{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T21:42:21Z","timestamp":1781732541613,"version":"3.54.5"},"reference-count":81,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2013,10,1]],"date-time":"2013-10-01T00:00:00Z","timestamp":1380585600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mechanisms of Ageing and Development"],"published-print":{"date-parts":[[2013,10]]},"DOI":"10.1016\/j.mad.2013.05.005","type":"journal-article","created":{"date-parts":[[2013,5,23]],"date-time":"2013-05-23T15:05:01Z","timestamp":1369321501000},"page":"434-439","source":"Crossref","is-referenced-by-count":16,"title":["ATM and the epigenetics of the neuronal genome"],"prefix":"10.1016","volume":"134","author":[{"given":"Karl","family":"Herrup","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.mad.2013.05.005_bib0005","doi-asserted-by":"crossref","first-page":"1194","DOI":"10.1073\/pnas.89.4.1194","article-title":"Photoreceptor degeneration induced by the expression of simian virus 40 large tumor antigen in the retina of transgenic mice","volume":"89","author":"al-Ubaidi","year":"1992","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"18","key":"10.1016\/j.mad.2013.05.005_bib0010","doi-asserted-by":"crossref","first-page":"3047","DOI":"10.1097\/00001756-199611250-00050","article-title":"Expression of the cyclin-dependent kinase inhibitor p16 in Alzheimer\u2019s disease","volume":"7","author":"Arendt","year":"1996","journal-title":"Neuroreport"},{"key":"10.1016\/j.mad.2013.05.005_bib0015","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1016\/S0306-4522(97)00509-5","article-title":"Cortical distribution of neurofibrillary tangles in Alzheimer\u2019s disease matches the pattern of neurons that retain their capacity of plastic remodelling in the adult brain","volume":"83","author":"Arendt","year":"1998","journal-title":"Neuroscience"},{"issue":"8\/9","key":"10.1016\/j.mad.2013.05.005_bib0020","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1007\/s007020050104","article-title":"Neuronal expression of cycline dependent kinase inhibitors of the INK4 family in Alzheimer\u2019s disease","volume":"105","author":"Arendt","year":"1998","journal-title":"Journal of Neural Transmission"},{"issue":"1","key":"10.1016\/j.mad.2013.05.005_bib0025","doi-asserted-by":"crossref","first-page":"15","DOI":"10.2353\/ajpath.2010.090955","article-title":"Selective cell death of hyperploid neurons in Alzheimer\u2019s disease","volume":"177","author":"Arendt","year":"2010","journal-title":"The American Journal of Pathology"},{"issue":"2","key":"10.1016\/j.mad.2013.05.005_bib0030","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1073\/pnas.97.2.871","article-title":"ATM is a cytoplasmic protein in mouse brain required to prevent lysosomal accumulation","volume":"97","author":"Barlow","year":"2000","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"25","key":"10.1016\/j.mad.2013.05.005_bib0035","doi-asserted-by":"crossref","first-page":"1395","DOI":"10.1016\/S0960-9822(98)00021-9","article-title":"Targeted disruption of the gene encoding DNA ligase IV leads to lethality in embryonic mice","volume":"8","author":"Barnes","year":"1998","journal-title":"Current Biology"},{"issue":"3","key":"10.1016\/j.mad.2013.05.005_bib0040","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1139\/o01-032","article-title":"Class II histone deacetylases: structure, function, and regulation","volume":"79","author":"Bertos","year":"2001","journal-title":"Biochemistry and Cell Biology"},{"issue":"25","key":"10.1016\/j.mad.2013.05.005_bib0045","doi-asserted-by":"crossref","first-page":"17482","DOI":"10.1074\/jbc.M601895200","article-title":"Nuclear ataxia-telangiectasia mutated (ATM) mediates the cellular response to DNA double strand breaks in human neuron-like cells","volume":"281","author":"Biton","year":"2006","journal-title":"The Journal of Biological Chemistry"},{"issue":"8","key":"10.1016\/j.mad.2013.05.005_bib0050","doi-asserted-by":"crossref","first-page":"2801","DOI":"10.1523\/JNEUROSCI.18-08-02801.1998","article-title":"Ectopic cell cycle proteins predict the sites of neuronal cell death in Alzheimer\u2019s disease brain","volume":"18","author":"Busser","year":"1998","journal-title":"The Journal of Neuroscience"},{"issue":"5911","key":"10.1016\/j.mad.2013.05.005_bib0055","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1126\/science.1166226","article-title":"HDAC4 regulates neuronal survival in normal and diseased retinas","volume":"323","author":"Chen","year":"2009","journal-title":"Science"},{"issue":"42","key":"10.1016\/j.mad.2013.05.005_bib0060","doi-asserted-by":"crossref","first-page":"9658","DOI":"10.1523\/JNEUROSCI.1773-05.2005","article-title":"Cyclin-dependent kinase 5 is essential for neuronal cell cycle arrest and differentiation","volume":"25","author":"Cicero","year":"2005","journal-title":"The Journal of Neuroscience"},{"issue":"6393","key":"10.1016\/j.mad.2013.05.005_bib0065","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1038\/359328a0","article-title":"Requirement for a functional Rb-1 gene in murine development","volume":"359","author":"Clarke","year":"1992","journal-title":"Nature"},{"issue":"5","key":"10.1016\/j.mad.2013.05.005_bib0070","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1002\/cne.22241","article-title":"Regional and subcellular distribution of HDAC4 in mouse brain","volume":"518","author":"Darcy","year":"2010","journal-title":"The Journal of Comparative Neurology"},{"issue":"5","key":"10.1016\/j.mad.2013.05.005_bib0075","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1016\/0896-6273(92)90247-B","article-title":"Disrupted cerebellar cortical development and progressive degeneration of Purkinje cells in SV40T antigen transgenic mice","volume":"9","author":"Feddersen","year":"1992","journal-title":"Neuron"},{"issue":"2","key":"10.1016\/j.mad.2013.05.005_bib0080","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1006\/mcne.1995.1014","article-title":"In vivo viability of postmitotic Purkinje neurons requires pRb family member function","volume":"6","author":"Feddersen","year":"1995","journal-title":"Molecular and Cellular Neurosciences"},{"issue":"1","key":"10.1016\/j.mad.2013.05.005_bib0085","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1006\/mcne.1997.0601","article-title":"Susceptibility to cell death induced by mutant SV40 T-antigen correlates with Purkinje neuron functional development","volume":"9","author":"Feddersen","year":"1997","journal-title":"Molecular and Cellular Neurosciences"},{"issue":"6","key":"10.1016\/j.mad.2013.05.005_bib0090","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.1016\/j.neuron.2008.11.029","article-title":"Genome-wide analysis of MEF2 transcriptional program reveals synaptic target genes and neuronal activity-dependent polyadenylation site selection","volume":"60","author":"Flavell","year":"2008","journal-title":"Neuron"},{"issue":"3","key":"10.1016\/j.mad.2013.05.005_bib0095","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/S1074-7613(00)80619-6","article-title":"A targeted DNA-PKcs-null mutation reveals DNA-PK-independent functions for KU in V(D)J recombination","volume":"9","author":"Gao","year":"1998","journal-title":"Immunity"},{"issue":"3","key":"10.1016\/j.mad.2013.05.005_bib0100","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/S0166-2236(99)01503-9","article-title":"Cell birth, cell death, cell diversity and DNA breaks: how do they all fit together?","volume":"23","author":"Gilmore","year":"2000","journal-title":"Trends in Neurosciences"},{"issue":"9","key":"10.1016\/j.mad.2013.05.005_bib0105","doi-asserted-by":"crossref","first-page":"4868","DOI":"10.1073\/pnas.96.9.4868","article-title":"Three proteins define a class of human histone deacetylases related to yeast Hda1p","volume":"96","author":"Grozinger","year":"1999","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"8","key":"10.1016\/j.mad.2013.05.005_bib0110","doi-asserted-by":"crossref","first-page":"2385","DOI":"10.1242\/dev.121.8.2385","article-title":"The induction of multiple cell cycle events precedes target-related neuronal death","volume":"121","author":"Herrup","year":"1995","journal-title":"Development"},{"issue":"3","key":"10.1016\/j.mad.2013.05.005_bib0115","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1055\/s-0032-1313915","article-title":"Neurodegeneration in ataxia telangiectasia: what is new? What is evident?","volume":"43","author":"Hoche","year":"2012","journal-title":"Neuropediatrics"},{"issue":"9","key":"10.1016\/j.mad.2013.05.005_bib0120","doi-asserted-by":"crossref","first-page":"3585","DOI":"10.1073\/pnas.0611671104","article-title":"The pRb\/E2F cell-cycle pathway mediates cell death in Parkinson\u2019s disease","volume":"104","author":"Hoglinger","year":"2007","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"8","key":"10.1016\/j.mad.2013.05.005_bib0125","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1093\/jnen\/61.8.678","article-title":"Cyclin D1 and cyclin E are co-localized with cyclo-oxygenase 2 (COX-2) in pyramidal neurons in Alzheimer disease temporal cortex","volume":"61","author":"Hoozemans","year":"2002","journal-title":"Journal of Neuropathology and Experimental Neurology"},{"issue":"6393","key":"10.1016\/j.mad.2013.05.005_bib0130","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1038\/359295a0","article-title":"Effects of an Rb mutation in the mouse","volume":"359","author":"Jacks","year":"1992","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.mad.2013.05.005_bib0135","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/S0047-6374(01)00334-7","article-title":"Altered subcellular distribution of transcriptional regulators in response to Abeta peptide and during Alzheimer\u2019s disease","volume":"123","author":"Jordan-Sciutto","year":"2001","journal-title":"Mechanisms of Ageing and Development"},{"issue":"1","key":"10.1016\/j.mad.2013.05.005_bib0140","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1093\/jnen\/62.1.68","article-title":"Expression patterns of retinoblastoma protein in Parkinson disease","volume":"62","author":"Jordan-Sciutto","year":"2003","journal-title":"Journal of Neuropathology and Experimental Neurology"},{"issue":"4","key":"10.1016\/j.mad.2013.05.005_bib0145","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1016\/S0896-6273(04)00017-0","article-title":"Cell cycle activation linked to neuronal cell death initiated by DNA damage","volume":"41","author":"Kruman","year":"2004","journal-title":"Neuron"},{"issue":"6393","key":"10.1016\/j.mad.2013.05.005_bib0150","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1038\/359288a0","article-title":"Mice deficient for Rb are nonviable and show defects in neurogenesis and haematopoiesis","volume":"359","author":"Lee","year":"1992","journal-title":"Nature"},{"key":"10.1016\/j.mad.2013.05.005_bib0155","doi-asserted-by":"crossref","first-page":"46","DOI":"10.3389\/fnins.2011.00046","article-title":"Reduced synchronization persistence in neural networks derived from atm-deficient mice","volume":"5","author":"Levine-Small","year":"2011","journal-title":"Frontiers in Neuroscience"},{"issue":"24","key":"10.1016\/j.mad.2013.05.005_bib0160","doi-asserted-by":"crossref","first-page":"2091","DOI":"10.1016\/j.cub.2009.10.039","article-title":"Cytoplasmic ATM in neurons modulates synaptic function","volume":"19","author":"Li","year":"2009","journal-title":"Current Biology"},{"issue":"20","key":"10.1016\/j.mad.2013.05.005_bib0165","doi-asserted-by":"crossref","first-page":"7568","DOI":"10.1523\/JNEUROSCI.0778-11.2011","article-title":"Stable brain ATM message and residual kinase-active ATM protein in ataxia-telangiectasia","volume":"31","author":"Li","year":"2011","journal-title":"The Journal of Neuroscience"},{"issue":"17","key":"10.1016\/j.mad.2013.05.005_bib0170","doi-asserted-by":"crossref","first-page":"10146","DOI":"10.1073\/pnas.95.17.10146","article-title":"ATM binds to beta-adaptin in cytoplasmic vesicles","volume":"95","author":"Lim","year":"1998","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"1","key":"10.1016\/j.mad.2013.05.005_bib0175","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.neulet.2003.09.004","article-title":"Neuronal expression of cell cycle-related proteins after brain ischaemia in man","volume":"353","author":"Love","year":"2003","journal-title":"Neuroscience Letters"},{"issue":"8","key":"10.1016\/j.mad.2013.05.005_bib0180","doi-asserted-by":"crossref","first-page":"1076","DOI":"10.1002\/dneu.20637","article-title":"HDAC4 inhibits cell-cycle progression and protects neurons from cell death","volume":"68","author":"Majdzadeh","year":"2008","journal-title":"Developmental Neurobiology"},{"issue":"5828","key":"10.1016\/j.mad.2013.05.005_bib0185","doi-asserted-by":"crossref","first-page":"1160","DOI":"10.1126\/science.1140321","article-title":"ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage","volume":"316","author":"Matsuoka","year":"2007","journal-title":"Science"},{"issue":"37","key":"10.1016\/j.mad.2013.05.005_bib0190","doi-asserted-by":"crossref","first-page":"8090","DOI":"10.1523\/JNEUROSCI.2263-04.2004","article-title":"Failed clearance of aneuploid embryonic neural progenitor cells leads to excess aneuploidy in the Atm-deficient but not the Trp53-deficient adult cerebral cortex","volume":"24","author":"McConnell","year":"2004","journal-title":"The Journal of Neuroscience"},{"issue":"26","key":"10.1016\/j.mad.2013.05.005_bib0195","doi-asserted-by":"crossref","first-page":"14400","DOI":"10.1073\/pnas.260501497","article-title":"Activation of the myocyte enhancer factor-2 transcription factor by calcium\/calmodulin-dependent protein kinase-stimulated binding of 14-3-3 to histone deacetylase 5","volume":"97","author":"McKinsey","year":"2000","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"6808","key":"10.1016\/j.mad.2013.05.005_bib0200","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1038\/35040593","article-title":"Signal-dependent nuclear export of a histone deacetylase regulates muscle differentiation","volume":"408","author":"McKinsey","year":"2000","journal-title":"Nature"},{"issue":"6","key":"10.1016\/j.mad.2013.05.005_bib0205","first-page":"1933","article-title":"Abnormal expression of the cell cycle regulators P16 and CDK4 in Alzheimer\u2019s disease","volume":"150","author":"McShea","year":"1997","journal-title":"The American Journal of Pathology"},{"issue":"8","key":"10.1016\/j.mad.2013.05.005_bib0210","doi-asserted-by":"crossref","first-page":"e12117","DOI":"10.1371\/journal.pone.0012117","article-title":"Delayed treatment with systemic (S)-roscovitine provides neuroprotection and inhibits in vivo CDK5 activity increase in animal stroke models","volume":"5","author":"Menn","year":"2010","journal-title":"PLoS ONE"},{"issue":"18","key":"10.1016\/j.mad.2013.05.005_bib0215","doi-asserted-by":"crossref","first-page":"5099","DOI":"10.1093\/emboj\/18.18.5099","article-title":"HDAC4 deacetylase associates with and represses the MEF2 transcription factor","volume":"18","author":"Miska","year":"1999","journal-title":"EMBO Journal"},{"issue":"26","key":"10.1016\/j.mad.2013.05.005_bib0220","doi-asserted-by":"crossref","first-page":"6859","DOI":"10.1523\/JNEUROSCI.0379-07.2007","article-title":"Aneuploidy and DNA replication in the normal human brain and Alzheimer\u2019s disease","volume":"27","author":"Mosch","year":"2007","journal-title":"The Journal of Neuroscience"},{"issue":"1","key":"10.1016\/j.mad.2013.05.005_bib0225","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1207\/S15326942DN1701_04","article-title":"Judgment of duration in individuals with ataxia-telangiectasia","volume":"17","author":"Mostofsky","year":"2000","journal-title":"Developmental Neuropsychology"},{"issue":"3","key":"10.1016\/j.mad.2013.05.005_bib0230","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1007\/s004010050617","article-title":"Expression of cell division markers in the hippocampus in Alzheimer\u2019s disease and other neurodegenerative conditions","volume":"93","author":"Nagy","year":"1997","journal-title":"Acta Neuropathologica"},{"issue":"5","key":"10.1016\/j.mad.2013.05.005_bib0235","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1016\/0092-8674(95)90474-3","article-title":"Beta-NAP, a cerebellar degeneration antigen, is a neuron-specific vesicle coat protein","volume":"82","author":"Newman","year":"1995","journal-title":"Cell"},{"issue":"6","key":"10.1016\/j.mad.2013.05.005_bib0240","doi-asserted-by":"crossref","first-page":"2131","DOI":"10.1523\/JNEUROSCI.23-06-02131.2003","article-title":"Cell cycle regulators in the neuronal death pathway of amyotrophic lateral sclerosis caused by mutant superoxide dismutase 1","volume":"23","author":"Nguyen","year":"2003","journal-title":"The Journal of Neuroscience"},{"issue":"1","key":"10.1016\/j.mad.2013.05.005_bib0245","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1038\/nrg1746","article-title":"The role of double-strand break repair - insights from human genetics","volume":"7","author":"O\u2018Driscoll","year":"2006","journal-title":"Nature reviews. Genetics"},{"issue":"20","key":"10.1016\/j.mad.2013.05.005_bib0250","doi-asserted-by":"crossref","first-page":"8747","DOI":"10.1523\/JNEUROSCI.19-20-08747.1999","article-title":"Role of cell cycle regulatory proteins in cerebellar granule neuron apoptosis","volume":"19","author":"Padmanabhan","year":"1999","journal-title":"The Journal of Neuroscience"},{"issue":"14","key":"10.1016\/j.mad.2013.05.005_bib0255","doi-asserted-by":"crossref","first-page":"8161","DOI":"10.1074\/jbc.271.14.8161","article-title":"Inhibitors of cyclin-dependent kinases promote survival of post-mitotic neuronally differentiated PC12 cells and sympathetic neurons","volume":"271","author":"Park","year":"1996","journal-title":"The Journal of Biological Chemistry"},{"issue":"23","key":"10.1016\/j.mad.2013.05.005_bib0260","doi-asserted-by":"crossref","first-page":"8975","DOI":"10.1523\/JNEUROSCI.17-23-08975.1997","article-title":"Cyclin dependent kinase inhibitors and dominant negative cyclin dependent kinase 4 and 6 promote survival of NGF-deprived sympathetic neurons","volume":"17","author":"Park","year":"1997","journal-title":"The Journal of Neuroscience"},{"issue":"4","key":"10.1016\/j.mad.2013.05.005_bib0265","doi-asserted-by":"crossref","first-page":"1256","DOI":"10.1523\/JNEUROSCI.17-04-01256.1997","article-title":"G1\/S cell cycle blockers and inhibitors of cyclin-dependent kinases suppress camptothecin-induced neuronal apoptosis","volume":"17","author":"Park","year":"1997","journal-title":"The Journal of Neuroscience"},{"issue":"2","key":"10.1016\/j.mad.2013.05.005_bib0270","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1083\/jcb.143.2.457","article-title":"Cyclin-dependent kinases participate in death of neurons evoked by DNA- damaging agents","volume":"143","author":"Park","year":"1998","journal-title":"The Journal of Cell Biology"},{"issue":"3","key":"10.1016\/j.mad.2013.05.005_bib0275","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1523\/JNEUROSCI.18-03-00830.1998","article-title":"Multiple pathways of neuronal death induced by DNA-damaging agents, NGF deprivation, and oxidative stress","volume":"18","author":"Park","year":"1998","journal-title":"The Journal of Neuroscience"},{"issue":"6","key":"10.1016\/j.mad.2013.05.005_bib0280","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1016\/S0197-4580(00)00220-7","article-title":"Cell cycle regulators in neuronal death evoked by excitotoxic stress: implications for neurodegeneration and its treatment","volume":"21","author":"Park","year":"2000","journal-title":"Neurobiology of Aging"},{"issue":"3","key":"10.1016\/j.mad.2013.05.005_bib0285","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1016\/S0002-9440(10)63879-5","article-title":"Alterations in G(1) to S Phase Cell-Cycle Regulators during Amyotrophic Lateral Sclerosis","volume":"162","author":"Ranganathan","year":"2003","journal-title":"The American Journal of Pathology"},{"issue":"4","key":"10.1016\/j.mad.2013.05.005_bib0290","doi-asserted-by":"crossref","first-page":"377","DOI":"10.3233\/JAD-2001-3403","article-title":"Hyperphosphorylation of the retinoblastoma gene product and altered subcellular distribution of E2F-1 during Alzheimer\u2019s disease and amyotrophic lateral sclerosis","volume":"3","author":"Ranganathan","year":"2001","journal-title":"Journal of Alzheimer\u2019s Disease"},{"issue":"9","key":"10.1016\/j.mad.2013.05.005_bib0295","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1101\/gad.1639608","article-title":"Mutations in String\/CDC25 inhibit cell cycle re-entry and neurodegeneration in a Drosophila model of Ataxia telangiectasia","volume":"22","author":"Rimkus","year":"2008","journal-title":"Genes and Development"},{"issue":"32","key":"10.1016\/j.mad.2013.05.005_bib0300","doi-asserted-by":"crossref","first-page":"8496","DOI":"10.1523\/JNEUROSCI.1008-07.2007","article-title":"Effects of Alzheimer\u2019s disease on different cortical layers: the role of intrinsic differences in Abeta susceptibility","volume":"27","author":"Romito-DiGiacomo","year":"2007","journal-title":"The Journal of Neuroscience"},{"issue":"1","key":"10.1016\/j.mad.2013.05.005_bib0305","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/S0304-3940(99)00509-1","article-title":"Cell cycle-related protein expression in vascular dementia and Alzheimer\u2019s disease","volume":"271","author":"Smith","year":"1999","journal-title":"Neuroscience Letters"},{"issue":"6","key":"10.1016\/j.mad.2013.05.005_bib0310","doi-asserted-by":"crossref","first-page":"1397","DOI":"10.1093\/emboj\/19.6.1397","article-title":"Neonatal lethality with abnormal neurogenesis in mice deficient in DNA polymerase beta","volume":"19","author":"Sugo","year":"2000","journal-title":"EMBO Journal"},{"issue":"6","key":"10.1016\/j.mad.2013.05.005_bib0315","doi-asserted-by":"crossref","first-page":"1490","DOI":"10.1182\/blood-2011-08-373639","article-title":"Mitochondrial dysfunction in ataxia-telangiectasia","volume":"119","author":"Valentin-Vega","year":"2012","journal-title":"Blood"},{"issue":"43","key":"10.1016\/j.mad.2013.05.005_bib0320","doi-asserted-by":"crossref","first-page":"10786","DOI":"10.1523\/JNEUROSCI.2441-08.2008","article-title":"Abeta oligomers induce neuronal cell cycle events in Alzheimer\u2019s disease","volume":"28","author":"Varvel","year":"2008","journal-title":"The Journal of Neuroscience"},{"issue":"12","key":"10.1016\/j.mad.2013.05.005_bib0325","doi-asserted-by":"crossref","first-page":"3692","DOI":"10.1172\/JCI39716","article-title":"NSAIDs prevent, but do not reverse, neuronal cell cycle reentry in a mouse model of Alzheimer disease","volume":"119","author":"Varvel","year":"2009","journal-title":"The Journal of Clinical Investigation"},{"issue":"4","key":"10.1016\/j.mad.2013.05.005_bib0330","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1016\/j.cell.2004.10.024","article-title":"Histone deacetylase 4 controls chondrocyte hypertrophy during skeletogenesis","volume":"119","author":"Vega","year":"2004","journal-title":"Cell"},{"issue":"3","key":"10.1016\/j.mad.2013.05.005_bib0335","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1083\/jcb.132.3.413","article-title":"Mitotic mechanisms in Alzheimer\u2019s disease?","volume":"132","author":"Vincent","year":"1996","journal-title":"Journal of Cell Biology"},{"issue":"4","key":"10.1016\/j.mad.2013.05.005_bib0340","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/S0197-4580(98)00071-2","article-title":"Mitotic phosphoepitopes precede paired helical filaments in Alzheimer\u2019s disease","volume":"19","author":"Vincent","year":"1998","journal-title":"Neurobiology of Aging"},{"issue":"5","key":"10.1016\/j.mad.2013.05.005_bib0345","doi-asserted-by":"crossref","first-page":"315","DOI":"10.3109\/17518423.2011.603368","article-title":"Cognitive and speech-language performance in children with ataxia telangiectasia","volume":"14","author":"Vinck","year":"2011","journal-title":"Developmental Neurorehabilitation"},{"issue":"17","key":"10.1016\/j.mad.2013.05.005_bib0350","doi-asserted-by":"crossref","first-page":"5992","DOI":"10.1128\/MCB.21.17.5992-6005.2001","article-title":"Histone deacetylase 4 possesses intrinsic nuclear import and export signals","volume":"21","author":"Wang","year":"2001","journal-title":"Molecular and Cellular Biology"},{"issue":"11","key":"10.1016\/j.mad.2013.05.005_bib0355","doi-asserted-by":"crossref","first-page":"7816","DOI":"10.1128\/MCB.19.11.7816","article-title":"HDAC4, a human histone deacetylase related to yeast HDA1, is a transcriptional corepressor","volume":"19","author":"Wang","year":"1999","journal-title":"Molecular and Cellular Biology"},{"issue":"48","key":"10.1016\/j.mad.2013.05.005_bib0360","doi-asserted-by":"crossref","first-page":"34277","DOI":"10.1074\/jbc.274.48.34277","article-title":"Localization of a portion of extranuclear ATM to peroxisomes","volume":"274","author":"Watters","year":"1999","journal-title":"The Journal of Biological Chemistry"},{"issue":"7","key":"10.1016\/j.mad.2013.05.005_bib0365","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1016\/j.tins.2005.05.002","article-title":"To die or grow: Parkinson\u2019s disease and cancer","volume":"28","author":"West","year":"2005","journal-title":"Trends in Neurosciences"},{"issue":"6","key":"10.1016\/j.mad.2013.05.005_bib0370","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1016\/S0197-4580(00)00219-0","article-title":"Beta-amyloid activated microglia induce cell cycling and cell death in cultured cortical neurons","volume":"21","author":"Wu","year":"2000","journal-title":"Neurobiology of Aging"},{"issue":"10","key":"10.1016\/j.mad.2013.05.005_bib0375","doi-asserted-by":"crossref","first-page":"2522","DOI":"10.1523\/JNEUROSCI.4946-04.2005","article-title":"Loss of neuronal cell cycle control in ataxia-telangiectasia: a unified disease mechanism","volume":"25","author":"Yang","year":"2005","journal-title":"The Journal of Neuroscience"},{"issue":"8","key":"10.1016\/j.mad.2013.05.005_bib0380","doi-asserted-by":"crossref","first-page":"2661","DOI":"10.1523\/JNEUROSCI.21-08-02661.2001","article-title":"DNA replication precedes neuronal cell death in Alzheimer\u2019s disease","volume":"21","author":"Yang","year":"2001","journal-title":"The Journal of Neuroscience"},{"issue":"7","key":"10.1016\/j.mad.2013.05.005_bib0385","doi-asserted-by":"crossref","first-page":"2557","DOI":"10.1523\/JNEUROSCI.23-07-02557.2003","article-title":"Neuronal cell death is preceded by cell cycle events at all stages of Alzheimer\u2019s disease","volume":"23","author":"Yang","year":"2003","journal-title":"The Journal of Neuroscience"},{"issue":"3","key":"10.1016\/j.mad.2013.05.005_bib0390","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1523\/JNEUROSCI.3707-05.2006","article-title":"Ectopic cell cycle events link human Alzheimer\u2019s disease and amyloid precursor protein transgenic mouse models","volume":"26","author":"Yang","year":"2006","journal-title":"The Journal of Neuroscience"},{"issue":"8\u20139","key":"10.1016\/j.mad.2013.05.005_bib0395","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1016\/j.mad.2011.06.005","article-title":"The excitatory neurotransmitter glutamate stimulates DNA repair to increase neuronal resiliency","volume":"132","author":"Yang","year":"2011","journal-title":"Mechanisms of Ageing and Development"},{"issue":"37","key":"10.1016\/j.mad.2013.05.005_bib0400","doi-asserted-by":"crossref","first-page":"35042","DOI":"10.1074\/jbc.M105086200","article-title":"The modular nature of histone deacetylase HDAC4 confers phosphorylation-dependent intracellular trafficking","volume":"276","author":"Zhao","year":"2001","journal-title":"The Journal of Biological Chemistry"},{"issue":"5","key":"10.1016\/j.mad.2013.05.005_bib0405","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1002\/jnr.20028","article-title":"Elevated expression of a regulator of the G2\/M phase of the cell cycle, neuronal CIP-1-associated regulator of cyclin B, in Alzheimer\u2019s disease","volume":"75","author":"Zhu","year":"2004","journal-title":"Journal of Neuroscience Research"}],"container-title":["Mechanisms of Ageing and Development"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S004763741300064X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S004763741300064X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,2,22]],"date-time":"2022-02-22T18:48:49Z","timestamp":1645555729000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S004763741300064X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,10]]},"references-count":81,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2013,10]]}},"alternative-id":["S004763741300064X"],"URL":"https:\/\/doi.org\/10.1016\/j.mad.2013.05.005","relation":{},"ISSN":["0047-6374"],"issn-type":[{"value":"0047-6374","type":"print"}],"subject":[],"published":{"date-parts":[[2013,10]]}}}