{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T01:50:05Z","timestamp":1793670605854,"version":"4.5.1"},"reference-count":37,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100013145","name":"Primary Research and Development Plan of Zhejiang Province","doi-asserted-by":"publisher","award":["2024C03277"],"award-info":[{"award-number":["2024C03277"]}],"id":[{"id":"10.13039\/501100013145","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82473210"],"award-info":[{"award-number":["82473210"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007219","name":"Shanghai Municipal Natural Science Foundation","doi-asserted-by":"publisher","award":["24ZR1464400"],"award-info":[{"award-number":["24ZR1464400"]}],"id":[{"id":"10.13039\/100007219","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","lungcancerjournal.info","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Lung Cancer"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1016\/j.lungcan.2025.108838","type":"journal-article","created":{"date-parts":[[2025,11,15]],"date-time":"2025-11-15T05:13:06Z","timestamp":1763183586000},"page":"108838","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Threshold of adequate resection margin for sub-lobar resection in peripheral clinical stage IA1-2 non-small cell lung cancer with tumor spread through air spaces"],"prefix":"10.1016","volume":"210","author":[{"given":"Hanbo","family":"Pan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wanyu","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weicheng","family":"Kong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaqi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hang","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen","family":"Ge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Tian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junwei","family":"Ning","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhizhuo","family":"Dai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiyang","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang","family":"Fang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guomo","family":"Ruan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongjie","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaomin","family":"Niu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengwei","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guodong","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4098-9477","authenticated-orcid":false,"given":"Qingquan","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.lungcan.2025.108838_b0005","first-page":"12","article-title":"Cancer statistics, 2024","volume":"74","author":"Siegel","year":"2024","journal-title":"CA Cancer J Clin."},{"issue":"2","key":"10.1016\/j.lungcan.2025.108838_b0010","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/j.jtho.2016.10.020","article-title":"Breaking new ground: the evolving concept of spread through air spaces (STAS)","volume":"12","author":"Warth","year":"2017","journal-title":"J. Thorac. Oncol."},{"issue":"3","key":"10.1016\/j.lungcan.2025.108838_b0015","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.cllc.2021.10.004","article-title":"Meta-analysis of lobectomy and sublobar resection for stage I non-small cell lung cancer with spread through air spaces","volume":"23","author":"Li","year":"2022","journal-title":"Clin. Lung Cancer"},{"key":"10.1016\/j.lungcan.2025.108838_b0020","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.lungcan.2020.04.026","article-title":"The role of spread through air spaces (STAS) in lung adenocarcinoma prognosis and therapeutic decision making","volume":"146","author":"Toki","year":"2020","journal-title":"Lung Cancer"},{"issue":"5","key":"10.1016\/j.lungcan.2025.108838_b0025","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1016\/j.jtcvs.2023.01.030","article-title":"Analysis of recurrence in lung adenocarcinoma with spread through air spaces","volume":"166","author":"Khalil","year":"2023","journal-title":"J. Thorac. Cardiovasc. Surg."},{"issue":"7","key":"10.1016\/j.lungcan.2025.108838_b0030","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.1016\/j.jtho.2024.03.015","volume":"19","author":"Travis","year":"2024","journal-title":"J. Thorac. Oncol."},{"issue":"10335","key":"10.1016\/j.lungcan.2025.108838_b0035","doi-asserted-by":"crossref","first-page":"1607","DOI":"10.1016\/S0140-6736(21)02333-3","article-title":"Segmentectomy versus lobectomy in small-sized peripheral non-small-cell lung cancer (JCOG0802\/WJOG4607L): a multicentre, open-label, phase 3, randomised, controlled, non-inferiority trial","volume":"399","author":"Saji","year":"2022","journal-title":"Lancet"},{"issue":"6","key":"10.1016\/j.lungcan.2025.108838_b0040","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1056\/NEJMoa2212083","article-title":"Lobar or sublobar resection for peripheral stage IA non-small-cell lung cancer","volume":"388","author":"Altorki","year":"2023","journal-title":"N. Engl. J. Med."},{"issue":"23","key":"10.1016\/j.lungcan.2025.108838_b0045","doi-asserted-by":"crossref","first-page":"2449","DOI":"10.1200\/JCO.2013.50.8762","article-title":"Recurrence and survival outcomes after anatomic segmentectomy versus lobectomy for clinical stage I non-small-cell lung cancer: a propensity-matched analysis","volume":"32","author":"Landreneau","year":"2014","journal-title":"J. Clin. Oncol."},{"issue":"4","key":"10.1016\/j.lungcan.2025.108838_b0050","doi-asserted-by":"crossref","first-page":"249","DOI":"10.6004\/jnccn.2204.0023","article-title":"Non-small cell lung cancer, version 4.2024, NCCN clinical practice guidelines in oncology","volume":"22","author":"Riely","year":"2024","journal-title":"J Natl Compr Canc Netw"},{"key":"10.1016\/j.lungcan.2025.108838_b0055","unstructured":"[Chinese Medical Association guideline for clinical diagnosis and treatment of lung cancer (2024 edition)]. Zhonghua Zhong Liu Za Zhi. Sep 23 2024;46(9):805-843. doi:10.3760\/cma.j.cn112152-20240510-00189."},{"issue":"6","key":"10.1016\/j.lungcan.2025.108838_b0060","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1007\/s00281-015-0518-0","article-title":"\u03b2-amyloid, microglia, and the inflammasome in Alzheimer\u2019s disease","volume":"37","author":"Gold","year":"2015","journal-title":"Semin. Immunopathol."},{"issue":"5","key":"10.1016\/j.lungcan.2025.108838_b0065","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1097\/JTO.0000000000000486","article-title":"Tumor spread through air spaces is an important pattern of invasion and impacts the frequency and location of recurrences after limited resection for small stage I lung adenocarcinomas","volume":"10","author":"Kadota","year":"2015","journal-title":"J. Thorac. Oncol."},{"issue":"4","key":"10.1016\/j.lungcan.2025.108838_b0070","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1016\/j.athoracsur.2024.03.007","article-title":"Spread through air spaces in residual tumor classification for clinical IA lung adenocarcinoma","volume":"118","author":"Si","year":"2024","journal-title":"Ann. Thorac. Surg."},{"issue":"8","key":"10.1016\/j.lungcan.2025.108838_b0075","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1097\/PAS.0000000000001285","article-title":"Limited resection is associated with a higher risk of locoregional recurrence than lobectomy in stage I lung adenocarcinoma with tumor spread through air spaces","volume":"43","author":"Kadota","year":"2019","journal-title":"Am. J. Surg. Pathol."},{"issue":"1","key":"10.1016\/j.lungcan.2025.108838_b0080","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.jtho.2018.09.005","article-title":"Lobectomy is associated with better outcomes than sublobar resection in spread through air spaces (STAS)-positive T1 lung adenocarcinoma: a propensity score-matched analysis","volume":"14","author":"Eguchi","year":"2019","journal-title":"J. Thorac. Oncol."},{"issue":"7","key":"10.1016\/j.lungcan.2025.108838_b0085","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1016\/j.jtho.2024.02.011","article-title":"The international association for the study of lung cancer lung cancer staging project: proposals for revision of the TNM stage groups in the forthcoming (ninth) edition of the TNM classification for lung cancer","volume":"19","author":"Rami-Porta","year":"2024","journal-title":"J. Thorac. Oncol."},{"issue":"3","key":"10.1016\/j.lungcan.2025.108838_b0090","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1016\/j.jtho.2019.10.019","article-title":"The IASLC lung cancer staging project: analysis of resection margin status and proposals for residual tumor descriptors for non-small cell lung cancer","volume":"15","author":"Edwards","year":"2020","journal-title":"J. Thorac. Oncol."},{"issue":"2","key":"10.1016\/j.lungcan.2025.108838_b0095","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1097\/JTO.0b013e318206a221","article-title":"International association for the study of lung cancer\/american thoracic society\/european respiratory society international multidisciplinary classification of lung adenocarcinoma","volume":"6","author":"Travis","year":"2011","journal-title":"J. Thorac. Oncol."},{"issue":"9","key":"10.1016\/j.lungcan.2025.108838_b0100","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.1097\/JTO.0000000000000630","article-title":"The 2015 world health organization classification of lung tumors: impact of genetic, clinical and radiologic advances since the 2004 classification","volume":"10","author":"Travis","year":"2015","journal-title":"J. Thorac. Oncol."},{"issue":"11","key":"10.1016\/j.lungcan.2025.108838_b0105","doi-asserted-by":"crossref","first-page":"1509","DOI":"10.1097\/PAS.0000000000001788","article-title":"Spread through air spaces (STAS) in non-small cell lung carcinoma: evidence supportive of an in vivo phenomenon","volume":"45","author":"Gross","year":"2021","journal-title":"Am. J. Surg. Pathol."},{"issue":"3","key":"10.1016\/j.lungcan.2025.108838_b0110","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1016\/j.jtcvs.2023.11.030","article-title":"Preoperative predictors of spread through air spaces in lung cancer","volume":"168","author":"Tasnim","year":"2024","journal-title":"J. Thorac. Cardiovasc. Surg."},{"issue":"4","key":"10.1016\/j.lungcan.2025.108838_b0115","doi-asserted-by":"crossref","first-page":"1670","DOI":"10.1016\/j.jtcvs.2018.04.126","article-title":"Computed tomography features of resected lung adenocarcinomas with spread through air spaces","volume":"156","author":"Toyokawa","year":"2018","journal-title":"J. Thorac. Cardiovasc. Surg."},{"issue":"3","key":"10.1016\/j.lungcan.2025.108838_b0120","doi-asserted-by":"crossref","first-page":"624","DOI":"10.21037\/tcr-22-2593","article-title":"Advances in the prediction of spread through air spaces with imaging in lung cancer: a narrative review","volume":"12","author":"Wang","year":"2023","journal-title":"Transl. Cancer Res."},{"issue":"11","key":"10.1016\/j.lungcan.2025.108838_b0125","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1016\/j.diii.2022.06.002","article-title":"3D convolutional neural network model from contrast-enhanced CT to predict spread through air spaces in non-small cell lung cancer","volume":"103","author":"Tao","year":"2022","journal-title":"Diagn. Interv. Imaging"},{"key":"10.1016\/j.lungcan.2025.108838_b0130","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1016\/j.xjon.2024.07.018","article-title":"Improving prediction accuracy of spread through air spaces in clinical-stage T1N0 lung adenocarcinoma using computed tomography imaging models","volume":"21","author":"Dou","year":"2024","journal-title":"JTCVS Open."},{"issue":"6","key":"10.1016\/j.lungcan.2025.108838_b0135","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1007\/s11604-021-01240-3","article-title":"Development and validation of a CT-based nomogram to predict spread through air space (STAS) in peripheral stage IA lung adenocarcinoma","volume":"40","author":"Chen","year":"2022","journal-title":"Jpn. J. Radiol."},{"key":"10.1016\/j.lungcan.2025.108838_b0140","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.lungcan.2021.11.017","article-title":"Preoperative CT-based peritumoral and tumoral radiomic features prediction for tumor spread through air spaces in clinical stage I lung adenocarcinoma","volume":"163","author":"Liao","year":"2022","journal-title":"Lung Cancer (Amsterdam, Netherlands)."},{"issue":"3","key":"10.1016\/j.lungcan.2025.108838_b0145","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1016\/j.athoracsur.2021.07.075","article-title":"Radiomic values from high-grade subtypes to predict spread through air spaces in lung adenocarcinoma","volume":"114","author":"Chen","year":"2022","journal-title":"Ann. Thorac. Surg."},{"issue":"3","key":"10.1016\/j.lungcan.2025.108838_b0150","doi-asserted-by":"crossref","first-page":"1536","DOI":"10.1245\/s10434-023-14565-2","article-title":"CT-based deep-learning model for spread-through-air-spaces prediction in ground glass-predominant lung adenocarcinoma","volume":"31","author":"Lin","year":"2024","journal-title":"Ann. Surg. Oncol."},{"key":"10.1016\/j.lungcan.2025.108838_b0155","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejrad.2025.112249","article-title":"CT-based radiomics models for predicting spread through air space in lung cancer: a systematic review and meta-analysis","volume":"190","author":"Chen","year":"2025","journal-title":"Eur. J. Radiol."},{"issue":"1","key":"10.1016\/j.lungcan.2025.108838_b0160","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1186\/s40364-023-00539-9","article-title":"Improving the prediction of Spreading through air spaces (STAS) in primary lung cancer with a dynamic dual-delta hybrid machine learning model: a multicenter cohort study","volume":"11","author":"Jin","year":"2023","journal-title":"Biomarker Res."},{"key":"10.1016\/j.lungcan.2025.108838_b0165","doi-asserted-by":"crossref","DOI":"10.1016\/j.lungcan.2025.108438","article-title":"Tumour spread through air spaces is a determiner for treatment of clinical stage I non-small cell lung Cancer: Thoracoscopic segmentectomy vs lobectomy","volume":"201","author":"Huang","year":"2025","journal-title":"Lung Cancer"},{"issue":"2","key":"10.1016\/j.lungcan.2025.108838_b0170","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1016\/j.atssr.2024.12.011","article-title":"Lobectomy vs segmentectomy in stage I non-small cell lung cancer with lymphatic vascular invasion","volume":"3","author":"Stanley","year":"2025","journal-title":"Ann Thorac Surg Short Rep."},{"issue":"9","key":"10.1016\/j.lungcan.2025.108838_b0175","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1001\/jamaoncol.2024.2491","article-title":"Recurrence of non-small cell lung cancer with visceral pleural invasion: a secondary analysis of a randomized clinical trial","volume":"10","author":"Altorki","year":"2024","journal-title":"JAMA Oncol."},{"issue":"10","key":"10.1016\/j.lungcan.2025.108838_b0180","doi-asserted-by":"crossref","first-page":"1830","DOI":"10.1200\/JCO.22.02186","article-title":"Adjuvant osimertinib for resected EGFR-mutated stage IB-IIIA Non-small-cell lung cancer: updated results from the phase III randomized ADAURA trial","volume":"41","author":"Herbst","year":"2023","journal-title":"J. Clin. Oncol."},{"issue":"13","key":"10.1016\/j.lungcan.2025.108838_b0185","doi-asserted-by":"crossref","DOI":"10.3390\/cancers17132077","article-title":"Neoadjuvant, perioperative, and adjuvant immunotherapy in early-stage surgically resectable non-small cell lung cancer: updates and future perspectives","volume":"17","author":"Gathers","year":"2025","journal-title":"Cancers"}],"container-title":["Lung Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0169500225007305?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0169500225007305?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T20:29:06Z","timestamp":1766089746000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0169500225007305"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":37,"alternative-id":["S0169500225007305"],"URL":"https:\/\/doi.org\/10.1016\/j.lungcan.2025.108838","relation":{},"ISSN":["0169-5002"],"issn-type":[{"value":"0169-5002","type":"print"}],"subject":[],"published":{"date-parts":[[2025,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Threshold of adequate resection margin for sub-lobar resection in peripheral clinical stage IA1-2 non-small cell lung cancer with tumor spread through air spaces","name":"articletitle","label":"Article Title"},{"value":"Lung Cancer","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.lungcan.2025.108838","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"108838"}}