{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T22:10:09Z","timestamp":1770415809889,"version":"3.49.0"},"reference-count":57,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"researcher\u2019s intramural funds (ATENEO Funds, University of Pisa)"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Mechanisms of Ageing and Development"],"published-print":{"date-parts":[[2017,1]]},"DOI":"10.1016\/j.mad.2016.04.003","type":"journal-article","created":{"date-parts":[[2016,4,11]],"date-time":"2016-04-11T14:08:04Z","timestamp":1460383684000},"page":"105-111","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":16,"special_numbering":"PA","title":["Methylation analysis of DNA repair genes in Alzheimer\u2019s disease"],"prefix":"10.1016","volume":"161","author":[{"given":"Fabio","family":"Copped\u00e8","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pierpaola","family":"Tannorella","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Stoccoro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucia","family":"Chico","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriele","family":"Siciliano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ubaldo","family":"Bonuccelli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucia","family":"Migliore","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.mad.2016.04.003_bib0005","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/S0006-8993(99)02004-1","article-title":"DNA strand breaks in Alzheimer's disease","volume":"849","author":"Adamec","year":"1999","journal-title":"Brain Res."},{"key":"10.1016\/j.mad.2016.04.003_bib0010","unstructured":"American Psychiatric Association, 1994. Diagnostic and Statistical Manual of Mental Disorders Source Information, 4th ed., U.S. National Library of Medicine (Ed.)."},{"key":"10.1016\/j.mad.2016.04.003_bib0015","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/j.trsl.2014.05.006","article-title":"Epigenomics of Alzheimer's disease","volume":"165","author":"Bennett","year":"2015","journal-title":"Transl. Res."},{"key":"10.1016\/j.mad.2016.04.003_bib0020","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.1016\/j.bbi.2011.01.017","article-title":"DNA methylation in repetitive elements and Alzheimer disease","volume":"25","author":"Bollati","year":"2011","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.mad.2016.04.003_bib0025","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1016\/j.neurobiolaging.2014.01.004","article-title":"Base excision DNA repair levels in mitochondrial lysates of Alzheimer's disease","volume":"35","author":"Canugovi","year":"2014","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.mad.2016.04.003_bib0030","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.neulet.2015.08.012","article-title":"Peripheral leukocyte expression of the potential biomarker proteins Bdnf, Sirt1, and Psen1 is not regulated by promoter methylation in Alzheimer's disease patients","volume":"605","author":"Carboni","year":"2015","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.mad.2016.04.003_bib0035","doi-asserted-by":"crossref","first-page":"36","DOI":"10.2174\/156720509787313970","article-title":"DNA damage and repair in Alzheimer's disease","volume":"6","author":"Copped\u00e8","year":"2009","journal-title":"Curr. Alzheimer Res."},{"key":"10.1016\/j.mad.2016.04.003_bib0040","doi-asserted-by":"crossref","first-page":"953","DOI":"10.3233\/JAD-2010-1415","article-title":"Evidence linking genetics, environment, and epigenetics to impaired DNA repair in Alzheimer's disease","volume":"20","author":"Copped\u00e8","year":"2010","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.mad.2016.04.003_bib0045","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.mrfmmm.2014.11.010","article-title":"DNA damage in neurodegenerative diseases","volume":"776","author":"Copped\u00e8","year":"2015","journal-title":"Mutat. Res."},{"key":"10.1016\/j.mad.2016.04.003_bib0050","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1016\/j.neulet.2006.12.035","article-title":"A Ser326Cys polymorphism in the DNA repair gene hOGG1 is not associated with sporadic Alzheimer's disease","volume":"414","author":"Copped\u00e8","year":"2007","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.mad.2016.04.003_bib0055","doi-asserted-by":"crossref","first-page":"621","DOI":"10.4161\/epi.27956","article-title":"Gene promoter methylation in colorectal cancer and healthy adjacent mucosa specimens: correlation with physiological and pathological characteristics, and with biomarkers of one-carbon metabolism","volume":"9","author":"Copped\u00e8","year":"2014","journal-title":"Epigenetics"},{"key":"10.1016\/j.mad.2016.04.003_bib0060","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/j.jns.2010.09.020","article-title":"Variants and polymorphisms of DNA base excision repair genes and Alzheimer's disease","volume":"300","author":"Copped\u00e8","year":"2011","journal-title":"J. Neurol. Sci."},{"key":"10.1016\/j.mad.2016.04.003_bib0065","doi-asserted-by":"crossref","first-page":"1156","DOI":"10.1038\/nn.3786","article-title":"Alzheimer's disease: early alterations in brain DNA methylation at ANK1, BIN1, RHBDF2 and other loci","volume":"17","author":"De Jager","year":"2014","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.mad.2016.04.003_bib0070","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1007\/s10072-007-0744-x","article-title":"The Arg194Trp polymorphism in DNA repair gene XRCC1 and the risk for sporadic late-onset Alzheimer's disease","volume":"28","author":"Dogru-Abbasoglu","year":"2007","journal-title":"Neurol. Sci."},{"key":"10.1016\/j.mad.2016.04.003_bib0075","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1089\/dna.2009.0926","article-title":"Expression and polymorphisms of gene 8-oxoguanine glycosylase 1 and the level of oxidative DNA damage in peripheral blood lymphocytes of patients with Alzheimer's disease","volume":"28","author":"Dorszewska","year":"2009","journal-title":"DNA Cell Biol."},{"key":"10.1016\/j.mad.2016.04.003_bib0080","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1016\/j.dnarep.2008.01.003","article-title":"OGG1 is degraded by calpain following oxidative stress and cisplatin exposure","volume":"7","author":"Hill","year":"2008","journal-title":"DNA Repair"},{"key":"10.1016\/j.mad.2016.04.003_bib0085","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1007\/s004010100418","article-title":"Expression of 8-oxoguanine DNA glycosylase is reduced and associated with neurofibrillary tangles in Alzheimer's disease brain","volume":"103","author":"Iida","year":"2002","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.mad.2016.04.003_bib0090","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.freeradbiomed.2013.05.010","article-title":"Alzheimer's disease-associated polymorphisms in human OGG1 alter catalytic activity and sensitize cells to DNA damage","volume":"63","author":"Jacob","year":"2013","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.mad.2016.04.003_bib0095","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.molbrainres.2004.05.023","article-title":"Deficiency of the Mre11 DNA repair complex in Alzheimer's disease brains","volume":"128","author":"Jacobsen","year":"2004","journal-title":"Brain Res. Mol. Brain Res."},{"key":"10.1016\/j.mad.2016.04.003_bib0100","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1159\/000381985","article-title":"Variants of base excision repair genes MUTYH, PARP1 and XRCC1 in Alzheimer's disease risk","volume":"71","author":"Kwiatkowski","year":"2015","journal-title":"Neuropsychobiology"},{"key":"10.1016\/j.mad.2016.04.003_bib0105","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.mrfmmm.2014.12.012","article-title":"Genome instability biomarkers and blood micronutrient risk profiles associated with mild cognitive impairment and Alzheimer's disease","volume":"776","author":"Lee","year":"2015","journal-title":"Mutat. Res."},{"key":"10.1016\/j.mad.2016.04.003_bib0110","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1016\/0006-291X(85)91953-9","article-title":"Deficient repair of DNA lesions in Alzheimer's disease fibroblasts","volume":"129","author":"Li","year":"1985","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.mad.2016.04.003_bib0115","doi-asserted-by":"crossref","first-page":"e59064","DOI":"10.1371\/journal.pone.0059064","article-title":"MLH1 promoter methylation frequency in colorectal cancer patients and related clinicopathological and molecular features","volume":"8","author":"Li","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.mad.2016.04.003_bib0120","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1186\/1868-7083-6-22","article-title":"Quantitative methodology is critical for assessing DNA methylation and impacts on correlation with patient outcome","volume":"6","author":"Lim","year":"2014","journal-title":"Clin. Epigenet."},{"key":"10.1016\/j.mad.2016.04.003_bib0125","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1016\/j.tox.2011.10.016","article-title":"S-Adenosylhomocysteine enhances DNA damage through increased beta-amyloid formation and inhibition of the DNA-repair enzyme OGG1b in microglial BV-2 cells","volume":"290","author":"Lin","year":"2011","journal-title":"Toxicology"},{"key":"10.1016\/j.mad.2016.04.003_bib0130","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1002\/jcla.20379","article-title":"Evaluation of the poly(ADP-ribose) polymerase-1 gene variants in Alzheimer's disease","volume":"24","author":"Liu","year":"2010","journal-title":"J. Clin. Lab. Anal."},{"key":"10.1016\/j.mad.2016.04.003_bib0135","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1093\/brain\/122.2.247","article-title":"Increased poly(ADP-ribosyl)ation of nuclear proteins in Alzheimer's disease","volume":"122","author":"Love","year":"1999","journal-title":"Brain"},{"key":"10.1016\/j.mad.2016.04.003_bib0140","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/S0006-8993(99)02335-5","article-title":"Decreased base excision repair and increased helicase activity in Alzheimer's disease brain","volume":"855","author":"Lovell","year":"2000","journal-title":"Brain Res."},{"key":"10.1016\/j.mad.2016.04.003_bib0145","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/j.mad.2011.08.003","article-title":"Oxidatively modified nucleic acids in preclinical Alzheimer's disease (PCAD) brain","volume":"132","author":"Lovell","year":"2011","journal-title":"Mech. Ageing Dev."},{"key":"10.1016\/j.mad.2016.04.003_bib0150","doi-asserted-by":"crossref","first-page":"1164","DOI":"10.1038\/nn.3782","article-title":"Methylomic profiling implicates cortical deregulation of ANK1 in Alzheimer's disease","volume":"17","author":"Lunnon","year":"2014","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.mad.2016.04.003_bib0155","doi-asserted-by":"crossref","first-page":"2759","DOI":"10.1093\/nar\/gkm189","article-title":"Identification and characterization of OGG1 mutations in patients with Alzheimer's disease","volume":"35","author":"Mao","year":"2007","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.mad.2016.04.003_bib0160","doi-asserted-by":"crossref","first-page":"e6617","DOI":"10.1371\/journal.pone.0006617","article-title":"Epigenetic differences in cortical neurons from a pair of monozygotic twins discordant for Alzheimer's disease","volume":"4","author":"Mastroeni","year":"2009","journal-title":"PLoS One"},{"key":"10.1016\/j.mad.2016.04.003_bib0165","doi-asserted-by":"crossref","first-page":"793","DOI":"10.18632\/aging.100810","article-title":"Defective mitochondrial respiration, altered dNTP pools and reduced AP endonuclease 1 activity in peripheral blood mononuclear cells of Alzheimer's disease patients","volume":"7","author":"Maynard","year":"2015","journal-title":"Aging (Milano)"},{"key":"10.1016\/j.mad.2016.04.003_bib0170","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.jalz.2011.03.005","article-title":"The diagnosis of dementia due to Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease","volume":"7","author":"McKhann","year":"2011","journal-title":"Alzheimers Dement"},{"key":"10.1016\/j.mad.2016.04.003_bib0175","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1002\/ana.410360510","article-title":"Oxidative damage to mitochondrial DNA is increased in Alzheimer's disease","volume":"36","author":"Mecocci","year":"1994","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.mad.2016.04.003_bib0180","doi-asserted-by":"crossref","first-page":"e52501","DOI":"10.1371\/journal.pone.0052501","article-title":"Comparison study of MS-HRM and pyrosequencing techniques for quantification of APC and CDKN2A gene methylation","volume":"8","author":"Migheli","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.mad.2016.04.003_bib0185","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1016\/j.neurobiolaging.2004.07.016","article-title":"Oxidative DNA damage in peripheral leukocytes of mild cognitive impairment and AD patients","volume":"26","author":"Migliore","year":"2005","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.mad.2016.04.003_bib0190","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.3233\/JAD-140141","article-title":"Proteomic analysis of cerebrospinal fluid in Alzheimer's disease: wanted dead or alive","volume":"44","author":"Ol\u00e1h","year":"2015","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.mad.2016.04.003_bib0195","doi-asserted-by":"crossref","first-page":"161","DOI":"10.11613\/BM.2015.017","article-title":"Aberrant methylation patterns in cancer: a clinical view","volume":"25","author":"Paska","year":"2015","journal-title":"Biochem. Med. (Zagreb)"},{"key":"10.1016\/j.mad.2016.04.003_bib0200","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.3233\/JAD-141452","article-title":"Epigenetic modifications in Alzheimer's disease: cause or effect","volume":"43","author":"Piaceri","year":"2015","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.mad.2016.04.003_bib0205","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/0022-510X(84)90051-0","article-title":"DNA damage and chronic neuronal degenerations","volume":"64","author":"Robison","year":"1984","journal-title":"J. Neurol. Sci."},{"key":"10.1016\/j.mad.2016.04.003_bib0210","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1002\/ana.410210306","article-title":"Alzheimer's disease cells exhibit defective repair of alkylating agent-induced DNA damage","volume":"21","author":"Robison","year":"1987","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.mad.2016.04.003_bib0215","doi-asserted-by":"crossref","first-page":"347","DOI":"10.3389\/fnbeh.2015.00347","article-title":"Epigenetic alterations in Alzheimer's disease","volume":"9","author":"Sanchez-Mut","year":"2015","journal-title":"Front. Behav. Neurosci."},{"key":"10.1016\/j.mad.2016.04.003_bib0220","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1016\/j.freeradbiomed.2008.06.003","article-title":"Altered 8-oxoguanine glycosylase in mild cognitive impairment and late-stage Alzheimer's disease brain","volume":"45","author":"Shao","year":"2008","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.mad.2016.04.003_bib0225","doi-asserted-by":"crossref","first-page":"e99897","DOI":"10.1371\/journal.pone.0099897","article-title":"Repair of oxidative DNA damage, cell-cycle regulation and neuronal death may influence the clinical manifestation of Alzheimer's disease","volume":"9","author":"Silva","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.mad.2016.04.003_bib0230","doi-asserted-by":"crossref","first-page":"165","DOI":"10.3233\/JAD-130428","article-title":"Analysis of HSPA8 and HSPA9 mRNA expression and promoter methylation in the brain and blood of Alzheimer's disease patients","volume":"38","author":"Silva","year":"2014","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.mad.2016.04.003_bib0235","doi-asserted-by":"crossref","first-page":"8897","DOI":"10.1038\/ncomms9897","article-title":"DNA repair factor BRCA1 depletion occurs in Alzheimer brains and impairs cognitive function in mice","volume":"6","author":"Suberbielle","year":"2015","journal-title":"Nat. Commun."},{"key":"10.1016\/j.mad.2016.04.003_bib0240","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1093\/nar\/gku1356","article-title":"DNA polymerase beta deficiency leads to neurodegeneration and exacerbates Alzheimer disease phenotypes","volume":"43","author":"Sykora","year":"2015","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.mad.2016.04.003_bib0245","doi-asserted-by":"crossref","first-page":"2749","DOI":"10.1097\/00001756-199808240-00012","article-title":"Immunohistochemical localization of redox factor-1 (Ref-1) in Alzheimer's hippocampus","volume":"9","author":"Tan","year":"1998","journal-title":"Neuroreport"},{"key":"10.1016\/j.mad.2016.04.003_bib0250","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.neulet.2015.06.009","article-title":"Methylation analysis of multiple genes in blood DNA of Alzheimer's disease and healthy individuals","volume":"600","author":"Tannorella","year":"2015","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.mad.2016.04.003_bib0255","doi-asserted-by":"crossref","first-page":"e2698","DOI":"10.1371\/journal.pone.0002698","article-title":"Age-specific epigenetic drift in late-onset Alzheimer's disease","volume":"3","author":"Wang","year":"2008","journal-title":"PLoS One"},{"key":"10.1016\/j.mad.2016.04.003_bib0260","doi-asserted-by":"crossref","first-page":"815","DOI":"10.3109\/02713683.2014.957778","article-title":"Altered DNA methylation and expression profiles of 8-oxoguanine DNA glycosylase 1 in lens tissue from age-related cataract patients","volume":"40","author":"Wang","year":"2015","journal-title":"Curr. Eye Res."},{"key":"10.1016\/j.mad.2016.04.003_bib0265","doi-asserted-by":"crossref","first-page":"5545","DOI":"10.1093\/nar\/gkm605","article-title":"Defective DNA base excision repair in brain from individuals with Alzheimer's disease and amnestic mild cognitive impairment","volume":"35","author":"Weissman","year":"2007","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.mad.2016.04.003_bib0270","doi-asserted-by":"crossref","first-page":"e41","DOI":"10.1093\/nar\/gkm013","article-title":"Methylation-sensitive high resolution melting (MS-HRM): a new approach for sensitive and high-throughput assessment of methylation","volume":"35","author":"Wojdacz","year":"2007","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.mad.2016.04.003_bib0275","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1001\/jamaneurol.2014.3049","article-title":"Association of Brain DNA methylation in SORL1, ABCA7, HLA-DRB5, SLC24A4, and BIN1 with pathological diagnosis of Alzheimer disease","volume":"72","author":"Yu","year":"2015","journal-title":"JAMA Neurol."},{"key":"10.1016\/j.mad.2016.04.003_bib0280","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1016\/j.freeradbiomed.2009.02.006","article-title":"Epigenetics, oxidative stress, and Alzheimer disease","volume":"46","author":"Zawia","year":"2009","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.mad.2016.04.003_bib0285","doi-asserted-by":"crossref","first-page":"17869","DOI":"10.1038\/srep17869","article-title":"Association of BRCA1 promoter methylation with sporadic breast cancers: evidence from 40 studies","volume":"5","author":"Zhang","year":"2015","journal-title":"Sci. Rep."}],"container-title":["Mechanisms of Ageing and Development"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0047637416300458?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0047637416300458?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,9,6]],"date-time":"2019-09-06T09:49:09Z","timestamp":1567763349000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0047637416300458"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,1]]},"references-count":57,"alternative-id":["S0047637416300458"],"URL":"https:\/\/doi.org\/10.1016\/j.mad.2016.04.003","relation":{},"ISSN":["0047-6374"],"issn-type":[{"value":"0047-6374","type":"print"}],"subject":[],"published":{"date-parts":[[2017,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Methylation analysis of DNA repair genes in Alzheimer\u2019s disease","name":"articletitle","label":"Article Title"},{"value":"Mechanisms of Ageing and Development","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mad.2016.04.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Ireland Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}