{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T23:03:37Z","timestamp":1773270217809,"version":"3.50.1"},"reference-count":25,"publisher":"Elsevier BV","issue":"11","license":[{"start":{"date-parts":[[2005,11,1]],"date-time":"2005-11-01T00:00:00Z","timestamp":1130803200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mechanisms of Ageing and Development"],"published-print":{"date-parts":[[2005,11]]},"DOI":"10.1016\/j.mad.2005.06.010","type":"journal-article","created":{"date-parts":[[2005,8,9]],"date-time":"2005-08-09T07:30:18Z","timestamp":1123572618000},"page":"1201-1205","source":"Crossref","is-referenced-by-count":24,"title":["LRRK2 mutations are not common in Alzheimer's disease"],"prefix":"10.1016","volume":"126","author":[{"given":"Mathias","family":"Toft","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sigrid Botne","family":"Sando","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stacey","family":"Melquist","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Owen A.","family":"Ross","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Linda R.","family":"White","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan O.","family":"Aasly","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew J.","family":"Farrer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.mad.2005.06.010_bib1","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1002\/ana.20456","article-title":"Clinical features of LRRK2-associated Parkinson's disease in central Norway","volume":"57","author":"Aasly","year":"2005","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.mad.2005.06.010_bib2","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1002\/(SICI)1099-1166(199706)12:6<619::AID-GPS554>3.0.CO;2-H","article-title":"The Clock Drawing Test for dementia of the Alzheimer's type: a comparison of three scoring methods in a memory disorders clinic","volume":"12","author":"Brodaty","year":"1997","journal-title":"Int. J. Geriatr. Psychiatry"},{"key":"10.1016\/j.mad.2005.06.010_bib3","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1126\/science.8346443","article-title":"Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families","volume":"261","author":"Corder","year":"1993","journal-title":"Science"},{"key":"10.1016\/j.mad.2005.06.010_bib4","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1016\/S0140-6736(05)17829-5","article-title":"A frequent LRRK2 gene mutation associated with autosomal dominant Parkinson's disease","volume":"365","author":"Di Fonzo","year":"2005","journal-title":"Lancet"},{"key":"10.1016\/j.mad.2005.06.010_bib5","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1038\/nm1113","article-title":"Neurodegenerative diseases: a decade of discoveries paves the way for therapeutic breakthroughs","volume":"10","author":"Forman","year":"2005","journal-title":"Nat. Med."},{"key":"10.1016\/j.mad.2005.06.010_bib6","first-page":"415","article-title":"A common LRRK2 mutation in idiopathic Parkinson's disease","volume":"365","author":"Gilks","year":"2005","journal-title":"Lancet"},{"key":"10.1016\/j.mad.2005.06.010_bib7","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1017\/S0033291700005742","article-title":"The Informant Questionnaire on Cognitive Decline in the Elderly (IQCODE): socio-demographic correlates, reliability, validity and some norms","volume":"19","author":"Jorm","year":"1989","journal-title":"Psychol. Med."},{"key":"10.1016\/j.mad.2005.06.010_bib8","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1086\/429256","article-title":"Identification of a novel LRRK2 mutation linked to autosomal dominant Parkinsonism: evidence of a common founder across European populations","volume":"76","author":"Kachergus","year":"2005","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.mad.2005.06.010_bib9","doi-asserted-by":"crossref","first-page":"2901","DOI":"10.1001\/jama.292.23.2901","article-title":"Mixed dementia: emerging concepts and therapeutic implications","volume":"292","author":"Langa","year":"2004","journal-title":"JAMA"},{"key":"10.1016\/j.mad.2005.06.010_bib10","doi-asserted-by":"crossref","first-page":"1854","DOI":"10.1212\/WNL.55.12.1854","article-title":"Research evaluation and diagnosis of probable Alzheimer's disease over the last two decades: I","volume":"55","author":"Lopez","year":"2000","journal-title":"Neurology"},{"key":"10.1016\/j.mad.2005.06.010_bib11","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/S1474-4422(03)00619-7","article-title":"Dementia with Lewy bodies","volume":"3","author":"McKeith","year":"2004","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.mad.2005.06.010_bib12","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1212\/WNL.47.5.1113","article-title":"Consensus guidelines for the clinical and pathologic diagnosis of dementia with Lewy bodies (DLB): report of the consortium on DLB international workshop","volume":"47","author":"McKeith","year":"1996","journal-title":"Neurology"},{"key":"10.1016\/j.mad.2005.06.010_bib13","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1212\/WNL.34.7.939","article-title":"Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease","volume":"34","author":"McKhann","year":"1984","journal-title":"Neurology"},{"key":"10.1016\/j.mad.2005.06.010_bib14","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1192\/bjp.134.4.382","article-title":"A new depression scale designed to be sensitive to change","volume":"134","author":"Montgomery","year":"1979","journal-title":"Br. J. Psychiatry"},{"key":"10.1016\/j.mad.2005.06.010_bib15","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1097\/00019052-200108000-00002","article-title":"The genetics of late-onset Alzheimer's disease","volume":"14","author":"Myers","year":"2001","journal-title":"Curr. Opin. Neurol."},{"key":"10.1016\/j.mad.2005.06.010_bib16","first-page":"410","article-title":"Genetic screening for a single common LRRK2 mutation in familial Parkinson's disease","volume":"365","author":"Nichols","year":"2005","journal-title":"Lancet"},{"key":"10.1016\/j.mad.2005.06.010_bib17","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1016\/j.neuron.2004.10.023","article-title":"Cloning of the gene containing mutations that cause PARK8-linked Parkinson's disease","volume":"44","author":"Paisan-Ruiz","year":"2004","journal-title":"Neuron"},{"key":"10.1016\/j.mad.2005.06.010_bib18","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.1001\/jama.1997.03550150041033","article-title":"Complete genomic screen in late-onset familial Alzheimer disease. Evidence for a new locus on chromosome 12","volume":"278","author":"Pericak-Vance","year":"1997","journal-title":"JAMA"},{"issue":"Suppl.","key":"10.1016\/j.mad.2005.06.010_bib19","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1038\/nm1066","article-title":"Protein aggregation and neurodegenerative disease","volume":"10","author":"Ross","year":"2004","journal-title":"Nat. Med."},{"key":"10.1016\/j.mad.2005.06.010_bib20","doi-asserted-by":"crossref","first-page":"922","DOI":"10.1086\/302828","article-title":"Fine mapping of the chromosome 12 late-onset Alzheimer disease locus: potential genetic and phenotypic heterogeneity","volume":"66","author":"Scott","year":"2000","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.mad.2005.06.010_bib21","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1038\/42166","article-title":"Alpha-synuclein in Lewy bodies","volume":"388","author":"Spillantini","year":"1997","journal-title":"Nature"},{"key":"10.1016\/j.mad.2005.06.010_bib22","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1136\/jnnp.57.4.416","article-title":"Clinical and neuropathological criteria for frontotemporal dementia","volume":"57","year":"1994","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"10.1016\/j.mad.2005.06.010_bib23","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.1016\/S0140-6736(05)74809-1","article-title":"LRRK2 mutations and Parkinsonism","volume":"365","author":"Toft","year":"2005","journal-title":"Lancet"},{"key":"10.1016\/j.mad.2005.06.010_bib24","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/S1353-8020(97)00013-8","article-title":"German\u2013Canadian family (family A) with Parkinsonism, amyotrophy, and dementia: longitudinal observations","volume":"3","author":"Wszolek","year":"1997","journal-title":"Parkinsonism Relat. Disord."},{"key":"10.1016\/j.mad.2005.06.010_bib25","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1016\/j.neuron.2004.11.005","article-title":"Mutations in LRRK2 cause autosomal-dominant Parkinsonism with pleomorphic pathology","volume":"44","author":"Zimprich","year":"2004","journal-title":"Neuron"}],"container-title":["Mechanisms of Ageing and Development"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0047637405001491?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0047637405001491?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,3,13]],"date-time":"2019-03-13T04:35:25Z","timestamp":1552451725000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0047637405001491"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,11]]},"references-count":25,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2005,11]]}},"alternative-id":["S0047637405001491"],"URL":"https:\/\/doi.org\/10.1016\/j.mad.2005.06.010","relation":{},"ISSN":["0047-6374"],"issn-type":[{"value":"0047-6374","type":"print"}],"subject":[],"published":{"date-parts":[[2005,11]]}}}