{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T05:54:47Z","timestamp":1771480487636,"version":"3.50.1"},"reference-count":11,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2014,11,1]],"date-time":"2014-11-01T00:00:00Z","timestamp":1414800000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"NIH Office of Research Infrastructure Programs","award":["P40 OD010440"],"award-info":[{"award-number":["P40 OD010440"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Mechanisms of Ageing and Development"],"published-print":{"date-parts":[[2014,11]]},"DOI":"10.1016\/j.mad.2014.08.002","type":"journal-article","created":{"date-parts":[[2014,8,26]],"date-time":"2014-08-26T19:29:53Z","timestamp":1409081393000},"page":"1-4","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"special_numbering":"C","title":["Fluorodeoxyuridine enhances the heat shock response and decreases polyglutamine aggregation in an HSF-1-dependent manner in Caenorhabditis elegans"],"prefix":"10.1016","volume":"141-142","author":[{"given":"Jessica","family":"Brunquell","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philip","family":"Bowers","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandy D.","family":"Westerheide","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.mad.2014.08.002_bib0005","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1016\/j.mad.2010.03.002","article-title":"The use of FUdR can cause prolonged longevity in mutant nematodes","volume":"131","author":"Aitlhadj","year":"2010","journal-title":"Mech. Ageing Dev."},{"key":"10.1016\/j.mad.2014.08.002_bib0010","doi-asserted-by":"crossref","first-page":"759","DOI":"10.18632\/aging.100605","article-title":"A DNA synthesis inhibitor is protective against proteotoxic stressors via modulation of fertility pathways in Caenorhabditis elegans","volume":"5","author":"Angeli","year":"2013","journal-title":"Aging (Albany, NY)"},{"key":"10.1016\/j.mad.2014.08.002_bib0015","first-page":"287","article-title":"Mechanisms of action of FdUMP[10]: metabolite activation and thymidylate synthase inhibition","volume":"18","author":"Bijnsdorp","year":"2007","journal-title":"Oncol. Rep."},{"key":"10.1016\/j.mad.2014.08.002_bib0020","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.mad.2011.11.002","article-title":"Fluorodeoxyuridine affects the identification of metabolic responses to daf-2 status in Caenorhabditis elegans","volume":"133","author":"Davies","year":"2012","journal-title":"Mech. Ageing Dev."},{"key":"10.1016\/j.mad.2014.08.002_bib0025","doi-asserted-by":"crossref","first-page":"e85964","DOI":"10.1371\/journal.pone.0085964","article-title":"Fluorodeoxyuridine improves Caenorhabditis elegans proteostasis independent of reproduction onset","volume":"9","author":"Feldman","year":"2014","journal-title":"PLOS ONE"},{"key":"10.1016\/j.mad.2014.08.002_bib0030","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/0047-6374(80)90090-1","article-title":"A simple method for maintaining large, aging populations of Caenorhabditis elegans","volume":"12","author":"Gandhi","year":"1980","journal-title":"Mech. Ageing Dev."},{"key":"10.1016\/j.mad.2014.08.002_bib0035","doi-asserted-by":"crossref","first-page":"1937","DOI":"10.1534\/genetics.104.028423","article-title":"The L-type cyclin CYL-1 and the heat-shock-factor HSF-1 are required for heat-shock-induced protein expression in Caenorhabditis elegans","volume":"168","author":"Hajdu-Cronin","year":"2004","journal-title":"Genetics"},{"key":"10.1016\/j.mad.2014.08.002_bib0040","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/0531-5565(78)90047-5","article-title":"Sterilization and growth inhibition of Caenorhabditis elegans by 5-fluorodeoxyuridine","volume":"13","author":"Hosono","year":"1978","journal-title":"Exp. Gerontol."},{"key":"10.1016\/j.mad.2014.08.002_bib0045","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1093\/geronj\/34.1.28","article-title":"Synchronous growth and aging of Caenorhabditis elegans in the presence of fluorodeoxyuridine","volume":"34","author":"Mitchell","year":"1979","journal-title":"J. Gerontol."},{"key":"10.1016\/j.mad.2014.08.002_bib0050","doi-asserted-by":"crossref","first-page":"10417","DOI":"10.1073\/pnas.152161099","article-title":"The threshold for polyglutamine-expansion protein aggregation and cellular toxicity is dynamic and influenced by aging in Caenorhabditis elegans","volume":"99","author":"Morley","year":"2002","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.mad.2014.08.002_bib0055","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1016\/j.mad.2011.08.006","article-title":"FUdR causes a twofold increase in the lifespan of the mitochondrial mutant gas-1","volume":"132","author":"Van Raamsdonk","year":"2011","journal-title":"Mech. Ageing Dev."}],"container-title":["Mechanisms of Ageing and Development"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0047637414000566?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0047637414000566?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,30]],"date-time":"2018-09-30T08:59:01Z","timestamp":1538297941000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0047637414000566"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,11]]},"references-count":11,"alternative-id":["S0047637414000566"],"URL":"https:\/\/doi.org\/10.1016\/j.mad.2014.08.002","relation":{},"ISSN":["0047-6374"],"issn-type":[{"value":"0047-6374","type":"print"}],"subject":[],"published":{"date-parts":[[2014,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Fluorodeoxyuridine enhances the heat shock response and decreases polyglutamine aggregation in an HSF-1-dependent manner in Caenorhabditis elegans","name":"articletitle","label":"Article Title"},{"value":"Mechanisms of Ageing and Development","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mad.2014.08.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier Ireland Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}