{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T00:26:44Z","timestamp":1793924804578,"version":"4.8.0"},"reference-count":41,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T00:00:00Z","timestamp":1790035200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100010564","name":"German Center for Lung Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010564","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","lungcancerjournal.info","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Lung Cancer"],"published-print":{"date-parts":[[2026,11]]},"DOI":"10.1016\/j.lungcan.2026.109628","type":"journal-article","created":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T22:40:50Z","timestamp":1789944050000},"page":"109628","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Longitudinal transcriptomic profiling of paired early and metastatic EGFR-mutant lung adenocarcinomas reveals molecular programs associated with disease progression"],"prefix":"10.1016","volume":"221","author":[{"given":"Alejandro Pallares","family":"Robles","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7966-8980","authenticated-orcid":false,"given":"Petros","family":"Christopoulos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Allg\u00e4uer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-1000-8052","authenticated-orcid":false,"given":"Klaus","family":"Kluck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-4272-8152","authenticated-orcid":false,"given":"Sebastian","family":"Graf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajkumar","family":"Savai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claus Peter","family":"Heu\u00dfel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hauke","family":"Winter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7638-2506","authenticated-orcid":false,"given":"Felix","family":"Herth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9511-055X","authenticated-orcid":false,"given":"Michael","family":"Thomas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Schirmacher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Kazdal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Budczies","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Albrecht","family":"Stenzinger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4426-2400","authenticated-orcid":false,"given":"Martina","family":"Kirchner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.lungcan.2026.109628_b0005","first-page":"10","article-title":"Cancer statistics, 2025","volume":"75","author":"Siegel","year":"2025","journal-title":"CA Cancer J. Clin."},{"issue":"1","key":"10.1016\/j.lungcan.2026.109628_b0010","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1007\/s40291-021-00563-1","article-title":"Worldwide prevalence of epidermal growth factor receptor mutations in non-small cell lung cancer: a meta-analysis","volume":"26","author":"Melosky","year":"2022","journal-title":"Mol. Diagn. Ther."},{"issue":"2","key":"10.1016\/j.lungcan.2026.109628_b0015","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1056\/NEJMoa2304594","article-title":"Overall Survival with Osimertinib in Resected EGFR-Mutated NSCLC","volume":"389","author":"Tsuboi","year":"2023","journal-title":"N. Engl. J. Med."},{"issue":"31","key":"10.1016\/j.lungcan.2026.109628_b0020","doi-asserted-by":"crossref","first-page":"4045","DOI":"10.2217\/fon-2021-0549","article-title":"Neoadjuvant osimertinib with\/without chemotherapy versus chemotherapy alone for EGFR-mutated resectable non-small-cell lung cancer: NeoADAURA","volume":"17","author":"Tsuboi","year":"2021","journal-title":"Future Oncol."},{"issue":"1","key":"10.1016\/j.lungcan.2026.109628_b0025","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1056\/NEJMoa1913662","article-title":"Overall Survival with Osimertinib in Untreated, EGFR-Mutated Advanced NSCLC","volume":"382","author":"Ramalingam","year":"2020","journal-title":"N. Engl. J. Med."},{"issue":"1","key":"10.1016\/j.lungcan.2026.109628_b0030","doi-asserted-by":"crossref","DOI":"10.1080\/07853890.2025.2574526","article-title":"Precision navigation through the labyrinth: overcoming EGFR resistance in non-small cell lung cancer","volume":"57","author":"Wang","year":"2025","journal-title":"Ann. Med."},{"issue":"7511","key":"10.1016\/j.lungcan.2026.109628_b0035","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1038\/nature13385","article-title":"Comprehensive molecular profiling of lung adenocarcinoma","volume":"511","author":"The Cancer Genome Atlas Research Network","year":"2014","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.lungcan.2026.109628_b0040","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1038\/s41467-017-02584-z","article-title":"Elucidating the genomic architecture of Asian EGFR-mutant lung adenocarcinoma through multi-region exome sequencing","volume":"9","author":"Nahar","year":"2018","journal-title":"Nat. Commun."},{"issue":"5","key":"10.1016\/j.lungcan.2026.109628_b0045","doi-asserted-by":"crossref","first-page":"2883","DOI":"10.21037\/jtd.2020.03.78","article-title":"Impact of concurrent genomic alterations in epidermal growth factor receptor (EGFR)-mutated lung cancer","volume":"12","author":"Gini","year":"2020","journal-title":"J. Thorac. Dis."},{"issue":"7957","key":"10.1016\/j.lungcan.2026.109628_b0050","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1038\/s41586-023-05729-x","article-title":"The evolution of non-small cell lung cancer metastases in TRACERx","volume":"616","author":"Al Bakir","year":"2023","journal-title":"Nature"},{"key":"10.1016\/j.lungcan.2026.109628_b0055","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1038\/s41698-020-00130-7","article-title":"Feasibility and first reports of the MATCH-R repeated biopsy trial at Gustave Roussy","volume":"4","author":"Recondo","year":"2020","journal-title":"npj Precis. Oncol."},{"issue":"50","key":"10.1016\/j.lungcan.2026.109628_b0060","doi-asserted-by":"crossref","first-page":"82013","DOI":"10.18632\/oncotarget.13307","article-title":"Transcriptomic-metabolomic reprogramming in EGFR-mutant NSCLC early adaptive drug escape linking TGF\u03b22-bioenergetics-mitochondrial priming","volume":"7","author":"Thiagarajan","year":"2016","journal-title":"Oncotarget"},{"issue":"6","key":"10.1016\/j.lungcan.2026.109628_b0065","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1038\/s41571-020-0340-z","article-title":"Lineage plasticity in cancer: a shared pathway of therapeutic resistance","volume":"17","author":"Quintanal-Villalonga","year":"2020","journal-title":"Nat. Rev. Clin. Oncol."},{"issue":"1","key":"10.1016\/j.lungcan.2026.109628_b0070","doi-asserted-by":"crossref","first-page":"5120","DOI":"10.1038\/s41467-020-18794-x","article-title":"Concepts of extracellular matrix remodelling in tumour progression and metastasis","volume":"11","author":"Winkler","year":"2020","journal-title":"Nat. Commun."},{"issue":"8","key":"10.1016\/j.lungcan.2026.109628_b0075","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.1038\/s41591-018-0096-5","article-title":"Phenotype molding of stromal cells in the lung tumor microenvironment","volume":"24","author":"Lambrechts","year":"2018","journal-title":"Nat. Med."},{"key":"10.1016\/j.lungcan.2026.109628_b0080","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1007\/978-3-030-34025-4_6","article-title":"Metabolic plasticity of tumor cells: how they do adapt to food deprivation","volume":"1219","author":"Schoonjans","year":"2020","journal-title":"Adv. Exp. Med. Biol."},{"issue":"7753","key":"10.1016\/j.lungcan.2026.109628_b0085","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1038\/s41586-019-1103-9","article-title":"Prioritization of cancer therapeutic targets using CRISPR-Cas9 screens","volume":"568","author":"Behan","year":"2019","journal-title":"Nature"},{"issue":"3","key":"10.1016\/j.lungcan.2026.109628_b0090","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1002\/ijc.32133","article-title":"Combined targeted DNA and RNA sequencing of advanced NSCLC in routine molecular diagnostics: analysis of the first 3,000 Heidelberg cases","volume":"145","author":"Volckmar","year":"2019","journal-title":"Int. J. Cancer."},{"issue":"2","key":"10.1016\/j.lungcan.2026.109628_b0095","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.jtho.2025.10.010","article-title":"Advancing lung cancer staging: integrating IASLC recommendations and bioinformatics to delineate tumor origins","volume":"21","author":"Allg\u00e4uer","year":"2026","journal-title":"J. Thorac. Oncol."},{"issue":"3","key":"10.1016\/j.lungcan.2026.109628_b0100","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1021\/acs.jproteome.5b01091","article-title":"A description of the clinical proteomic tumor analysis consortium (CPTAC) common data analysis pipeline","volume":"15","author":"Rudnick","year":"2016","journal-title":"J. Proteome Res."},{"issue":"12","key":"10.1016\/j.lungcan.2026.109628_b0105","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1186\/s13059-014-0550-8","article-title":"Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2","volume":"15","author":"Love","year":"2014","journal-title":"Genome Biol."},{"issue":"1","key":"10.1016\/j.lungcan.2026.109628_b0110","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1186\/s13059-016-1070-5","article-title":"Estimating thepopulation abundance of tissue-infiltrating immune and stromal cell populations using gene expression","volume":"17","author":"Becht","year":"2016","journal-title":"Genome Biol."},{"issue":"5","key":"10.1016\/j.lungcan.2026.109628_b0115","doi-asserted-by":"crossref","first-page":"1","DOI":"10.18637\/jss.v039.i05","article-title":"Regularization Paths for Cox's Proportional Hazards Model via Coordinate Descent","volume":"39","author":"Simon","year":"2011","journal-title":"J. Stat. Softw."},{"issue":"1","key":"10.1016\/j.lungcan.2026.109628_b0125","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1097\/JTO.0000000000000042","article-title":"Validation of a histology-independent prognostic gene signature for early-stage, non\u2013small-cell lung cancer including stage IA patients","volume":"9","author":"Der","year":"2014","journal-title":"J. Thorac. Oncol."},{"key":"10.1016\/j.lungcan.2026.109628_b0120","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1186\/s40425-017-0215-8","article-title":"Gene expression markers of tumor infiltrating leukocytes","volume":"5","author":"Danaher","year":"2017","journal-title":"J. Immunother. Cancer"},{"issue":"7957","key":"10.1016\/j.lungcan.2026.109628_b0130","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1038\/s41586-023-05783-5","article-title":"The evolution of lung cancer and impact of subclonal selection in TRACERx","volume":"616","author":"Frankell","year":"2023","journal-title":"Nature"},{"issue":"2","key":"10.1016\/j.lungcan.2026.109628_b0135","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1038\/s41571-024-00971-2","article-title":"The changing treatment landscape of EGFR-mutant non-small-cell lung cancer","volume":"22","author":"Zhou","year":"2025","journal-title":"Nat. Rev. Clin. Oncol."},{"issue":"7957","key":"10.1016\/j.lungcan.2026.109628_b0140","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1038\/s41586-023-05706-4","article-title":"Genomic\u2013transcriptomic evolution in lung cancer and metastasis","volume":"616","author":"Mart\u00ednez-Ruiz","year":"2023","journal-title":"Nature"},{"key":"10.1016\/j.lungcan.2026.109628_b0145","doi-asserted-by":"crossref","DOI":"10.1016\/j.canlet.2026.218246","article-title":"Unraveling stress-adaptation pathways in cancer: Functional dissection through CRISPR-based genetic screens","volume":"644","author":"Mokhles","year":"2026","journal-title":"Cancer Lett."},{"issue":"1","key":"10.1016\/j.lungcan.2026.109628_b0150","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1007\/s44162-026-00147-9","article-title":"Metabolic reprogramming in non-small cell lung cancer: unraveling therapeutic vulnerabilities and resistance mechanisms","volume":"5","author":"Addissouky","year":"2026","journal-title":"J. Rare Diseases"},{"issue":"8099","key":"10.1016\/j.lungcan.2026.109628_b0155","doi-asserted-by":"crossref","first-page":"1292","DOI":"10.1038\/s41586-025-09898-9","article-title":"Nutrient requirements of organ-specific metastasis in breast cancer","volume":"649","author":"Abbott","year":"2026","journal-title":"Nature"},{"key":"10.1016\/j.lungcan.2026.109628_b0160","doi-asserted-by":"crossref","DOI":"10.1016\/j.tranon.2023.101813","article-title":"Tumor-infiltrating platelets promote the growth of lung adenocarcinoma","volume":"39","author":"Li","year":"2024","journal-title":"Transl. Oncol."},{"key":"10.1016\/j.lungcan.2026.109628_b0165","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2022.876051","article-title":"Platelet activation in High D-dimer plasma plays a role in acquired resistance to epidermal growth factor receptor tyrosine kinase inhibitors in patients with mutant lung adenocarcinoma","volume":"12","author":"Lee","year":"2022","journal-title":"Front. Oncol."},{"issue":"1","key":"10.1016\/j.lungcan.2026.109628_b0170","doi-asserted-by":"crossref","first-page":"1152","DOI":"10.1186\/s12885-020-07650-2","article-title":"Effects of reduced platelet count on the prognosis for patients with non-small cell lung cancer treated with EGFR-TKI: a retrospective study","volume":"20","author":"Xu","year":"2020","journal-title":"BMC Cancer"},{"issue":"1","key":"10.1016\/j.lungcan.2026.109628_b0175","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1007\/s13402-025-01143-9","article-title":"Spatially resolved whole-transcriptomic profiling of EGFR-mutated lung adenocarcinomas stratified by PD-L1 expression","volume":"49","author":"Yu","year":"2025","journal-title":"Cell. Oncol."},{"issue":"4","key":"10.1016\/j.lungcan.2026.109628_b0180","doi-asserted-by":"crossref","DOI":"10.1111\/1759-7714.70025","article-title":"A novel DNA repair-gene model to predict responses to Immunotherapy and Prognosis in patients with EGFR-mutant non-small cell lung cancer","volume":"16","author":"Wang","year":"2025","journal-title":"Thorac Cancer"},{"issue":"1","key":"10.1016\/j.lungcan.2026.109628_b0185","doi-asserted-by":"crossref","first-page":"37596","DOI":"10.1038\/s41598-025-20159-7","article-title":"Integrated machine learning survival framework for consensus modeling in a large multicenter cohort of NSCLC resistant to aumolertinib","volume":"15","author":"Wu","year":"2025","journal-title":"Sci. Rep."},{"issue":"10","key":"10.1016\/j.lungcan.2026.109628_b0190","doi-asserted-by":"crossref","first-page":"e1431","DOI":"10.1002\/ctm2.1431","article-title":"Integrated analysis of EGFR mutated non-small cell lung cancer reveals two distinct molecular subtypes","volume":"13","author":"Bai","year":"2023","journal-title":"Clin. Transl. Med."},{"issue":"1","key":"10.1016\/j.lungcan.2026.109628_b0195","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1038\/s41698-024-00736-1","article-title":"ERO1A levels are a prognostic indicator in EGFR mutated non small cell lung cancer","volume":"8","author":"Voronkova","year":"2024","journal-title":"npj Precis. Oncol."},{"issue":"1","key":"10.1016\/j.lungcan.2026.109628_b0200","doi-asserted-by":"crossref","first-page":"10164","DOI":"10.1038\/s41467-024-54434-4","article-title":"Proteogenomic analysis reveals non-small cell lung cancer subtypes predicting chromosome instability, and tumor microenvironment","volume":"15","author":"Song","year":"2024","journal-title":"Nat. Commun."},{"issue":"6","key":"10.1016\/j.lungcan.2026.109628_b0205","doi-asserted-by":"crossref","DOI":"10.1016\/j.heliyon.2025.e43007","article-title":"Robust prognostic biomarkers and a risk prediction model specific to EGFR-mutated lung adenocarcinoma patients via multicohort meta-analysis","volume":"11","author":"Park","year":"2025","journal-title":"Heliyon"}],"container-title":["Lung Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0169500226006896?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0169500226006896?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T23:52:25Z","timestamp":1793922745000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0169500226006896"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,11]]},"references-count":41,"alternative-id":["S0169500226006896"],"URL":"https:\/\/doi.org\/10.1016\/j.lungcan.2026.109628","relation":{},"ISSN":["0169-5002"],"issn-type":[{"value":"0169-5002","type":"print"}],"subject":[],"published":{"date-parts":[[2026,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Longitudinal transcriptomic profiling of paired early and metastatic EGFR-mutant lung adenocarcinomas reveals molecular programs associated with disease progression","name":"articletitle","label":"Article Title"},{"value":"Lung Cancer","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.lungcan.2026.109628","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"109628"}}