{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T15:39:56Z","timestamp":1791214796660,"version":"4.1.0"},"reference-count":125,"publisher":"Elsevier BV","issue":"7-8","license":[{"start":{"date-parts":[[2008,7,1]],"date-time":"2008-07-01T00:00:00Z","timestamp":1214870400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mechanisms of Ageing and Development"],"published-print":{"date-parts":[[2008,7]]},"DOI":"10.1016\/j.mad.2008.03.008","type":"journal-article","created":{"date-parts":[[2008,3,26]],"date-time":"2008-03-26T13:32:24Z","timestamp":1206538344000},"page":"483-491","source":"Crossref","is-referenced-by-count":77,"title":["DNA strand breaks, neurodegeneration and aging in the brain"],"prefix":"10.1016","volume":"129","author":[{"given":"Sachin","family":"Katyal","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter J.","family":"McKinnon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"7112","key":"10.1016\/j.mad.2008.03.008_bib1","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1038\/nature05164","article-title":"The neurodegenerative disease protein aprataxin resolves abortive DNA ligation intermediates","volume":"443","author":"Ahel","year":"2006","journal-title":"Nature"},{"issue":"2","key":"10.1016\/j.mad.2008.03.008_bib2","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/j.cell.2005.12.031","article-title":"XLF interacts with the XRCC4-DNA ligase IV complex to promote DNA nonhomologous end-joining","volume":"124","author":"Ahnesorg","year":"2006","journal-title":"Cell"},{"issue":"6","key":"10.1016\/j.mad.2008.03.008_bib3","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1016\/j.molcel.2007.10.024","article-title":"Crystal structure of human XLF: a twist in nonhomologous DNA end-joining","volume":"28","author":"Andres","year":"2007","journal-title":"Mol. Cell"},{"issue":"1","key":"10.1016\/j.mad.2008.03.008_bib4","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/S0092-8674(00)80086-0","article-title":"Atm-deficient mice: a paradigm of ataxia-telangiectasia","volume":"86","author":"Barlow","year":"1996","journal-title":"Cell"},{"issue":"25","key":"10.1016\/j.mad.2008.03.008_bib5","doi-asserted-by":"crossref","first-page":"1395","DOI":"10.1016\/S0960-9822(98)00021-9","article-title":"Targeted disruption of the gene encoding DNA ligase IV leads to lethality in embryonic mice","volume":"8","author":"Barnes","year":"1998","journal-title":"Curr. Biol."},{"issue":"2","key":"10.1016\/j.mad.2008.03.008_bib6","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1089\/ars.2007.9.211","article-title":"The contribution of the DNA damage response to neuronal viability","volume":"9","author":"Barzilai","year":"2007","journal-title":"Antioxid. Redox. Signal."},{"issue":"2","key":"10.1016\/j.mad.2008.03.008_bib7","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1038\/5669","article-title":"Neurotrophin-3 is required for proper cerebellar development","volume":"2","author":"Bates","year":"1999","journal-title":"Nat. Neurosci."},{"issue":"5","key":"10.1016\/j.mad.2008.03.008_bib8","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1038\/ng1769","article-title":"High levels of mitochondrial DNA deletions in substantia nigra neurons in aging and Parkinson disease","volume":"38","author":"Bender","year":"2006","journal-title":"Nat. Genet."},{"issue":"8","key":"10.1016\/j.mad.2008.03.008_bib9","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1038\/nrg1656","article-title":"Telomeres and human disease: ageing, cancer and beyond","volume":"6","author":"Blasco","year":"2005","journal-title":"Nat. Rev. Genet."},{"issue":"7","key":"10.1016\/j.mad.2008.03.008_bib10","doi-asserted-by":"crossref","first-page":"3336","DOI":"10.1073\/pnas.97.7.3336","article-title":"Abnormal development of Purkinje cells and lymphocytes in Atm mutant mice","volume":"97","author":"Borghesani","year":"2000","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"issue":"5","key":"10.1016\/j.mad.2008.03.008_bib11","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1101\/gad.1067403","article-title":"Essential and dispensable roles of ATR in cell cycle arrest and genome maintenance","volume":"17","author":"Brown","year":"2003","journal-title":"Genes Dev."},{"issue":"2","key":"10.1016\/j.mad.2008.03.008_bib12","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/j.cell.2005.12.030","article-title":"Cernunnos, a novel nonhomologous end-joining factor, is mutated in human immunodeficiency with microcephaly","volume":"124","author":"Buck","year":"2006","journal-title":"Cell"},{"issue":"9","key":"10.1016\/j.mad.2008.03.008_bib13","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1016\/S1568-7864(03)00118-6","article-title":"XRCC1 and DNA strand break repair","volume":"2","author":"Caldecott","year":"2003","journal-title":"DNA Repair"},{"issue":"24","key":"10.1016\/j.mad.2008.03.008_bib14","doi-asserted-by":"crossref","first-page":"6610","DOI":"10.1093\/emboj\/cdg630","article-title":"The Mre11 complex is required for ATM activation and the G2\/M checkpoint","volume":"22","author":"Carson","year":"2003","journal-title":"EMBO J."},{"issue":"3","key":"10.1016\/j.mad.2008.03.008_bib15","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/j.freeradbiomed.2006.11.009","article-title":"Accumulation of oxidatively generated DNA damage in the brain: a mechanism of neurotoxicity","volume":"42","author":"Chen","year":"2007","journal-title":"Free Radic. Biol. Med."},{"issue":"11","key":"10.1016\/j.mad.2008.03.008_bib16","doi-asserted-by":"crossref","first-page":"1493","DOI":"10.1016\/j.dnarep.2004.06.017","article-title":"The ataxia-oculomotor apraxia 1 gene product has a role distinct from ATM and interacts with the DNA strand break repair proteins XRCC1 and XRCC4","volume":"3","author":"Clements","year":"2004","journal-title":"DNA Repair"},{"issue":"2","key":"10.1016\/j.mad.2008.03.008_bib17","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1038\/ng1001-184","article-title":"Early-onset ataxia with ocular motor apraxia and hypoalbuminemia is caused by mutations in a new HIT superfamily gene","volume":"29","author":"Date","year":"2001","journal-title":"Nat. Genet."},{"issue":"56","key":"10.1016\/j.mad.2008.03.008_bib18","doi-asserted-by":"crossref","first-page":"7792","DOI":"10.1038\/sj.onc.1210876","article-title":"The clinical manifestation of a defective response to DNA double-strand breaks as exemplified by Nijmegen breakage syndrome","volume":"26","author":"Demuth","year":"2007","journal-title":"Oncogene"},{"issue":"20","key":"10.1016\/j.mad.2008.03.008_bib19","doi-asserted-by":"crossref","first-page":"2385","DOI":"10.1093\/hmg\/ddh278","article-title":"An inducible null mutant murine model of Nijmegen breakage syndrome proves the essential function of NBS1 in chromosomal stability and cell viability","volume":"13","author":"Demuth","year":"2004","journal-title":"Hum. Mol. Genet."},{"issue":"7","key":"10.1016\/j.mad.2008.03.008_bib20","first-page":"S9","article-title":"The age of cancer: telomeres, checkpoints, and longevity","volume":"111","author":"DePinho","year":"2003","journal-title":"J. Clin. Invest."},{"issue":"7","key":"10.1016\/j.mad.2008.03.008_bib21","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1038\/ncb1270","article-title":"Role of Nbs1 in the activation of the Atm kinase revealed in humanized mouse models","volume":"7","author":"Difilippantonio","year":"2005","journal-title":"Nat. Cell. Biol."},{"issue":"4","key":"10.1016\/j.mad.2008.03.008_bib22","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1038\/ng1297-431","article-title":"Rapid accumulation of genome rearrangements in liver but not in brain of old mice","volume":"17","author":"Dolle","year":"1997","journal-title":"Nat. Genet."},{"issue":"21","key":"10.1016\/j.mad.2008.03.008_bib23","first-page":"7263","article-title":"Nbn heterozygosity renders mice susceptible to tumor formation and ionizing radiation-induced tumorigenesis","volume":"63","author":"Dumon-Jones","year":"2003","journal-title":"Cancer Res."},{"issue":"4","key":"10.1016\/j.mad.2008.03.008_bib24","doi-asserted-by":"crossref","first-page":"1260","DOI":"10.1016\/j.neuroscience.2006.08.048","article-title":"DNA single-strand break repair and spinocerebellar ataxia with axonal neuropathy-1","volume":"145","author":"el-Khamisy","year":"2007","journal-title":"Neuroscience"},{"issue":"7029","key":"10.1016\/j.mad.2008.03.008_bib25","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1038\/nature03314","article-title":"Defective DNA single-strand break repair in spinocerebellar ataxia with axonal neuropathy-1","volume":"434","author":"El-Khamisy","year":"2005","journal-title":"Nature"},{"issue":"23","key":"10.1016\/j.mad.2008.03.008_bib26","doi-asserted-by":"crossref","first-page":"13084","DOI":"10.1073\/pnas.93.23.13084","article-title":"Pleiotropic defects in ataxia-telangiectasia protein-deficient mice","volume":"93","author":"Elson","year":"1996","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"issue":"49","key":"10.1016\/j.mad.2008.03.008_bib27","doi-asserted-by":"crossref","first-page":"17312","DOI":"10.1073\/pnas.0407162101","article-title":"Accelerated telomere shortening in response to life stress","volume":"101","author":"Epel","year":"2004","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"issue":"3","key":"10.1016\/j.mad.2008.03.008_bib28","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.psyneuen.2005.08.011","article-title":"Cell aging in relation to stress arousal and cardiovascular disease risk factors","volume":"31","author":"Epel","year":"2006","journal-title":"Psychoneuroendocrinology"},{"issue":"20","key":"10.1016\/j.mad.2008.03.008_bib29","doi-asserted-by":"crossref","first-page":"10887","DOI":"10.1073\/pnas.93.20.10887","article-title":"Ligand-activated site-specific recombination in mice","volume":"93","author":"Feil","year":"1996","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"issue":"6","key":"10.1016\/j.mad.2008.03.008_bib30","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1016\/S1097-2765(00)80264-6","article-title":"DNA ligase IV deficiency in mice leads to defective neurogenesis and embryonic lethality via the p53 pathway","volume":"5","author":"Frank","year":"2000","journal-title":"Mol. Cell"},{"issue":"11","key":"10.1016\/j.mad.2008.03.008_bib31","doi-asserted-by":"crossref","first-page":"2732","DOI":"10.1038\/sj.emboj.7601703","article-title":"BRCA2 is required for neurogenesis and suppression of medulloblastoma","volume":"26","author":"Frappart","year":"2007","journal-title":"EMBO J."},{"issue":"4","key":"10.1016\/j.mad.2008.03.008_bib32","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1385\/NMM:8:4:495","article-title":"Ataxia-telangiectasia and related diseases","volume":"8","author":"Frappart","year":"2006","journal-title":"Neuromol. Med."},{"issue":"5","key":"10.1016\/j.mad.2008.03.008_bib33","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1038\/nm1228","article-title":"An essential function for NBS1 in the prevention of ataxia and cerebellar defects","volume":"11","author":"Frappart","year":"2005","journal-title":"Nat. Med."},{"issue":"2","key":"10.1016\/j.mad.2008.03.008_bib34","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.dnarep.2005.09.009","article-title":"Database of mouse strains carrying targeted mutations in genes affecting biological responses to DNA damage version 7","volume":"5","author":"Friedberg","year":"2006","journal-title":"DNA Repair"},{"issue":"7","key":"10.1016\/j.mad.2008.03.008_bib35","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1016\/S0092-8674(00)81714-6","article-title":"A critical role for DNA end-joining proteins in both lymphogenesis and neurogenesis","volume":"95","author":"Gao","year":"1998","journal-title":"Cell"},{"issue":"2","key":"10.1016\/j.mad.2008.03.008_bib36","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/S1084-9521(02)00019-8","article-title":"Getting around lethality with inducible Cre-mediated excision","volume":"13","author":"Garcia","year":"2002","journal-title":"Semin. Cell Dev. Biol."},{"issue":"3","key":"10.1016\/j.mad.2008.03.008_bib37","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1016\/j.pharmthera.2006.12.003","article-title":"Conditional gene targeting in the mouse nervous system: insights into brain function and diseases","volume":"113","author":"Gaveriaux-Ruff","year":"2007","journal-title":"Pharmacol. Ther."},{"issue":"20","key":"10.1016\/j.mad.2008.03.008_bib38","doi-asserted-by":"crossref","first-page":"2369","DOI":"10.1093\/hmg\/ddh274","article-title":"Analysis of DNA ligase IV mutations found in LIG4 syndrome patients: the impact of two linked polymorphisms","volume":"13","author":"Girard","year":"2004","journal-title":"Hum. Mol. Genet."},{"issue":"9","key":"10.1016\/j.mad.2008.03.008_bib39","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/S0166-2236(98)01313-7","article-title":"The cells and molecules that make a cerebellum","volume":"21","author":"Goldowitz","year":"1998","journal-title":"Trends Neurosci."},{"issue":"2","key":"10.1016\/j.mad.2008.03.008_bib40","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1086\/303023","article-title":"Autozygosity mapping of a Seckel syndrome locus to chromosome 3q22. 1-q24","volume":"67","author":"Goodship","year":"2000","journal-title":"Am. J. Hum. Genet."},{"issue":"22","key":"10.1016\/j.mad.2008.03.008_bib41","doi-asserted-by":"crossref","first-page":"7466","DOI":"10.1093\/nar\/gkm756","article-title":"Changes in DNA repair during aging","volume":"35","author":"Gorbunova","year":"2007","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.mad.2008.03.008_bib42","article-title":"Mutations in pericentrin cause Seckel syndrome with defective ATR-dependent DNA damage signaling","author":"Griffith","year":"2007","journal-title":"Nat. Genet."},{"issue":"1\u20132","key":"10.1016\/j.mad.2008.03.008_bib43","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.abb.2006.02.018","article-title":"Studies on genomic DNA topology and stability in brain regions of Parkinson's disease","volume":"449","author":"Hegde","year":"2006","journal-title":"Arch. Biochem. Biophys."},{"issue":"7","key":"10.1016\/j.mad.2008.03.008_bib44","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1016\/j.dnarep.2007.02.006","article-title":"DNA double-strand break repair: from mechanistic understanding to cancer treatment","volume":"6","author":"Helleday","year":"2007","journal-title":"DNA Repair"},{"issue":"5366","key":"10.1016\/j.mad.2008.03.008_bib45","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1126\/science.280.5366.1089","article-title":"Requirement for Atm in ionizing radiation-induced cell death in the developing central nervous system","volume":"280","author":"Herzog","year":"1998","journal-title":"Science"},{"issue":"22","key":"10.1016\/j.mad.2008.03.008_bib46","doi-asserted-by":"crossref","first-page":"4732","DOI":"10.1038\/sj.emboj.7601885","article-title":"Spinocerebellar ataxia with axonal neuropathy: consequence of a Tdp1 recessive neomorphic mutation?","volume":"26","author":"Hirano","year":"2007","journal-title":"EMBO J."},{"issue":"8","key":"10.1016\/j.mad.2008.03.008_bib47","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1016\/j.neurobiolaging.2005.06.002","article-title":"Mitochondrial and nuclear DNA-repair capacity of various brain regions in mouse is altered in an age-dependent manner","volume":"27","author":"Imam","year":"2006","journal-title":"Neurobiol. Aging"},{"issue":"3","key":"10.1016\/j.mad.2008.03.008_bib48","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1093\/gerona\/58.3.B205","article-title":"Age-related base excision repair activity in mouse brain and liver nuclear extracts","volume":"58","author":"Intano","year":"2003","journal-title":"J. Gerontol."},{"issue":"1","key":"10.1016\/j.mad.2008.03.008_bib49","first-page":"1","article-title":"Deficiency of the Mre11 DNA repair complex in Alzheimer's disease brains","volume":"128","author":"Jacobsen","year":"2004","journal-title":"Brain Res."},{"key":"10.1016\/j.mad.2008.03.008_bib50","series-title":"Developmental Neurobiology","author":"Jacobsen","year":"1991"},{"issue":"4","key":"10.1016\/j.mad.2008.03.008_bib51","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1038\/nrc777","article-title":"Conditional mouse models of sporadic cancer","volume":"2","author":"Jonkers","year":"2002","journal-title":"Nat. Rev. Cancer"},{"issue":"6","key":"10.1016\/j.mad.2008.03.008_bib52","doi-asserted-by":"crossref","first-page":"1447","DOI":"10.1093\/emboj\/21.6.1447","article-title":"Targeted disruption of NBS1 reveals its roles in mouse development and DNA repair","volume":"21","author":"Kang","year":"2002","journal-title":"EMBO J."},{"issue":"7015","key":"10.1016\/j.mad.2008.03.008_bib53","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1038\/nature03097","article-title":"Cell-cycle checkpoints and cancer","volume":"432","author":"Kastan","year":"2004","journal-title":"Nature"},{"issue":"22","key":"10.1016\/j.mad.2008.03.008_bib54","doi-asserted-by":"crossref","first-page":"4720","DOI":"10.1038\/sj.emboj.7601869","article-title":"TDP1 facilitates chromosomal single-strand break repair in neurons and is neuroprotective in vivo","volume":"26","author":"Katyal","year":"2007","journal-title":"EMBO J."},{"issue":"19","key":"10.1016\/j.mad.2008.03.008_bib55","doi-asserted-by":"crossref","DOI":"10.4161\/cc.6.19.4757","article-title":"DNA repair deficiency and neurodegeneration","volume":"6","author":"Katyal","year":"2007","journal-title":"Cell Cycle"},{"key":"10.1016\/j.mad.2008.03.008_bib56","doi-asserted-by":"crossref","first-page":"1423","DOI":"10.1101\/gad.1200304","article-title":"Phosphorylation of SMC1 is a critical downstream event in the ATM-NBS1-BRCA1 pathway","volume":"18","author":"Kitagawa","year":"2004","journal-title":"Genes Dev."},{"issue":"8\u20139","key":"10.1016\/j.mad.2008.03.008_bib57","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1016\/j.dnarep.2004.03.023","article-title":"NBS1 and its functional role in the DNA damage response","volume":"3","author":"Kobayashi","year":"2004","journal-title":"DNA Repair"},{"issue":"5","key":"10.1016\/j.mad.2008.03.008_bib58","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1038\/ng1778","article-title":"Mitochondrial DNA deletions are abundant and cause functional impairment in aged human substantia nigra neurons","volume":"38","author":"Kraytsberg","year":"2006","journal-title":"Nat. Genet."},{"issue":"5229","key":"10.1016\/j.mad.2008.03.008_bib59","doi-asserted-by":"crossref","first-page":"1427","DOI":"10.1126\/science.7660125","article-title":"Inducible gene targeting in mice","volume":"269","author":"Kuhn","year":"1995","journal-title":"Science"},{"issue":"5","key":"10.1016\/j.mad.2008.03.008_bib60","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1016\/j.cell.2005.12.041","article-title":"TopBP1 activates the ATR-ATRIP complex","volume":"124","author":"Kumagai","year":"2006","journal-title":"Cell"},{"issue":"8","key":"10.1016\/j.mad.2008.03.008_bib61","doi-asserted-by":"crossref","first-page":"931","DOI":"10.4161\/cc.6.8.4180","article-title":"ATM activation and DNA damage response","volume":"6","author":"Lavin","year":"2007","journal-title":"Cell Cycle"},{"issue":"4","key":"10.1016\/j.mad.2008.03.008_bib62","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.1016\/j.neuroscience.2006.07.026","article-title":"Responding to DNA double-strand breaks in the nervous system","volume":"145","author":"Lee","year":"2007","journal-title":"Neuroscience"},{"issue":"11","key":"10.1016\/j.mad.2008.03.008_bib63","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1016\/j.biochi.2003.10.011","article-title":"Repair of DNA double-strand breaks by non-homologous end joining","volume":"85","author":"Lees-Miller","year":"2003","journal-title":"Biochimie"},{"issue":"1","key":"10.1016\/j.mad.2008.03.008_bib64","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1038\/sj.emboj.7601942","article-title":"Crystal structure of human XLF\/Cernunnos reveals unexpected differences from XRCC4 with implications for NHEJ","volume":"27","author":"Li","year":"2008","journal-title":"EMBO J."},{"issue":"9","key":"10.1016\/j.mad.2008.03.008_bib65","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1038\/nrm1202","article-title":"Mechanism and regulation of human non-homologous DNA end-joining","volume":"4","author":"Lieber","year":"2003","journal-title":"Nat. Rev."},{"issue":"6","key":"10.1016\/j.mad.2008.03.008_bib66","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1097\/MOP.0b013e32801080e8","article-title":"Disorders of cerebellar growth and development","volume":"18","author":"Limperopoulos","year":"2006","journal-title":"Curr. Opin. Pediatr."},{"issue":"4","key":"10.1016\/j.mad.2008.03.008_bib67","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/j.cell.2005.01.028","article-title":"DNA repair, genome stability, and aging","volume":"120","author":"Lombard","year":"2005","journal-title":"Cell"},{"issue":"6994","key":"10.1016\/j.mad.2008.03.008_bib68","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1038\/nature02661","article-title":"Gene regulation and DNA damage in the ageing human brain","volume":"429","author":"Lu","year":"2004","journal-title":"Nature"},{"issue":"5828","key":"10.1016\/j.mad.2008.03.008_bib69","doi-asserted-by":"crossref","first-page":"1160","DOI":"10.1126\/science.1140321","article-title":"ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage","volume":"316","author":"Matsuoka","year":"2007","journal-title":"Science"},{"issue":"8","key":"10.1016\/j.mad.2008.03.008_bib70","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1038\/sj.embor.7400210","article-title":"ATM and ataxia-telangiectasia","volume":"5","author":"McKinnon","year":"2004","journal-title":"EMBO Rep."},{"key":"10.1016\/j.mad.2008.03.008_bib71","first-page":"837","article-title":"DNA strand break repair and human genetic disease","author":"McKinnon","year":"2007","journal-title":"Annu. Rev. Genom. Hum. Genet."},{"issue":"2","key":"10.1016\/j.mad.2008.03.008_bib72","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1038\/ng1001-189","article-title":"The gene mutated in ataxia-ocular apraxia 1 encodes the new HIT\/Zn-finger protein aprataxin","volume":"29","author":"Moreira","year":"2001","journal-title":"Nat. Genet."},{"issue":"7145","key":"10.1016\/j.mad.2008.03.008_bib73","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1038\/nature05875","article-title":"DNA repair is limiting for haematopoietic stem cells during ageing","volume":"447","author":"Nijnik","year":"2007","journal-title":"Nature"},{"issue":"2","key":"10.1016\/j.mad.2008.03.008_bib74","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1002\/bies.10227","article-title":"When parsimony backfires: neglecting DNA repair may doom neurons in Alzheimer's disease","volume":"25","author":"Nouspikel","year":"2003","journal-title":"Bioessays"},{"issue":"8\u20139","key":"10.1016\/j.mad.2008.03.008_bib75","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.1016\/j.dnarep.2004.03.025","article-title":"An overview of three new disorders associated with genetic instability: LIG4 syndrome, RS-SCID and ATR-Seckel syndrome","volume":"3","author":"O\u2019Driscoll","year":"2004","journal-title":"DNA Repair"},{"issue":"1","key":"10.1016\/j.mad.2008.03.008_bib76","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1038\/nrg1746","article-title":"The role of double-strand break repair\u2014insights from human genetics","volume":"7","author":"O\u2019Driscoll","year":"2006","journal-title":"Nat. Rev. Genet."},{"issue":"15","key":"10.1016\/j.mad.2008.03.008_bib77","doi-asserted-by":"crossref","first-page":"6861","DOI":"10.1073\/pnas.89.15.6861","article-title":"Tissue- and site-specific DNA recombination in transgenic mice","volume":"89","author":"Orban","year":"1992","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"issue":"26","key":"10.1016\/j.mad.2008.03.008_bib78","doi-asserted-by":"crossref","first-page":"10017","DOI":"10.1073\/pnas.0602436103","article-title":"Selective utilization of nonhomologous end-joining and homologous recombination DNA repair pathways during nervous system development","volume":"103","author":"Orii","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"issue":"7","key":"10.1016\/j.mad.2008.03.008_bib79","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1016\/j.dnarep.2007.02.015","article-title":"The ATR pathway: fine-tuning the fork","volume":"6","author":"Paulsen","year":"2007","journal-title":"DNA Repair"},{"issue":"9","key":"10.1016\/j.mad.2008.03.008_bib80","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1016\/S0962-8924(03)00170-3","article-title":"The cellular response to DNA double-strand breaks: defining the sensors and mediators","volume":"13","author":"Petrini","year":"2003","journal-title":"Trends Cell Biol."},{"issue":"4","key":"10.1016\/j.mad.2008.03.008_bib81","doi-asserted-by":"crossref","first-page":"1330","DOI":"10.1016\/j.neuroscience.2006.09.032","article-title":"DNA repair in aging rat neurons","volume":"145","author":"Rao","year":"2007","journal-title":"Neuroscience"},{"issue":"6","key":"10.1016\/j.mad.2008.03.008_bib82","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1016\/j.cell.2007.08.043","article-title":"Defective DNA repair and neurodegenerative disease","volume":"130","author":"Rass","year":"2007","journal-title":"Cell"},{"issue":"1","key":"10.1016\/j.mad.2008.03.008_bib83","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/j.ajhg.2007.09.018","article-title":"Nature of mitochondrial DNA deletions in substantia nigra neurons","volume":"82","author":"Reeve","year":"2008","journal-title":"Am. J. Hum. Genet."},{"issue":"9","key":"10.1016\/j.mad.2008.03.008_bib84","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/S0166-2236(00)01625-8","article-title":"Linking DNA damage and neurodegeneration","volume":"23","author":"Rolig","year":"2000","journal-title":"Trends Neurosci."},{"issue":"7145","key":"10.1016\/j.mad.2008.03.008_bib85","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1038\/nature05862","article-title":"Deficiencies in DNA damage repair limit the function of haematopoietic stem cells with age","volume":"447","author":"Rossi","year":"2007","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.mad.2008.03.008_bib86","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.neurobiolaging.2005.10.019","article-title":"The aging brain: accumulation of DNA damage or neuron loss?","volume":"28","author":"Rutten","year":"2007","journal-title":"Neurobiol. Aging"},{"issue":"50","key":"10.1016\/j.mad.2008.03.008_bib87","doi-asserted-by":"crossref","first-page":"17323","DOI":"10.1073\/pnas.0408041101","article-title":"Organismal stress and telomeric aging: an unexpected connection","volume":"101","author":"Sapolsky","year":"2004","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"issue":"2","key":"10.1016\/j.mad.2008.03.008_bib88","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1021\/cr040466q","article-title":"RNA polymerase encounters with DNA damage: transcription-coupled repair or transcriptional mutagenesis?","volume":"106","author":"Saxowsky","year":"2006","journal-title":"Chem. Rev."},{"issue":"3","key":"10.1016\/j.mad.2008.03.008_bib89","doi-asserted-by":"crossref","first-page":"233","DOI":"10.4161\/cbt.2.3.373","article-title":"Histone H2AX in DNA damage and repair","volume":"2","author":"Sedelnikova","year":"2003","journal-title":"Cancer Biol. Ther."},{"issue":"4","key":"10.1016\/j.mad.2008.03.008_bib90","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1016\/j.neurobiolaging.2005.03.009","article-title":"DNA end joining activity is reduced in Alzheimer's disease","volume":"27","author":"Shackelford","year":"2006","journal-title":"Neurobiol. Aging"},{"issue":"5","key":"10.1016\/j.mad.2008.03.008_bib91","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1086\/379379","article-title":"RP2 and RPGR mutations and clinical correlations in patients with X-linked retinitis pigmentosa","volume":"73","author":"Sharon","year":"2003","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.mad.2008.03.008_bib92","first-page":"31635","article-title":"Ataxia-telangiectasia and the Nijmegen breakage syndrome: related disorders but genes apart","author":"Shiloh","year":"1997","journal-title":"Annu. Rev. Genet."},{"issue":"1","key":"10.1016\/j.mad.2008.03.008_bib93","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/S0959-437X(00)00159-3","article-title":"ATM and ATR: networking cellular responses to DNA damage","volume":"11","author":"Shiloh","year":"2001","journal-title":"Curr. Opin. Genet. Dev."},{"issue":"3","key":"10.1016\/j.mad.2008.03.008_bib94","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1038\/nrc1011","article-title":"ATM and related protein kinases: safeguarding genome integrity","volume":"3","author":"Shiloh","year":"2003","journal-title":"Nat. Rev. Cancer"},{"issue":"11","key":"10.1016\/j.mad.2008.03.008_bib95","first-page":"4561","article-title":"Atm knock-in mice harboring an in-frame deletion corresponding to the human ATM 7636del9 common mutation exhibit a variant phenotype","volume":"61","author":"Spring","year":"2001","journal-title":"Cancer Res."},{"issue":"19","key":"10.1016\/j.mad.2008.03.008_bib96","doi-asserted-by":"crossref","first-page":"3875","DOI":"10.1093\/nar\/24.19.3875","article-title":"Temporal control of the Cre recombinase in transgenic mice by a tetracycline responsive promoter","volume":"24","author":"St-Onge","year":"1996","journal-title":"Nucleic Acids Res."},{"issue":"7141","key":"10.1016\/j.mad.2008.03.008_bib97","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1038\/nature05740","article-title":"The carboxy terminus of NBS1 is required for induction of apoptosis by the MRE11 complex","volume":"447","author":"Stracker","year":"2007","journal-title":"Nature"},{"issue":"3","key":"10.1016\/j.mad.2008.03.008_bib98","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.1093\/genetics\/154.3.1291","article-title":"Mutation frequency and specificity with age in liver, bladder and brain of lacI transgenic mice","volume":"154","author":"Stuart","year":"2000","journal-title":"Genetics"},{"issue":"3","key":"10.1016\/j.mad.2008.03.008_bib99","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1038\/ncpneuro0448","article-title":"Mechanisms of disease: DNA repair defects and neurological disease","volume":"3","author":"Subba Rao","year":"2007","journal-title":"Nat. Clin. Pract."},{"issue":"1\u20132","key":"10.1016\/j.mad.2008.03.008_bib100","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1159\/000109256","article-title":"Purkinje cell loss in the cerebellar flocculus in patients with ataxia with ocular motor apraxia type 1\/early-onset ataxia with ocular motor apraxia and hypoalbuminemia","volume":"59","author":"Sugawara","year":"2008","journal-title":"Eur. Neurol."},{"issue":"2","key":"10.1016\/j.mad.2008.03.008_bib101","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1038\/ng987","article-title":"Mutation of TDP1, encoding a topoisomerase I-dependent DNA damage repair enzyme, in spinocerebellar ataxia with axonal neuropathy","volume":"32","author":"Takashima","year":"2002","journal-title":"Nat. Genet."},{"issue":"8\u20139","key":"10.1016\/j.mad.2008.03.008_bib102","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1016\/j.dnarep.2004.04.009","article-title":"Ataxia-telangiectasia-like disorder (ATLD)-its clinical presentation and molecular basis","volume":"3","author":"Taylor","year":"2004","journal-title":"DNA Repair"},{"issue":"6","key":"10.1016\/j.mad.2008.03.008_bib103","doi-asserted-by":"crossref","first-page":"1511","DOI":"10.1016\/S1097-2765(03)00455-6","article-title":"Checkpoint failure and chromosomal instability without lymphomagenesis in Mre11(ATLD1\/ATLD1) mice","volume":"12","author":"Theunissen","year":"2003","journal-title":"Mol. Cell"},{"issue":"6","key":"10.1016\/j.mad.2008.03.008_bib104","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1038\/nn1908","article-title":"Synapse formation on neurons born in the adult hippocampus","volume":"10","author":"Toni","year":"2007","journal-title":"Nat. Neurosci."},{"issue":"20","key":"10.1016\/j.mad.2008.03.008_bib105","doi-asserted-by":"crossref","first-page":"5612","DOI":"10.1093\/emboj\/cdg541","article-title":"Requirement of the MRN complex for ATM activation by DNA damage","volume":"22","author":"Uziel","year":"2003","journal-title":"EMBO J."},{"issue":"56","key":"10.1016\/j.mad.2008.03.008_bib106","doi-asserted-by":"crossref","first-page":"7731","DOI":"10.1038\/sj.onc.1210871","article-title":"Non-homologous end-joining, a sticky affair","volume":"26","author":"van Gent","year":"2007","journal-title":"Oncogene"},{"issue":"7147","key":"10.1016\/j.mad.2008.03.008_bib107","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1038\/nature05976","article-title":"Replication and protection of telomeres","volume":"447","author":"Verdun","year":"2007","journal-title":"Nature"},{"issue":"6","key":"10.1016\/j.mad.2008.03.008_bib108","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.tig.2004.04.007","article-title":"Transcripts of aging","volume":"20","author":"Vijg","year":"2004","journal-title":"Trends Genet."},{"issue":"7","key":"10.1016\/j.mad.2008.03.008_bib109","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1038\/35081558","article-title":"Genetic regulation of cerebellar development","volume":"2","author":"Wang","year":"2001","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.mad.2008.03.008_bib110","first-page":"631","article-title":"Early events in the DNA damage response","author":"Ward","year":"2004","journal-title":"Curr. Top. Dev. Biol."},{"issue":"4","key":"10.1016\/j.mad.2008.03.008_bib111","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1111\/j.1651-2227.1981.tb05740.x","article-title":"A new chromosomal instability disorder: the Nijmegen breakage syndrome","volume":"70","author":"Weemaes","year":"1981","journal-title":"Acta Paediatr. Scand."},{"issue":"16","key":"10.1016\/j.mad.2008.03.008_bib112","doi-asserted-by":"crossref","first-page":"5545","DOI":"10.1093\/nar\/gkm605","article-title":"Defective DNA base excision repair in brain from individuals with Alzheimer's disease and amnestic mild cognitive impairment","volume":"35","author":"Weissman","year":"2007","journal-title":"Nucleic Acids Res."},{"issue":"6","key":"10.1016\/j.mad.2008.03.008_bib113","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1038\/nrm1127","article-title":"Molecular views of recombination proteins and their control","volume":"4","author":"West","year":"2003","journal-title":"Nature Rev."},{"issue":"8","key":"10.1016\/j.mad.2008.03.008_bib114","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1016\/S0960-9822(02)00763-7","article-title":"A murine model of Nijmegen breakage syndrome","volume":"12","author":"Williams","year":"2002","journal-title":"Curr. Biol."},{"issue":"9","key":"10.1016\/j.mad.2008.03.008_bib115","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1002\/em.20346","article-title":"Processing of nonconventional DNA strand break ends","volume":"48","author":"Wilson","year":"2007","journal-title":"Environ. Mol. Mutagen."},{"issue":"4","key":"10.1016\/j.mad.2008.03.008_bib116","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1016\/j.dnarep.2006.10.017","article-title":"The mechanics of base excision repair, and its relationship to aging and disease","volume":"6","author":"Wilson","year":"2007","journal-title":"DNA Repair"},{"issue":"2","key":"10.1016\/j.mad.2008.03.008_bib117","doi-asserted-by":"crossref","first-page":"R55","DOI":"10.1016\/j.cub.2006.12.012","article-title":"Neurodegeneration: nicked to death","volume":"17","author":"Wilson","year":"2007","journal-title":"Curr. Biol."},{"key":"10.1016\/j.mad.2008.03.008_bib118","first-page":"40363","article-title":"DNA double-strand break repair: all's well that ends well","author":"Wyman","year":"2006","journal-title":"Annu. Rev. Genet."},{"issue":"15","key":"10.1016\/j.mad.2008.03.008_bib119","doi-asserted-by":"crossref","first-page":"2985","DOI":"10.1093\/nar\/25.15.2985","article-title":"Conditional gene targeted deletion by Cre recombinase demonstrates the requirement for the double-strand break repair Mre11 protein in murine embryonic stem cells","volume":"25","author":"Xiao","year":"1997","journal-title":"Nucleic Acids Res."},{"issue":"19","key":"10.1016\/j.mad.2008.03.008_bib120","doi-asserted-by":"crossref","first-page":"2401","DOI":"10.1101\/gad.10.19.2401","article-title":"Dual roles of ATM in the cellular response to radiation and in cell growth control","volume":"10","author":"Xu","year":"1996","journal-title":"Genes Dev."},{"issue":"8","key":"10.1016\/j.mad.2008.03.008_bib121","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.1016\/j.yexcr.2005.12.026","article-title":"The retinitis pigmentosa-mutated RP2 protein exhibits exonuclease activity and translocates to the nucleus in response to DNA damage","volume":"312","author":"Yoon","year":"2006","journal-title":"Exp. Cell Res."},{"issue":"11","key":"10.1016\/j.mad.2008.03.008_bib122","doi-asserted-by":"crossref","first-page":"e201","DOI":"10.1371\/journal.pgen.0030201","article-title":"AGEMAP: a gene expression database for aging in mice","volume":"3","author":"Zahn","year":"2007","journal-title":"PLoS Genet."},{"issue":"11","key":"10.1016\/j.mad.2008.03.008_bib123","doi-asserted-by":"crossref","first-page":"4518","DOI":"10.1073\/pnas.0611734104","article-title":"Defective DNA repair and increased genomic instability in Cernunnos-XLF-deficient murine ES cells","volume":"104","author":"Zha","year":"2007","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.mad.2008.03.008_bib124","doi-asserted-by":"crossref","DOI":"10.1038\/nature06562","article-title":"A role for adult TLX-positive neural stem cells in learning and behaviour","author":"Zhang","year":"2008","journal-title":"Nature"},{"issue":"2","key":"10.1016\/j.mad.2008.03.008_bib125","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/S0960-9822(01)00019-7","article-title":"Targeted disruption of the Nijmegen breakage syndrome gene NBS1 leads to early embryonic lethality in mice","volume":"11","author":"Zhu","year":"2001","journal-title":"Curr. Biol."}],"container-title":["Mechanisms of Ageing and Development"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0047637408000742?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0047637408000742?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,9,6]],"date-time":"2021-09-06T14:06:45Z","timestamp":1630937205000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0047637408000742"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,7]]},"references-count":125,"journal-issue":{"issue":"7-8","published-print":{"date-parts":[[2008,7]]}},"alternative-id":["S0047637408000742"],"URL":"https:\/\/doi.org\/10.1016\/j.mad.2008.03.008","relation":{},"ISSN":["0047-6374"],"issn-type":[{"value":"0047-6374","type":"print"}],"subject":[],"published":{"date-parts":[[2008,7]]}}}