{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T15:39:14Z","timestamp":1792251554460,"version":"4.4.0"},"reference-count":125,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2009,9,1]],"date-time":"2009-09-01T00:00:00Z","timestamp":1251763200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mechanisms of Ageing and Development"],"published-print":{"date-parts":[[2009,9]]},"DOI":"10.1016\/j.mad.2009.06.009","type":"journal-article","created":{"date-parts":[[2009,7,5]],"date-time":"2009-07-05T08:15:27Z","timestamp":1246781727000},"page":"553-563","source":"Crossref","is-referenced-by-count":21,"title":["Human genetic variations: Beacons on the pathways to successful ageing"],"prefix":"10.1016","volume":"130","author":[{"given":"Christie","family":"Cluett","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Melzer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.mad.2009.06.009_bib1","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1186\/1755-8794-1-44","article-title":"A genome-wide association study for late-onset Alzheimer's disease using DNA pooling","volume":"1","author":"Abraham","year":"2008","journal-title":"BMC Med. Genomics"},{"key":"10.1016\/j.mad.2009.06.009_bib2","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1006\/bbrc.1998.9170","article-title":"Induction of inhibitory Smad6 and Smad7 mRNA by TGF-beta family members","volume":"249","author":"Afrakhte","year":"1998","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.mad.2009.06.009_bib3","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1126\/science.1156409","article-title":"Genetic mapping in human disease","volume":"322","author":"Altshuler","year":"2008","journal-title":"Science"},{"key":"10.1016\/j.mad.2009.06.009_bib4","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1038\/ng.109","article-title":"Genome-wide association scan of tag SNPs identifies a susceptibility locus for lung cancer at 15q25.1","volume":"40","author":"Amos","year":"2008","journal-title":"Nat. Genet."},{"key":"10.1016\/j.mad.2009.06.009_bib5","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1089\/rej.2008.0827","article-title":"Association of the FOXO3A locus with extreme longevity in a Southern Italian Centenarian Study","volume":"12","author":"Anselmi","year":"2009","journal-title":"Rejuvenation Res."},{"key":"10.1016\/j.mad.2009.06.009_bib6","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1038\/ng.269","article-title":"Loci influencing lipid levels and coronary heart disease risk in 16 European population cohorts","volume":"41","author":"Aulchenko","year":"2009","journal-title":"Nat. Genet."},{"key":"10.1016\/j.mad.2009.06.009_bib7","first-page":"7","article-title":"Insulin and aging","author":"Bartke","year":"2008","journal-title":"Cell Cycle"},{"key":"10.1016\/j.mad.2009.06.009_bib8","series-title":"Life Extension in the Dwarf Mouse. Current Topics in Developmental Biology","author":"Bartke","year":"2004"},{"key":"10.1016\/j.mad.2009.06.009_bib9","doi-asserted-by":"crossref","first-page":"B340","DOI":"10.1093\/gerona\/56.8.B340","article-title":"Genes that prolong life: relationships of growth hormone and growth to aging and life span","volume":"56","author":"Bartke","year":"2001","journal-title":"J. Gerontol. A: Biol. Sci. Med. Sci."},{"key":"10.1016\/j.mad.2009.06.009_bib10","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1016\/j.biocel.2004.10.013","article-title":"The signals and pathways activating cellular senescence","volume":"37","author":"Ben-Porath","year":"2005","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"10.1016\/j.mad.2009.06.009_bib11","doi-asserted-by":"crossref","first-page":"4143","DOI":"10.1242\/jcs.114.23.4143","article-title":"Complexes of tetraspanins with integrins: more than meets the eye","volume":"114","author":"Berditchevski","year":"2001","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.mad.2009.06.009_bib12","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1016\/j.ajhg.2008.10.008","article-title":"Genome-wide association analysis reveals putative Alzheimer's disease susceptibility loci in addition to APOE","volume":"83","author":"Bertram","year":"2008","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.mad.2009.06.009_bib13","doi-asserted-by":"crossref","first-page":"44656","DOI":"10.1074\/jbc.M406151200","article-title":"Cdc123 and checkpoint forkhead associated with RING proteins control the cell cycle by controlling eIF2gamma abundance","volume":"279","author":"Bieganowski","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.mad.2009.06.009_bib14","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1146\/annurev.nutr.23.011702.073203","article-title":"Nutrient regulation of cell cycle progression","volume":"24","author":"Bohnsack","year":"2004","journal-title":"Annu. Rev. Nutr."},{"key":"10.1016\/j.mad.2009.06.009_bib15","doi-asserted-by":"crossref","first-page":"1315","DOI":"10.1038\/ng.2007.18","article-title":"A genome-wide association study shows that common alleles of SMAD7 influence colorectal cancer risk","volume":"39","author":"Broderick","year":"2007","journal-title":"Nat. Genet."},{"key":"10.1016\/j.mad.2009.06.009_bib16","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.arr.2007.02.005","article-title":"Hormonal regulation of longevity in mammals","volume":"6","author":"Brown-Borg","year":"2007","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.mad.2009.06.009_bib17","doi-asserted-by":"crossref","first-page":"3415","DOI":"10.1038\/sj.onc.1210128","article-title":"PML4 induces differentiation by Myc destabilization","volume":"26","author":"Buschbeck","year":"2007","journal-title":"Oncogene"},{"key":"10.1016\/j.mad.2009.06.009_bib18","doi-asserted-by":"crossref","first-page":"a399","DOI":"10.1136\/bmj.a399","article-title":"New model of health promotion and disease prevention for the 21st century","volume":"337","author":"Butler","year":"2008","journal-title":"BMJ"},{"key":"10.1016\/j.mad.2009.06.009_bib19","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1007\/s10522-006-9020-3","article-title":"Mortality partitions and their relevance to research on senescence","volume":"7","author":"Carnes","year":"2006","journal-title":"Biogerontology"},{"key":"10.1016\/j.mad.2009.06.009_bib20","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1016\/j.mad.2008.09.016","article-title":"Does senescence give rise to disease?","volume":"129","author":"Carnes","year":"2008","journal-title":"Mech. Ageing Dev."},{"key":"10.1016\/j.mad.2009.06.009_bib21","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1038\/ng.305","article-title":"Genetic variation in PCDH11X is associated with susceptibility to late-onset Alzheimer's disease","volume":"41","author":"Carrasquillo","year":"2009","journal-title":"Nat. Genet."},{"key":"10.1016\/j.mad.2009.06.009_bib22","doi-asserted-by":"crossref","first-page":"10895","DOI":"10.1073\/pnas.0402857101","article-title":"Older age becomes common late in human evolution","volume":"101","author":"Caspari","year":"2004","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.mad.2009.06.009_bib23","doi-asserted-by":"crossref","first-page":"1636","DOI":"10.1038\/sj.onc.1207271","article-title":"A candidate tumor suppressor HtrA1 is downregulated in ovarian cancer","volume":"23","author":"Chien","year":"2004","journal-title":"Oncogene"},{"key":"10.1016\/j.mad.2009.06.009_bib24","doi-asserted-by":"crossref","first-page":"7597","DOI":"10.1074\/jbc.M409380200","article-title":"Disruption of the mthfd1 gene reveals a monofunctional 10-formyltetrahydrofolate synthetase in mammalian mitochondria","volume":"280","author":"Christensen","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.mad.2009.06.009_bib25","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1126\/science.1133807","article-title":"HTRA1 promoter polymorphism in wet age-related macular degeneration","volume":"314","author":"Dewan","year":"2006","journal-title":"Science"},{"key":"10.1016\/j.mad.2009.06.009_bib26","doi-asserted-by":"crossref","first-page":"1204","DOI":"10.1038\/ng.219","article-title":"A genome-wide association study identifies six susceptibility loci for chronic lymphocytic leukemia","volume":"40","author":"Di Bernardo","year":"2008","journal-title":"Nat. Genet."},{"key":"10.1016\/j.mad.2009.06.009_bib27","doi-asserted-by":"crossref","first-page":"a2467","DOI":"10.1136\/bmj.a2467","article-title":"Incidence of cardiovascular disease and cancer in advanced age: prospective cohort study","volume":"337","author":"Driver","year":"2008","journal-title":"BMJ"},{"key":"10.1016\/j.mad.2009.06.009_bib28","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.1002\/jcb.10478","article-title":"Involvement of MEKK1\/ERK\/P21Waf1\/Cip1 signal transduction pathway in inhibition of IGF-I-mediated cell growth response by methylglyoxal","volume":"88","author":"Du","year":"2003","journal-title":"J. Cell. Biochem."},{"key":"10.1016\/j.mad.2009.06.009_bib29","doi-asserted-by":"crossref","first-page":"R109","DOI":"10.1093\/hmg\/ddn287","article-title":"Genome-wide association studies in cancer","volume":"17","author":"Easton","year":"2008","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.mad.2009.06.009_bib30","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1038\/nature05887","article-title":"Genome-wide association study identifies novel breast cancer susceptibility loci","volume":"447","author":"Easton","year":"2007","journal-title":"Nature"},{"key":"10.1016\/j.mad.2009.06.009_bib31","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1038\/ng.90","article-title":"Multiple newly identified loci associated with prostate cancer susceptibility","volume":"40","author":"Eeles","year":"2008","journal-title":"Nat. Genet."},{"key":"10.1016\/j.mad.2009.06.009_bib32","doi-asserted-by":"crossref","first-page":"6736","DOI":"10.1073\/pnas.111158898","article-title":"Lifespan extension and delayed immune and collagen aging in mutant mice with defects in growth hormone production","volume":"98","author":"Flurkey","year":"2001","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.mad.2009.06.009_bib33","doi-asserted-by":"crossref","first-page":"S173","DOI":"10.1301\/nr.2007.dec.S173-S176","article-title":"Inflammaging as a major characteristic of old people: can it be prevented or cured?","volume":"65","author":"Franceschi","year":"2007","journal-title":"Nutr. Rev."},{"key":"10.1016\/j.mad.2009.06.009_bib34","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1038\/nature06258","article-title":"A second generation human haplotype map of over 3.1 million SNPs","volume":"449","author":"Frazer","year":"2007","journal-title":"Nature"},{"key":"10.1016\/j.mad.2009.06.009_bib35","doi-asserted-by":"crossref","first-page":"2225","DOI":"10.1126\/science.1069424","article-title":"The structure of haplotype blocks in the human genome","volume":"296","author":"Gabriel","year":"2002","journal-title":"Science"},{"key":"10.1016\/j.mad.2009.06.009_bib36","doi-asserted-by":"crossref","first-page":"4340","DOI":"10.1073\/pnas.0800441105","article-title":"Genome-wide association study provides evidence for a breast cancer risk locus at 6q22.33","volume":"105","author":"Gold","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.mad.2009.06.009_bib37","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1038\/ng1750","article-title":"Variation in factor B (BF) and complement component 2 (C2) genes is associated with age-related macular degeneration","volume":"38","author":"Gold","year":"2006","journal-title":"Nat. Genet."},{"key":"10.1016\/j.mad.2009.06.009_bib38","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1093\/hmg\/ddm031","article-title":"Evidence for novel susceptibility genes for late-onset Alzheimer's disease from a genome-wide association study of putative functional variants","volume":"16","author":"Grupe","year":"2007","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.mad.2009.06.009_bib39","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1038\/ng1999","article-title":"Genome-wide association study identifies a second prostate cancer susceptibility variant at 8q24","volume":"39","author":"Gudmundsson","year":"2007","journal-title":"Nat. Genet."},{"key":"10.1016\/j.mad.2009.06.009_bib40","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1038\/ng.89","article-title":"Common sequence variants on 2p15 and Xp11.22 confer susceptibility to prostate cancer","volume":"40","author":"Gudmundsson","year":"2008","journal-title":"Nat. Genet."},{"key":"10.1016\/j.mad.2009.06.009_bib41","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1038\/ng2062","article-title":"Two variants on chromosome 17 confer prostate cancer risk, and the one in TCF2 protects against type 2 diabetes","volume":"39","author":"Gudmundsson","year":"2007","journal-title":"Nat. Genet."},{"key":"10.1016\/j.mad.2009.06.009_bib42","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1038\/ng2015","article-title":"Multiple regions within 8q24 independently affect risk for prostate cancer","volume":"39","author":"Haiman","year":"2007","journal-title":"Nat. Genet."},{"key":"10.1016\/j.mad.2009.06.009_bib43","doi-asserted-by":"crossref","first-page":"1759","DOI":"10.1056\/NEJMra0808700","article-title":"Genomewide association studies and human disease","volume":"360","author":"Hardy","year":"2009","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.mad.2009.06.009_bib44","doi-asserted-by":"crossref","first-page":"20753","DOI":"10.1073\/pnas.0707650104","article-title":"Recent acceleration of human adaptive evolution","volume":"104","author":"Hawks","year":"2007","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.mad.2009.06.009_bib45","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1038\/ng.72","article-title":"The same sequence variant on 9p21 associates with myocardial infarction, abdominal aortic aneurysm and intracranial aneurysm","volume":"40","author":"Helgadottir","year":"2008","journal-title":"Nat. Genet."},{"key":"10.1016\/j.mad.2009.06.009_bib46","doi-asserted-by":"crossref","first-page":"1491","DOI":"10.1126\/science.1142842","article-title":"A common variant on chromosome 9p21 affects the risk of myocardial infarction","volume":"8","author":"Helgadottir","year":"2007","journal-title":"Science"},{"key":"10.1016\/j.mad.2009.06.009_bib47","doi-asserted-by":"crossref","first-page":"32730","DOI":"10.1074\/jbc.M205476200","article-title":"An adjacent pair of human NUDT genes on chromosome X are preferentially expressed in testis and encode two new isoforms of diphosphoinositol polyphosphate phosphohydrolase","volume":"277","author":"Hidaka","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.mad.2009.06.009_bib48","doi-asserted-by":"crossref","first-page":"1426","DOI":"10.1038\/ng.262","article-title":"Meta-analysis of genome-wide association data identifies four new susceptibility loci for colorectal cancer","volume":"40","author":"Houlston","year":"2008","journal-title":"Nat. Genet."},{"key":"10.1016\/j.mad.2009.06.009_bib49","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1128\/MCB.00961-08","article-title":"Regulation of telomerase activity by interferon regulatory factors 4 and 8 in immune cells","volume":"29","author":"Hrdlickova","year":"2009","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.mad.2009.06.009_bib50","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1016\/j.bbrc.2008.02.047","article-title":"Human DDA3 is an oncoprotein down-regulated by p53 and DNA damage","volume":"369","author":"Hsieh","year":"2008","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.mad.2009.06.009_bib51","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1038\/ng1890","article-title":"A common CFH haplotype, with deletion of CFHR1 and CFHR3, is associated with lower risk of age-related macular degeneration","volume":"38","author":"Hughes","year":"2006","journal-title":"Nat. Genet."},{"key":"10.1016\/j.mad.2009.06.009_bib52","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1038\/nature06885","article-title":"A susceptibility locus for lung cancer maps to nicotinic acetylcholine receptor subunit genes on 15q25","volume":"452","author":"Hung","year":"2008","journal-title":"Nature"},{"key":"10.1016\/j.mad.2009.06.009_bib53","doi-asserted-by":"crossref","first-page":"2760","DOI":"10.1056\/NEJMp0804318","article-title":"From Darwin's finches to canaries in the coal mine--mining the genome for new biology","volume":"358","author":"Hunter","year":"2008","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.mad.2009.06.009_bib54","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1038\/ng2075","article-title":"A genome-wide association study identifies alleles in FGFR2 associated with risk of sporadic postmenopausal breast cancer","volume":"39","author":"Hunter","year":"2007","journal-title":"Nat. Genet."},{"key":"10.1016\/j.mad.2009.06.009_bib55","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1038\/nature05159","article-title":"Stem-cell ageing modified by the cyclin-dependent kinase inhibitor p16INK4a","volume":"443","author":"Janzen","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.mad.2009.06.009_bib56","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1016\/j.mad.2008.04.001","article-title":"Cellular senescence and organismal aging","volume":"129","author":"Jeyapalan","year":"2008","journal-title":"Mech. Ageing Dev."},{"key":"10.1016\/j.mad.2009.06.009_bib57","doi-asserted-by":"crossref","first-page":"1240","DOI":"10.1056\/NEJMoa0706728","article-title":"Polymorphisms associated with cholesterol and risk of cardiovascular events","volume":"358","author":"Kathiresan","year":"2008","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.mad.2009.06.009_bib58","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1038\/ng.75","article-title":"Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humans","volume":"40","author":"Kathiresan","year":"2008","journal-title":"Nat. Genet."},{"key":"10.1016\/j.mad.2009.06.009_bib59","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1038\/ng.291","article-title":"Common variants at 30 loci contribute to polygenic dyslipidemia","volume":"41","author":"Kathiresan","year":"2009","journal-title":"Nat. Genet."},{"key":"10.1016\/j.mad.2009.06.009_bib60","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.1038\/ng.229","article-title":"Sequence variant on 8q24 confers susceptibility to urinary bladder cancer","volume":"40","author":"Kiemeney","year":"2008","journal-title":"Nat. Genet."},{"key":"10.1016\/j.mad.2009.06.009_bib61","doi-asserted-by":"crossref","first-page":"13995","DOI":"10.1074\/jbc.M300253200","article-title":"Glycogen synthase kinase 3 beta is a natural activator of mitogen-activated protein kinase\/extracellular signal-regulated kinase kinase kinase 1 (MEKK1)","volume":"278","author":"Kim","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.mad.2009.06.009_bib62","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1038\/451644a","article-title":"A systematic look at an old problem","volume":"451","author":"Kirkwood","year":"2008","journal-title":"Nature"},{"key":"10.1016\/j.mad.2009.06.009_bib63","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1038\/nature05092","article-title":"p16INK4a induces an age-dependent decline in islet regenerative potential","volume":"443","author":"Krishnamurthy","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.mad.2009.06.009_bib64","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1111\/j.1474-9726.2008.00366.x","article-title":"Genes encoding longevity: from model organisms to humans","volume":"7","author":"Kuningas","year":"2008","journal-title":"Aging Cell"},{"key":"10.1016\/j.mad.2009.06.009_bib65","doi-asserted-by":"crossref","first-page":"19826","DOI":"10.1074\/jbc.M706201200","article-title":"Cooperative roles of c-Abl and Cdk5 in regulation of p53 in response to oxidative stress","volume":"283","author":"Lee","year":"2008","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.mad.2009.06.009_bib66","unstructured":"Lescai, F., Marchegiani, F., Franceschi, C., in press. Pon1 is a longevity gene: results of a meta-analysis. Ageing Res. Rev. (Corrected Proof)."},{"key":"10.1016\/j.mad.2009.06.009_bib67","doi-asserted-by":"crossref","first-page":"20001","DOI":"10.1073\/pnas.0709986104","article-title":"Effects of rearrangement and allelic exclusion of JJAZ1\/SUZ12 on cell proliferation and survival","volume":"104","author":"Li","year":"2007","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.mad.2009.06.009_bib68","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1001\/archneurol.2007.3","article-title":"Candidate single-nucleotide polymorphisms from a genomewide association study of Alzheimer disease","volume":"65","author":"Li","year":"2008","journal-title":"Arch. Neurol."},{"key":"10.1016\/j.mad.2009.06.009_bib69","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1038\/ng1871","article-title":"CFH haplotypes without the Y402H coding variant show strong association with susceptibility to age-related macular degeneration","volume":"38","author":"Li","year":"2006","journal-title":"Nat. Genet."},{"key":"10.1016\/j.mad.2009.06.009_bib70","doi-asserted-by":"crossref","first-page":"1326","DOI":"10.1093\/jnci\/djn268","article-title":"Familial aggregation of common sequence variants on 15q24-25.1 in lung cancer","volume":"100","author":"Liu","year":"2008","journal-title":"J. Natl. Cancer Inst."},{"key":"10.1016\/j.mad.2009.06.009_bib71","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1038\/ng1873","article-title":"Common variation in three genes, including a noncoding variant in CFH, strongly influences risk of age-related macular degeneration","volume":"38","author":"Maller","year":"2006","journal-title":"Nat. Genet."},{"key":"10.1016\/j.mad.2009.06.009_bib72","doi-asserted-by":"crossref","first-page":"1404","DOI":"10.1038\/ng.254","article-title":"Lung cancer susceptibility locus at 5p15.33","volume":"40","author":"Mckay","year":"2008","journal-title":"Nat. Genet."},{"key":"10.1016\/j.mad.2009.06.009_bib73","doi-asserted-by":"crossref","first-page":"1488","DOI":"10.1126\/science.1142447","article-title":"A common allele on chromosome 9 associated with coronary heart disease","volume":"316","author":"Mcpherson","year":"2007","journal-title":"Science"},{"key":"10.1016\/j.mad.2009.06.009_bib74","first-page":"128","article-title":"A common variant of the p16(INK4a) genetic region is associated with physical function in older people","author":"Melzer","year":"2007","journal-title":"Mech. Ageing Dev."},{"key":"10.1016\/j.mad.2009.06.009_bib75","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1136\/bmj.39506.601053.BE","article-title":"Genetic tests for common diseases: new insights, old concerns","volume":"336","author":"Melzer","year":"2008","journal-title":"BMJ"},{"issue":"4","key":"10.1016\/j.mad.2009.06.009_bib76","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1186\/1741-7015-4-34","article-title":"Effects of the diabetes linked TCF7L2 polymorphism in a representative older population","volume":"20","author":"Melzer","year":"2006","journal-title":"BMC Med."},{"key":"10.1016\/j.mad.2009.06.009_bib77","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1038\/nature05091","article-title":"Increasing p16INK4a expression decreases forebrain progenitors and neurogenesis during ageing","volume":"443","author":"Molofsky","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.mad.2009.06.009_bib78","doi-asserted-by":"crossref","first-page":"1711","DOI":"10.1093\/eurheartj\/ehp161","article-title":"Common lipid-altering gene variants are associated with therapeutic intervention thresholds of lipid levels in older people","volume":"30","author":"Murray","year":"2009","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.mad.2009.06.009_bib79","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1016\/j.clinbiochem.2008.01.004","article-title":"Changes in mRNA and protein levels of human HtrA1, HtrA2 and HtrA3 in ovarian cancer","volume":"41","author":"Narkiewicz","year":"2008","journal-title":"Clin. Biochem."},{"key":"10.1016\/j.mad.2009.06.009_bib80","first-page":"1137","article-title":"Immunohistochemical survey of p16(INK4A) expression in normal human adult and infant tissues","volume":"79","author":"Nielsen","year":"1999","journal-title":"Lab. Invest."},{"key":"10.1016\/j.mad.2009.06.009_bib81","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1007\/s10522-007-9116-4","article-title":"Lack of replication of genetic associations with human longevity","volume":"9","author":"Novelli","year":"2008","journal-title":"Biogerontology"},{"key":"10.1016\/j.mad.2009.06.009_bib82","first-page":"779","article-title":"The possible correlation of Notch-1 and Notch-2 with clinical outcome and tumour clinicopathological parameters in human breast cancer","volume":"14","author":"Parr","year":"2004","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.mad.2009.06.009_bib83","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1016\/0092-8674(95)90214-7","article-title":"Alternative reading frames of the INK4a tumor suppressor gene encode two unrelated proteins capable of inducing cell cycle arrest","volume":"83","author":"Quelle","year":"1995","journal-title":"Cell"},{"key":"10.1016\/j.mad.2009.06.009_bib84","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1038\/ng.296","article-title":"Sequence variants at the TERT-CLPTM1L locus associate with many cancer types","volume":"41","author":"Rafnar","year":"2009","journal-title":"Nat. Genet."},{"key":"10.1016\/j.mad.2009.06.009_bib85","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1038\/gt.2008.166","article-title":"Progress & prospects: gene therapy in aging","volume":"16","author":"Rattan","year":"2008","journal-title":"Gene Ther."},{"key":"10.1016\/j.mad.2009.06.009_bib86","doi-asserted-by":"crossref","first-page":"1505","DOI":"10.1016\/S0140-6736(08)60599-1","article-title":"Bone mineral density, osteoporosis, and osteoporotic fractures: a genome-wide association study","volume":"371","author":"Richards","year":"2008","journal-title":"Lancet"},{"key":"10.1016\/j.mad.2009.06.009_bib87","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1002\/ar.20550","article-title":"Receptor activator of nuclear factor kappa B ligand (RANKL) modulates the expression of genes involved in apoptosis and cell cycle in human osteoclasts","volume":"290","author":"Rimondi","year":"2007","journal-title":"Anat. Rec. (Hoboken)"},{"key":"10.1016\/j.mad.2009.06.009_bib88","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1126\/science.3299702","article-title":"Human aging: usual and successful","volume":"237","author":"Rowe","year":"1987","journal-title":"Science"},{"key":"10.1016\/j.mad.2009.06.009_bib89","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/S1073-4449(00)70008-2","article-title":"Successful aging and disease prevention","volume":"7","author":"Rowe","year":"2000","journal-title":"Adv. Ren. Replace. Ther."},{"key":"10.1016\/j.mad.2009.06.009_bib90","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/S0896-6273(00)00036-2","article-title":"NRAGE, a novel MAGE protein, interacts with the p75 neurotrophin receptor and facilitates nerve growth factor-dependent apoptosis","volume":"27","author":"Salehi","year":"2000","journal-title":"Neuron"},{"key":"10.1016\/j.mad.2009.06.009_bib91","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1056\/NEJMoa072366","article-title":"Genomewide association analysis of coronary artery disease","volume":"357","author":"Samani","year":"2007","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.mad.2009.06.009_bib92","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.1126\/science.1142358","article-title":"Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels","volume":"316","author":"Saxena","year":"2007","journal-title":"Science"},{"key":"10.1016\/j.mad.2009.06.009_bib93","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.1126\/science.1142382","article-title":"A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants","volume":"316","author":"Scott","year":"2007","journal-title":"Science"},{"key":"10.1016\/j.mad.2009.06.009_bib94","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1096\/fj.07-9261com","article-title":"Evidence for lifespan extension and delayed age-related biomarkers in insulin receptor substrate 1 null mice","volume":"22","author":"Selman","year":"2008","journal-title":"FASEB J."},{"key":"10.1016\/j.mad.2009.06.009_bib95","doi-asserted-by":"crossref","first-page":"1751","DOI":"10.1016\/j.exger.2004.06.025","article-title":"Ink4a\/Arf links senescence and aging","volume":"39","author":"Sharpless","year":"2004","journal-title":"Exp. Gerontol."},{"key":"10.1016\/j.mad.2009.06.009_bib96","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1038\/nrm2241","article-title":"How stem cells age and why this makes us grow old","volume":"8","author":"Sharpless","year":"2007","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.mad.2009.06.009_bib97","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1097\/01.SLA.0000059969.64262.87","article-title":"Rating the risk factors for breast cancer","volume":"237","author":"Singletary","year":"2003","journal-title":"Ann. Surg."},{"key":"10.1016\/j.mad.2009.06.009_bib98","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1038\/nature05616","article-title":"A genome-wide association study identifies novel risk loci for type 2 diabetes","volume":"445","author":"Sladek","year":"2007","journal-title":"Nature"},{"key":"10.1016\/j.mad.2009.06.009_bib99","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1038\/ng2064","article-title":"Common variants on chromosomes 2q35 and 16q12 confer susceptibility to estrogen receptor-positive breast cancer","volume":"39","author":"Stacey","year":"2007","journal-title":"Nat. Genet."},{"key":"10.1016\/j.mad.2009.06.009_bib100","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1038\/ng2043","article-title":"A variant in CDKAL1 influences insulin response and risk of type 2 diabetes","volume":"39","author":"Steinthorsdottir","year":"2007","journal-title":"Nat. Genet."},{"key":"10.1016\/j.mad.2009.06.009_bib101","doi-asserted-by":"crossref","first-page":"2355","DOI":"10.1056\/NEJMoa0801197","article-title":"Multiple genetic loci for bone mineral density and fractures","volume":"358","author":"Styrkarsdottir","year":"2008","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.mad.2009.06.009_bib102","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1038\/ng.284","article-title":"New sequence variants associated with bone mineral density","volume":"41","author":"Styrkarsdottir","year":"2009","journal-title":"Nat. Genet."},{"key":"10.1016\/j.mad.2009.06.009_bib103","doi-asserted-by":"crossref","first-page":"6833","DOI":"10.1073\/pnas.87.17.6833","article-title":"Molecular cloning of cDNA for the human tumor-associated antigen CO-029 and identification of related transmembrane antigens","volume":"87","author":"Szala","year":"1990","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.mad.2009.06.009_bib104","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1038\/ng.133","article-title":"Genome-wide association scan identifies a colorectal cancer susceptibility locus on 11q23 and replicates risk loci at 8q24 and 18q21","volume":"40","author":"Tenesa","year":"2008","journal-title":"Nat. Genet."},{"key":"10.1016\/j.mad.2009.06.009_bib105","doi-asserted-by":"crossref","first-page":"2784","DOI":"10.1093\/hmg\/ddl220","article-title":"Systematic review and meta-analysis of the association between complement factor H Y402H polymorphisms and age-related macular degeneration","volume":"15","author":"Thakkinstian","year":"2006","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.mad.2009.06.009_bib106","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1038\/ng.91","article-title":"Multiple loci identified in a genome-wide association study of prostate cancer","volume":"40","author":"Thomas","year":"2008","journal-title":"Nat. Genet."},{"key":"10.1016\/j.mad.2009.06.009_bib107","doi-asserted-by":"crossref","first-page":"984","DOI":"10.1038\/ng2085","article-title":"A genome-wide association scan of tag SNPs identifies a susceptibility variant for colorectal cancer at 8q24.21","volume":"39","author":"Tomlinson","year":"2007","journal-title":"Nat. Genet."},{"key":"10.1016\/j.mad.2009.06.009_bib108","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1038\/ng.111","article-title":"A genome-wide association study identifies colorectal cancer susceptibility loci on chromosomes 10p14 and 8q23.3","volume":"40","author":"Tomlinson","year":"2008","journal-title":"Nat. Genet."},{"key":"10.1016\/j.mad.2009.06.009_bib109","doi-asserted-by":"crossref","first-page":"1098","DOI":"10.1038\/ng.208","article-title":"SNPs in KCNQ1 are associated with susceptibility to type 2 diabetes in East Asian and European populations","volume":"40","author":"Unoki","year":"2008","journal-title":"Nat. Genet."},{"key":"10.1016\/j.mad.2009.06.009_bib110","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1038\/nature07216","article-title":"Puzzles, promises and a cure for ageing","volume":"454","author":"Vijg","year":"2008","journal-title":"Nature"},{"key":"10.1016\/j.mad.2009.06.009_bib111","doi-asserted-by":"crossref","first-page":"1407","DOI":"10.1038\/ng.273","article-title":"Common 5p15.33 and 6p21. 33 variants influence lung cancer risk","volume":"40","author":"Wang","year":"2008","journal-title":"Nat. Genet."},{"key":"10.1016\/j.mad.2009.06.009_bib112","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1038\/nature05911","article-title":"Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls","volume":"447","author":"Wellcome Trust Case Control","year":"2007","journal-title":"Nature"},{"key":"10.1016\/j.mad.2009.06.009_bib113","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/S0014-5793(04)00353-9","article-title":"hNRAGE, a human neurotrophin receptor interacting MAGE homologue, regulates p53 transcriptional activity and inhibits cell proliferation","volume":"564","author":"Wen","year":"2004","journal-title":"FEBS Lett."},{"key":"10.1016\/j.mad.2009.06.009_bib114","doi-asserted-by":"crossref","first-page":"13987","DOI":"10.1073\/pnas.0801030105","article-title":"FOXO3A genotype is strongly associated with human longevity","volume":"105","author":"Willcox","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.mad.2009.06.009_bib115","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1093\/gerona\/63.11.1201","article-title":"Life at the extreme limit: phenotypic characteristics of supercentenarians in Okinawa","volume":"63","author":"Willcox","year":"2008","journal-title":"J. Gerontol. A: Biol. Sci. Med. Sci."},{"key":"10.1016\/j.mad.2009.06.009_bib116","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1038\/ng.76","article-title":"Newly identified loci that influence lipid concentrations and risk of coronary artery disease","volume":"40","author":"Willer","year":"2008","journal-title":"Nat. Genet."},{"key":"10.1016\/j.mad.2009.06.009_bib117","doi-asserted-by":"crossref","first-page":"992","DOI":"10.1126\/science.1133811","article-title":"A variant of the HTRA1 gene increases susceptibility to age-related macular degeneration","volume":"314","author":"Yang","year":"2006","journal-title":"Science"},{"key":"10.1016\/j.mad.2009.06.009_bib118","doi-asserted-by":"crossref","first-page":"1092","DOI":"10.1038\/ng.207","article-title":"Variants in KCNQ1 are associated with susceptibility to type 2 diabetes mellitus","volume":"40","author":"Yasuda","year":"2008","journal-title":"Nat. Genet."},{"key":"10.1016\/j.mad.2009.06.009_bib119","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1038\/ng2022","article-title":"Genome-wide association study of prostate cancer identifies a second risk locus at 8q24","volume":"39","author":"Yeager","year":"2007","journal-title":"Nat. Genet."},{"key":"10.1016\/j.mad.2009.06.009_bib120","doi-asserted-by":"crossref","first-page":"1797","DOI":"10.4049\/jimmunol.170.4.1797","article-title":"Cooperation of TNF family members CD40 ligand, receptor activator of NF-kappa B ligand, and TNF-alpha in the activation of dendritic cells and the expansion of viral specific CD8+ T cell memory responses in HIV-1-infected and HIV-1-uninfected individuals","volume":"170","author":"Yu","year":"2003","journal-title":"J. Immunol."},{"key":"10.1016\/j.mad.2009.06.009_bib121","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1038\/ng2089","article-title":"Genome-wide association scan identifies a colorectal cancer susceptibility locus on chromosome 8q24","volume":"39","author":"Zanke","year":"2007","journal-title":"Nat. Genet."},{"key":"10.1016\/j.mad.2009.06.009_bib122","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1038\/ng.120","article-title":"Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes","volume":"40","author":"Zeggini","year":"2008","journal-title":"Nat. Genet."},{"key":"10.1016\/j.mad.2009.06.009_bib123","doi-asserted-by":"crossref","DOI":"10.1126\/science.1142364","article-title":"Replication of genome-wide association signals in U.K. samples reveals risk loci for type 2 diabetes","author":"Zeggini","year":"2007","journal-title":"Science"},{"key":"10.1016\/j.mad.2009.06.009_bib124","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1038\/ng.318","article-title":"Genome-wide association study identifies a new breast cancer susceptibility locus at 6q25.1","volume":"41","author":"Zheng","year":"2009","journal-title":"Nat. Genet."},{"key":"10.1016\/j.mad.2009.06.009_bib125","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1038\/sj.onc.1201178","article-title":"Expression of the p16(INK4a) tumor suppressor versus other INK4 family members during mouse development and aging","volume":"15","author":"Zindy","year":"1997","journal-title":"Oncogene"}],"container-title":["Mechanisms of Ageing and Development"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S004763740900089X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S004763740900089X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,10,8]],"date-time":"2021-10-08T04:38:29Z","timestamp":1633667909000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S004763740900089X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,9]]},"references-count":125,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2009,9]]}},"alternative-id":["S004763740900089X"],"URL":"https:\/\/doi.org\/10.1016\/j.mad.2009.06.009","relation":{},"ISSN":["0047-6374"],"issn-type":[{"value":"0047-6374","type":"print"}],"subject":[],"published":{"date-parts":[[2009,9]]}}}