossref","first-page":"1903","DOI":"10.1001\/jama.2017.17426","article-title":"Effect of an Indwelling pleural catheter vs talc pleurodesis on hospitalization days in patients with malignant pleural effusion: the AMPLE randomized clinical trial","volume":"318","author":"Thomas","year":"2017","journal-title":"JAMA J. Am. Med. Assoc."},{"issue":"10","key":"10.1016\/j.lungcan.2025.108814_b0015","doi-asserted-by":"crossref","first-page":"2380","DOI":"10.1183\/09031936.97.10102383","article-title":"Pleurodesis in malignant pleural effusions: a randomized study of tetracycline versus bleomycin","volume":"10","author":"Martinez-Moragon","year":"1997","journal-title":"Eur. Respir. J."},{"issue":"6","key":"10.1016\/j.lungcan.2025.108814_b0020","first-page":"1052","article-title":"Pleural controversies: indwelling pleural catheter vs. pleurodesis for malignant pleural effusions","volume":"7","author":"Fortin","year":"2015","journal-title":"J. Thorac. Dis."},{"issue":"9","key":"10.1016\/j.lungcan.2025.108814_b0025","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1016\/S2213-2600(18)30288-1","article-title":"Aggressive versus symptom-guided drainage of malignant pleural effusion via indwelling pleural catheters (AMPLE-2): an open-label randomised trial","volume":"6","author":"Muruganandan","year":"2018","journal-title":"Lancet Respiratory Med."},{"issue":"6","key":"10.1016\/j.lungcan.2025.108814_b0030","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1007\/S12325-010-0031-8","article-title":"Management of malignant pleural effusions","volume":"27","author":"Uzbeck","year":"2010","journal-title":"Adv. Ther."},{"issue":"1","key":"10.1016\/j.lungcan.2025.108814_b0035","doi-asserted-by":"crossref","DOI":"10.1183\/13993003.00349-2018","article-title":"ERS\/EACTS statement on the management of malignant pleural effusions","volume":"52","author":"Bibby","year":"2018","journal-title":"Eur. Respir. J."},{"issue":"4","key":"10.1016\/j.lungcan.2025.108814_b0040","first-page":"472","article-title":"Antitumor effect of para-toluenesulfonamide against lung cancer xenograft in a mouse model","volume":"5","author":"Gao","year":"2013","journal-title":"J. Thorac. Dis."},{"issue":"10","key":"10.1016\/j.lungcan.2025.108814_b0045","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.1097\/CAD.0000000000000283","article-title":"Para-toluenesulfonamide induces tongue squamous cell carcinoma cell death through disturbing lysosomal stability","volume":"26","author":"Liu","year":"2015","journal-title":"Anticancer Drugs"},{"key":"10.1016\/j.lungcan.2025.108814_b0050","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.3389\/fphar.2018.01223","article-title":"Para-toluenesulfonamide induces anti-tumor activity through Akt-dependent and -independent mTOR\/p70S6K pathway: roles of lipid raft and cholesterol contents","volume":"9","author":"Hsu","year":"2018","journal-title":"Front. Pharmacol."},{"issue":"9","key":"10.1016\/j.lungcan.2025.108814_b0055","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1097\/CAD.0b013e32832fe48f","article-title":"Gemcitabine plus cisplatin chemotherapy with concurrent para-toluenesulfonamide local injection therapy for peripherally advanced nonsmall cell lung cancer larger than 3\u2009cm in the greatest dimension","volume":"20","author":"He","year":"2009","journal-title":"Anticancer Drugs"},{"issue":"46","key":"10.1016\/j.lungcan.2025.108814_b0060","doi-asserted-by":"crossref","first-page":"6861","DOI":"10.3748\/wjg.v18.i46.6861","article-title":"Puncture injection of para-toluenesulfonamide combined with chemoembolization for advanced hepatocellular carcinoma","volume":"18","author":"He","year":"2012","journal-title":"World J Gastroenterol: WJG"},{"key":"10.1016\/j.lungcan.2025.108814_b0065","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.lungcan.2016.05.012","article-title":"Effects of para\u2013toluenesulfonamide intratumoral injection on non-small cell lung carcinoma with severe central airway obstruction: a multi-center, non-randomized, single-arm, open-label trial","volume":"98","author":"Li","year":"2016","journal-title":"Lung Cancer (Amsterdam, Netherlands)"},{"key":"10.1016\/j.lungcan.2025.108814_b0070","doi-asserted-by":"crossref","first-page":"7","DOI":"10.25259\/Cytojournal_18_2021","article-title":"Adequacy of pleural fluid cytology for comprehensive molecular analysis of lung adenocarcinoma: experience of a large health-care system","volume":"19","author":"Dalvi","year":"2022","journal-title":"Cytojournal"},{"issue":"1","key":"10.1016\/j.lungcan.2025.108814_b0075","doi-asserted-by":"crossref","first-page":"15205","DOI":"10.1038\/ncomms15205","article-title":"Mutant KRAS promotes malignant pleural effusion formation","volume":"8","author":"Agalioti","year":"2017","journal-title":"Nat. Commun."},{"key":"10.1016\/j.lungcan.2025.108814_b0080","doi-asserted-by":"crossref","unstructured":"G.T. Stathopoulos, A. Kollintza, D. Orphanidou, R.W. Light, C. Roussos, T.S. Blackwell, I. Kalomenidis, C. Moschos, I. Psallidas, T.P. Sherrill, E.N. Pitsinos, S. Vassiliou, M. Karatza, S.A. Papiris, D. Graf, Tumor necrosis factor-\u03b1 promotes malignant pleural effusion, Cancer research (Chicago, Ill.) 67(20) (2007) 9825-9834.","DOI":"10.1158\/0008-5472.CAN-07-1064"},{"issue":"5","key":"10.1016\/j.lungcan.2025.108814_b0085","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.1378\/chest.113.5.1305","article-title":"Sclerotherapy for malignant pleural effusions: a prospective randomized trial of bleomycin vs doxycycline with small-bore catheter drainage","volume":"113","author":"Patz","year":"1998","journal-title":"Chest"},{"key":"10.1016\/j.lungcan.2025.108814_b0090","doi-asserted-by":"crossref","unstructured":"M. Hazlinger, F. Ctvrtlik, K. Langova, M. Herman, Quantification of pleural effusion on CT by simple measurement, Biomedical papers of the Medical Faculty of the University Palack\u00fd, Olomouc, Czechoslovakia 158(1) (2014) 107-111.","DOI":"10.5507\/bp.2012.042"},{"issue":"7","key":"10.1016\/j.lungcan.2025.108814_b0095","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1164\/rccm.201807-1415ST","article-title":"Management of malignant pleural effusions. An official ATS\/STS\/STR clinical practice guideline","volume":"198","author":"Feller-Kopman","year":"2018","journal-title":"Am. J. Respiratory Critical Care Med."},{"issue":"3","key":"10.1016\/j.lungcan.2025.108814_b0100","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/j.tips.2016.12.005","article-title":"Complex pathologic roles of RIPK1 and RIPK3: moving beyond necroptosis","volume":"38","author":"Wegner","year":"2017","journal-title":"Trends Pharmacol. Sci."},{"issue":"16","key":"10.1016\/j.lungcan.2025.108814_b0105","doi-asserted-by":"crossref","first-page":"22219","DOI":"10.18632\/oncotarget.7924","article-title":"Key roles of necroptotic factors in promoting tumor growth","volume":"7","author":"Liu","year":"2016","journal-title":"Oncotarget"},{"key":"10.1016\/j.lungcan.2025.108814_b0110","doi-asserted-by":"crossref","first-page":"15205","DOI":"10.1038\/ncomms15205","article-title":"Mutant KRAS promotes malignant pleural effusion formation","volume":"8","author":"Agalioti","year":"2017","journal-title":"Nat. Commun."},{"issue":"1","key":"10.1016\/j.lungcan.2025.108814_b0115","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1186\/s12935-024-03211-w","article-title":"Immune modulation in malignant pleural effusion: from microenvironment to therapeutic implications","volume":"24","author":"Ge","year":"2024","journal-title":"Cancer Cell Int."},{"issue":"31","key":"10.1016\/j.lungcan.2025.108814_b0120","doi-asserted-by":"crossref","first-page":"4300","DOI":"10.1038\/sj.onc.1209464","article-title":"Autocrine IL-6-induced Stat3 activation contributes to the pathogenesis of lung adenocarcinoma and malignant pleural effusion","volume":"25","author":"Yeh","year":"2006","journal-title":"Oncogene"},{"issue":"3","key":"10.1016\/j.lungcan.2025.108814_b0125","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1378\/chest.127.3.909","article-title":"Phase III intergroup study of Talc Poudrage vs Talc Slurry sclerosis for malignant pleural effusion","volume":"127","author":"Dresler","year":"2005","journal-title":"Chest"},{"issue":"8","key":"10.1016\/j.lungcan.2025.108814_b0130","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1038\/nri3862","article-title":"Molecular and cellular insights into T cell exhaustion","volume":"15","author":"Wherry","year":"2015","journal-title":"Nat. Rev. Immunol."},{"issue":"4","key":"10.1016\/j.lungcan.2025.108814_b0135","first-page":"128","article-title":"Tetracycline pleurodesis for malignant pleural effusion-a review of 38 cases","volume":"39","author":"Tettey","year":"2005","journal-title":"Ghana Med. J."},{"issue":"3","key":"10.1016\/j.lungcan.2025.108814_b0140","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1378\/chest.14-2401","article-title":"Intrapleural fibrinolysis for the treatment of indwelling pleural catheter-related symptomatic loculations: a multicenter observational study","volume":"148","author":"Thomas","year":"2015","journal-title":"Chest"}],"container-title":["Lung Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0169500225007068?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0169500225007068?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T13:28:05Z","timestamp":1766064485000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0169500225007068"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":28,"alternative-id":["S0169500225007068"],"URL":"https:\/\/doi.org\/10.1016\/j.lungcan.2025.108814","relation":{},"ISSN":["0169-5002"],"issn-type":[{"type":"print","value":"0169-5002"}],"subject":[],"published":{"date-parts":[[2025,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A novel agent, p-toluenesulfonamide, in the management of malignant pleural effusions","name":"articletitle","label":"Article Title"},{"value":"Lung Cancer","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.lungcan.2025.108814","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"108814"}}