{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,28]],"date-time":"2026-06-28T16:45:22Z","timestamp":1782665122429,"version":"3.54.5"},"reference-count":18,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T00:00:00Z","timestamp":1777248000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","lungcancerjournal.info","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Lung Cancer"],"published-print":{"date-parts":[[2026,6]]},"DOI":"10.1016\/j.lungcan.2026.109420","type":"journal-article","created":{"date-parts":[[2026,4,19]],"date-time":"2026-04-19T05:04:35Z","timestamp":1776575075000},"page":"109420","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Utilization of invasive mediastinal nodal staging and prevalence of occult nodal disease in patients with synchronous primary lung cancers"],"prefix":"10.1016","volume":"216","author":[{"given":"Nanruoyi","family":"Zhou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8989-9638","authenticated-orcid":false,"given":"Stella","family":"Tsui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Toumbacaris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9757-1325","authenticated-orcid":false,"given":"Kay See","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-6250-1521","authenticated-orcid":false,"given":"Joseph","family":"Dycoco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2153-1308","authenticated-orcid":false,"given":"Alexis P.","family":"Chidi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine D.","family":"Gray","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Smita","family":"Sihag","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3814-5144","authenticated-orcid":false,"given":"Bernard J.","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew J.","family":"Bott","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prasad S.","family":"Adusumilli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1655-4473","authenticated-orcid":false,"given":"Daniela","family":"Molena","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valerie W.","family":"Rusch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manjit S.","family":"Bains","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaetano","family":"Rocco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7305-876X","authenticated-orcid":false,"given":"James M.","family":"Isbell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3318-0146","authenticated-orcid":false,"given":"David R.","family":"Jones","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.lungcan.2026.109420_b0005","first-page":"12","article-title":"Cancer statistics, 2024","volume":"74","author":"Siegel","year":"2024","journal-title":"CA Cancer J. Clin."},{"issue":"2","key":"10.1016\/j.lungcan.2026.109420_b0010","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1002\/cam4.3614","article-title":"Characteristics and prognosis of synchronous multiple primary lung cancer after surgical treatment: a systematic review and meta\u2010analysis of current evidence","volume":"10","author":"Tie","year":"2021","journal-title":"Cancer Med."},{"issue":"4","key":"10.1016\/j.lungcan.2026.109420_b0015","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1016\/S0022-5223(19)40289-4","article-title":"Multiple primary lung cancers","volume":"70","author":"Martini","year":"1975","journal-title":"J. Thorac. Cardiovasc. Surg."},{"key":"10.1016\/j.lungcan.2026.109420_b0020","unstructured":"National Comprehensive Cancer Network. Non-Small Cell Lung Cancer Version 3.2026. Updated 12\/24\/25. Accessed March 5, 2026. https:\/\/www.nccn.org\/professionals\/physician_gls\/pdf\/nscl.pdf."},{"issue":"5","key":"10.1016\/j.lungcan.2026.109420_b0025","doi-asserted-by":"crossref","first-page":"e369S","DOI":"10.1378\/chest.12-2362","article-title":"Special treatment issues in non-small cell lung cancer","volume":"143","author":"Kozower","year":"2013","journal-title":"Chest"},{"issue":"5","key":"10.1016\/j.lungcan.2026.109420_b0030","doi-asserted-by":"crossref","first-page":"e211S","DOI":"10.1378\/chest.12-2355","article-title":"Methods for staging non-small cell lung cancer","volume":"143","author":"Silvestri","year":"2013","journal-title":"Chest"},{"issue":"5","key":"10.1016\/j.lungcan.2026.109420_b0035","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1093\/ejcts\/ezu028","article-title":"Revised ESTS guidelines for preoperative mediastinal lymph node staging for non-small-cell lung cancer","volume":"45","author":"De Leyn","year":"2014","journal-title":"Eur. J. Cardiothorac. Surg."},{"issue":"2","key":"10.1016\/j.lungcan.2026.109420_b0040","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.jtho.2019.09.221","article-title":"A novel algorithm to differentiate between multiple primary lung cancers and intrapulmonary metastasis in multiple lung cancers with multiple pulmonary sites of involvement","volume":"15","author":"Suh","year":"2020","journal-title":"J. Thorac. Oncol."},{"issue":"1","key":"10.1016\/j.lungcan.2026.109420_b0045","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1148\/radiol.2017161659","article-title":"Guidelines for management of incidental pulmonary nodules detected on CT images: from the Fleischner Society 2017","volume":"284","author":"Macmahon","year":"2017","journal-title":"Radiology"},{"issue":"13","key":"10.1016\/j.lungcan.2026.109420_b0050","doi-asserted-by":"crossref","first-page":"4282","DOI":"10.1245\/s10434-013-3212-2","article-title":"Preoperative consolidation-to-tumor ratio and SUVmax stratify the risk of recurrence in patients undergoing limited resection for lung adenocarcinoma\u22642cm","volume":"20","author":"Nitadori","year":"2013","journal-title":"Ann. Surg. Oncol."},{"issue":"5","key":"10.1016\/j.lungcan.2026.109420_b0055","doi-asserted-by":"crossref","first-page":"1168","DOI":"10.1016\/j.ejcts.2009.12.013","article-title":"Incidence of occult mediastinal node involvement in cN0 non-small-cell lung cancer patients after negative uptake of positron emission tomography\/computer tomography scan","volume":"37","author":"G\u00f3mez-Caro","year":"2010","journal-title":"Eur. J. Cardiothorac. Surg."},{"key":"10.1016\/j.lungcan.2026.109420_b0060","doi-asserted-by":"crossref","DOI":"10.1016\/j.eclinm.2024.102478","article-title":"Role of invasive mediastinal nodal staging in survival outcomes of patients with non-small cell lung cancer and without radiologic lymph node metastasis: a retrospective cohort study","volume":"69","author":"Kim","year":"2024","journal-title":"eClinicalMedicine"},{"key":"10.1016\/j.lungcan.2026.109420_b0065","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.lungcan.2020.10.022","article-title":"Occult lymph node metastases in clinical N0\/N1 NSCLC; a single center in-depth analysis","volume":"150","author":"Beyaz","year":"2020","journal-title":"Lung Cancer"},{"issue":"1","key":"10.1016\/j.lungcan.2026.109420_b0070","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.jtcvs.2014.08.075","article-title":"Utility of mediastinoscopy in clinical stage I lung cancers at risk for occult mediastinal nodal metastases","volume":"149","author":"Fernandez","year":"2015","journal-title":"J. Thorac. Cardiovasc. Surg."},{"issue":"13","key":"10.1016\/j.lungcan.2026.109420_b0075","doi-asserted-by":"crossref","first-page":"3475","DOI":"10.3390\/cancers15133475","article-title":"True prevalence of unforeseen N2 disease in NSCLC: a systematic review + meta-analysis","volume":"15","author":"Hui","year":"2023","journal-title":"Cancers"},{"issue":"1","key":"10.1016\/j.lungcan.2026.109420_b0080","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.athoracsur.2007.03.081","article-title":"Risk factors for occult mediastinal metastases in clinical stage I non-small cell lung cancer","volume":"84","author":"Lee","year":"2007","journal-title":"Ann. Thorac. Surg."},{"issue":"22","key":"10.1016\/j.lungcan.2026.109420_b0085","doi-asserted-by":"crossref","first-page":"3785","DOI":"10.1200\/JCO.23.00867","article-title":"Mediastinal staging in non\u2013small-cell lung cancer: saying goodbye to mediastinoscopy","volume":"41","author":"Dunne","year":"2023","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.lungcan.2026.109420_b0090","article-title":"The impact of preoperative invasive nodal staging on unexpected mediastinal upstaging in early-stage non-small cell lung cancer","author":"Banks","year":"2025","journal-title":"Ann. Surg. Oncol."}],"container-title":["Lung Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0169500226004812?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0169500226004812?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,28]],"date-time":"2026-06-28T16:21:30Z","timestamp":1782663690000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0169500226004812"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":18,"alternative-id":["S0169500226004812"],"URL":"https:\/\/doi.org\/10.1016\/j.lungcan.2026.109420","relation":{},"ISSN":["0169-5002"],"issn-type":[{"value":"0169-5002","type":"print"}],"subject":[],"published":{"date-parts":[[2026,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Utilization of invasive mediastinal nodal staging and prevalence of occult nodal disease in patients with synchronous primary lung cancers","name":"articletitle","label":"Article Title"},{"value":"Lung Cancer","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.lungcan.2026.109420","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"109420"}}