{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T20:12:51Z","timestamp":1784146371809,"version":"3.55.0"},"reference-count":171,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,9,1]],"date-time":"2017-09-01T00:00:00Z","timestamp":1504224000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Mechanisms of Ageing and Development"],"published-print":{"date-parts":[[2017,9]]},"DOI":"10.1016\/j.mad.2017.08.008","type":"journal-article","created":{"date-parts":[[2017,8,24]],"date-time":"2017-08-24T04:17:18Z","timestamp":1503548238000},"page":"6-15","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":93,"special_numbering":"C","title":["HDAC inhibitors: A new promising drug class in anti-aging research"],"prefix":"10.1016","volume":"166","author":[{"given":"Elena G.","family":"Pasyukova","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander M.","family":"Vaiserman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.mad.2017.08.008_bib0005","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.pharmthera.2014.11.003","article-title":"Histone deacetylases as therapeutic targets\u2013from cancer to cardiac disease","volume":"147","author":"Abend","year":"2015","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.mad.2017.08.008_bib0010","doi-asserted-by":"crossref","first-page":"447","DOI":"10.2217\/epi-2016-0136","article-title":"The acetyl code in rheumatoid arthritis and other rheumatic diseases","volume":"9","author":"Angiolilli","year":"2017","journal-title":"Epigenomics"},{"key":"10.1016\/j.mad.2017.08.008_bib0015","doi-asserted-by":"crossref","first-page":"B390","DOI":"10.1093\/gerona\/57.11.B390","article-title":"Different age-specific demographic profiles are generated in the same normal-lived Drosophila strain by different longevity stimuli","volume":"57","author":"Arking","year":"2002","journal-title":"J. Gerontol. A Biol. Sci. Med. Sci."},{"key":"10.1016\/j.mad.2017.08.008_bib0020","series-title":"Lifespan Extension: Single Cell Organisms to Man","first-page":"59","article-title":"Overview of the genomic architecture of longevity","author":"Arking","year":"2009"},{"issue":"Suppl. 1","key":"10.1016\/j.mad.2017.08.008_bib0025","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1080\/07924259.2014.978028","article-title":"Independent chemical regulation of health and senescent spans in Drosophila","volume":"59","author":"Arking","year":"2015","journal-title":"Invertebr. Reprod. Dev."},{"key":"10.1016\/j.mad.2017.08.008_bib0030","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.mad.2013.12.006","article-title":"Present and future of anti-ageing epigenetic diets","volume":"136\u2013137","author":"Bacalini","year":"2014","journal-title":"Mech. Ageing Dev."},{"key":"10.1016\/j.mad.2017.08.008_bib0035","doi-asserted-by":"crossref","first-page":"206","DOI":"10.18632\/aging.100435","article-title":"dSir2 deficiency in the fatbody, but not muscles, affects systemic insulin signaling, fat mobilization and starvation survival in flies","volume":"4","author":"Banerjee","year":"2012","journal-title":"Aging (Albany NY)"},{"key":"10.1016\/j.mad.2017.08.008_bib0040","doi-asserted-by":"crossref","first-page":"1485","DOI":"10.1016\/j.celrep.2012.11.013","article-title":"dSir2 in the adult fat body, but not in muscles, regulates lifespan in a diet-dependent manner","volume":"2","author":"Banerjee","year":"2012","journal-title":"Cell Rep."},{"key":"10.1016\/j.mad.2017.08.008_bib0045","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1038\/cr.2011.22","article-title":"Regulation of chromatin by histone modifications","volume":"21","author":"Bannister","year":"2011","journal-title":"Cell Res."},{"key":"10.1016\/j.mad.2017.08.008_bib0050","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1038\/nrc3130","article-title":"A decade of exploring the cancer epigenome\u2013biological and translational implications","volume":"11","author":"Baylin","year":"2011","journal-title":"Nat. Rev. Cancer"},{"issue":"Pt 7","key":"10.1016\/j.mad.2017.08.008_bib0055","doi-asserted-by":"crossref","first-page":"1441","DOI":"10.1242\/jcs.136390","article-title":"HDAC1 activates FoxO and is both sufficient and required for skeletal muscle atrophy","volume":"127","author":"Beharry","year":"2014","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.mad.2017.08.008_bib0060","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1038\/nrm4048","article-title":"Epigenetic regulation of ageing: linking environmental inputs to genomic stability","volume":"16","author":"Benayoun","year":"2015","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.mad.2017.08.008_bib0065","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1089\/ars.2013.5776","article-title":"Targeting histone deacetylases in diseases: where are we?","volume":"23","author":"Benedetti","year":"2015","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.mad.2017.08.008_bib0070","doi-asserted-by":"crossref","first-page":"3572","DOI":"10.1172\/JCI79942","article-title":"HDAC inhibitor-dependent transcriptome and memory reinstatement in cognitive decline models","volume":"125","author":"Benito","year":"2015","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.mad.2017.08.008_bib0075","first-page":"5","article-title":"Biochemical genetic pathways that modulate aging in multiple species","author":"Bitto","year":"2015","journal-title":"Cold Spring Harb. Perspect. Med."},{"key":"10.1016\/j.mad.2017.08.008_bib0080","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1242\/dmm.010389","article-title":"Cellular and molecular mechanisms of muscle atrophy","volume":"6","author":"Bonaldo","year":"2013","journal-title":"Dis. Model Mech."},{"key":"10.1016\/j.mad.2017.08.008_bib0085","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1016\/j.molcel.2016.05.013","article-title":"The aging epigenome","volume":"62","author":"Booth","year":"2016","journal-title":"Mol. Cell"},{"key":"10.1016\/j.mad.2017.08.008_bib0090","first-page":"220","article-title":"Epigenetics in cancer: what's the future?","volume":"25","author":"Boumber","year":"2011","journal-title":"Oncology (Williston Park)"},{"key":"10.1016\/j.mad.2017.08.008_bib0095","doi-asserted-by":"crossref","first-page":"205","DOI":"10.2217\/epi.13.5","article-title":"Epigenomics and the regulation of aging","volume":"5","author":"Boyd-Kirkup","year":"2013","journal-title":"Epigenomics"},{"issue":"Suppl. 1","key":"10.1016\/j.mad.2017.08.008_bib0100","doi-asserted-by":"crossref","first-page":"S17","DOI":"10.1093\/gerona\/glu042","article-title":"Epigenetics of aging and aging-related disease","volume":"69","author":"Brunet","year":"2014","journal-title":"J. Gerontol. A Biol. Sci. Med. Sci."},{"key":"10.1016\/j.mad.2017.08.008_bib0105","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1677\/jme.0.0240083","article-title":"Sodium butyrate\/retinoic acid costimulation induces apoptosis-independent growth arrest and cell differentiation in normal and ras-transformed seminal vesicle epithelial cells unresponsive to retinoic acid","volume":"24","author":"Buommino","year":"2000","journal-title":"J. Mol. Endocrinol."},{"key":"10.1016\/j.mad.2017.08.008_bib0110","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1038\/nature10296","article-title":"Absence of effects of Sir2 overexpression on lifespan in C. elegans and Drosophila","volume":"477","author":"Burnett","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.mad.2017.08.008_bib0115","doi-asserted-by":"crossref","first-page":"30483","DOI":"10.3390\/ijms161226236","article-title":"Epigenetics of aging and Alzheimer's disease: implications for pharmacogenomics and drug response","volume":"16","author":"Cacabelos","year":"2015","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.mad.2017.08.008_bib0120","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1002\/ddr.21219","article-title":"Epigenomic networking in drug development: from pathogenic mechanisms to pharmacogenomics","volume":"75","author":"Cacabelos","year":"2014","journal-title":"Drug Dev. Res."},{"key":"10.1016\/j.mad.2017.08.008_bib0125","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1007\/s10787-012-0166-0","article-title":"Epigenetic regulation of inflammation: progressing from broad acting histone deacetylase (HDAC) inhibitors to targeting specific HDACs","volume":"21","author":"Cantley","year":"2013","journal-title":"Inflammopharmacology"},{"key":"10.1016\/j.mad.2017.08.008_bib0130","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/S1568-1637(02)00003-X","article-title":"Regulation of lifespan by histone deacetylase","volume":"1","author":"Chang","year":"2002","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.mad.2017.08.008_bib0135","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/S0003-9861(02)00564-7","article-title":"Histone acetylation is involved in hsp70 gene transcription regulation in Drosophila melanogaster","volume":"408","author":"Chen","year":"2002","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.mad.2017.08.008_bib0140","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1615\/CritRevOncog.2015012997","article-title":"Histone deacetylases and mechanisms of regulation of gene expression","volume":"20","author":"Chen","year":"2015","journal-title":"Crit. Rev. Oncog."},{"key":"10.1016\/j.mad.2017.08.008_bib0145","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1186\/s12933-015-0262-8","article-title":"Histone deacetylase (HDAC) inhibition improves myocardial function and prevents cardiac remodeling in diabetic mice","volume":"14","author":"Chen","year":"2015","journal-title":"Cardiovasc. Diabetol."},{"key":"10.1016\/j.mad.2017.08.008_bib0150","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1016\/j.ygeno.2005.07.007","article-title":"Individual histone deacetylases in Drosophila modulate transcription of distinct genes","volume":"86","author":"Cho","year":"2005","journal-title":"Genomics"},{"key":"10.1016\/j.mad.2017.08.008_bib0155","doi-asserted-by":"crossref","first-page":"378","DOI":"10.2119\/molmed.2011.00021","article-title":"Histone deacetylase (HDAC) inhibition as a novel treatment for diabetes mellitus","volume":"17","author":"Christensen","year":"2011","journal-title":"Mol. Med."},{"key":"10.1016\/j.mad.2017.08.008_bib0160","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1089\/ars.2014.5863","article-title":"Mechanisms of histone deacetylase inhibitor-regulated gene expression in cancer cells","volume":"23","author":"Chueh","year":"2015","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.mad.2017.08.008_bib0165","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1007\/s12272-015-0571-1","article-title":"Histone deacetylase inhibitors in hematological malignancies and solid tumors","volume":"38","author":"Chun","year":"2015","journal-title":"Arch. Pharm. Res."},{"key":"10.1016\/j.mad.2017.08.008_bib0170","doi-asserted-by":"crossref","first-page":"5076","DOI":"10.2174\/1381612811319280006","article-title":"Phenylbutyrate is a multifaceted drug that exerts neuroprotective effects and reverses the Alzheime\u0155s disease-like phenotype of a commonly used mouse model","volume":"19","author":"Cuadrado-Tejedor","year":"2013","journal-title":"Curr. Pharm. Des."},{"key":"10.1016\/j.mad.2017.08.008_bib0175","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1038\/nature08085","article-title":"Histone H4 lysine 16 acetylation regulates cellular lifespan","volume":"459","author":"Dang","year":"2009","journal-title":"Nature"},{"key":"10.1016\/j.mad.2017.08.008_bib0180","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1016\/j.drudis.2013.11.012","article-title":"Small molecule inhibitors of histone acetyltransferases and deacetylases are potential drugs for inflammatory diseases","volume":"19","author":"Dekker","year":"2014","journal-title":"Drug Discov. Today"},{"key":"10.1016\/j.mad.2017.08.008_bib0185","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1002\/jcb.20532","article-title":"Prospects: histone deacetilase inhibitors","volume":"96","author":"Dokmanovic","year":"2005","journal-title":"J. Cell Biochem."},{"key":"10.1016\/j.mad.2017.08.008_bib0190","doi-asserted-by":"crossref","first-page":"621","DOI":"10.18632\/aging.100683","article-title":"D-beta-hydroxybutyrate extends lifespan in C. elegans","volume":"6","author":"Edwards","year":"2014","journal-title":"Aging (Albany NY)"},{"key":"10.1016\/j.mad.2017.08.008_bib0195","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.1038\/ncb1975","article-title":"Induction of autophagy by spermidine promotes longevity","volume":"11","author":"Eisenberg","year":"2009","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.mad.2017.08.008_bib0200","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1016\/j.cmet.2014.02.010","volume":"19","author":"Eisenberg","year":"2014","journal-title":"Cell Metab."},{"key":"10.1016\/j.mad.2017.08.008_bib0205","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.tins.2016.10.008","article-title":"The threshold theory for Parkinson's disease","volume":"40","author":"Engelender","year":"2017","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.mad.2017.08.008_bib0210","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.pharmthera.2014.02.012","article-title":"Posttranslational modifications of histone deacetylases: implications for cardiovascular diseases","volume":"143","author":"Eom","year":"2014","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.mad.2017.08.008_bib0215","first-page":"84","article-title":"The role of immunosenescence in the development of age-related diseases","volume":"68","author":"F\u00fcl\u00f6p","year":"2016","journal-title":"Rev. Invest. Clin."},{"key":"10.1016\/j.mad.2017.08.008_bib0220","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1016\/j.cell.2005.08.042","article-title":"Sir2 blocks extreme life-span extension","volume":"123","author":"Fabrizio","year":"2005","journal-title":"Cell"},{"key":"10.1016\/j.mad.2017.08.008_bib0225","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.yjmcc.2015.03.010","article-title":"Non-sirtuin histone deacetylases in the control of cardiac aging","volume":"83","author":"Ferguson","year":"2015","journal-title":"J. Mol. Cell Cardiol."},{"key":"10.1016\/j.mad.2017.08.008_bib0230","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.nlm.2016.07.002","article-title":"The aging memory: modulating epigenetic modifications to improve cognitive function","volume":"133","author":"Fonseca","year":"2016","journal-title":"Neurobiol. Learn. Mem."},{"key":"10.1016\/j.mad.2017.08.008_bib0235","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1126\/science.1172539","article-title":"Extending healthy lifespan ?from yeast to humans","volume":"328","author":"Fontana","year":"2010","journal-title":"Science"},{"key":"10.1016\/j.mad.2017.08.008_bib0240","doi-asserted-by":"crossref","first-page":"e48992","DOI":"10.1371\/journal.pone.0048992","article-title":"Cross-species functional genomic analysis identifies resistance genes of the histone deacetylase inhibitor valproic acid","volume":"7","author":"Forthun","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.mad.2017.08.008_bib0245","doi-asserted-by":"crossref","first-page":"1218","DOI":"10.1093\/gerona\/glw240","article-title":"Chronic inflammation: accelerator of biological aging","volume":"72","author":"Foug\u00e8re","year":"2017","journal-title":"J. Gerontol. A Biol. Sci. Med. Sci."},{"key":"10.1016\/j.mad.2017.08.008_bib0250","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/j.exger.2010.08.007","article-title":"dSir2 and longevity in Drosophila","volume":"46","author":"Frankel","year":"2011","journal-title":"Exp. Gerontol."},{"key":"10.1016\/j.mad.2017.08.008_bib0255","doi-asserted-by":"crossref","first-page":"1112","DOI":"10.18632\/aging.100856","article-title":"RPD3 histone deacetylase and nutrition have distinct but interacting effects on Drosophila longevity","volume":"7","author":"Frankel","year":"2014","journal-title":"Aging (Albany NY)"},{"key":"10.1016\/j.mad.2017.08.008_bib0260","doi-asserted-by":"crossref","first-page":"55","DOI":"10.2174\/1570159X13666151021111609","article-title":"Histone Deacetylase (HDAC) Inhibitors\u2013emerging roles in neuronal memory, learning, synaptic plasticity and neural regeneration","volume":"14","author":"Ganai","year":"2016","journal-title":"Curr. Neuropharmacol."},{"key":"10.1016\/j.mad.2017.08.008_bib0265","doi-asserted-by":"crossref","first-page":"25748","DOI":"10.1074\/jbc.M111871200","article-title":"Cloning and functional characterization of HDAC11., a novel member of the human histone deacetylase family","volume":"277","author":"Gao","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.mad.2017.08.008_bib0270","doi-asserted-by":"crossref","first-page":"1509","DOI":"10.2337\/db08-1637","article-title":"Butyrate improves insulin sensitivity and increases energy expenditure in mice","volume":"58","author":"Gao","year":"2009","journal-title":"Diabetes"},{"key":"10.1016\/j.mad.2017.08.008_bib0275","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.gene.2005.09.010","article-title":"Acetylation and deacetylation of non-histone proteins","volume":"363","author":"Glozak","year":"2005","journal-title":"Gene"},{"key":"10.1016\/j.mad.2017.08.008_bib0280","doi-asserted-by":"crossref","first-page":"e1006272","DOI":"10.1371\/journal.pgen.1006272","article-title":"Acetylation reader proteins: linking acetylation signaling to genome maintenance and cancer","volume":"12","author":"Gong","year":"2016","journal-title":"PLoS Genet."},{"key":"10.1016\/j.mad.2017.08.008_bib0285","doi-asserted-by":"crossref","first-page":"187","DOI":"10.3233\/JAD-2011-110080","article-title":"Sodium butyrate improves memory function in an Alzheimer's disease mouse model when administered at an advanced stage of disease progression","volume":"26","author":"Govindarajan","year":"2011","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.mad.2017.08.008_bib0290","doi-asserted-by":"crossref","first-page":"1479","DOI":"10.2174\/156802612802652420","article-title":"Towards isozyme-selective HDAC inhibitors for interrogating disease","volume":"12","author":"Gupta","year":"2012","journal-title":"Curr. Top. Med. Chem."},{"key":"10.1016\/j.mad.2017.08.008_bib0295","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1192\/bjp.bp.115.167569","article-title":"Alzheimer's disease: the amyloid hypothesis on trial","volume":"208","author":"Harrison","year":"2016","journal-title":"Br. J. Psychiatry"},{"key":"10.1016\/j.mad.2017.08.008_bib0300","doi-asserted-by":"crossref","first-page":"4200","DOI":"10.1111\/bph.13208","article-title":"Neurorestoration induced by the HDAC inhibitor sodium valproate in the lactacystin model of Parkinson's is associated with histone acetylation and up-regulation of neurotrophic factors","volume":"172","author":"Harrison","year":"2015","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.mad.2017.08.008_bib0305","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.neulet.2015.12.052","article-title":"Associated degeneration of ventral tegmental area dopaminergic neurons in the rat nigrostriatal lactacystin model of parkinsonism and their neuroprotection by valproate","volume":"614","author":"Harrison","year":"2016","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.mad.2017.08.008_bib0310","doi-asserted-by":"crossref","first-page":"2782","DOI":"10.1111\/bph.13058","article-title":"Sodium butyrate epigenetically modulates high-fat diet-induced skeletal muscle mitochondrial adaptation., obesity and insulin resistance through nucleosome positioning","volume":"172","author":"Henagan","year":"2015","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.mad.2017.08.008_bib0315","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1038\/ncomms1001","article-title":"Sirt1 improves healthy ageing and protects from metabolic syndrome-associated cancer","volume":"1","author":"Herranz","year":"2010","journal-title":"Nat. Commun."},{"key":"10.1016\/j.mad.2017.08.008_bib0320","doi-asserted-by":"crossref","first-page":"315","DOI":"10.18632\/aging.100553","article-title":"Overexpression of Sir2 in the adult fat body is sufficient to extend lifespan of male and female Drosophila","volume":"5","author":"Hoffmann","year":"2013","journal-title":"Aging (Albany NY)"},{"key":"10.1016\/j.mad.2017.08.008_bib0325","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1016\/j.mam.2012.06.006","article-title":"Aging epigenetics: causes and consequences","volume":"34","author":"Huidobro","year":"2013","journal-title":"Mol. Aspects. Med."},{"key":"10.1016\/j.mad.2017.08.008_bib0330","doi-asserted-by":"crossref","first-page":"227","DOI":"10.2165\/11591280-000000000-00000","article-title":"Clinical and experimental applications of sodium phenylbutyrate","volume":"11","author":"Iannitti","year":"2011","journal-title":"Drugs R. D."},{"key":"10.1016\/j.mad.2017.08.008_bib0335","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1038\/35001622","article-title":"Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase","volume":"403","author":"Imai","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.mad.2017.08.008_bib0340","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.arr.2014.11.005","article-title":"Calorie restriction mimetics: can you have your cake and eat it, too?","volume":"20","author":"Ingram","year":"2015","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.mad.2017.08.008_bib0345","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/j.nbd.2012.01.016","article-title":"Histone deacetylase (HDAC) inhibitors targeting HDAC3 and HDAC1 ameliorate polyglutamine-elicited phenotypes in model systems of Huntington's disease","volume":"46","author":"Jia","year":"2012","journal-title":"Neurobil. Dis."},{"key":"10.1016\/j.mad.2017.08.008_bib0350","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1038\/nrd772","article-title":"Histone-deacetylase inhibitors: novel drugs for the treatment of cancer","volume":"1","author":"Johnstone","year":"2002","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.mad.2017.08.008_bib0355","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1111\/acel.12349","article-title":"DNA methylation and healthy human aging","volume":"14","author":"Jones","year":"2015","journal-title":"Aging Cell"},{"key":"10.1016\/j.mad.2017.08.008_bib0360","doi-asserted-by":"crossref","first-page":"6058","DOI":"10.2174\/1381612820666140314153818","article-title":"Determinants of longevity: genetics., biomarkers and therapeutic approaches","volume":"20","author":"Jylh\u00e4v\u00e4","year":"2014","journal-title":"Curr. Pharm. Des."},{"key":"10.1016\/j.mad.2017.08.008_bib0365","doi-asserted-by":"crossref","first-page":"2570","DOI":"10.1101\/gad.13.19.2570","article-title":"The SIR2\/3\/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms","volume":"13","author":"Kaeberlein","year":"1999","journal-title":"Genes Dev."},{"key":"10.1016\/j.mad.2017.08.008_bib0370","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1186\/1741-7007-2-23","article-title":"Acetylation of insulin receptor substrate-1 is permissive for tyrosine phosphorylation","volume":"2","author":"Kaiser","year":"2004","journal-title":"BMC Biol."},{"key":"10.1016\/j.mad.2017.08.008_bib0375","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1038\/nature10815","article-title":"The sirtuin SIRT6 regulates lifespan in male mice","volume":"483","author":"Kanfi","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.mad.2017.08.008_bib0380","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1073\/pnas.022631999","article-title":"Life extension in Drosophila by feeding a drug","volume":"99","author":"Kang","year":"2002","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.mad.2017.08.008_bib0385","doi-asserted-by":"crossref","first-page":"771","DOI":"10.2174\/1568026616666160414124628","article-title":"Epigenetic basis of neuronal and synaptic plasticity","volume":"17","author":"Karpova","year":"2017","journal-title":"Curr. Top. Med. Chem."},{"key":"10.1016\/j.mad.2017.08.008_bib0390","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.cbi.2014.02.001","article-title":"Protective role of sodium butyrate, a HDAC inhibitor on beta-cell proliferation., function and glucose homeostasis through modulation of p38\/ERK MAPK and apoptotic pathways: study in juvenile diabetic rat","volume":"213","author":"Khan","year":"2014","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.mad.2017.08.008_bib0395","doi-asserted-by":"crossref","first-page":"3125","DOI":"10.1091\/mbc.10.10.3125","article-title":"Modulation of life-span by histone deacetylase genes in Saccharomyces cerevisiae","volume":"10","author":"Kim","year":"1999","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.mad.2017.08.008_bib0400","doi-asserted-by":"crossref","first-page":"714","DOI":"10.2174\/1568026615666150825125857","article-title":"Histone and non-histone targets of dietary deacetylase inhibitors","volume":"16","author":"Kim","year":"2016","journal-title":"Curr. Top. Med. Chem."},{"key":"10.1016\/j.mad.2017.08.008_bib0405","doi-asserted-by":"crossref","first-page":"2520","DOI":"10.1038\/emboj.2011.162","article-title":"Cellular stress response pathways and ageing: intricate molecular relationships","volume":"30","author":"Kourtis","year":"2011","journal-title":"EMBO J."},{"key":"10.1016\/j.mad.2017.08.008_bib0410","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1021\/bi400936h","article-title":"Divergent kinetics differentiate the mechanism of action of two HDAC inhibitors","volume":"53","author":"Kral","year":"2014","journal-title":"Biochemistry"},{"key":"10.1016\/j.mad.2017.08.008_bib0415","doi-asserted-by":"crossref","first-page":"12325","DOI":"10.1073\/pnas.1102789108","article-title":"Histone H4 lysine 16 hypoacetylation is associated with defective DNA repair and premature senescence in Zmpste24-deficient mice","volume":"108","author":"Krishnan","year":"2011","journal-title":"Proc. Natl Acad. Sci. U. S. A."},{"key":"10.1016\/j.mad.2017.08.008_bib0420","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1266\/ggs.81.341","article-title":"Involvement of Drosophila Sir2-like genes in the regulation of lifespan","volume":"81","author":"Kusama","year":"2006","journal-title":"Genes Genet. Syst."},{"key":"10.1016\/j.mad.2017.08.008_bib0425","doi-asserted-by":"crossref","first-page":"469","DOI":"10.4103\/0973-1482.137937","article-title":"Epigenetic therapy of cancer with histone deacetylase inhibitors","volume":"10","author":"Lakshmaiah","year":"2014","journal-title":"J. Cancer Res. Ther."},{"key":"10.1016\/j.mad.2017.08.008_bib0430","doi-asserted-by":"crossref","first-page":"e1002473","DOI":"10.1371\/journal.pgen.1002473","article-title":"Heterochromatin formation promotes longevity and represses ribosomal RNA synthesis","volume":"8","author":"Larson","year":"2012","journal-title":"PLoS Genet."},{"key":"10.1016\/j.mad.2017.08.008_bib0435","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1038\/icb.2011.94","article-title":"Histone deacetylase inhibitors in the generation of the anti-tumour immune response","volume":"90","author":"Leggatt","year":"2012","journal-title":"Immunol. Cell Biol."},{"key":"10.1016\/j.mad.2017.08.008_bib0440","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.cbpa.2016.06.019","article-title":"Histone deacetylase 3 (HDAC 3) as emerging drug target in NF-\u03baB-mediated inflammation","volume":"33","author":"Leus","year":"2016","journal-title":"Curr. Opin. Chem. Biol."},{"key":"10.1016\/j.mad.2017.08.008_bib0445","doi-asserted-by":"crossref","first-page":"640","DOI":"10.2174\/1566524011313040013","article-title":"Immunomodulatory effects of histone deacetylase inhibitors","volume":"13","author":"Licciardi","year":"2013","journal-title":"Curr. Mol. Med."},{"key":"10.1016\/j.mad.2017.08.008_bib0450","doi-asserted-by":"crossref","first-page":"226","DOI":"10.3389\/fncel.2015.00226","article-title":"Histone acetylation modifiers in the pathogenesis of Alzheimer's disease","volume":"9","author":"Lu","year":"2015","journal-title":"Front. Cell. Neurosci."},{"key":"10.1016\/j.mad.2017.08.008_bib0455","doi-asserted-by":"crossref","first-page":"415","DOI":"10.2174\/1568026615666150813145629","article-title":"Selective histone deacetylase inhibitors with anticancer activity","volume":"16","author":"Ma","year":"2016","journal-title":"Curr. Top. Med. Chem."},{"key":"10.1016\/j.mad.2017.08.008_bib0460","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1016\/j.chembiol.2016.06.011","article-title":"Innovative strategies for selective inhibition of histone deacetylases","volume":"23","author":"Maolanon","year":"2016","journal-title":"Cell Chem. Biol."},{"key":"10.1016\/j.mad.2017.08.008_bib0465","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1002\/cbic.201600519","article-title":"Natural and synthetic macrocyclic inhibitors of the histone deacetylase enzymes","volume":"18","author":"Maolanon","year":"2017","journal-title":"Chembiochem"},{"key":"10.1016\/j.mad.2017.08.008_bib0470","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1586\/14789450.2.5.719","article-title":"Histone structure and nucleosome stability","volume":"2","author":"Mari\u00f1o-Ram\u00edrez","year":"2005","journal-title":"Expert Rev. Proteomics"},{"key":"10.1016\/j.mad.2017.08.008_bib0475","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1002\/biot.201000183","article-title":"Modeling human diseases in Caenorhabditis elegans","volume":"5","author":"Markaki","year":"2010","journal-title":"Biotechnol. J."},{"key":"10.1016\/j.mad.2017.08.008_bib0480","doi-asserted-by":"crossref","first-page":"e1000921","DOI":"10.1371\/journal.pgen.1000921","article-title":"A microarray-based genetic screen for yeast chronological aging factors","volume":"6","author":"Matecic","year":"2010","journal-title":"PLoS Genet."},{"key":"10.1016\/j.mad.2017.08.008_bib0485","doi-asserted-by":"crossref","first-page":"119","DOI":"10.4161\/epi.7.2.18764","article-title":"Basic concepts of epigenetics: impact of environmental signals on gene expression","volume":"7","author":"Mazzio","year":"2012","journal-title":"Epigenetics"},{"key":"10.1016\/j.mad.2017.08.008_bib0490","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1016\/j.exger.2012.09.006","article-title":"Chemical regulation of mid- and late-life longevities in Drosophila","volume":"48","author":"McDonald","year":"2013","journal-title":"Exp. Gerontol."},{"key":"10.1016\/j.mad.2017.08.008_bib0495","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1242\/dmm.023317","article-title":"FlyBase portals to human disease research using Drosophila models","volume":"9","author":"Millburn","year":"2016","journal-title":"Dis. Model Mech."},{"key":"10.1016\/j.mad.2017.08.008_bib0500","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/j.cell.2005.11.044","article-title":"Genomic instability and aging-like phenotype in the absence of mammalian SIRT6","volume":"124","author":"Mostoslavsky","year":"2006","journal-title":"Cell"},{"key":"10.1016\/j.mad.2017.08.008_bib0505","doi-asserted-by":"crossref","first-page":"3898","DOI":"10.3390\/molecules20033898","article-title":"Histone deacetylase inhibitors in clinical studies as templates for new anticancer agents","volume":"20","author":"Mottamal","year":"2015","journal-title":"Molecules"},{"key":"10.1016\/j.mad.2017.08.008_bib0510","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.pbiomolbio.2015.02.009","article-title":"Insects as model to study the epigenetic basis of disease","volume":"118","author":"Mukherjee","year":"2015","journal-title":"Prog. Biophys. Mol. Biol."},{"key":"10.1016\/j.mad.2017.08.008_bib0515","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.diabres.2014.08.009","article-title":"\u03b2-hydroxybutyrate: much more than a metabolite","volume":"106","author":"Newman","year":"2014","journal-title":"Diabetes Res. Clin. Pract."},{"key":"10.1016\/j.mad.2017.08.008_bib0520","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1615\/CritRevOncog.2014012463","article-title":"Deacetylation of chromatin and gene expression regulation: a new target for epigenetic therapy","volume":"20","author":"Olzscha","year":"2015","journal-title":"Crit. Rev. Oncog."},{"key":"10.1016\/j.mad.2017.08.008_bib0525","doi-asserted-by":"crossref","first-page":"e1600584","DOI":"10.1126\/sciadv.1600584","article-title":"Epigenetics and aging","volume":"2","author":"Pal","year":"2016","journal-title":"Sci. Adv."},{"key":"10.1016\/j.mad.2017.08.008_bib0530","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.coi.2014.03.007","article-title":"Inflammation., ageing and chronic disease","volume":"29","author":"Pawelec","year":"2014","journal-title":"Curr. Opin. Immunol."},{"key":"10.1016\/j.mad.2017.08.008_bib0535","doi-asserted-by":"crossref","first-page":"455","DOI":"10.15252\/embr.201541132","article-title":"Lifespan extension by targeting a link between metabolism and histone acetylation in Drosophila","volume":"17","author":"Peleg","year":"2016","journal-title":"EMBO Rep."},{"key":"10.1016\/j.mad.2017.08.008_bib0540","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1016\/j.tibs.2016.05.008","article-title":"The metabolic impact on histone acetylation and transcription in ageing","volume":"41","author":"Peleg","year":"2016","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/j.mad.2017.08.008_bib0545","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1007\/978-1-4939-2474-5_7","article-title":"Histone deacetylase activity assay","volume":"1288","author":"Peng","year":"2015","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.mad.2017.08.008_bib0550","doi-asserted-by":"crossref","first-page":"re12","DOI":"10.1126\/scisignal.aaa0069","article-title":"Histone deacetylases in memory and cognition","volume":"7","author":"Penney","year":"2014","journal-title":"Sci. Signal."},{"key":"10.1016\/j.mad.2017.08.008_bib0555","doi-asserted-by":"crossref","first-page":"30","DOI":"10.3389\/fncel.2013.00030","article-title":"Targeting specific HATs for neurodegenerative disease treatment: translating basic biology to therapeutic possibilities","volume":"7","author":"Pirooznia","year":"2013","journal-title":"Front. Cell Neurosci."},{"key":"10.1016\/j.mad.2017.08.008_bib0560","doi-asserted-by":"crossref","first-page":"2442","DOI":"10.1016\/j.bbadis.2015.08.017","article-title":"Sirtuin regulation in aging and injury","volume":"1852","author":"Poulose","year":"2015","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.mad.2017.08.008_bib0565","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1101\/gad.254144.114","article-title":"Trimethylation of Lys36 on H3 restricts gene expression change during aging and impacts lifespan","volume":"29","author":"Pu","year":"2015","journal-title":"Genes Dev."},{"key":"10.1016\/j.mad.2017.08.008_bib0570","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1038\/leu.2010.276","article-title":"Histone deacetylase inhibitors for the treatment of myelodysplastic syndrome and acute myeloid leukemia","volume":"25","author":"Quintas-Cardama","year":"2011","journal-title":"Leukemia"},{"key":"10.1016\/j.mad.2017.08.008_bib0575","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.cell.2012.01.003","article-title":"Aging, rejuvenation, and epigenetic reprogramming: resetting the aging clock","volume":"148","author":"Rando","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.mad.2017.08.008_bib0580","doi-asserted-by":"crossref","first-page":"1721","DOI":"10.1038\/npp.2008.229","article-title":"Phenylbutyrate ameliorates cognitive deficit and reduces tau pathology in an Alzheimer's disease mouse model","volume":"34","author":"Ricobaraza","year":"2009","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.mad.2017.08.008_bib0585","doi-asserted-by":"crossref","first-page":"1040","DOI":"10.1002\/hipo.20883","article-title":"Phenylbutyrate rescues dendritic spine loss associated with memory deficits in a mouse model of Alzheimer disease","volume":"22","author":"Ricobaraza","year":"2012","journal-title":"Hippocampus"},{"key":"10.1016\/j.mad.2017.08.008_bib0590","doi-asserted-by":"crossref","first-page":"e1002235","DOI":"10.1371\/journal.pgen.1002235","article-title":"The evolutionarily conserved longevity determinants HCF-1 and SIR-2. 1\/SIRT1 collaborate to regulate DAF-16\/FOXO","volume":"7","author":"Rizki","year":"2011","journal-title":"PLoS Genet."},{"key":"10.1016\/j.mad.2017.08.008_bib0595","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1016\/j.ejmech.2016.05.047","article-title":"Inside HDACs with more selective HDAC inhibitors","volume":"121","author":"Roche","year":"2016","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.mad.2017.08.008_bib0600","doi-asserted-by":"crossref","first-page":"15998","DOI":"10.1073\/pnas.0404184101","article-title":"Sir2 mediates longevity in the fly through a pathway related to calorie restriction","volume":"101","author":"Rogina","year":"2004","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.mad.2017.08.008_bib0605","doi-asserted-by":"crossref","first-page":"1745","DOI":"10.1126\/science.1078986","article-title":"Longevity regulation by Drosophila Rpd3 deacetylase and caloric restriction","volume":"298","author":"Rogina","year":"2002","journal-title":"Science"},{"key":"10.1016\/j.mad.2017.08.008_bib0610","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.molonc.2007.01.001","article-title":"The role of histone deacetylases (HDACs) in human cancer","volume":"1","author":"Ropero","year":"2007","journal-title":"Mol. Oncol."},{"key":"10.1016\/j.mad.2017.08.008_bib0615","doi-asserted-by":"crossref","first-page":"347","DOI":"10.3389\/fnbeh.2015.00347","article-title":"Epigenetic alterations in Alzheimer's disease","volume":"9","author":"Sanchez-Mut","year":"2015","journal-title":"Front. Behav. Neurosci."},{"key":"10.1016\/j.mad.2017.08.008_bib0620","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1016\/j.cmet.2013.07.013","article-title":"Sirt1 extends lifespan and delays aging in mice through the regulation of Nk2 homeobox 1 in the DMH and LH","volume":"18","author":"Satoh","year":"2013","journal-title":"Cell Metab."},{"key":"10.1016\/j.mad.2017.08.008_bib0625","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1038\/nchembio.1352","article-title":"Role of sirtuins in lifespan regulation is linked to methylation of nicotinamide","volume":"9","author":"Schmeisser","year":"2013","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.mad.2017.08.008_bib0630","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1615\/CritRevOncog.2014012393","article-title":"Modulation of immune responses by histone deacetylase inhibitors","volume":"20","author":"Schotterl","year":"2015","journal-title":"Crit. Rev. Oncog."},{"key":"10.1016\/j.mad.2017.08.008_bib0635","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1016\/j.bbagrm.2010.08.012","article-title":"Tuning acetylation levels with HAT activators: therapeutic strategy in neurodegenerative diseases","volume":"1799","author":"Selvi","year":"2010","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.mad.2017.08.008_bib0640","doi-asserted-by":"crossref","first-page":"1362","DOI":"10.1101\/gad.263707.115","article-title":"H3K36 methylation promotes longevity by enhancing transcriptional fidelity","volume":"29","author":"Sen","year":"2015","journal-title":"Genes Dev."},{"key":"10.1016\/j.mad.2017.08.008_bib0645","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1016\/j.cell.2016.07.050","article-title":"Epigenetic mechanisms of longevity and aging","volume":"166","author":"Sen","year":"2016","journal-title":"Cell"},{"key":"10.1016\/j.mad.2017.08.008_bib0650","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1046\/j.1474-9728.2002.00007.x","article-title":"Spatio-temporal analysis of gene expression during aging in Drosophila melanogaster","volume":"1","author":"Seroude","year":"2002","journal-title":"Aging Cell"},{"key":"10.1016\/j.mad.2017.08.008_bib0655","doi-asserted-by":"crossref","first-page":"a018713","DOI":"10.1101\/cshperspect.a018713","article-title":"Erasers of histone acetylation: the histone deacetylase enzymes","volume":"6","author":"Seto","year":"2014","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"10.1016\/j.mad.2017.08.008_bib0660","first-page":"303294","article-title":"2015. Targeting histone deacetylases: a novel approach in Parkinson's disease","author":"Sharma","year":"2015","journal-title":"Parkinsons Dis."},{"key":"10.1016\/j.mad.2017.08.008_bib0665","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/j.neuropharm.2016.01.025","article-title":"Epigenetic modifications by inhibiting histone deacetylases reverse memory impairment in insulin resistance induced cognitive deficit in mice","volume":"105","author":"Sharma","year":"2016","journal-title":"Neuropharmacology"},{"issue":"Pt A","key":"10.1016\/j.mad.2017.08.008_bib0670","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1016\/j.phrs.2016.09.009","article-title":"Histone deacetylase inhibitors: future therapeutics for insulin resistance and type 2 diabetes","volume":"113","author":"Sharma","year":"2016","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.mad.2017.08.008_bib0675","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1016\/j.tplants.2015.07.005","article-title":"Histone acetylation enzymes coordinate metabolism and gene expression","volume":"20","author":"Shen","year":"2015","journal-title":"Trends Plant. Sci."},{"key":"10.1016\/j.mad.2017.08.008_bib0680","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1016\/j.neuroscience.2013.04.037","article-title":"Sodium butyrate improves locomotor impairment and early mortality in a rotenone-induced Drosophila model of Parkinson's disease","volume":"246","author":"St Laurent","year":"2013","journal-title":"Neuroscience"},{"issue":"6857","key":"10.1016\/j.mad.2017.08.008_bib0685","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1038\/35099568","article-title":"Histone deacetylase inhibitors arrest polyglutamine-dependent neurodegeneration in Drosophila","volume":"413","author":"Steffan","year":"2001","journal-title":"Nature"},{"key":"10.1016\/j.mad.2017.08.008_bib0690","doi-asserted-by":"crossref","first-page":"e0128517","DOI":"10.1371\/journal.pone.0128517","article-title":"Impacts of chromatin states and long-range genomic segments on aging and DNA methylation","volume":"10","author":"Sun","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.mad.2017.08.008_bib0695","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.bcp.2008.04.004","article-title":"Trichostatin A improves insulin stimulated glucose utilization and insulin signaling transduction through the repression of HDAC2","volume":"76","author":"Sun","year":"2008","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.mad.2017.08.008_bib0700","first-page":"31","article-title":"Review of bioanalytical assays for the quantitation of various HDAC inhibitors such as vorinostat, belinostat, panobinostat, romidepsin and chidamine","author":"Suresh","year":"2017","journal-title":"Biomed. Chromatogr."},{"key":"10.1016\/j.mad.2017.08.008_bib0705","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1093\/abbs\/36.9.618","article-title":"Trichostatin A extends the lifespan of Drosophila melanogaster by elevating hsp22 expression","volume":"36","author":"Tao","year":"2004","journal-title":"Acta Biochim. Biophys. Sin. (Shanghai)"},{"key":"10.1016\/j.mad.2017.08.008_bib0710","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1038\/35065638","article-title":"Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans","volume":"410","author":"Tissenbaum","year":"2001","journal-title":"Nature"},{"key":"10.1016\/j.mad.2017.08.008_bib0715","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1242\/dmm.023762","article-title":"Drosophila tools and assays for the study of human diseases","volume":"9","author":"Ugur","year":"2016","journal-title":"Dis. Model Mech."},{"key":"10.1016\/j.mad.2017.08.008_bib0720","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/j.tips.2016.02.003","article-title":"Longevity-promoting pharmaceuticals: is it a time for implementation?","volume":"37","author":"Vaiserman","year":"2016","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.mad.2017.08.008_bib0725","doi-asserted-by":"crossref","first-page":"224","DOI":"10.3389\/fgene.2012.00224","article-title":"Epigenetic drugs: a novel anti-aging strategy?","volume":"3","author":"Vaiserman","year":"2012","journal-title":"Front. Genet."},{"key":"10.1016\/j.mad.2017.08.008_bib0730","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1134\/S2079057013010153","article-title":"Effect of the histone deacetylase inhibitor sodium butyrate on the viability and lifespan in Drosophila melanogaster","volume":"3","author":"Vaiserman","year":"2013","journal-title":"Adv. Gerontol."},{"key":"10.1016\/j.mad.2017.08.008_bib0735","first-page":"111","article-title":"Determination of geroprotective potential of sodium butyrate in Drosophila melanogaster: long-term effects","volume":"26","author":"Vaiserman","year":"2013","journal-title":"Adv. Gerontol."},{"key":"10.1016\/j.mad.2017.08.008_bib0740","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.arr.2016.08.004","article-title":"Anti-aging pharmacology: promises and pitfalls","volume":"31","author":"Vaiserman","year":"2016","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.mad.2017.08.008_bib0745","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1089\/rej.2007.0579","article-title":"Epigenetic engineering and its possible role in anti-aging intervention","volume":"11","author":"Vaiserman","year":"2008","journal-title":"Rejuvenation Res."},{"key":"10.1016\/j.mad.2017.08.008_bib0750","first-page":"413","article-title":"Hormesis and epigenetics: is there a link?","volume":"10","author":"Vaiserman","year":"2011","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.mad.2017.08.008_bib0755","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1186\/s13148-015-0130-0","article-title":"Epidemiologic evidence for association between adverse environmental exposures in early life and epigenetic variation: a potential link to disease susceptibility?","volume":"7","author":"Vaiserman","year":"2015","journal-title":"Clin. Epigenetics"},{"key":"10.1016\/j.mad.2017.08.008_bib0760","doi-asserted-by":"crossref","first-page":"1629","DOI":"10.2174\/0929867043365099","article-title":"Trichostatin A-like hydroxamate histone deacetylase inhibitors as therapeutic agents: toxicological point of view","volume":"11","author":"Vanhaecke","year":"2004","journal-title":"Curr. Med. Chem."},{"key":"10.1016\/j.mad.2017.08.008_bib0765","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/S0531-5565(96)00155-6","article-title":"The heterochromatin loss model of aging. Exp","volume":"32","author":"Villeponteau","year":"1997","journal-title":"Exp. Gerontol."},{"key":"10.1016\/j.mad.2017.08.008_bib0770","doi-asserted-by":"crossref","first-page":"17","DOI":"10.3233\/NHA-160005","article-title":"Emerging roles for histone deacetylases in age-related muscle atrophy","volume":"4","author":"Walsh","year":"2016","journal-title":"Nutr. Healthy Aging"},{"key":"10.1016\/j.mad.2017.08.008_bib0775","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1111\/acel.12387","article-title":"The histone deacetylase inhibitor butyrate improves metabolism and reduces muscle atrophy during aging","volume":"14","author":"Walsh","year":"2015","journal-title":"Aging Cell"},{"key":"10.1016\/j.mad.2017.08.008_bib0780","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.mad.2005.09.005","article-title":"Overlapping and distinct functions for a Caenorhabditis elegans SIR2 and DAF-16\/FOXO","volume":"127","author":"Wang","year":"2006","journal-title":"Mech. Ageing Dev."},{"key":"10.1016\/j.mad.2017.08.008_bib0785","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1111\/j.1474-9726.2011.00680.x","article-title":"Phenylbutyric acid reduces amyloid plaques and rescues cognitive behavior in AD transgenic mice","volume":"10","author":"Wiley","year":"2011","journal-title":"Aging Cell"},{"key":"10.1016\/j.mad.2017.08.008_bib0790","doi-asserted-by":"crossref","first-page":"274","DOI":"10.3389\/fgene.2013.00274","article-title":"Chromatin structure and transposable elements in organismal aging","volume":"4","author":"Wood","year":"2013","journal-title":"Front. Genet."},{"key":"10.1016\/j.mad.2017.08.008_bib0795","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1111\/j.1474-9726.2010.00624.x","article-title":"Chromatin remodeling in the aging genome of Drosophila","volume":"9","author":"Wood","year":"2010","journal-title":"Aging Cell"},{"key":"10.1016\/j.mad.2017.08.008_bib0800","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1158\/1078-0432.CCR-06-1261","article-title":"Suberoylanilide hydroxamic acid, a histone deacetylase inhibitor: effects on gene expression and growth of glioma cells in vitro and in vivo","volume":"13","author":"Yin","year":"2007","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.mad.2017.08.008_bib0805","doi-asserted-by":"crossref","first-page":"12580","DOI":"10.1074\/jbc.M511677200","article-title":"Sodium butyrate ameliorates histone hypoacetylation and neurodegenerative phenotypes in a mouse model for DRPLA","volume":"281","author":"Ying","year":"2006","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.mad.2017.08.008_bib0810","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.expneurol.2011.06.003","article-title":"Treatment with trichostatin A initiated after disease onset delays disease progression and increases survival in a mouse model of amyotrophic lateral sclerosis","volume":"231","author":"Yoo","year":"2011","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.mad.2017.08.008_bib0815","doi-asserted-by":"crossref","first-page":"1","DOI":"10.4068\/cmj.2016.52.1.1","article-title":"HDAC and HDAC inhibitor: from cancer to cardiovascular diseases","volume":"52","author":"Yoon","year":"2016","journal-title":"Chonnam. Med. J."},{"key":"10.1016\/j.mad.2017.08.008_bib0820","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.mad.2016.02.003","article-title":"Regulation of SIRT1 in aging: roles in mitochondrial function and biogenesis","volume":"155","author":"Yuan","year":"2016","journal-title":"Mech. Ageing Dev."},{"key":"10.1016\/j.mad.2017.08.008_bib0825","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1038\/nsmb.2470","article-title":"Regulation of nucleosome dynamics by histone modifications","volume":"20","author":"Zentner","year":"2013","journal-title":"Nat. Struct. Mol. Biol."},{"key":"10.1016\/j.mad.2017.08.008_bib0830","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1242\/jeb.01439","article-title":"Lifespan extension and elevated hsp gene expression in Drosophila caused by histone deacetylase inhibitors","volume":"208","author":"Zhao","year":"2005","journal-title":"J. Exp. Biol."},{"key":"10.1016\/j.mad.2017.08.008_bib0835","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1016\/j.bbrc.2004.11.118","article-title":"Histone acetylation regulates both transcription initiation and elongation of hsp22 gene in Drosophila","volume":"326","author":"Zhao","year":"2005","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.mad.2017.08.008_bib0840","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1038\/sj.cr.7310074","article-title":"Effects of histone deacetylase inhibitors on transcriptional regulation of the hsp70 gene in Drosophila","volume":"16","author":"Zhao","year":"2006","journal-title":"Cell Res."},{"key":"10.1016\/j.mad.2017.08.008_bib0845","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s11010-007-9547-x","article-title":"Roles of histone acetylation modification in basal and inducible expression of hsp26 gene in D. melanogaster","volume":"306","author":"Zhao","year":"2007","journal-title":"Mol. Cell Biochem."},{"key":"10.1016\/j.mad.2017.08.008_bib0850","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1093\/cvr\/cvr003","article-title":"Role of histone deacetylases in vascular cell homeostasis and arteriosclerosis","volume":"90","author":"Zhou","year":"2011","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.mad.2017.08.008_bib0855","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1186\/1471-2202-12-50","article-title":"Histone deacetylase inhibitors SAHA and sodium butyrate block G1-to-S cell cycle progression in neurosphere formation by adult subventricular cells","volume":"12","author":"Zhou","year":"2011","journal-title":"BMC Neurosci."}],"container-title":["Mechanisms of Ageing and Development"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0047637417300696?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0047637417300696?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,8,25]],"date-time":"2023-08-25T02:41:21Z","timestamp":1692931281000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0047637417300696"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,9]]},"references-count":171,"alternative-id":["S0047637417300696"],"URL":"https:\/\/doi.org\/10.1016\/j.mad.2017.08.008","relation":{},"ISSN":["0047-6374"],"issn-type":[{"value":"0047-6374","type":"print"}],"subject":[],"published":{"date-parts":[[2017,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"HDAC inhibitors: A new promising drug class in anti-aging research","name":"articletitle","label":"Article Title"},{"value":"Mechanisms of Ageing and Development","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mad.2017.08.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}