{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T18:15:52Z","timestamp":1792606552161,"version":"4.5.0"},"reference-count":90,"publisher":"Elsevier BV","issue":"1-2","license":[{"start":{"date-parts":[[2009,1,1]],"date-time":"2009-01-01T00:00:00Z","timestamp":1230768000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mechanisms of Ageing and Development"],"published-print":{"date-parts":[[2009,1]]},"DOI":"10.1016\/j.mad.2008.06.003","type":"journal-article","created":{"date-parts":[[2008,7,11]],"date-time":"2008-07-11T10:35:51Z","timestamp":1215772551000},"page":"40-45","source":"Crossref","is-referenced-by-count":105,"title":["Inflammation, ageing and cancer"],"prefix":"10.1016","volume":"130","author":[{"given":"Sonya","family":"Vasto","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Carruba","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Domenico","family":"Lio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppina","family":"Colonna-Romano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danilo","family":"Di Bona","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppina","family":"Candore","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Calogero","family":"Caruso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.mad.2008.06.003_bib1","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1016\/j.humimm.2007.10.006","article-title":"Association of Toll-like receptor-4 (Asp299Gly and Thr399Ileu) gene polymorphisms with gastritis and precancerous lesions","volume":"68","author":"Achyut","year":"2007","journal-title":"Hum. Immunol."},{"key":"10.1016\/j.mad.2008.06.003_bib2","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.gde.2008.01.003","article-title":"Pathways connecting inflammation and cancer","volume":"18","author":"Allavena","year":"2008","journal-title":"Curr. Opin. Genet. Dev."},{"key":"10.1016\/j.mad.2008.06.003_bib3","series-title":"Cancer Facts and Figures 2007","author":"American Cancer Society","year":"2007"},{"key":"10.1016\/j.mad.2008.06.003_bib4","doi-asserted-by":"crossref","first-page":"112","DOI":"10.4161\/cc.7.1.5137","article-title":"Regulation of the p14ARF promoter by DNA methylation","volume":"1","author":"Badal","year":"2008","journal-title":"Cell Cycle"},{"key":"10.1016\/j.mad.2008.06.003_bib5","first-page":"2339","article-title":"Role of Toll-like receptor 4 in acute myocardial infarction and longevity","volume":"292","author":"Balistreri","year":"2004","journal-title":"JAMA"},{"key":"10.1016\/j.mad.2008.06.003_bib6","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1196\/annals.1404.003","article-title":"Role of TLR4 polymorphisms in inflammatory responses: implications for unsuccessful aging","volume":"1119","author":"Balistreri","year":"2007","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.mad.2008.06.003_bib7","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1016\/S0531-5565(02)00137-7","article-title":"What studies on human longevity tell us about the risk for cancer in the oldest old: data and hypotheses on the genetics and immunology of centenarians","volume":"37","author":"Bonaf\u00e8","year":"2002","journal-title":"Exp. Gerontol."},{"key":"10.1016\/j.mad.2008.06.003_bib8","first-page":"285","article-title":"The clinical impact of systemic low-level inflammation in elderly populations. With special reference to cardiovascular disease, dementia and mortality","volume":"53","author":"Bruunsgaard","year":"2006","journal-title":"Dan. Med. Bull."},{"key":"10.1016\/j.mad.2008.06.003_bib9","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1126\/science.1116801","article-title":"Suppressing cancer: the importance of being senescent","volume":"309","author":"Campisi","year":"2005","journal-title":"Science"},{"key":"10.1016\/j.mad.2008.06.003_bib10","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1016\/j.exger.2003.10.027","article-title":"Major histocompatibility complex and sporadic Alzheimer's disease: a critical reappraisal","volume":"39","author":"Candore","year":"2004","journal-title":"Exp. Gerontol."},{"key":"10.1016\/j.mad.2008.06.003_bib11","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1089\/rej.2006.9.143","article-title":"Biology of longevity: role of the innate immune system","volume":"9","author":"Candore","year":"2006","journal-title":"Rejuvenation Res."},{"key":"10.1016\/j.mad.2008.06.003_bib12","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1196\/annals.1386.051","article-title":"Immunogenetics, gender, and longevity","volume":"1089","author":"Candore","year":"2006","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.mad.2008.06.003_bib13","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.exger.2007.06.004","article-title":"Human longevity within an evolutionary perspective: the peculiar paradigm of a post-reproductive genetics","volume":"43","author":"Capri","year":"2008","journal-title":"Exp. Gerontol."},{"key":"10.1016\/j.mad.2008.06.003_bib14","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1093\/gerona\/63.5.454","article-title":"A genetic-demographic approach reveals male-specific association between survival and tumor necrosis factor (a\/g)-308 polymorphism","volume":"63","author":"Cardelli","year":"2008","journal-title":"J. Gerontol. A Biol. Sci. Med. Sci."},{"key":"10.1016\/j.mad.2008.06.003_bib15","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1196\/annals.1322.001","article-title":"Aging, longevity, inflammation, and cancer","volume":"1028","author":"Caruso","year":"2004","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.mad.2008.06.003_bib16","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1126\/science.307.5707.208","article-title":"Inflammation and life-span","volume":"307","author":"Caruso","year":"2005","journal-title":"Science"},{"key":"10.1016\/j.mad.2008.06.003_bib17","series-title":"Pawelec G. Immunosenescence","isbn-type":"print","doi-asserted-by":"crossref","DOI":"10.1007\/978-0-387-76842-7_14","article-title":"The genetics of innate immunity and inflammation in ageing, age-related diseases and longevity","author":"Caruso","year":"2007","ISBN":"https:\/\/id.crossref.org\/isbn\/9780387768403"},{"key":"10.1016\/j.mad.2008.06.003_bib18","doi-asserted-by":"crossref","first-page":"1982","DOI":"10.1158\/1055-9965.EPI-07-0325","article-title":"Association between Toll-like receptor gene cluster (TLR6, TLR1, and TLR10) and prostate cancer","volume":"16","author":"Chen","year":"2007","journal-title":"Cancer Epidemiol. Biomarkers Prev."},{"key":"10.1016\/j.mad.2008.06.003_bib19","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1038\/sj.onc.1210907","article-title":"Cancers take their Toll\u2014the function and regulation of Toll-like receptors in cancer cells","volume":"27","author":"Chen","year":"2008","journal-title":"Oncogene"},{"key":"10.1016\/j.mad.2008.06.003_bib20","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1038\/sj.bjc.6603874","article-title":"COX2 genetic variation, NSAIDs, and advanced prostate cancer risk","volume":"97","author":"Cheng","year":"2007","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.mad.2008.06.003_bib21","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1074\/jbc.271.2.736","article-title":"Interleukin 6 induces the expression of vascular endothelial growth factor","volume":"271","author":"Cohen","year":"1996","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.mad.2008.06.003_bib22","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1038\/nature01322","article-title":"Inflammation and cancer","volume":"420","author":"Coussens","year":"2002","journal-title":"Nature"},{"key":"10.1016\/j.mad.2008.06.003_bib23","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1002\/jcb.20477","article-title":"Interleukin-6 regulation of prostate cancer cell growth","volume":"95","author":"Culig","year":"2005","journal-title":"J. Cell Biochem."},{"key":"10.1016\/j.mad.2008.06.003_bib24","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1002\/pros.20694","article-title":"TNF polymorphisms and prostate cancer risk","volume":"68","author":"Danforth","year":"2008","journal-title":"Prostate"},{"key":"10.1016\/j.mad.2008.06.003_bib25","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1245\/s10434-006-9122-9","article-title":"Host cytokine genotype is related to adverse prognosis and systemic inflammation in gastro-oesophageal cancer","volume":"14","author":"Deans","year":"2007","journal-title":"Ann. Surg. Oncol."},{"key":"10.1016\/j.mad.2008.06.003_bib26","doi-asserted-by":"crossref","first-page":"2035","DOI":"10.1016\/j.febslet.2005.02.055","article-title":"Inflamm-ageing and lifelong antigenic load as major determinants of ageing rate and longevity","volume":"579","author":"De Martinis","year":"2005","journal-title":"FEBS Lett."},{"key":"10.1016\/j.mad.2008.06.003_bib27","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.yexmp.2005.11.004","article-title":"Inflammation markers predicting frailty and mortality in the elderly","volume":"80","author":"De Martinis","year":"2006","journal-title":"Exp. Mol. Pathol."},{"key":"10.1016\/j.mad.2008.06.003_bib28","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1038\/35041694","article-title":"The age of cancer","volume":"408","author":"DePinho","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.mad.2008.06.003_bib29","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1016\/j.humpath.2007.10.030","article-title":"Epstein-Barr virus-associated epithelial and mesenchymal neoplasms","volume":"39","author":"Deyrup","year":"2008","journal-title":"Hum. Pathol."},{"key":"10.1016\/j.mad.2008.06.003_bib30","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1097\/00008390-199502000-00008","article-title":"Elevated serum levels of interleukin-10 in patients with metastatic malignant melanoma","volume":"5","author":"Dummer","year":"1995","journal-title":"Melanoma Res."},{"key":"10.1016\/j.mad.2008.06.003_bib31","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.ejca.2003.08.010","article-title":"Her2 and COX2 expression in human prostate cancer","volume":"40","author":"Edwards","year":"2004","journal-title":"Eur. J. Cancer"},{"key":"10.1016\/j.mad.2008.06.003_bib32","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1146\/annurev.med.51.1.245","article-title":"Age-associated increased interleukin-6 gene expression, late-life diseases, and frailty","volume":"51","author":"Ershler","year":"2000","journal-title":"Annu. Rev. Med."},{"key":"10.1016\/j.mad.2008.06.003_bib33","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1038\/nature05985","article-title":"The common biology of cancer and ageing","volume":"448","author":"Finkel","year":"2007","journal-title":"Nature"},{"key":"10.1016\/j.mad.2008.06.003_bib34","first-page":"325","article-title":"Review: molecular pathology of cyclooxygenase-2 in cancer-induced angiogenesis","volume":"31","author":"Fosslien","year":"2001","journal-title":"Ann. Clin. Lab. Sci."},{"key":"10.1016\/j.mad.2008.06.003_bib35","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1172\/JCI30111","article-title":"Inflammation, atrophy, and gastric cancer","volume":"117","author":"Fox","year":"2007","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.mad.2008.06.003_bib36","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.mad.2006.11.016","article-title":"Inflammaging and anti-inflammaging: a systemic perspective on aging and longevity emerged from studies in humans","volume":"128","author":"Franceschi","year":"2007","journal-title":"Mech. Ageing Dev."},{"key":"10.1016\/j.mad.2008.06.003_bib37","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.exger.2007.06.006","article-title":"IMUSCE. The extreme longevity: the state of the art in Italy","volume":"43","author":"Franceschi","year":"2008","journal-title":"Exp. Gerontol."},{"key":"10.1016\/j.mad.2008.06.003_bib38","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1111\/j.1572-0241.2007.01572.x","article-title":"Tumor necrosis factor-alpha polymorphisms in ulcerative colitis-associated colorectal cancer","volume":"103","author":"Garrity-Park","year":"2008","journal-title":"Am. J. Gastroenterol."},{"key":"10.1016\/j.mad.2008.06.003_bib39","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1016\/j.ejca.2008.02.047","article-title":"Systematic review of the association between circulating interleukin-6 (IL-6) and cancer","volume":"44","author":"Heikkil\u00e4","year":"2008","journal-title":"Eur. J. Cancer"},{"key":"10.1016\/j.mad.2008.06.003_bib40","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1042\/bj20030407","article-title":"Principles of interleukin (IL)-6-type cytokine signalling and its regulation","volume":"374","author":"Heinrich","year":"2003","journal-title":"Biochem. J."},{"key":"10.1016\/j.mad.2008.06.003_bib41","doi-asserted-by":"crossref","first-page":"1911","DOI":"10.1002\/cncr.22999","article-title":"Interleukin-6 and its receptor in cancer: implications for translational therapeutics","volume":"110","author":"Hong","year":"2007","journal-title":"Cancer"},{"key":"10.1016\/j.mad.2008.06.003_bib42","first-page":"4243","article-title":"COX1 and COX2 polymorphisms and gastric cancer risk in a Polish population","volume":"27","author":"Hou","year":"2007","journal-title":"Anticancer Res."},{"key":"10.1016\/j.mad.2008.06.003_bib43","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1002\/ijc.2910580114","article-title":"Regulation of ICAM-1 (CD54) expression in human breast cancer cell lines by interleukin 6 and fibroblast-derived factors","volume":"58","author":"Hutchins","year":"1994","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.mad.2008.06.003_bib44","unstructured":"International Agency for Research on Cancer. Globocan 2000. IARC 2002."},{"key":"10.1016\/j.mad.2008.06.003_bib45","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s10254-003-0012-2","article-title":"IL-6 signal transduction and its physiological roles: the signal orchestration model","volume":"149","author":"Kamimura","year":"2003","journal-title":"Rev. Physiol. Biochem. Pharmacol."},{"key":"10.1016\/j.mad.2008.06.003_bib46","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1002\/bies.10111","article-title":"p53 and ageing: too much of a good thing?","volume":"24","author":"Kirkwood","year":"2002","journal-title":"Bioessays"},{"key":"10.1016\/j.mad.2008.06.003_bib47","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1016\/j.exger.2004.01.009","article-title":"Inflammatory mediators in the elderly","volume":"39","author":"Krabbe","year":"2004","journal-title":"Exp. Gerontol."},{"key":"10.1016\/j.mad.2008.06.003_bib48","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1186\/1742-4933-2-8","article-title":"Innate immunity and inflammation in ageing: a key for understanding age-related diseases","volume":"2","author":"Licastro","year":"2005","journal-title":"Immun. Ageing"},{"key":"10.1016\/j.mad.2008.06.003_bib49","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1172\/JCI31537","article-title":"A cytokine-mediated link between innate immunity, inflammation, and cancer","volume":"117","author":"Lin","year":"2007","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.mad.2008.06.003_bib50","first-page":"295","article-title":"Interleukin-6-174G\/C polymorphism in breast cancer and uterine leiomyoma patients: a population-based case control study","volume":"29","author":"Litovkin","year":"2007","journal-title":"Exp. Oncol."},{"key":"10.1016\/j.mad.2008.06.003_bib51","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1016\/S0140-6736(08)60241-X","article-title":"Tumour immunity: effector response to tumour and role of the microenvironment","volume":"371","author":"Mantovani","year":"2008","journal-title":"Lancet"},{"key":"10.1016\/j.mad.2008.06.003_bib52","doi-asserted-by":"crossref","first-page":"2371","DOI":"10.1084\/jem.180.6.2371","article-title":"Interleukin 10 pretreatment protects target cells from tumor- and allo-specific cytotoxic T cells and downregulates HLA class I expression","volume":"180","author":"Matsuda","year":"1994","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.mad.2008.06.003_bib53","doi-asserted-by":"crossref","first-page":"4525","DOI":"10.1158\/0008-5472.CAN-05-3987","article-title":"Genetic polymorphisms of interleukin-1B (IL-1B), IL-6, IL-8, and IL-10 and risk of prostate cancer","volume":"66","author":"Michaud","year":"2006","journal-title":"Cancer Res."},{"key":"10.1016\/j.mad.2008.06.003_bib54","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/S0047-6374(00)00136-6","article-title":"Cancer incidence in old age","volume":"117","author":"Miyaishi","year":"2000","journal-title":"Mech. Ageing Dev."},{"key":"10.1016\/j.mad.2008.06.003_bib55","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1016\/j.exger.2008.01.001","article-title":"Zinc deficiency and IL-6-174G\/C polymorphism in old people from different European countries: effect of zinc supplementation. ZINCAGE study","volume":"43","author":"Mocchegiani","year":"2008","journal-title":"Exp. Gerontol."},{"key":"10.1016\/j.mad.2008.06.003_bib56","doi-asserted-by":"crossref","first-page":"2774","DOI":"10.2741\/2884","article-title":"TNF and cancer: the two sides of the coin","volume":"13","author":"Mocellin","year":"2008","journal-title":"Front Biosci."},{"key":"10.1016\/j.mad.2008.06.003_bib57","doi-asserted-by":"crossref","first-page":"2373","DOI":"10.1111\/j.1572-0241.2007.01373.x","article-title":"COX-2 CA-haplotype is a risk factor for the development of esophageal adenocarcinoma","volume":"102","author":"Moons","year":"2007","journal-title":"Am. J. Gastroenterol."},{"key":"10.1016\/j.mad.2008.06.003_bib58","doi-asserted-by":"crossref","first-page":"2194","DOI":"10.1172\/JCI116446","article-title":"Tumor necrosis factor and its receptors in human ovarian cancer: potential role in disease progression","volume":"91","author":"Naylor","year":"1993","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.mad.2008.06.003_bib59","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1038\/nrc1046","article-title":"Radical causes of cancer","volume":"3","author":"Perwez Hussain","year":"2003","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.mad.2008.06.003_bib60","doi-asserted-by":"crossref","first-page":"S253","DOI":"10.1301\/nr.2007.dec.S253-S259","article-title":"Inflammatory biomarkers and risks of myocardial infarction, stroke, diabetes, and total mortality: implications for longevity","volume":"65","author":"Ridker","year":"2007","journal-title":"Nutr. Rev."},{"key":"10.1016\/j.mad.2008.06.003_bib61","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.cytogfr.2007.01.015","article-title":"Paradoxical effects of cytokines in tumor immune surveillance and tumor immune escape","volume":"18","author":"Salazar-Onfray","year":"2007","journal-title":"Cytokine Growth Factor Rev."},{"key":"10.1016\/j.mad.2008.06.003_bib62","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1002\/ana.10265","article-title":"Early inflammation and dementia: a 25-year follow-up of the Honolulu-Asia Aging Study","volume":"52","author":"Schmidt","year":"2002","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.mad.2008.06.003_bib63","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1016\/S0955-0674(00)00278-7","article-title":"Putting the stress on senescence","volume":"13","author":"Serrano","year":"2001","journal-title":"Curr. Opin. Cell Biol."},{"key":"10.1016\/j.mad.2008.06.003_bib64","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1038\/nrm2242","article-title":"Cancer and ageing: convergent and divergent mechanisms","volume":"8","author":"Serrano","year":"2007","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.mad.2008.06.003_bib65","first-page":"217","article-title":"Chronic inflammation and cancer","volume":"16","author":"Shacter","year":"2002","journal-title":"Oncology"},{"key":"10.1016\/j.mad.2008.06.003_bib66","doi-asserted-by":"crossref","first-page":"R71","DOI":"10.1186\/bcr1629","article-title":"Genetic polymorphisms in the cyclooxygenase-2 gene, use of nonsteroidal anti-inflammatory drugs, and breast cancer risk","volume":"8","author":"Shen","year":"2006","journal-title":"Breast Cancer Res."},{"key":"10.1016\/j.mad.2008.06.003_bib67","doi-asserted-by":"crossref","DOI":"10.1016\/j.canlet.2008.03.028","article-title":"Cancer related inflammation: the macrophage connection","author":"Sica","year":"2008","journal-title":"Cancer Lett."},{"key":"10.1016\/j.mad.2008.06.003_bib68","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1007\/s10552-007-9049-x","article-title":"IL6 genotypes and colon and rectal cancer","volume":"18","author":"Slattery","year":"2007","journal-title":"Cancer Causes Control"},{"key":"10.1016\/j.mad.2008.06.003_bib69","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1002\/(SICI)1097-0142(19960401)77:7<1367::AID-CNCR22>3.0.CO;2-Z","article-title":"Cancer mortality at very old age","volume":"77","author":"Smith","year":"1996","journal-title":"Cancer"},{"key":"10.1016\/j.mad.2008.06.003_bib70","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1146\/annurev.biochem.69.1.145","article-title":"Cyclooxygenases: structural, cellular and molecular biology","volume":"69","author":"Smith","year":"2006","journal-title":"Annu. Rev. Biochem."},{"key":"10.1016\/j.mad.2008.06.003_bib71","first-page":"189","article-title":"Interleukin 10 (IL-10) inhibition of primary human prostate cell-induced angiogenesis: IL-10 stimulation of tissue inhibitor of metalloproteinase-1 and inhibition of matrix metalloproteinase (MMP)-2\/MMP-9 secretion","volume":"5","author":"Stearns","year":"1999","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.mad.2008.06.003_bib72","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/S0165-6147(02)00043-3","article-title":"Cyclooxygenase 2: a molecular target for cancer prevention and treatment","volume":"24","author":"Subbaramaiah","year":"2003","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.mad.2008.06.003_bib73","doi-asserted-by":"crossref","first-page":"2929","DOI":"10.1016\/j.molimm.2008.01.025","article-title":"Rapamycin suppresses TLR4-triggered IL-6 and PGE(2) production of colon cancer cells by inhibiting TLR4 expression and NF-kappaB activation","volume":"45","author":"Sun","year":"2008","journal-title":"Mol. Immunol."},{"key":"10.1016\/j.mad.2008.06.003_bib74","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1158\/1055-9965.EPI-05-0645","article-title":"Interactions of sequence variants in interleukin-1 receptor-associated kinase 4 and the toll-like receptor 6-1-10 gene cluster increase prostate cancer risk","volume":"15","author":"Sun","year":"2006","journal-title":"Cancer Epidemiol. Biomarkers Prev."},{"key":"10.1016\/j.mad.2008.06.003_bib75","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1016\/S1470-2045(03)01196-3","article-title":"Tumor necrosis factor \u03b1: a potential target for the therapy of solid tumors","volume":"4","author":"Szlosarek","year":"2003","journal-title":"Lancet Oncol."},{"key":"10.1016\/j.mad.2008.06.003_bib76","doi-asserted-by":"crossref","first-page":"2074","DOI":"10.1111\/j.1532-5415.2004.52561.x","article-title":"Lower all-cause, cardiovascular, and cancer mortality in centenarians\u2019 offspring","volume":"52","author":"Terry","year":"2004","journal-title":"J. Am. Geriatr. Soc."},{"key":"10.1016\/j.mad.2008.06.003_bib77","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1158\/1055-9965.EPI-05-0626","article-title":"Plasma C-reactive protein and risk of cancer: a prospective study from Greece","volume":"15","author":"Trichopoulos","year":"2006","journal-title":"Cancer Epidemiol. Biomarkers Prev."},{"key":"10.1016\/j.mad.2008.06.003_bib78","first-page":"3","article-title":"The biology of aging","volume":"70","author":"Troen","year":"2003","journal-title":"Mt. Sinai J. Med."},{"key":"10.1016\/j.mad.2008.06.003_bib79","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1146\/annurev.med.53.082901.103952","article-title":"Cyclooxygenase-2: a therapeutic target","volume":"53","author":"Turini","year":"2002","journal-title":"Annu. Rev. Med."},{"key":"10.1016\/j.mad.2008.06.003_bib80","doi-asserted-by":"crossref","DOI":"10.1016\/j.clim.2008.03.519","article-title":"Association of interleukin-6 (-174G>C) promoter polymorphism with risk of squamous cell esophageal cancer and tumor location: an exploratory study","author":"Upadhyay","year":"2008","journal-title":"Clin. Immunol."},{"key":"10.1016\/j.mad.2008.06.003_bib81","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1111\/j.1349-7006.2007.00711.x","article-title":"Genetic polymorphisms of cyclooxygenase-2 and colorectal adenoma risk: the Self Defense Forces Health Study","volume":"99","author":"Ueda","year":"2008","journal-title":"Cancer Sci."},{"key":"10.1016\/j.mad.2008.06.003_bib82","first-page":"309","article-title":"The interleukin-10 (-1082A\/G) polymorphism is strongly associated with increased risk for oral squamous cell carcinoma","volume":"28","author":"Vairaktaris","year":"2008","journal-title":"Anticancer Res."},{"key":"10.1016\/j.mad.2008.06.003_bib83","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1177\/172460080602100409","article-title":"Strong association of interleukin-6-174 G>C promoter polymorphism with increased risk of oral cancer","volume":"21","author":"Vairaktaris","year":"2006","journal-title":"Int. J. Biol. Markers"},{"key":"10.1016\/j.mad.2008.06.003_bib84","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.mad.2006.11.015","article-title":"Inflammatory networks in ageing, age-related diseases and longevity","volume":"128","author":"Vasto","year":"2007","journal-title":"Mech. Ageing Dev."},{"key":"10.1016\/j.mad.2008.06.003_bib85","doi-asserted-by":"crossref","DOI":"10.1016\/j.brainresrev.2007.12.001","article-title":"Inflammation, genes and zinc in Alzheimer's disease","author":"Vasto","year":"2008","journal-title":"Brain Res. Rev."},{"key":"10.1016\/j.mad.2008.06.003_bib86","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1097\/CEJ.0b013e3282b6fcff","article-title":"Antitumor necrosis factor-alpha therapy and potential cancer inhibition","volume":"17","author":"Williams","year":"2008","journal-title":"Eur. J. Cancer Prev."},{"key":"10.1016\/j.mad.2008.06.003_bib87","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1158\/0008-5472.CAN-07-2917","article-title":"Yin-yang activities and vicious cycles in the tumor microenvironment","volume":"68","author":"Witz","year":"2008","journal-title":"Cancer Res."},{"key":"10.1016\/j.mad.2008.06.003_bib88","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1007\/s10038-008-0273-3","article-title":"Polymorphisms of tumor necrosis factor-alpha are associated with increased susceptibility to gastric cancer: a meta-analysis","volume":"53","author":"Zhang","year":"2008","journal-title":"J. Hum. Genet."},{"key":"10.1016\/j.mad.2008.06.003_bib89","doi-asserted-by":"crossref","first-page":"2918","DOI":"10.1158\/0008-5472.CAN-03-3280","article-title":"Sequence variants of toll-like receptor 4 are associated with prostate cancer risk: results from the Cancer Prostate in Sweden Study","volume":"64","author":"Zheng","year":"2004","journal-title":"Cancer Res."},{"key":"10.1016\/j.mad.2008.06.003_bib90","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/S0002-9149(99)00653-0","article-title":"Effects of total pathogen burden on coronary artery disease risk and C-reactive protein levels","volume":"85","author":"Zhu","year":"2000","journal-title":"Am. J. Cardiol."}],"container-title":["Mechanisms of Ageing and Development"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0047637408001589?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0047637408001589?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,5,12]],"date-time":"2019-05-12T16:24:00Z","timestamp":1557678240000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0047637408001589"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,1]]},"references-count":90,"journal-issue":{"issue":"1-2","published-print":{"date-parts":[[2009,1]]}},"alternative-id":["S0047637408001589"],"URL":"https:\/\/doi.org\/10.1016\/j.mad.2008.06.003","relation":{},"ISSN":["0047-6374"],"issn-type":[{"value":"0047-6374","type":"print"}],"subject":[],"published":{"date-parts":[[2009,1]]}}}