{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T06:10:33Z","timestamp":1790748633265,"version":"4.1.0"},"reference-count":58,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T00:00:00Z","timestamp":1601510400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T00:00:00Z","timestamp":1601510400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100009708","name":"Novo Nordisk Fonden","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009708","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007405","name":"Hjerteforeningen","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007405","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001825","name":"Danish Agency for Science and Higher Education","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001825","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Mechanisms of Ageing and Development"],"published-print":{"date-parts":[[2020,10]]},"DOI":"10.1016\/j.mad.2020.111336","type":"journal-article","created":{"date-parts":[[2020,9,9]],"date-time":"2020-09-09T11:22:55Z","timestamp":1599650575000},"page":"111336","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":40,"special_numbering":"C","title":["Aging, calcium channel signaling and vascular tone"],"prefix":"10.1016","volume":"191","author":[{"given":"Osama F.","family":"Harraz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars J\u00f8rn","family":"Jensen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.mad.2020.111336_bib0005","doi-asserted-by":"crossref","first-page":"H58","DOI":"10.1152\/ajpheart.00476.2012","article-title":"Identification of L- and T-type Ca2+ channels in rat cerebral arteries: role in myogenic tone development","volume":"304","author":"Abd El-Rahman","year":"2013","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"issue":"6","key":"10.1016\/j.mad.2020.111336_bib0010","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1113\/expphysiol.2009.051250","article-title":"Exercise training attenuates ageing-induced BKCa channel downregulation in rat coronary arteries","volume":"95","author":"Albarwani","year":"2010","journal-title":"Exp. Physiol."},{"issue":"3","key":"10.1016\/j.mad.2020.111336_bib0015","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1113\/jphysiol.1902.sp000911","article-title":"On the local reactions of the arterial wall to changes of internal pressure","volume":"28","author":"Bayliss","year":"1902","journal-title":"J. Physiol."},{"issue":"4","key":"10.1016\/j.mad.2020.111336_bib0020","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1111\/apha.12066","article-title":"Myogenic tone is impaired at low arterial pressure in mice deficient in the low-voltage-activated CaV3.1 T-type Ca2+ channel","volume":"207","author":"Bj\u00f6rling","year":"2013","journal-title":"Acta Physiol."},{"issue":"2","key":"10.1016\/j.mad.2020.111336_bib0025","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1159\/000151767","article-title":"The role of L- and T-type calcium channels in local and remote calcium responses in rat mesenteric terminal arterioles","volume":"46","author":"Braunstein","year":"2009","journal-title":"J. Vasc. Res."},{"key":"10.1016\/j.mad.2020.111336_bib0030","article-title":"BK channels in cardiovascular diseases and aging","author":"Carvalho-de-Souza","year":"2013","journal-title":"Aging Dis."},{"issue":"5649","key":"10.1016\/j.mad.2020.111336_bib0035","doi-asserted-by":"crossref","first-page":"1416","DOI":"10.1126\/science.1089268","article-title":"Abnormal coronary function in mice deficient in \u03b11H T-type Ca2+ channels","volume":"302","author":"Chen","year":"2003","journal-title":"Science"},{"issue":"6","key":"10.1016\/j.mad.2020.111336_bib0040","doi-asserted-by":"crossref","first-page":"1393","DOI":"10.1161\/HYPERTENSIONAHA.112.201780","article-title":"Blood pressure tracking over the adult life course: patterns and correlates in the Framingham heart study","volume":"60","author":"Cheng","year":"2012","journal-title":"Hypertension (Dallas, Tex.: 1979)"},{"issue":"7797","key":"10.1016\/j.mad.2020.111336_bib0045","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1038\/s41586-020-2026-1","article-title":"Caveolae in CNS arterioles mediate neurovascular coupling","volume":"579","author":"Chow","year":"2020","journal-title":"Nature"},{"issue":"2","key":"10.1016\/j.mad.2020.111336_bib0050","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1161\/CIRCRESAHA.111.258145","article-title":"Acidosis dilates brain parenchymal arterioles by conversion of calcium waves to sparks to activate BK channels","volume":"110","author":"Dabertrand","year":"2012","journal-title":"Circ. Res."},{"issue":"1\u20133","key":"10.1016\/j.mad.2020.111336_bib0055","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.ejphar.2009.11.055","article-title":"A comparative study of alpha-adrenergic receptor mediated Ca2+ signals and contraction in intact human and mouse vascular smooth muscle","volume":"629","author":"Dai","year":"2010","journal-title":"Eur. J. Pharmacol."},{"issue":"4","key":"10.1016\/j.mad.2020.111336_bib0060","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/j.mad.2005.12.001","article-title":"Effects of aging on Ca2+ signaling in murine mesenteric arterial smooth muscle cells","volume":"127","author":"Del Corsso","year":"2006","journal-title":"Mech. Ageing Dev."},{"issue":"14","key":"10.1016\/j.mad.2020.111336_bib0065","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.88942","article-title":"Vascular mineralocorticoid receptor regulates microRNA-155 to promote vasoconstriction and rising blood pressure with aging","volume":"1","author":"DuPont","year":"2016","journal-title":"JCI Insight"},{"issue":"20","key":"10.1016\/j.mad.2020.111336_bib0070","doi-asserted-by":"crossref","first-page":"4863","DOI":"10.1113\/JP276923","article-title":"Differential targeting and signalling of voltage-gated T-type Cav3.2 and L-type Cav1.2 channels to ryanodine receptors in mesenteric arteries","volume":"596","author":"Fan","year":"2018","journal-title":"J. Physiol. (Lond.)"},{"issue":"1","key":"10.1016\/j.mad.2020.111336_bib0075","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1080\/19336950.2019.1688910","article-title":"Elementary calcium signaling in arterial smooth muscle","volume":"13","author":"Fan","year":"2019","journal-title":"Channels (Austin, Tex.)"},{"key":"10.1016\/j.mad.2020.111336_bib0080","doi-asserted-by":"crossref","DOI":"10.1111\/acel.13134","article-title":"Age attenuates the T-type CaV3.2-RyR axis in vascular smooth muscle","author":"Fan","year":"2020","journal-title":"Aging Cell"},{"key":"10.1016\/j.mad.2020.111336_bib0085","article-title":"Mouse models in aging research","author":"Flurkey","year":"2007","journal-title":"Faculty Research 2000-2009"},{"key":"10.1016\/j.mad.2020.111336_bib0090","doi-asserted-by":"crossref","DOI":"10.1161\/01.ATV.0000070546.16946.3A","article-title":"Caveolin, caveolae, and endothelial cell function","author":"Frank","year":"2003","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"issue":"2","key":"10.1016\/j.mad.2020.111336_bib0095","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0088975","article-title":"Attenuation of L-type Ca2+ channel expression and vasomotor response in the aorta with age in both Wistar-Kyoto and spontaneously hypertensive rats","volume":"9","author":"Fukuda","year":"2014","journal-title":"PLoS One"},{"issue":"6","key":"10.1016\/j.mad.2020.111336_bib0100","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1007\/s00424-012-1195-7","article-title":"Effect of aging on calcium signaling in C57Bl6J mouse cerebral arteries","volume":"465","author":"Georgeon-Chartier","year":"2013","journal-title":"Pflugers Arch."},{"issue":"4","key":"10.1016\/j.mad.2020.111336_bib0105","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1111\/apha.12070","article-title":"Functional and pharmacological consequences of the distribution of voltage-gated calcium channels in the renal blood vessels","volume":"207","author":"Hansen","year":"2013","journal-title":"Acta Physiol. (Oxf. Engl.)"},{"issue":"13","key":"10.1016\/j.mad.2020.111336_bib0110","article-title":"Protein kinase a regulation of T-type Ca2+ channels in rat cerebral arterial smooth muscle","volume":"126","author":"Harraz","year":"2013","journal-title":"J. Cell. Sci."},{"issue":"7","key":"10.1016\/j.mad.2020.111336_bib0115","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCRESAHA.114.304056","article-title":"CaV3.2 channels and the induction of negative feedback in cerebral arteries","volume":"115","author":"Harraz","year":"2014","journal-title":"Circ. Res."},{"issue":"8","key":"10.1016\/j.mad.2020.111336_bib0120","doi-asserted-by":"crossref","DOI":"10.1161\/ATVBAHA.115.305736","article-title":"Genetic ablation of CaV3.2 channels enhances the arterial myogenic response by modulating the RyR-BKCa axis","volume":"35","author":"Harraz","year":"2015","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"issue":"5","key":"10.1016\/j.mad.2020.111336_bib0125","doi-asserted-by":"crossref","DOI":"10.1085\/jgp.201511361","article-title":"CaV1.2\/CaV3.x channels mediate divergent vasomotor responses in human cerebral arteries","volume":"145","author":"Harraz","year":"2015","journal-title":"J. Gen. Physiol."},{"issue":"4","key":"10.1016\/j.mad.2020.111336_bib0130","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1113\/JP273329","article-title":"Interplay among distinct Ca2+ conductances drives Ca2+ sparks\/spontaneous transient outward currents in rat cerebral arteries","volume":"595","author":"Hashad","year":"2017","journal-title":"J. Physiol."},{"issue":"10","key":"10.1016\/j.mad.2020.111336_bib0135","doi-asserted-by":"crossref","first-page":"2371","DOI":"10.1161\/ATVBAHA.118.311394","article-title":"Caveolae link CaV3.2 channels to BKCa-mediated feedback in vascular smooth muscle","volume":"38","author":"Hashad","year":"2018","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"issue":"11","key":"10.1016\/j.mad.2020.111336_bib0140","doi-asserted-by":"crossref","first-page":"H1512","DOI":"10.1152\/ajpheart.00492.2013","article-title":"Aging increases capacitance and spontaneous transient outward current amplitude of smooth muscle cells from murine superior epigastric arteries","volume":"306","author":"Hayoz","year":"2014","journal-title":"Am. J. Physiol. - Heart Circ. Physiol."},{"issue":"11","key":"10.1016\/j.mad.2020.111336_bib0145","doi-asserted-by":"crossref","first-page":"2692","DOI":"10.1161\/01.STR.0000034791.52151.6B","article-title":"Mechanism of extracellular K+-induced local and conducted responses in cerebral penetrating arterioles","volume":"33","author":"Horiuchi","year":"2002","journal-title":"Stroke"},{"issue":"1","key":"10.1016\/j.mad.2020.111336_bib0150","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1097\/MNH.0b013e3283186f82","article-title":"Membrane rafts and caveolae in cardiovascular signaling","volume":"18","author":"Insel","year":"2009","journal-title":"Curr. Opin. Nephrol. Hypertens."},{"issue":"3","key":"10.1016\/j.mad.2020.111336_bib0155","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1080\/19336950.2016.1273997","article-title":"T-type Ca2+ channels and autoregulation of local blood flow","volume":"11","author":"Jensen","year":"2017","journal-title":"Channels"},{"issue":"1","key":"10.1016\/j.mad.2020.111336_bib0160","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1139\/Y08-101","article-title":"Is there a role for T-type Ca2+ channels in regulation of vasomotor tone in mesenteric arterioles?","volume":"87","author":"Jensen","year":"2009","journal-title":"Can. J. Physiol. Pharmacol."},{"issue":"1","key":"10.1016\/j.mad.2020.111336_bib0165","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1111\/j.1469-7793.1998.199br.x","article-title":"Regulation of arterial diameter and wall [Ca2+] in cerebral arteries of rat by membrane potential and intravascular pressure","volume":"508","author":"Knot","year":"1998","journal-title":"J. Physiol."},{"issue":"1","key":"10.1016\/j.mad.2020.111336_bib0170","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1111\/j.1469-7793.1998.211br.x","article-title":"Ryanodine receptors regulate arterial diameter and wall [Ca2+] in cerebral arteries of rat via Ca2+-dependent K+ channels","volume":"508","author":"Knot","year":"1998","journal-title":"J. Physiol."},{"key":"10.1016\/j.mad.2020.111336_bib0175","doi-asserted-by":"crossref","DOI":"10.1016\/j.cardiores.2005.01.015","article-title":"Exaggerated coronary vasoreactivity to endothelin-1 in aged rats: role of protein kinase C","author":"Korzick","year":"2005","journal-title":"Cardiovasc. Res."},{"issue":"6","key":"10.1016\/j.mad.2020.111336_bib0180","doi-asserted-by":"crossref","first-page":"1226","DOI":"10.1038\/jcbfm.2010.11","article-title":"Dihydropyridine-insensitive calcium currents contribute to function of small cerebral arteries","volume":"30","author":"Kuo","year":"2010","journal-title":"J. Cereb. Blood Flow Metab."},{"issue":"Suppl 1(SUPPL. 1)","key":"10.1016\/j.mad.2020.111336_bib0185","doi-asserted-by":"crossref","first-page":"S81","DOI":"10.1016\/0167-5273(89)90097-1","article-title":"Arterial pressure and aging","volume":"25","author":"Lakatta","year":"1989","journal-title":"Int. J. Cardiol."},{"key":"10.1016\/j.mad.2020.111336_bib0190","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.yjmcc.2015.04.005","article-title":"So! What\u2019s aging? Is cardiovascular aging a disease?","volume":"83","author":"Lakatta","year":"2015","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.mad.2020.111336_bib0195","doi-asserted-by":"crossref","first-page":"153","DOI":"10.3389\/fmed.2019.00153","article-title":"Pathophysiological role of caveolae in hypertension","volume":"6","author":"Lian","year":"2019","journal-title":"Front. Med."},{"issue":"5","key":"10.1016\/j.mad.2020.111336_bib0200","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1038\/hr.2016.167","article-title":"Epigenetic regulation of L-type voltage-gated Ca2+ channels in mesenteric arteries of aging hypertensive rats","volume":"40","author":"Liao","year":"2017","journal-title":"Hypertens. Res."},{"issue":"2","key":"10.1016\/j.mad.2020.111336_bib0205","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1161\/01.RES.88.2.210","article-title":"Decreased expression of voltage- and Ca2+-activated K+ channels in coronary smooth muscle during aging","volume":"88","author":"Marijic","year":"2001","journal-title":"Circ. Res."},{"issue":"20","key":"10.1016\/j.mad.2020.111336_bib0210","doi-asserted-by":"crossref","first-page":"5881","DOI":"10.1113\/JP271470","article-title":"Age-dependent impact of CaV3.2 T-type calcium channel deletion on myogenic tone and flow-mediated vasodilatation in small arteries","volume":"594","author":"Mikkelsen","year":"2016","journal-title":"J. Physiol."},{"issue":"22","key":"10.1016\/j.mad.2020.111336_bib0215","doi-asserted-by":"crossref","first-page":"6027","DOI":"10.1093\/emboj\/cdg583","article-title":"Dominant role of smooth muscle L-type calcium channel Cav1.2 for blood pressure regulation","volume":"22","author":"Moosmang","year":"2003","journal-title":"EMBO J."},{"issue":"4 Pt 1","key":"10.1016\/j.mad.2020.111336_bib0220","doi-asserted-by":"crossref","first-page":"C799","DOI":"10.1152\/ajpcell.1995.268.4.C799","article-title":"Physiological roles and properties of potassium channels in arterial smooth muscle","volume":"268","author":"Nelson","year":"1995","journal-title":"Am. J. Physiol."},{"issue":"5236","key":"10.1016\/j.mad.2020.111336_bib0225","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1126\/science.270.5236.633","article-title":"Relaxation of arterial smooth muscle by calcium sparks","volume":"270","author":"Nelson","year":"1995","journal-title":"Science (New York, N.Y.)"},{"issue":"1","key":"10.1016\/j.mad.2020.111336_bib0230","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.yjmcc.2009.08.021","article-title":"Cardiac T-type Ca2+ channels in the heart","volume":"48","author":"Ono","year":"2010","journal-title":"J. Mol. Cell. Cardiol."},{"issue":"6","key":"10.1016\/j.mad.2020.111336_bib0235","first-page":"624","article-title":"The laboratory rat : relating its age with human\u2019s","volume":"4","author":"Pallav Sengupta","year":"2013","journal-title":"Int. J. Prev. Med."},{"issue":"6670","key":"10.1016\/j.mad.2020.111336_bib0240","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1038\/36110","article-title":"Molecular characterization of a neuronal low-voltage-activated T-type calcium channel","volume":"391","author":"Perez-Reyes","year":"1998","journal-title":"Nature"},{"issue":"497","key":"10.1016\/j.mad.2020.111336_bib0245","doi-asserted-by":"crossref","DOI":"10.1126\/scisignal.aan2694","article-title":"Microtubule structures underlying the sarcoplasmic reticulum support peripheral coupling sites to regulate smooth muscle contractility","volume":"10","author":"Pritchard","year":"2017","journal-title":"Sci. Signal."},{"issue":"43","key":"10.1016\/j.mad.2020.111336_bib0250","doi-asserted-by":"crossref","first-page":"21874","DOI":"10.1073\/pnas.1911304116","article-title":"Nanoscale coupling of junctophilin-2 and ryanodine receptors regulates vascular smooth muscle cell contractility","volume":"116","author":"Pritchard","year":"2019","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.mad.2020.111336_bib0255","doi-asserted-by":"crossref","DOI":"10.1016\/j.nut.2005.04.002","article-title":"Comparing rat\u2019s to human\u2019s age: How old is my rat in people years?","author":"Quinn","year":"2005","journal-title":"Nutrition"},{"issue":"5","key":"10.1016\/j.mad.2020.111336_bib0260","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.1016\/j.neurobiolaging.2013.10.090","article-title":"Age-related downregulation of the CaV3.1 T-type calcium channel as a mediator of amyloid beta production","volume":"35","author":"Rice","year":"2014","journal-title":"Neurobiol. Aging"},{"issue":"6","key":"10.1016\/j.mad.2020.111336_bib0265","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1161\/01.RES.76.6.1057","article-title":"Dilatation of cerebral arterioles in response to activation of adenylate cyclase is dependent on activation of Ca2+-Dependent K+ channels","volume":"76","author":"Taguchi","year":"1995","journal-title":"Circ. Res."},{"issue":"6","key":"10.1016\/j.mad.2020.111336_bib0270","doi-asserted-by":"crossref","first-page":"H2285","DOI":"10.1152\/ajpheart.00488.2011","article-title":"Relationship between Ca2+ sparklets and sarcoplasmic reticulum Ca2+ load and release in rat cerebral arterial smooth muscle","volume":"301","author":"Takeda","year":"2011","journal-title":"Am. J. Physiol.-Heart Circ. Physiol."},{"issue":"4","key":"10.1016\/j.mad.2020.111336_bib0275","doi-asserted-by":"crossref","DOI":"10.1152\/ajprenal.00016.2014","article-title":"Differential effect of T-type voltage-gated Ca2+ channel disruption on renal plasma flow and glomerular filtration rate in vivo","volume":"307","author":"Thuesen","year":"2014","journal-title":"Am. J. Physiol. - Renal Physiol."},{"issue":"11","key":"10.1016\/j.mad.2020.111336_bib0280","doi-asserted-by":"crossref","first-page":"1732","DOI":"10.1038\/jcbfm.2013.143","article-title":"Age-related autoregulatory dysfunction and cerebromicrovascular injury in mice with angiotensin II-induced hypertension","volume":"33","author":"Toth","year":"2013","journal-title":"J. Cereb. Blood Flow Metab."},{"issue":"7693","key":"10.1016\/j.mad.2020.111336_bib0285","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1038\/nature25739","article-title":"A molecular atlas of cell types and zonation in the brain vasculature","volume":"554","author":"Vanlandewijck","year":"2018","journal-title":"Nature"},{"issue":"2","key":"10.1016\/j.mad.2020.111336_bib0290","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.ceca.2006.04.025","article-title":"Role of T-type Ca2+ channels in the heart","volume":"40","author":"Vassort","year":"2006","journal-title":"Cell Calcium"}],"container-title":["Mechanisms of Ageing and Development"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0047637420301329?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0047637420301329?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T17:45:37Z","timestamp":1758649537000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0047637420301329"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10]]},"references-count":58,"alternative-id":["S0047637420301329"],"URL":"https:\/\/doi.org\/10.1016\/j.mad.2020.111336","relation":{},"ISSN":["0047-6374"],"issn-type":[{"value":"0047-6374","type":"print"}],"subject":[],"published":{"date-parts":[[2020,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Aging, calcium channel signaling and vascular tone","name":"articletitle","label":"Article Title"},{"value":"Mechanisms of Ageing and Development","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mad.2020.111336","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"111336"}}