{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T18:33:39Z","timestamp":1787682819958,"version":"build-2784847793"},"reference-count":87,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Mechanisms of Ageing and Development"],"published-print":{"date-parts":[[2022,1]]},"DOI":"10.1016\/j.mad.2021.111597","type":"journal-article","created":{"date-parts":[[2021,11,12]],"date-time":"2021-11-12T10:46:41Z","timestamp":1636714001000},"page":"111597","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":16,"special_numbering":"C","title":["Metformin treatment of juvenile mice alters aging-related developmental and metabolic phenotypes"],"prefix":"10.1016","volume":"201","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8330-4960","authenticated-orcid":false,"given":"Yun","family":"Zhu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yimin","family":"Fang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4093-6703","authenticated-orcid":false,"given":"David","family":"Medina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2569-557X","authenticated-orcid":false,"given":"Andrzej","family":"Bartke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9996-7331","authenticated-orcid":false,"given":"Rong","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"5","key":"10.1016\/j.mad.2021.111597_bib0005","doi-asserted-by":"crossref","DOI":"10.3390\/ijms19051308","article-title":"Insulin-like growth factor (IGF) system in liver diseases","volume":"19","author":"Adamek","year":"2018","journal-title":"Int. J. Mol. Sci."},{"issue":"3","key":"10.1016\/j.mad.2021.111597_bib0010","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.critrevonc.2013.01.005","article-title":"The key role of growth hormone-insulin-IGF-1 signaling in aging and cancer","volume":"87","author":"Anisimov","year":"2013","journal-title":"Crit. Rev. Oncol. Hematol."},{"issue":"1","key":"10.1016\/j.mad.2021.111597_bib0015","doi-asserted-by":"crossref","first-page":"46","DOI":"10.4161\/15384101.2014.973308","article-title":"Sex differences in aging, life span and spontaneous tumorigenesis in 129\/Sv mice neonatally exposed to metformin","volume":"14","author":"Anisimov","year":"2015","journal-title":"Cell Cycle"},{"issue":"2","key":"10.1016\/j.mad.2021.111597_bib0020","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1007\/s11357-017-9971-0","article-title":"IGF-1 has sexually dimorphic, pleiotropic, and time-dependent effects on healthspan, pathology, and lifespan","volume":"39","author":"Ashpole","year":"2017","journal-title":"Geroscience"},{"issue":"1","key":"10.1016\/j.mad.2021.111597_bib0025","doi-asserted-by":"crossref","first-page":"19","DOI":"10.5534\/wjmh.180018","article-title":"Growth hormone and aging: updated review","volume":"37","author":"Bartke","year":"2019","journal-title":"World J. Mens Health"},{"issue":"1","key":"10.1016\/j.mad.2021.111597_bib0030","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1023\/A:1022448532248","article-title":"Insulin-like growth factor 1 (IGF-1) and aging: controversies and new insights","volume":"4","author":"Bartke","year":"2003","journal-title":"Biogerontology"},{"issue":"12","key":"10.1016\/j.mad.2021.111597_bib0035","doi-asserted-by":"crossref","first-page":"4066","DOI":"10.18632\/aging.102037","article-title":"Anti-aging interventions affect lifespan variability in sex, strain, diet and drug dependent fashion","volume":"11","author":"Bartke","year":"2019","journal-title":"Aging (Albany NY)"},{"issue":"6","key":"10.1016\/j.mad.2021.111597_bib0040","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1016\/j.cmet.2016.05.011","article-title":"Metformin as a tool to target aging","volume":"23","author":"Barzilai","year":"2016","journal-title":"Cell Metab."},{"issue":"6","key":"10.1016\/j.mad.2021.111597_bib0045","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1016\/j.ghir.2008.05.005","article-title":"Role of the GH\/IGF-1 axis in lifespan and healthspan: lessons from animal models","volume":"18","author":"Berryman","year":"2008","journal-title":"Growth Horm. IGF Res."},{"issue":"11","key":"10.1016\/j.mad.2021.111597_bib0050","doi-asserted-by":"crossref","first-page":"e26891","DOI":"10.1371\/journal.pone.0026891","article-title":"Does reduced IGF-1R signaling in Igf1r+\/- mice alter aging?","volume":"6","author":"Bokov","year":"2011","journal-title":"PLoS One"},{"issue":"10","key":"10.1016\/j.mad.2021.111597_bib0055","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1093\/gerona\/glu073","article-title":"Type 2 diabetes and antidiabetic medications in relation to dementia diagnosis","volume":"69","author":"Cheng","year":"2014","journal-title":"J. Gerontol. A Biol. Sci. Med. Sci."},{"issue":"8","key":"10.1016\/j.mad.2021.111597_bib0060","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1172\/JCI7308","article-title":"CREB-independent regulation by CBP is a novel mechanism of human growth hormone gene expression","volume":"104","author":"Cohen","year":"1999","journal-title":"J. Clin. Invest."},{"issue":"7","key":"10.1016\/j.mad.2021.111597_bib0065","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1111\/j.1469-7610.2007.01742.x","article-title":"Developmental trajectories of depressive symptoms from early childhood to late adolescence: gender differences and adult outcome","volume":"48","author":"Dekker","year":"2007","journal-title":"J. Child Psychol. Psych."},{"issue":"1","key":"10.1016\/j.mad.2021.111597_bib0070","doi-asserted-by":"crossref","first-page":"51","DOI":"10.2337\/dc14-0886","article-title":"HbA1c as a predictor of diabetes and as an outcome in the diabetes prevention program: a randomized clinical trial","volume":"38","author":"Diabetes Prevention Program Research","year":"2015","journal-title":"Diabetes Care"},{"issue":"3","key":"10.1016\/j.mad.2021.111597_bib0075","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/0047-6374(78)90015-5","article-title":"Ageing, metabolic immunodepression and carcinogenesis","volume":"8","author":"Dilman","year":"1978","journal-title":"Mech. Ageing Dev."},{"issue":"1","key":"10.1016\/j.mad.2021.111597_bib0080","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1016\/j.mce.2013.09.028","article-title":"Nutritional signals and reproduction","volume":"382","author":"Dupont","year":"2014","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.mad.2021.111597_bib0085","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.mce.2017.09.030","article-title":"Effects of metformin on cell growth and AMPK activity in pituitary adenoma cell cultures, focusing on the interaction with adenylyl cyclase activating signals","volume":"470","author":"Faggi","year":"2018","journal-title":"Mol. Cell. Endocrinol."},{"issue":"10","key":"10.1016\/j.mad.2021.111597_bib0090","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1038\/s41574-019-0242-2","article-title":"Understanding the glucoregulatory mechanisms of metformin in type 2 diabetes mellitus","volume":"15","author":"Foretz","year":"2019","journal-title":"Nat. Rev. Endocrinol."},{"issue":"143","key":"10.1016\/j.mad.2021.111597_bib0095","doi-asserted-by":"crossref","DOI":"10.3791\/59074","article-title":"Probiotic studies in neonatal mice using gavage","author":"Francis","year":"2019","journal-title":"J. Vis. Exp."},{"issue":"9","key":"10.1016\/j.mad.2021.111597_bib0100","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1158\/1940-6207.CAPR-13-0424","article-title":"Metformin and cancer risk and mortality: a systematic review and meta-analysis taking into account biases and confounders","volume":"7","author":"Gandini","year":"2014","journal-title":"Cancer Prev. Res. Phila."},{"issue":"11","key":"10.1016\/j.mad.2021.111597_bib0105","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1203\/00006450-198611000-00024","article-title":"Fertility onset, spermatogenesis, and pubertal development in male rats: effect of graded underfeeding","volume":"20","author":"Glass","year":"1986","journal-title":"Pediatr. Res."},{"issue":"10","key":"10.1016\/j.mad.2021.111597_bib0110","doi-asserted-by":"crossref","first-page":"3989","DOI":"10.1210\/jc.2013-1452","article-title":"Lifestyle and metformin treatment favorably influence lipoprotein subfraction distribution in the Diabetes Prevention Program","volume":"98","author":"Goldberg","year":"2013","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"4","key":"10.1016\/j.mad.2021.111597_bib0115","first-page":"251","article-title":"Progesterone-induced secretion of growth hormone, insulin-like growth factor I and prolactin by human breast cancer explants","volume":"15","author":"Gregoraszczuk","year":"2001","journal-title":"Gynecol. Endocrinol."},{"issue":"5","key":"10.1016\/j.mad.2021.111597_bib0120","doi-asserted-by":"crossref","first-page":"1470","DOI":"10.1016\/j.fertnstert.2005.05.027","article-title":"Effect of metformin on the growth hormone response to growth hormone-releasing hormone in obese women with polycystic ovary syndrome","volume":"84","author":"Guido","year":"2005","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.mad.2021.111597_bib0125","doi-asserted-by":"crossref","first-page":"692","DOI":"10.3389\/fendo.2019.00692","article-title":"Role of mTOR signaling in female reproduction","volume":"10","author":"Guo","year":"2019","journal-title":"Front. Endocrinol. (Lausanne)"},{"issue":"4","key":"10.1016\/j.mad.2021.111597_bib0130","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1095\/biolreprod32.4.773","article-title":"Food restriction and reproductive development in wild house mice","volume":"32","author":"Hamilton","year":"1985","journal-title":"Biol. Reprod."},{"issue":"10","key":"10.1016\/j.mad.2021.111597_bib0135","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1038\/nrm2249","article-title":"AMP-activated\/SNF1 protein kinases: conserved guardians of cellular energy","volume":"8","author":"Hardie","year":"2007","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"49","key":"10.1016\/j.mad.2021.111597_bib0140","doi-asserted-by":"crossref","first-page":"20125","DOI":"10.1074\/jbc.M117.811547","article-title":"Loss of hepatic AMP-activated protein kinase impedes the rate of glycogenolysis but not gluconeogenic fluxes in exercising mice","volume":"292","author":"Hughey","year":"2017","journal-title":"J. Biol. Chem."},{"issue":"8","key":"10.1016\/j.mad.2021.111597_bib0145","doi-asserted-by":"crossref","first-page":"2888","DOI":"10.1210\/jc.2006-0336","article-title":"Metformin treatment to prevent early puberty in girls with precocious pubarche","volume":"91","author":"Ibanez","year":"2006","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"2","key":"10.1016\/j.mad.2021.111597_bib0150","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1016\/j.fertnstert.2010.08.052","article-title":"Early metformin therapy to delay menarche and augment height in girls with precocious pubarche","volume":"95","author":"Ibanez","year":"2011","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.mad.2021.111597_bib0155","article-title":"The gut microbiome, metformin, and aging","author":"Induri","year":"2021","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"10.1016\/j.mad.2021.111597_bib0160","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.arr.2017.05.008","article-title":"Calorie restriction in rodents: caveats to consider","volume":"39","author":"Ingram","year":"2017","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.mad.2021.111597_bib0165","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-017-10010-z","article-title":"Results from C-11-metformin-PET scans, tissue analysis and cellular drug-sensitivity assays questions the view that biguanides affects tumor respiration directly","volume":"7","author":"Iversen","year":"2017","journal-title":"Sci. Rep."},{"issue":"2","key":"10.1016\/j.mad.2021.111597_bib0170","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1002\/(SICI)1098-2795(199706)47:2<175::AID-MRD8>3.0.CO;2-J","article-title":"Stimulatory effect of growth hormone on in vitro maturation of bovine oocytes is exerted through cumulus cells and not mediated by IGF-I","volume":"47","author":"Izadyar","year":"1997","journal-title":"Mol. Reprod. Dev."},{"issue":"4","key":"10.1016\/j.mad.2021.111597_bib0175","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1002\/(SICI)1098-2795(199908)53:4<398::AID-MRD5>3.0.CO;2-I","article-title":"Messenger RNA expression and protein localization of growth hormone in bovine ovarian tissue and in cumulus oocyte complexes (COCs) during in vitro maturation","volume":"53","author":"Izadyar","year":"1999","journal-title":"Mol. Reprod. Dev."},{"issue":"7","key":"10.1016\/j.mad.2021.111597_bib0180","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1007\/s11892-016-0751-5","article-title":"Insulin resistance of puberty","volume":"16","author":"Kelsey","year":"2016","journal-title":"Curr. Diab. Rep."},{"issue":"2","key":"10.1016\/j.mad.2021.111597_bib0185","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/S0739-7240(97)00081-7","article-title":"Progestin-induced growth hormone (GH) production in the treatment of dogs with congenital GH deficiency","volume":"15","author":"Kooistra","year":"1998","journal-title":"Domest. Anim. Endocrinol."},{"issue":"10","key":"10.1016\/j.mad.2021.111597_bib0190","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1055\/a-0584-0006","article-title":"The effect of metformin on serum gonadotropin levels in postmenopausal women with diabetes and prediabetes: a pilot study","volume":"126","author":"Krysiak","year":"2018","journal-title":"Exp. Clin. Endocrinol. Diabetes"},{"issue":"1","key":"10.1016\/j.mad.2021.111597_bib0195","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.cmet.2020.04.001","article-title":"Benefits of metformin in attenuating the hallmarks of aging","volume":"32","author":"Kulkarni","year":"2020","journal-title":"Cell Metab."},{"issue":"4","key":"10.1016\/j.mad.2021.111597_bib0200","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.2337\/db06-0918","article-title":"Factors associated with diabetes onset during metformin versus placebo therapy in the diabetes prevention program","volume":"56","author":"Lachin","year":"2007","journal-title":"Diabetes"},{"issue":"1","key":"10.1016\/j.mad.2021.111597_bib0205","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1210\/endrev\/bnaa023","article-title":"Cellular and molecular mechanisms of metformin action","volume":"42","author":"LaMoia","year":"2021","journal-title":"Endocr. Rev."},{"issue":"Suppl 1","key":"10.1016\/j.mad.2021.111597_bib0210","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/jhn.12212","article-title":"Nutrition in early life and the programming of adult disease: a review","volume":"28","author":"Langley-Evans","year":"2015","journal-title":"J. Hum. Nutr. Diet."},{"issue":"1","key":"10.1016\/j.mad.2021.111597_bib0215","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1002\/j.1550-8528.1998.tb00314.x","article-title":"Metformin decreases food consumption and induces weight loss in subjects with obesity with type II non-insulin-dependent diabetes","volume":"6","author":"Lee","year":"1998","journal-title":"Obes. Res."},{"key":"10.1016\/j.mad.2021.111597_bib0220","doi-asserted-by":"crossref","first-page":"2629","DOI":"10.2147\/DDDT.S309851","article-title":"Immunoregulatory Effect of Acanthopanax trifoliatus (L.) Merr. Polysaccharide on T1DM Mice","volume":"15","author":"Li","year":"2021","journal-title":"Drug Des. Devel. Ther."},{"issue":"6","key":"10.1016\/j.mad.2021.111597_bib0225","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1038\/s41591-020-0901-9","article-title":"Single-cell landscape of bronchoalveolar immune cells in patients with COVID-19","volume":"26","author":"Liao","year":"2020","journal-title":"Nat. Med."},{"key":"10.1016\/j.mad.2021.111597_bib0230","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.brainres.2012.01.028","article-title":"The effect of metformin on food intake and its potential role in hypothalamic regulation in obese diabetic rats","volume":"1444","author":"Lv","year":"2012","journal-title":"Brain Res."},{"issue":"17","key":"10.1016\/j.mad.2021.111597_bib0235","doi-asserted-by":"crossref","first-page":"2532","DOI":"10.2174\/1381612822666161201152941","article-title":"Is metformin a perfect drug? Updates in pharmacokinetics and pharmacodynamics","volume":"23","author":"Markowicz-Piasecka","year":"2017","journal-title":"Curr. Pharm. Des."},{"key":"10.1016\/j.mad.2021.111597_bib0240","doi-asserted-by":"crossref","first-page":"2192","DOI":"10.1038\/ncomms3192","article-title":"Metformin improves healthspan and lifespan in mice","volume":"4","author":"Martin-Montalvo","year":"2013","journal-title":"Nat. Commun."},{"issue":"1\u20132","key":"10.1016\/j.mad.2021.111597_bib0245","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1159\/000184763","article-title":"Sex steroids, growth hormone, insulin-like growth factor-1: neuroendocrine and metabolic regulation in puberty","volume":"45","author":"Mauras","year":"1996","journal-title":"Horm. Res."},{"issue":"3","key":"10.1016\/j.mad.2021.111597_bib0250","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1017\/S0029665109001396","article-title":"Animal models for the study of the developmental origins of health and disease","volume":"68","author":"McMullen","year":"2009","journal-title":"Proc. Nutr. Soc."},{"issue":"2","key":"10.1016\/j.mad.2021.111597_bib0255","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1530\/jrf.0.0570253","article-title":"Onset of puberty and duration of fertility in rats fed a restricted diet","volume":"57","author":"Merry","year":"1979","journal-title":"J. Reprod. Fertil."},{"issue":"8","key":"10.1016\/j.mad.2021.111597_bib0260","doi-asserted-by":"crossref","first-page":"960","DOI":"10.1111\/j.1532-5415.1999.tb01291.x","article-title":"Lifelong treatment with oral DHEA sulfate does not preserve immune function, prevent disease, or improve survival in genetically heterogeneous mice","volume":"47","author":"Miller","year":"1999","journal-title":"J. Am. Geriatr. Soc."},{"issue":"1","key":"10.1016\/j.mad.2021.111597_bib0265","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1046\/j.1474-9728.2002.00006.x","article-title":"Big mice die young: early life body weight predicts longevity in genetically heterogeneous mice","volume":"1","author":"Miller","year":"2002","journal-title":"Aging Cell"},{"key":"10.1016\/j.mad.2021.111597_bib0270","doi-asserted-by":"crossref","first-page":"e32","DOI":"10.5114\/amsad.2019.84411","article-title":"The association of quantitative insulin sensitivity indices (HOMA-IR and QUICKI) with anthropometric and cardiometabolic indicators in adolescents","volume":"4","author":"Mirzaalian","year":"2019","journal-title":"Arch. Med. Sci. Atheroscler Dis."},{"issue":"1","key":"10.1016\/j.mad.2021.111597_bib0275","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1186\/s12862-016-0768-z","article-title":"The effect of dietary restriction on reproduction: a meta-analytic perspective","volume":"16","author":"Moatt","year":"2016","journal-title":"BMC Evol. Biol."},{"issue":"3","key":"10.1016\/j.mad.2021.111597_bib0280","first-page":"173","article-title":"Relationship between growth hormone concentrations in bovine oocytes and follicular fluid and oocyte developmental competence","volume":"51","author":"Modina","year":"2007","journal-title":"Eur. J. Histochem."},{"issue":"1497","key":"10.1016\/j.mad.2021.111597_bib0285","doi-asserted-by":"crossref","first-page":"1635","DOI":"10.1098\/rstb.2007.0011","article-title":"Early growth conditions, phenotypic development and environmental change","volume":"363","author":"Monaghan","year":"2008","journal-title":"Philos. Trans. R. Soc. Lond., B, Biol. Sci."},{"issue":"6","key":"10.1016\/j.mad.2021.111597_bib0290","doi-asserted-by":"crossref","first-page":"625","DOI":"10.24953\/turkjped.2017.06.002","article-title":"Associations between anthropometric characteristics and insulin markers in mothers and their neonates and with neonate\u2019s birth weight: an observational cohort study","volume":"59","author":"Naseh","year":"2017","journal-title":"Turk. J. Pediatr."},{"issue":"12","key":"10.1016\/j.mad.2021.111597_bib0295","first-page":"5073","article-title":"Early life growth hormone treatment shortens longevity and decreases cellular stress resistance in long-lived mutant mice","volume":"24","author":"Panici","year":"2010","journal-title":"FASEB J."},{"issue":"2","key":"10.1016\/j.mad.2021.111597_bib0300","first-page":"238","article-title":"Effect of glucose tolerance factor (GTF) on lipid profile, blood glucose levels, and food intake in streptozotocin-induced diabetes in rats","volume":"15","author":"Patil","year":"2020","journal-title":"Maedica (Bucur)"},{"key":"10.1016\/j.mad.2021.111597_bib0305","doi-asserted-by":"crossref","first-page":"726182","DOI":"10.3389\/fendo.2021.726182","article-title":"Age-influenced receptors of advanced glycation end product overexpression associated with osteogenic differentiation impairment in patients with type 2 diabetes","volume":"12","author":"Phimphilai","year":"2021","journal-title":"Front. Endocrinol. (Lausanne)"},{"issue":"7","key":"10.1016\/j.mad.2021.111597_bib0310","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1038\/sj.ijo.0800454","article-title":"Measurement and long-term health risks of child and adolescent fatness","volume":"21","author":"Power","year":"1997","journal-title":"Int. J. Obes. Relat. Metab. Disord."},{"issue":"4","key":"10.1016\/j.mad.2021.111597_bib0315","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.3892\/ijmm.2015.2108","article-title":"Dual effect of metformin on growth inhibition and oestradiol production in breast cancer cells","volume":"35","author":"Rice","year":"2015","journal-title":"Int. J. Mol. Med."},{"issue":"2","key":"10.1016\/j.mad.2021.111597_bib0320","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1002\/fsn3.2090","article-title":"The hepatoprotective effects of fennel seeds extract and trans-Anethole in streptozotocin-induced liver injury in rats","volume":"9","author":"Samadi-Noshahr","year":"2021","journal-title":"Food Sci. Nutr."},{"issue":"1","key":"10.1016\/j.mad.2021.111597_bib0325","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1097\/GME.0000000000000710","article-title":"Ages at menarche and menopause and reproductive lifespan as predictors of exceptional longevity in women: the Women\u2019s Health Initiative","volume":"24","author":"Shadyab","year":"2017","journal-title":"Menopause"},{"issue":"4","key":"10.1016\/j.mad.2021.111597_bib0330","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1111\/acel.12342","article-title":"Longevity and skeletal muscle mass: the role of IGF signalling, the sirtuins, dietary restriction and protein intake","volume":"14","author":"Sharples","year":"2015","journal-title":"Aging Cell"},{"issue":"1","key":"10.1016\/j.mad.2021.111597_bib0335","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1111\/j.1748-1716.2009.01972.x","article-title":"LKB1 and AMP-activated protein kinase control of mTOR signalling and growth","volume":"196","author":"Shaw","year":"2009","journal-title":"Acta. Physiol. (Oxf)"},{"issue":"5","key":"10.1016\/j.mad.2021.111597_bib0340","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1093\/gerona\/glaa215","article-title":"17alpha-estradiol modulates IGF1 and hepatic gene expression in a sex-specific manner","volume":"76","author":"Sidhom","year":"2021","journal-title":"J. Gerontol. A Biol. Sci. Med. Sci."},{"key":"10.1016\/j.mad.2021.111597_bib0345","first-page":"6","article-title":"Longevity is impacted by growth hormone action during early postnatal period","author":"Sun","year":"2017","journal-title":"Elife"},{"issue":"8","key":"10.1016\/j.mad.2021.111597_bib0350","doi-asserted-by":"crossref","first-page":"e1002848","DOI":"10.1371\/journal.pmed.1002848","article-title":"Neonatal, infant, and childhood growth following metformin versus insulin treatment for gestational diabetes: a systematic review and meta-analysis","volume":"16","author":"Tarry-Adkins","year":"2019","journal-title":"PLoS Med."},{"issue":"1","key":"10.1016\/j.mad.2021.111597_bib0355","doi-asserted-by":"crossref","first-page":"1","DOI":"10.2478\/enr-2021-0001","article-title":"Temporal characterization of the insulin resistance during puberty in mice","volume":"55","author":"Teixeira","year":"2021","journal-title":"Endocr. Regul."},{"issue":"10","key":"10.1016\/j.mad.2021.111597_bib0360","doi-asserted-by":"crossref","first-page":"2131","DOI":"10.1016\/j.biochi.2012.01.017","article-title":"Insulin-sensitizing properties of adiponectin","volume":"94","author":"Tishinsky","year":"2012","journal-title":"Biochimie"},{"issue":"2","key":"10.1016\/j.mad.2021.111597_bib0365","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1095\/biolreprod.110.087023","article-title":"Metformin decreases GnRH- and activin-induced gonadotropin secretion in rat pituitary cells: potential involvement of adenosine 5\u2019 monophosphate-activated protein kinase (PRKA)","volume":"84","author":"Tosca","year":"2011","journal-title":"Biol. Reprod."},{"issue":"2","key":"10.1016\/j.mad.2021.111597_bib0370","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1007\/s42000-019-00093-w","article-title":"Metformin and gut microbiota: their interactions and their impact on diabetes","volume":"18","author":"Vallianou","year":"2019","journal-title":"Hormones Athens (Athens)"},{"issue":"12","key":"10.1016\/j.mad.2021.111597_bib0375","doi-asserted-by":"crossref","first-page":"1244","DOI":"10.1093\/gerona\/59.12.1244","article-title":"Hormone-treated snell dwarf mice regain fertility but remain long lived and disease resistant","volume":"59","author":"Vergara","year":"2004","journal-title":"J. Gerontol. A Biol. Sci. Med. Sci."},{"key":"10.1016\/j.mad.2021.111597_bib0380","doi-asserted-by":"crossref","first-page":"27","DOI":"10.3389\/fendo.2019.00027","article-title":"ROLE of IGF-1 system in the modulation of longevity: controversies and new insights from a centenarians\u2019 perspective","volume":"10","author":"Vitale","year":"2019","journal-title":"Front. Endocrinol. (Lausanne)"},{"key":"10.1016\/j.mad.2021.111597_bib0385","doi-asserted-by":"crossref","first-page":"290","DOI":"10.3389\/fnbeh.2018.00290","article-title":"Metformin administration during early postnatal life rescues autistic-like behaviors in the BTBR t+ Itpr3tf\/J mouse model of autism","volume":"12","author":"Wang","year":"2018","journal-title":"Front. Behav. Neurosci."},{"issue":"7","key":"10.1016\/j.mad.2021.111597_bib0390","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1093\/gerona\/glx257","article-title":"Deletion of Nrip1 extends female mice longevity, increases autophagy, and delays cell senescence","volume":"73","author":"Wang","year":"2018","journal-title":"J. Gerontol. A Biol. Sci. Med. Sci."},{"key":"10.1016\/j.mad.2021.111597_bib0395","doi-asserted-by":"crossref","DOI":"10.1093\/gerona\/glx257","article-title":"Deletion of Nrip1 extends female mice longevity, increases autophagy, and delays cell senescence","author":"Wang","year":"2018","journal-title":"J. Gerontol. A Biol. Sci. Med. Sci."},{"issue":"4","key":"10.1016\/j.mad.2021.111597_bib0400","doi-asserted-by":"crossref","first-page":"850","DOI":"10.2337\/dc11-1365","article-title":"Pubertal timing and growth influences cardiometabolic risk factors in adult males and females","volume":"35","author":"Widen","year":"2012","journal-title":"Diabetes Care"},{"key":"10.1016\/j.mad.2021.111597_bib0405","doi-asserted-by":"crossref","first-page":"14","DOI":"10.3389\/fncel.2017.00014","article-title":"Insulin-like growth factor 1: At the crossroads of brain development and aging","volume":"11","author":"Wrigley","year":"2017","journal-title":"Front. Cell. Neurosci."},{"issue":"2","key":"10.1016\/j.mad.2021.111597_bib0410","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1093\/toxsci\/70.2.238","article-title":"Effects of dietary restriction on growth, neurobehavior, and reproduction in developing Kunmin mice","volume":"70","author":"Wu","year":"2002","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.mad.2021.111597_bib0415","doi-asserted-by":"crossref","first-page":"104588","DOI":"10.1016\/j.phrs.2019.104588","article-title":"The influence of metformin on IGF-1 levels in humans: a systematic review and meta-analysis","volume":"151","author":"Yang","year":"2020","journal-title":"Pharmacol. Res."},{"issue":"3","key":"10.1016\/j.mad.2021.111597_bib0420","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1111\/j.1474-9726.2009.00478.x","article-title":"Aging in inbred strains of mice: study design and interim report on median lifespans and circulating IGF1 levels","volume":"8","author":"Yuan","year":"2009","journal-title":"Aging Cell"},{"issue":"21","key":"10.1016\/j.mad.2021.111597_bib0425","doi-asserted-by":"crossref","first-page":"8224","DOI":"10.1073\/pnas.1121113109","article-title":"Genetic coregulation of age of female sexual maturation and lifespan through circulating IGF1 among inbred mouse strains","volume":"109","author":"Yuan","year":"2012","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"11","key":"10.1016\/j.mad.2021.111597_bib0430","doi-asserted-by":"crossref","first-page":"e13263","DOI":"10.1111\/acel.13263","article-title":"Genetic differences and longevity-related phenotypes influence lifespan and lifespan variation in a sex-specific manner in mice","volume":"19","author":"Yuan","year":"2020","journal-title":"Aging Cell"},{"issue":"1","key":"10.1016\/j.mad.2021.111597_bib0435","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.aogh.2016.01.008","article-title":"Effects of environmental exposures on fetal and childhood growth trajectories","volume":"82","author":"Zheng","year":"2016","journal-title":"Ann. Glob. Health"}],"container-title":["Mechanisms of Ageing and Development"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S004763742100169X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S004763742100169X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T17:46:05Z","timestamp":1758649565000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S004763742100169X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1]]},"references-count":87,"alternative-id":["S004763742100169X"],"URL":"https:\/\/doi.org\/10.1016\/j.mad.2021.111597","relation":{},"ISSN":["0047-6374"],"issn-type":[{"value":"0047-6374","type":"print"}],"subject":[],"published":{"date-parts":[[2022,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Metformin treatment of juvenile mice alters aging-related developmental and metabolic phenotypes","name":"articletitle","label":"Article Title"},{"value":"Mechanisms of Ageing and Development","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mad.2021.111597","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"111597"}}