{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T23:28:58Z","timestamp":1782343738381,"version":"3.54.5"},"reference-count":14,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2005,12,1]],"date-time":"2005-12-01T00:00:00Z","timestamp":1133395200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2005,12,1]],"date-time":"2005-12-01T00:00:00Z","timestamp":1133395200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Mechanisms of Ageing and Development"],"published-print":{"date-parts":[[2005,12]]},"DOI":"10.1016\/j.mad.2005.07.007","type":"journal-article","created":{"date-parts":[[2005,9,7]],"date-time":"2005-09-07T15:11:20Z","timestamp":1126105880000},"page":"1274-1283","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":112,"title":["Regulation of multiple ageing-like phenotypes by inducible klotho gene expression in klotho mutant mice"],"prefix":"10.1016","volume":"126","author":[{"given":"Hiroaki","family":"Masuda","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hirotaka","family":"Chikuda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatsuo","family":"Suga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Kawaguchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Makoto","family":"Kuro-o","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.mad.2005.07.007_bib1","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1073\/pnas.022484299","article-title":"Association of human aging with a functional variant of klotho","volume":"99","author":"Arking","year":"2002","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.mad.2005.07.007_bib2","doi-asserted-by":"crossref","first-page":"1154","DOI":"10.1086\/375035","article-title":"KLOTHO allele status and the risk of early-onset occult coronary artery disease","volume":"72","author":"Arking","year":"2003","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.mad.2005.07.007_bib3","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1161\/01.RES.0000157171.04054.30","article-title":"Association between a functional variant of the KLOTHO gene and high-density lipoprotein cholesterol, blood pressure, stroke, and longevity","volume":"96","author":"Arking","year":"2005","journal-title":"Circ. Res."},{"key":"10.1016\/j.mad.2005.07.007_bib4","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1006\/bbrc.1999.2009","article-title":"Establishment of the anti-Klotho monoclonal antibodies and detection of Klotho protein in kidneys","volume":"267","author":"Kato","year":"2000","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.mad.2005.07.007_bib5","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1172\/JCI5705","article-title":"Independent impairment of osteoblast and osteoclast differentiation in klotho mouse exhibiting low-turnover osteopenia","volume":"104","author":"Kawaguchi","year":"1999","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.mad.2005.07.007_bib6","doi-asserted-by":"crossref","first-page":"1744","DOI":"10.1359\/jbmr.2002.17.10.1744","article-title":"Klotho gene polymorphisms associated with bone density of aged postmenopausal women","volume":"17","author":"Kawano","year":"2002","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.mad.2005.07.007_bib7","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1038\/36285","article-title":"Mutation of the mouse klotho gene leads to a syndrome resembling ageing","volume":"390","author":"Kuro-o","year":"1997","journal-title":"Nature"},{"key":"10.1016\/j.mad.2005.07.007_bib8","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1006\/bbrc.1997.8019","article-title":"Identification of the human klotho gene and its two transcripts encoding membrane and secreted klotho protein","volume":"242","author":"Matsumura","year":"1998","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.mad.2005.07.007_bib9","series-title":"Pathology of the fisher rat","first-page":"31","article-title":"Salivary glands","author":"Neuenschwander","year":"1990"},{"key":"10.1016\/j.mad.2005.07.007_bib10","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/S8756-3282(02)00786-X","article-title":"Association of klotho gene polymorphism with bone density and spondylosis of the lumbar spine in postmenopausal women","volume":"31","author":"Ogata","year":"2002","journal-title":"Bone"},{"key":"10.1016\/j.mad.2005.07.007_bib11","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1006\/bbrc.1998.8943","article-title":"Klotho protein protects against endothelial dysfunction","volume":"248","author":"Saito","year":"1998","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.mad.2005.07.007_bib12","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1006\/bbrc.2000.3470","article-title":"In vivo klotho gene delivery protects against endothelial dysfunction in multiple risk factor syndrome","volume":"276","author":"Saito","year":"2000","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.mad.2005.07.007_bib13","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1042\/bj2810829","article-title":"Two glucose transporter isoforms are sorted differentially and are expressed in distinct cellular compartments","volume":"281","author":"Shibasaki","year":"1992","journal-title":"Biochem. J."},{"key":"10.1016\/j.mad.2005.07.007_bib14","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/S0014-5793(98)00127-6","article-title":"Structure of the mouse klotho gene and its two transcripts encoding membrane and secreted protein","volume":"424","author":"Shiraki-Iida","year":"1998","journal-title":"FEBS Lett."}],"container-title":["Mechanisms of Ageing and Development"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0047637405001752?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0047637405001752?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T06:27:46Z","timestamp":1758608866000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0047637405001752"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,12]]},"references-count":14,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2005,12]]}},"alternative-id":["S0047637405001752"],"URL":"https:\/\/doi.org\/10.1016\/j.mad.2005.07.007","relation":{},"ISSN":["0047-6374"],"issn-type":[{"value":"0047-6374","type":"print"}],"subject":[],"published":{"date-parts":[[2005,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Regulation of multiple ageing-like phenotypes by inducible klotho gene expression in klotho mutant mice","name":"articletitle","label":"Article Title"},{"value":"Mechanisms of Ageing and Development","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mad.2005.07.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2005 Elsevier Ireland Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}