{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T14:22:25Z","timestamp":1793024545839,"version":"4.5.0"},"reference-count":219,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Mechanisms of Ageing and Development"],"published-print":{"date-parts":[[2022,6]]},"DOI":"10.1016\/j.mad.2022.111675","type":"journal-article","created":{"date-parts":[[2022,4,14]],"date-time":"2022-04-14T10:56:20Z","timestamp":1649933780000},"page":"111675","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":72,"special_numbering":"C","title":["Cellular senescence in the aging brain: A promising target for neurodegenerative diseases"],"prefix":"10.1016","volume":"204","author":[{"given":"Manas Ranjan","family":"Sahu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linchi","family":"Rani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rhea","family":"Subba","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amal Chandra","family":"Mondal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.mad.2022.111675_bib1","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1016\/j.cell.2008.03.038","article-title":"Chemokine signaling via the CXCR2 receptor reinforces senescence","volume":"133","author":"Acosta","year":"2008","journal-title":"Cell"},{"key":"10.1016\/j.mad.2022.111675_bib2","doi-asserted-by":"crossref","first-page":"978","DOI":"10.1038\/ncb2784","article-title":"A complex secretory program orchestrated by the inflammasome controls paracrine senescence","volume":"15","author":"Acosta","year":"2013","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.mad.2022.111675_bib3","first-page":"129","volume":"202","author":"Adams","year":"2013","journal-title":"Lysosome-mediated processing of chromatin in senescence. J. Cell Biol."},{"key":"10.1016\/j.mad.2022.111675_bib4","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1038\/nature12530","article-title":"Usp16 contributes to somatic stem-cell defects in Down\u2019s syndrome","volume":"501","author":"Adorno","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.mad.2022.111675_bib5","doi-asserted-by":"crossref","first-page":"3033","DOI":"10.1038\/onc.2009.159","article-title":"GATA4 is a regulator of astrocyte cell proliferation and apoptosis in the human and murine central nervous system","volume":"28","author":"Agnihotri","year":"2009","journal-title":"Oncogene"},{"key":"10.1016\/j.mad.2022.111675_bib6","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1002\/em.22206","article-title":"Loss of DNA polymerase \u03b2 induces cellular senescence","volume":"59","author":"Ahmed","year":"2018","journal-title":"Environ. Mol. Mutagen."},{"key":"10.1016\/j.mad.2022.111675_bib7","doi-asserted-by":"crossref","first-page":"3397","DOI":"10.18632\/aging.101655","article-title":"Cell cycle-dependent and -independent telomere shortening accompanies murine brain aging","volume":"10","author":"Ain","year":"2018","journal-title":"Aging (Albany NY)"},{"key":"10.1016\/j.mad.2022.111675_bib8","doi-asserted-by":"crossref","first-page":"1050","DOI":"10.3390\/cancers12041050","article-title":"DNA damage\/repair management in cancers","volume":"12","author":"Alhmoud","year":"2020","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.mad.2022.111675_bib9","doi-asserted-by":"crossref","first-page":"1086","DOI":"10.3109\/14767058.2013.768982","article-title":"Senescence in amniocytes and placentas from trisomy 21 pregnancies","volume":"26","author":"Amiel","year":"2013","journal-title":"J. Matern. Neonatal Med."},{"key":"10.1016\/j.mad.2022.111675_bib10","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1038\/s41586-020-2403-9","article-title":"Senolytic CAR T cells reverse senescence-associated pathologies","volume":"583","author":"Amor","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.mad.2022.111675_bib11","doi-asserted-by":"crossref","first-page":"1","DOI":"10.15252\/embj.2018100492","article-title":"Length\u2010independent telomere damage drives post\u2010mitotic cardiomyocyte senescence","volume":"38","author":"Anderson","year":"2019","journal-title":"EMBO J."},{"key":"10.1016\/j.mad.2022.111675_bib12","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.cell.2017.02.031","article-title":"Targeted apoptosis of senescent cells restores tissue homeostasis in response to chemotoxicity article targeted apoptosis of senescent cells restores tissue homeostasis in response to chemotoxicity and aging","volume":"169","author":"Baar","year":"2017","journal-title":"Cell"},{"key":"10.1016\/j.mad.2022.111675_bib13","doi-asserted-by":"crossref","first-page":"1208","DOI":"10.1172\/JCI95145","article-title":"Cellular senescence in brain aging and neurodegenerative diseases: evidence and perspectives","volume":"128","author":"Baker","year":"2018","journal-title":"J Clin Invest ."},{"key":"10.1016\/j.mad.2022.111675_bib14","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1038\/ncb1744","article-title":"Opposing roles for p16Ink4a and p19Arf in senescence and ageing caused by BubR1 insufficiency","volume":"10","author":"Baker","year":"2008","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.mad.2022.111675_bib15","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1038\/nature10600","article-title":"Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders","volume":"479","author":"Baker","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.mad.2022.111675_bib16","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1038\/nature16932","article-title":"Naturally occurring p16 Ink4a-positive cells shorten healthy lifespan","volume":"530","author":"Baker","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.mad.2022.111675_bib17","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1212\/WNL.0b013e3182a2ce0e","article-title":"T-cell homeostasis in pediatric multiple sclerosis: Old cells in young patients","volume":"81","author":"Balint","year":"2013","journal-title":"Neurology"},{"key":"10.1016\/j.mad.2022.111675_bib18","doi-asserted-by":"crossref","first-page":"144","DOI":"10.4062\/biomolther.2020.175","article-title":"Late passage cultivation induces aged astrocyte phenotypes in rat primary cultured cells","volume":"29","author":"Bang","year":"2021","journal-title":"Biomol. Ther."},{"key":"10.1016\/j.mad.2022.111675_bib19","doi-asserted-by":"crossref","first-page":"13761","DOI":"10.1074\/jbc.M111123200","article-title":"H2O2 induces a transient multi-phase cell cycle arrest in mouse fibroblasts through modulating cyclin D and p21Cip1 expression","volume":"277","author":"Barnouin","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.mad.2022.111675_bib20","doi-asserted-by":"crossref","first-page":"1407","DOI":"10.1089\/ars.2011.4124","article-title":"Lack of p53 decreases basal oxidative stress levels in the brain through upregulation of thioredoxin-1, biliverdin reductase-A, manganese superoxide dismutase, and nuclear factor kappa-B","volume":"16","author":"Barone","year":"2012","journal-title":"Antioxid. Redox Signal"},{"key":"10.1016\/j.mad.2022.111675_bib21","doi-asserted-by":"crossref","first-page":"2969","DOI":"10.1007\/s12035-016-9880-8","article-title":"Hippocampal astrocyte cultures from adult and aged rats reproduce changes in glial functionality observed in the aging brain","volume":"54","author":"Bellaver","year":"2017","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.mad.2022.111675_bib22","doi-asserted-by":"crossref","first-page":"931","DOI":"10.18632\/aging.100702","volume":"6","author":"Bernal","year":"2014","journal-title":"Aging-V6I11-100702"},{"key":"10.1016\/j.mad.2022.111675_bib23","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.neubiorev.2017.04.030","article-title":"The effects of aging in the hippocampus and cognitive decline","volume":"79","author":"Bettio","year":"2017","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.mad.2022.111675_bib24","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1093\/gerona\/glu231","article-title":"Long-term neuroglial cocultures as a brain aging model: Hallmarks of senescence, microRNA expression profiles, and comparison with in vivo models","volume":"71","author":"Bigagli","year":"2016","journal-title":"J. Gerontol. - Ser. A Biol. Sci. Med. Sci."},{"key":"10.1016\/j.mad.2022.111675_bib25","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/j.gene.2015.02.075","article-title":"Amniocytes from aneuploidy embryos have enhanced random aneuploidy and signs of senescence - can these findings be related to medical problems?","volume":"562","author":"Biron-Shental","year":"2015","journal-title":"Gene"},{"key":"10.1016\/j.mad.2022.111675_bib26","doi-asserted-by":"crossref","first-page":"2961","DOI":"10.1016\/j.yexcr.2010.06.021","article-title":"Stress-induced senescence in human and rodent astrocytes","volume":"316","author":"Bitto","year":"2010","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.mad.2022.111675_bib27","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1126\/science.279.5349.349","article-title":"Extension of life-span by introduction of telomerase into normal human cells","volume":"279","author":"Bodnar","year":"1998","journal-title":"Sci. (80-. )"},{"key":"10.1016\/j.mad.2022.111675_bib28","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/srep15326","article-title":"The asymmetry of telomere replication contributes to replicative senescence heterogeneity","volume":"5","author":"Bourgeron","year":"2015","journal-title":"Sci. Rep."},{"key":"10.1016\/j.mad.2022.111675_bib29","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.jaut.2011.11.006","article-title":"CX3CR1 drives cytotoxic CD4+CD28- T cells into the brain of multiple sclerosis patients","volume":"38","author":"Broux","year":"2012","journal-title":"J. Autoimmun."},{"key":"10.1016\/j.mad.2022.111675_bib30","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1111\/j.1365-2990.2010.01139.x","article-title":"Review: Cerebral microvascular pathology in ageing and neurodegeneration","volume":"37","author":"Brown","year":"2011","journal-title":"Neuropathol. Appl. Neurobiol."},{"key":"10.1016\/j.mad.2022.111675_bib31","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1016\/S0891-5849(02)00959-0","article-title":"Lipofuscin: Mechanisms of age-related accumulation and influence on cell function","volume":"33","author":"Brunk","year":"2002","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.mad.2022.111675_bib32","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1038\/ng894","article-title":"Amplification of PPM1D in human tumors abrogates p53 tumor-suppressor activity","volume":"31","author":"Bulavin","year":"2002","journal-title":"Nat. Genet."},{"key":"10.1016\/j.mad.2022.111675_bib33","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1016\/j.cell.2012.12.010","article-title":"Monitoring tumorigenesis and senescence in vivo with a p16 INK4a-luciferase model","volume":"152","author":"Burd","year":"2013","journal-title":"Cell"},{"key":"10.1016\/j.mad.2022.111675_bib34","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1038\/s41586-018-0543-y","article-title":"Clearance of senescent glial cells prevents tau-dependent pathology and cognitive decline","volume":"562","author":"Bussian","year":"2018","journal-title":"Nature"},{"key":"10.1016\/j.mad.2022.111675_bib35","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.freeradbiomed.2017.10.379","article-title":"Aging and Parkinson\u2019s disease: inflammaging, neuroinflammation and biological remodeling as key factors in pathogenesis","volume":"115","author":"Calabrese","year":"2018","journal-title":"Free Radic. Biol. Med."},{"issue":"4","key":"10.1016\/j.mad.2022.111675_bib36","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pone.0215277","article-title":"Necrosis, apoptosis, necroptosis, three modes of action of dopaminergic neuron neurotoxins","volume":"14","author":"Callizot","year":"2019","journal-title":"PLoS One."},{"key":"10.1016\/j.mad.2022.111675_bib37","doi-asserted-by":"crossref","first-page":"39457","DOI":"10.18632\/oncotarget.6277","article-title":"Changes in autophagy, proteasome activity and metabolism to determine a specific signature for acute and chronic senescent mesenchymal stromal cells","volume":"6","author":"Capasso","year":"2015","journal-title":"Oncotarget"},{"key":"10.1016\/j.mad.2022.111675_bib38","doi-asserted-by":"crossref","first-page":"922","DOI":"10.1126\/science.1069398","article-title":"Genomic instability in mice lacking histone H2AX","volume":"296","author":"Celeste","year":"2002","journal-title":"Sci. (80-. )"},{"key":"10.1016\/j.mad.2022.111675_bib39","first-page":"1","article-title":"Clearance of senescent cells by ABT263 rejuvenates aged hematopoietic stem cells in mice","author":"Chang","year":"2015","journal-title":"Nat. Med"},{"key":"10.1016\/j.mad.2022.111675_bib40","doi-asserted-by":"crossref","first-page":"1729","DOI":"10.1089\/ars.2010.3610","article-title":"P53 pro-oxidant activity in the central nervous system: Implication in aging and neurodegenerative diseases","volume":"15","author":"Chatoo","year":"2011","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.mad.2022.111675_bib41","doi-asserted-by":"crossref","first-page":"2125","DOI":"10.1101\/gad.17276711","article-title":"Control of the senescence-associated secretory phenotype by NF-\u03baB promotes senescence and enhances chemosensitivity","author":"Chien","year":"2011","journal-title":"Genes Dev."},{"key":"10.1016\/j.mad.2022.111675_bib42","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1016\/j.celrep.2017.12.092","article-title":"Cellular senescence is induced by the environmental neurotoxin paraquat and contributes to neuropathology linked to Parkinson\u2019s disease","volume":"22","author":"Chinta","year":"2018","journal-title":"Cell Rep."},{"key":"10.1016\/j.mad.2022.111675_bib43","doi-asserted-by":"crossref","first-page":"14168","DOI":"10.1074\/jbc.M111.222430","article-title":"Role of matrix metalloproteinase 3-mediated alpha-synuclein cleavage in dopaminergic cell death","volume":"286","author":"Choi","year":"2011","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.mad.2022.111675_bib44","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/acel.12937","article-title":"Astrocyte senescence: evidence and significance","volume":"18","author":"Cohen","year":"2019","journal-title":"Aging Cell"},{"key":"10.1016\/j.mad.2022.111675_bib45","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1111\/j.1750-3639.2008.00168.x","article-title":"Cell cycle elongation impairs proliferation of cerebellar granule cell precursors in the Ts65Dn mouse, an animal model for down syndrome","volume":"19","author":"Contestabile","year":"2009","journal-title":"Brain Pathol."},{"key":"10.1016\/j.mad.2022.111675_bib46","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1146\/annurev-pathol-121808-102144","article-title":"The senescence-associated secretory phenotype: the dark side of tumor suppression","volume":"5","author":"Copp\u00e9","year":"2010","journal-title":"Annu. Rev. Pathol. Mech. Dis."},{"key":"10.1016\/j.mad.2022.111675_bib47","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1016\/B978-0-12-394447-4.30066-9","article-title":"Cellular senescence","volume":"3","author":"Da Silva-\u00e1lvarez","year":"2016","journal-title":"Encycl. Cell Biol."},{"key":"10.1016\/j.mad.2022.111675_bib48","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1021\/acschemneuro.6b00078","article-title":"Human neural stem cell aging is counteracted by \u03b1-Glycerylphosphorylethanolamine","volume":"7","author":"Daniele","year":"2016","journal-title":"ACS Chem. Neurosci."},{"issue":"23","key":"10.1016\/j.mad.2022.111675_bib49","doi-asserted-by":"crossref","first-page":"6819","DOI":"10.1021\/jm060727j","volume":"49","author":"Das","year":"2006","journal-title":"J Med Chem."},{"key":"10.1016\/j.mad.2022.111675_bib50","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1196\/annals.1395.051","article-title":"The role of cellular senescence in Werner syndrome: toward therapeutic intervention in human premature aging","volume":"1100","author":"Davis","year":"2007","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.mad.2022.111675_bib51","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1093\/hmg\/5.2.283","article-title":"Elevation in the ratio of Cu\/Zn-superoxide dismutase to glutathione peroxidase activity induces features of cellular senescence and this effect is mediated by hydrogen peroxide","volume":"5","author":"De Haan","year":"1996","journal-title":"Hum. Mol. Genet."},{"issue":"12","key":"10.1016\/j.mad.2022.111675_bib52","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pone.0113387","article-title":"Long leukocyte telomere length at diagnosis is a risk factor for dementia progression in idiopathic parkinsonism","volume":"9","author":"Degerman","year":"2014","journal-title":"PLoS One."},{"key":"10.1016\/j.mad.2022.111675_bib53","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1038\/s43587-021-00142-3","article-title":"Profiling senescent cells in human brains reveals neurons with CDKN2D\/p19 and tau neuropathology","volume":"1","author":"Dehkordi","year":"2021","journal-title":"Nat. Aging"},{"issue":"1","key":"10.1016\/j.mad.2022.111675_bib54","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1172\/JCI28281","article-title":"Chronic lymphocytic leukemia requires BCL2 to sequester prodeath BIM, explaining sensitivity to BCL2 antagonist ABT-737","volume":"117","author":"Del Gaizo Moore","year":"2007","journal-title":"J Clin Invest."},{"key":"10.1016\/j.mad.2022.111675_bib55","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.ijdevneu.2008.10.002","article-title":"Time-course of blood-brain barrier disruption in senescence-accelerated mouse prone 8 (SAMP8) mice","volume":"27","author":"del Valle","year":"2009","journal-title":"Int. J. Dev. Neurosci."},{"issue":"5","key":"10.1016\/j.mad.2022.111675_bib56","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1016\/j.ccr.2006.08.027","article-title":"The BH3 mimetic ABT-737 targets selective Bcl-2 proteins and efficiently induces apoptosis via Bak\/Bax if Mcl-1 is neutralized","volume":"10","author":"Delft","year":"2006","journal-title":"Cancer Cell ."},{"key":"10.1016\/j.mad.2022.111675_bib57","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1016\/j.devcel.2014.11.012","article-title":"An essential role for senescent cells in optimal wound healing through secretion of PDGF-AA","volume":"31","author":"Demaria","year":"2014","journal-title":"Dev. Cell"},{"key":"10.1016\/j.mad.2022.111675_bib58","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1002\/mds.25495","article-title":"Changes in endolysosomal enzyme activities in cerebrospinal fluid of patients with Parkinson\u2019s disease","volume":"28","author":"Dijk","year":"2013","journal-title":"Mov Disord."},{"key":"10.1016\/j.mad.2022.111675_bib59","doi-asserted-by":"crossref","first-page":"9363","DOI":"10.1073\/pnas.92.20.9363","article-title":"A biomarker that identifies senescent human cells in culture and in aging skin in vivo","volume":"92","author":"Dimri","year":"1995","journal-title":"Proc. Natl. Acad. Sci. U. S. A"},{"key":"10.1016\/j.mad.2022.111675_bib60","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/acel.13079","article-title":"Amelioration of age-related brain function decline by Bruton\u2019s tyrosine kinase inhibition","volume":"19","author":"Ekpenyong-Akiba","year":"2020","journal-title":"Aging Cell"},{"key":"10.1016\/j.mad.2022.111675_bib61","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1152\/japplphysiol.91353.2008","article-title":"Vascular endothelial senescence: From mechanisms to pathophysiology","volume":"106","author":"Erusalimsky","year":"2009","journal-title":"J. Appl. Physiol."},{"issue":"5","key":"10.1016\/j.mad.2022.111675_bib62","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1007\/s00702-010-0482-8","article-title":"Neuropathology of sporadic Parkinson disease before the appearance of parkinsonism: preclinical Parkinson disease","volume":"118","author":"Ferrer","year":"2011","journal-title":"J Neural Transm (Vienna)."},{"key":"10.1016\/j.mad.2022.111675_bib63","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1002\/glia.10301","article-title":"Progressive telomere shortening occurs in cultured rat microglia, but not astrocytes","volume":"45","author":"Flanary","year":"2004","journal-title":"Glia"},{"key":"10.1016\/j.mad.2022.111675_bib64","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1093\/gerona\/glw053","article-title":"Meta-analysis of Telomere Length in Alzheimer\u2019s Disease","volume":"71","author":"Forero","year":"2016","journal-title":"J. Gerontol. - Ser. A Biol. Sci. Med. Sci."},{"key":"10.1016\/j.mad.2022.111675_bib65","doi-asserted-by":"crossref","first-page":"1536","DOI":"10.1038\/emboj.2011.69","article-title":"P38MAPK is a novel DNA damage response-independent regulator of the senescence-associated secretory phenotype","volume":"30","author":"Freund","year":"2011","journal-title":"EMBO J."},{"key":"10.1016\/j.mad.2022.111675_bib66","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/S0303-7207(01)00477-4","article-title":"Decreased proliferation and cell cycle arrest in neoplastic rat pituitary cells is associated with transforming growth factor-\u03b21-induced expression of p15\/INK4B","volume":"176","author":"Frost","year":"2001","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.mad.2022.111675_bib67","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41467-017-00314-z","article-title":"Identification of HSP90 inhibitors as a novel class of senolytics","volume":"8","author":"Fuhrmann-Stroissnigg","year":"2017","journal-title":"Nat. Commun."},{"key":"10.1016\/j.mad.2022.111675_bib68","first-page":"8","article-title":"Immunosenescence and inflamm-aging as two sides of the same coin: Friends or Foes?","author":"Fulop","year":"2018","journal-title":"Front. Immunol."},{"key":"10.1016\/j.mad.2022.111675_bib69","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1038\/ncb2466","article-title":"Telomeric DNA damage is irreparable and causes persistent DNA-damage-response activation","volume":"14","author":"Fumagalli","year":"2012","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.mad.2022.111675_bib70","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2021.109419","article-title":"Tau oligomer induced HMGB1 release contributes to cellular senescence and neuropathology linked to Alzheimer\u2019s disease and frontotemporal dementia","volume":"36","author":"Gaikwad","year":"2021","journal-title":"Cell Rep."},{"key":"10.1016\/j.mad.2022.111675_bib71","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.arr.2018.11.008","article-title":"Reversibility of irreversible aging","volume":"49","author":"Galkin","year":"2019","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.mad.2022.111675_bib72","doi-asserted-by":"crossref","first-page":"5220","DOI":"10.1038\/sj.onc.1209615","article-title":"RB and cell cycle progression","volume":"25","author":"Giacinti","year":"2006","journal-title":"Oncogene"},{"key":"10.1016\/j.mad.2022.111675_bib73","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1111\/j.1474-9726.2012.00807.x","article-title":"Is cellular senescence an example of antagonistic pleiotropy?","volume":"11","author":"Giaimo","year":"2012","journal-title":"Aging Cell"},{"key":"10.1016\/j.mad.2022.111675_bib74","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1007\/s00415-004-0348-9","article-title":"The role of oxidative stress in the pathogenesis of multiple sclerosis: the need for effective antioxidant therapy","volume":"251","author":"Gilgun-Sherki","year":"2004","journal-title":"J. Neurol."},{"key":"10.1016\/j.mad.2022.111675_bib75","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1111\/bcpt.13403","article-title":"Implicating endothelial cell senescence to dysfunction in the ageing and diseased brain","volume":"127","author":"Graves","year":"2020","journal-title":"Basic Clin. Pharmacol. Toxicol."},{"key":"10.1016\/j.mad.2022.111675_bib76","doi-asserted-by":"crossref","first-page":"1074","DOI":"10.1038\/s42255-019-0122-z","article-title":"Cardiac glycosides are broad-spectrum senolytics","volume":"1","author":"Guerrero","year":"2019","journal-title":"Nat. Metab."},{"key":"10.1016\/j.mad.2022.111675_bib77","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/acel.13133","article-title":"Galactose-modified duocarmycin prodrugs as senolytics","volume":"19","author":"Guerrero","year":"2020","journal-title":"Aging Cell"},{"key":"10.1016\/j.mad.2022.111675_bib78","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1016\/j.tins.2021.06.007","article-title":"Cellular senescence at the crossroads of inflammation and Alzheimer\u2019s disease","volume":"44","author":"Guerrero","year":"2021","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.mad.2022.111675_bib79","doi-asserted-by":"crossref","first-page":"1867","DOI":"10.18632\/aging.101268","article-title":"p16 and SAbetaGal can be induced in macrophages as part of a reversible response to physiological stimuli","volume":"9","author":"Hall","year":"2017","journal-title":"Aging (Albany NY)"},{"issue":"9","key":"10.1016\/j.mad.2022.111675_bib80","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1007\/s00277-010-0948-7","article-title":"Dasatinib impairs long-term expansion of leukemic progenitors in a subset of acute myeloid leukemia cases","volume":"89","author":"Han","year":"2010","journal-title":"Ann Hematol."},{"key":"10.1016\/j.mad.2022.111675_bib81","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1016\/0014-4827(61)90192-6","article-title":"The serial cultivation of human diploid cell strains","volume":"25","author":"Hayflick","year":"1961","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.mad.2022.111675_bib82","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/cddis.2013.437","article-title":"Amyloid-\u03b21-42 oligomer accelerates senescence in adult hippocampal neural stem\/progenitor cells via formylpeptide receptor 2","volume":"4","author":"He","year":"2013","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.mad.2022.111675_bib83","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/S0092-8674(01)00504-9","article-title":"The shortest telomere, not average telomere length, is critical for cell viability and chromosome stability","volume":"107","author":"Hemann","year":"2001","journal-title":"Cell"},{"key":"10.1016\/j.mad.2022.111675_bib84","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1016\/j.tcb.2018.02.001","article-title":"Hallmarks of cellular senescence","volume":"28","author":"Hernandez-Segura","year":"2018","journal-title":"Trends Cell Biol."},{"key":"10.1016\/j.mad.2022.111675_bib85","doi-asserted-by":"crossref","first-page":"1238","DOI":"10.1172\/JCI95148","article-title":"Mechanisms and functions of cellular senescence","volume":"128","author":"Herranz","year":"2018","journal-title":"J. Clin. Invest"},{"key":"10.1016\/j.mad.2022.111675_bib86","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1038\/ncb3225","article-title":"mTOR regulates MAPKAPK2 translation to control the senescence-associated secretory phenotype","volume":"17","author":"Herranz","year":"2015","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.mad.2022.111675_bib87","first-page":"3","article-title":"Telomeres are favoured targets of a persistent DNA damage response in ageing and stress-induced senescence","author":"Hewitt","year":"2012","journal-title":"Nat. Commun."},{"key":"10.1016\/j.mad.2022.111675_bib88","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1016\/j.ebiom.2019.08.069","article-title":"Senolytics decrease senescent cells in humans: preliminary report from a clinical trial of Dasatinib plus Quercetin in individuals with diabetic kidney disease","volume":"47","author":"Hickson","year":"2019","journal-title":"EBioMedicine"},{"key":"10.1016\/j.mad.2022.111675_bib89","doi-asserted-by":"crossref","first-page":"1922","DOI":"10.4161\/cc.24944","article-title":"\u03b1-Fucosidase as a novel convenient biomarker for cellular senescence","volume":"12","author":"Hildebrand","year":"2013","journal-title":"Cell Cycle"},{"key":"10.1016\/j.mad.2022.111675_bib90","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1007\/s00702-017-1721-z","article-title":"Leukocyte telomere length is linked to vascular risk factors not to Alzheimer\u2019s disease in the VITA study","volume":"124","author":"Hinterberger","year":"2017","journal-title":"J. Neural Transm."},{"key":"10.1016\/j.mad.2022.111675_bib91","first-page":"2020","article-title":"Proteostasis failure in neurodegenerative diseases: focus on oxidative stress","author":"H\u00f6hn","year":"2020","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.mad.2022.111675_bib92","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13024-017-0207-7","article-title":"Depletion of adult neurogenesis exacerbates cognitive deficits in Alzheimer\u2019s disease by compromising hippocampal inhibition","volume":"12","author":"Hollands","year":"2017","journal-title":"Mol. Neurodegener."},{"key":"10.1016\/j.mad.2022.111675_bib93","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2021.109228","article-title":"Replicative senescence dictates the emergence of disease-associated microglia and contributes to A\u03b2 pathology","volume":"35","author":"Hu","year":"2021","journal-title":"Cell Rep."},{"key":"10.1016\/j.mad.2022.111675_bib94","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1046\/j.1365-2443.2003.00620.x","article-title":"Mitogen-activated protein kinase p38 defines the common senescence-signalling pathway","volume":"8","author":"Iwasa","year":"2003","journal-title":"Genes Cells"},{"key":"10.1016\/j.mad.2022.111675_bib95","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/cells9030766","article-title":"The immune response against human cytomegalovirus links cellular to systemic senescence","volume":"9","author":"J Heath","year":"2020","journal-title":"Cells"},{"key":"10.1016\/j.mad.2022.111675_bib96","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1038\/sj.cdd.4401843","article-title":"Signals from within: the DNA-damage-induced NF-\u03baB response","volume":"13","author":"Janssens","year":"2006","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.mad.2022.111675_bib97","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1016\/j.cell.2005.09.036","article-title":"PIDD Mediates NF-\u03baB activation in response to DNA damage","volume":"123","author":"Janssens","year":"2005","journal-title":"Cell"},{"key":"10.1016\/j.mad.2022.111675_bib98","first-page":"775","article-title":"Local clearance of senescent cells attenuates the development of post-traumatic osteoarthritis and creates a pro-regenerative environment","volume":"23","author":"Jeon","year":"2017","journal-title":"Nat. Publ. Gr."},{"key":"10.1016\/j.mad.2022.111675_bib99","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1093\/jnen\/62.1.68","article-title":"Expression patterns of retinoblastoma protein in Parkinson disease","volume":"62","author":"Jordan-Sciutto","year":"2003","journal-title":"J Neuropathol Exp Neurol."},{"key":"10.1016\/j.mad.2022.111675_bib100","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1111\/j.1474-9726.2012.00870.x","article-title":"Postmitotic neurons develop a p21-dependent senescence-like phenotype driven by a DNA damage response","volume":"11","author":"Jurk","year":"2012","journal-title":"Aging Cell"},{"key":"10.1016\/j.mad.2022.111675_bib101","doi-asserted-by":"crossref","DOI":"10.1093\/gerona\/57.1.B16","article-title":"Leukocyte lysosomal enzymes in Alzheimer\u2019s disease and Down\u2019s syndrome","volume":"57","author":"Kalanj-Bognar","year":"2002","journal-title":"J. Gerontol. - Ser. A Biol. Sci. Med. Sci."},{"key":"10.1016\/j.mad.2022.111675_bib102","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1080\/15548627.2015.1121361","article-title":"How autophagy both activates and inhibits cellular senescence","volume":"12","author":"Kang","year":"2016","journal-title":"Autophagy"},{"key":"10.1016\/j.mad.2022.111675_bib103","first-page":"349","article-title":"The DNA damage response induces inflammation and senescence by inhibiting autophagy of GATA4","author":"Kang","year":"2015","journal-title":"Sci. (80-. )"},{"key":"10.1016\/j.mad.2022.111675_bib104","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1038\/nature12154","article-title":"A key role for mitochondrial gatekeeper pyruvate dehydrogenase in oncogene-induced senescence","volume":"498","author":"Kaplon","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.mad.2022.111675_bib105","doi-asserted-by":"crossref","first-page":"41","DOI":"10.3191\/thermalmed.35.41","article-title":"Stress-induced cellular senescence contributes to chronic inflammation and cancer progression","volume":"35","author":"Kobashigawa","year":"2019","journal-title":"Therm. Med."},{"key":"10.1016\/j.mad.2022.111675_bib106","series-title":"Nature Protocols","article-title":"Algorithmic assessment of cellular senescence in experimental and clinical specimens","author":"Kohli","year":"2021"},{"key":"10.1016\/j.mad.2022.111675_bib107","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.ebiom.2017.03.020","article-title":"Mitochondria in cell senescence: is mitophagy the weakest link?","volume":"21","author":"Korolchuk","year":"2017","journal-title":"EBioMedicine"},{"key":"10.1016\/j.mad.2022.111675_bib108","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1172\/JCI22475","article-title":"Ink4a\/Arf expression is a biomarker of aging","volume":"114","author":"Krishnamurthy","year":"2004","journal-title":"J. Clin. Invest."},{"issue":"10","key":"10.1016\/j.mad.2022.111675_bib109","doi-asserted-by":"crossref","DOI":"10.3390\/ijms19102937","article-title":"Ageing, cellular senescence and neurodegenerative disease","volume":"19","author":"Kritsilis","year":"2018","journal-title":"Int J Mol Sci."},{"key":"10.1016\/j.mad.2022.111675_bib110","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1038\/nrm4007","article-title":"P53 in survival, death and metabolic health: a lifeguard with a licence to kill","volume":"16","author":"Kruiswijk","year":"2015","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.mad.2022.111675_bib111","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1038\/nrc2560","article-title":"Senescence-messaging secretome: SMS-ing cellular stress","volume":"9","author":"Kuilman","year":"2009","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.mad.2022.111675_bib112","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1016\/j.cell.2008.03.039","article-title":"Oncogene-induced senescence relayed by an interleukin-dependent inflammatory network","volume":"133","author":"Kuilman","year":"2008","journal-title":"Cell"},{"key":"10.1016\/j.mad.2022.111675_bib113","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fcell.2021.645593","article-title":"Mechanisms of cellular senescence: cell cycle arrest and senescence associated secretory phenotype","volume":"9","author":"Kumari","year":"2021","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.mad.2022.111675_bib114","doi-asserted-by":"crossref","first-page":"3613","DOI":"10.1242\/jcs.113.20.3613","article-title":"Senescence-associated \u03b2-galactosidase reflects an increase in lysosomal mass during replicative ageing of human endothelial cells","volume":"113","author":"Kurz","year":"2000","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.mad.2022.111675_bib115","doi-asserted-by":"crossref","first-page":"607","DOI":"10.14348\/molcells.2017.0151","article-title":"Autophagy is pro-senescence when seen in close-up, but anti-senescence in long-shot","volume":"40","author":"Kwon","year":"2017","journal-title":"Mol. Cells"},{"key":"10.1016\/j.mad.2022.111675_bib116","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1111\/j.1474-9726.2012.00818.x","article-title":"Glucocorticoids suppress selected components of the senescence-associated secretory phenotype","volume":"11","author":"Laberge","year":"2012","journal-title":"Aging Cell"},{"key":"10.1016\/j.mad.2022.111675_bib117","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1038\/ncb3195","article-title":"MTOR regulates the pro-tumorigenic senescence-associated secretory phenotype by promoting IL1A translation","volume":"17","author":"Laberge","year":"2015","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.mad.2022.111675_bib118","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13024-015-0035-6","article-title":"Human neural stem cells alleviate Alzheimer-like pathology in a mouse model","volume":"10","author":"Lee","year":"2015","journal-title":"Mol. Neurodegener."},{"key":"10.1016\/j.mad.2022.111675_bib119","doi-asserted-by":"crossref","DOI":"10.1016\/j.mad.2021.111585","article-title":"A guide to senolytic intervention in neurodegenerative disease","volume":"200","author":"Lee","year":"2021","journal-title":"Mech. Ageing Dev."},{"key":"10.1016\/j.mad.2022.111675_bib120","doi-asserted-by":"crossref","first-page":"1485","DOI":"10.1016\/j.bcp.2008.07.017","article-title":"Activation of Nrf2-antioxidant signaling attenuates NF\u03baB-inflammatory response and elicits apoptosis","volume":"76","author":"Li","year":"2008","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.mad.2022.111675_bib121","first-page":"2","article-title":"NF-\u03baB signaling in inflammation","author":"Liu","year":"2017","journal-title":"Signal Transduct. Target. Ther."},{"issue":"6","key":"10.1016\/j.mad.2022.111675_bib122","doi-asserted-by":"crossref","first-page":"1194","DOI":"10.1016\/j.cell.2013.05.039","article-title":"The hallmarks of aging","volume":"153","author":"L\u00f3pez-Ot\u00edn","year":"2013","journal-title":"Cell"},{"key":"10.1016\/j.mad.2022.111675_bib123","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1046\/j.1471-4159.1999.0720771.x","article-title":"Increased DNA oxidation and decreased levels of repair products in Alzheimer\u2019s disease ventricular CSF","volume":"72","author":"Lovell","year":"1999","journal-title":"J. Neurochem."},{"key":"10.1016\/j.mad.2022.111675_bib124","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/j.jalz.2009.05.666","article-title":"Comparisons of telomere lengths in peripheral blood and cerebellum in Alzheimer \u2019 s disease","volume":"5","author":"Lukens","year":"2009","journal-title":"Alzheimer\u2019s Dement"},{"key":"10.1016\/j.mad.2022.111675_bib125","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.biocel.2014.11.001","article-title":"Abnormal cortical lysosomal \u03b2-hexosaminidase and \u03b2-galactosidase activity at post-synaptic sites during Alzheimer\u2019s disease progression","volume":"58","author":"Magini","year":"2015","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"10.1016\/j.mad.2022.111675_bib126","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1002\/ana.22230","article-title":"A Gradient of neuronal loss and meningeal inflammation in multiple sclerosis","volume":"68","author":"Magliozzi","year":"2010","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.mad.2022.111675_bib127","doi-asserted-by":"crossref","DOI":"10.1016\/j.yexcr.2020.112203","article-title":"Doxorubicin generates senescent microglia that exhibit altered proteomes, higher levels of cytokine secretion, and a decreased ability to internalize amyloid \u03b2","volume":"395","author":"Marques","year":"2020","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.mad.2022.111675_bib128","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1016\/j.molmed.2014.09.008","article-title":"Ageing as developmental decay: Insights from p16INK4a","volume":"20","author":"Martin","year":"2014","journal-title":"Trends Mol. Med."},{"key":"10.1016\/j.mad.2022.111675_bib129","first-page":"14","article-title":"Cellular senescence in neurodegenerative diseases","author":"Mart\u00ednez-cu\u00e9","year":"2020","journal-title":"Front Cell Neurosci."},{"key":"10.1016\/j.mad.2022.111675_bib130","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/S0960-9822(98)70137-X","article-title":"Inhibitors of cyclin-dependent kinases induce features of replicative senescence in early passage human diploid fibroblasts","volume":"8","author":"McConnell","year":"1998","journal-title":"Curr. Biol."},{"key":"10.1016\/j.mad.2022.111675_bib131","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1111\/j.1600-065X.2012.01101.x","article-title":"DNA damage-dependent NF-\u03baB activation: NEMO turns nuclear signaling inside out","volume":"246","author":"McCool","year":"2012","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.mad.2022.111675_bib132","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1083\/jcb.201708092","article-title":"Senescence and aging: causes, consequences, and therapeutic avenues","volume":"217","author":"McHugh","year":"2018","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.mad.2022.111675_bib133","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.stem.2021.12.002","article-title":"Down-syndrome-induced senescence disrupts the nuclear architecture of neural progenitors","volume":"29","author":"Meharena","year":"2022","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.mad.2022.111675_bib134","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1111\/acel.12075","article-title":"Metformin inhibits the senescence-associated secretory phenotype by interfering with IKK\/NF-jB activation","volume":"12","author":"Moiseeva","year":"2013","journal-title":"Aging Cell"},{"key":"10.1016\/j.mad.2022.111675_bib135","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1590\/S1807-59322009000500013","article-title":"Aging is not senescence: a short computer demonstration and implications for medical practice","volume":"64","author":"Monaco","year":"2009","journal-title":"Clinics"},{"key":"10.1016\/j.mad.2022.111675_bib136","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1679\/aohc.58.417","article-title":"Age changes in cerebellar oligodendrocytes: the appearance of nuclear filaments and increase in the volume density of the nucleus and in the number of dark cell forms","volume":"58","author":"Monteiro","year":"1995","journal-title":"Arch. Histol. Cytol."},{"issue":"16","key":"10.1016\/j.mad.2022.111675_bib137","doi-asserted-by":"crossref","first-page":"6175","DOI":"10.18632\/aging.102181","article-title":"Cortical neurons develop a senescence-like phenotype promoted by dysfunctional autophagy","volume":"11","author":"Moreno-blas","year":"2019","journal-title":"Aging (Albany NY)."},{"key":"10.1016\/j.mad.2022.111675_bib138","first-page":"17","article-title":"Tau protein aggregation is associated with cellular senescence in the brain","author":"Musi","year":"2018","journal-title":"Aging Cell"},{"key":"10.1016\/j.mad.2022.111675_bib139","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1016\/j.stem.2019.08.015","article-title":"Metformin restores CNS remyelination capacity by rejuvenating aged stem cells","volume":"25","author":"Neumann","year":"2019","journal-title":"Cell Stem Cell."},{"key":"10.1016\/j.mad.2022.111675_bib140","doi-asserted-by":"crossref","first-page":"9030","DOI":"10.1073\/pnas.1818348116","article-title":"Cellular senescence in progenitor cells contributes to diminished remyelination potential in progressive multiple sclerosis","volume":"116","author":"Nicaise","year":"2019","journal-title":"Proc. Natl. Acad. Sci. U. S. A"},{"key":"10.1016\/j.mad.2022.111675_bib141","first-page":"2018","article-title":"Cellular senescence and inflammaging in age-related diseases","author":"Olivieri","year":"2018","journal-title":"Mediat. Inflamm."},{"key":"10.1016\/j.mad.2022.111675_bib142","first-page":"8","article-title":"Senescence-associated secretory phenotype contributes to pathological angiogenesis in retinopathy","author":"Oubaha","year":"2016","journal-title":"Sci. Transl. Med"},{"issue":"17","key":"10.1016\/j.mad.2022.111675_bib143","doi-asserted-by":"crossref","first-page":"5229","DOI":"10.1021\/jm800109e","article-title":"Roscovitine-derived, dual-specificity inhibitors of cyclin-dependent kinases and casein kinases 1","volume":"51","author":"Oumata","year":"2008","journal-title":"J Med Chem."},{"key":"10.1016\/j.mad.2022.111675_bib144","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/j.ijrobp.2017.02.216","article-title":"Inhibition of Bcl-2 \/ xl with ABT-263 selectively kills senescent Type II pneumocytes and reverses persistent pulmonary fibrosis induced by ionizing radiation in mice","volume":"99","author":"Pan","year":"2017","journal-title":"Radiat. Oncol. Biol."},{"key":"10.1016\/j.mad.2022.111675_bib145","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fncel.2020.00178","article-title":"Aging, cellular senescence, and progressive multiple sclerosis","volume":"14","author":"Papadopoulos","year":"2020","journal-title":"Front. Cell. Neurosci."},{"key":"10.1016\/j.mad.2022.111675_bib146","doi-asserted-by":"crossref","first-page":"1138","DOI":"10.1371\/journal.pbio.0050110","article-title":"Mitochondrial dysfunction accounts for the stochastic heterogeneity in telomere-dependent senescence","volume":"5","author":"Passos","year":"2007","journal-title":"PLoS Biol."},{"key":"10.1016\/j.mad.2022.111675_bib147","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1111\/j.1365-2990.2007.00805.x","article-title":"Remyelination can be extensive in multiple sclerosis despite a long disease course","volume":"33","author":"Patani","year":"2007","journal-title":"Neuropathol. Appl. Neurobiol."},{"key":"10.1016\/j.mad.2022.111675_bib148","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-018-22342-5","article-title":"Muscle stem cell dysfunction impairs muscle regeneration in a mouse model of Down syndrome","volume":"8","author":"Pawlikowski","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.mad.2022.111675_bib149","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1016\/j.mad.2007.07.002","article-title":"Increased permeability of blood-brain barrier on the hippocampus of a murine model of senescence","volume":"128","author":"Pelegr\u00ed","year":"2007","journal-title":"Mech. Ageing Dev."},{"key":"10.1016\/j.mad.2022.111675_bib150","doi-asserted-by":"crossref","first-page":"81099","DOI":"10.18632\/oncotarget.12752","article-title":"Is senescence-associated \u03b2-galactosidase a marker of neuronal senescence?","volume":"7","author":"Piechota","year":"2016","journal-title":"Oncotarget"},{"key":"10.1016\/j.mad.2022.111675_bib151","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1093\/gerona\/gls183","article-title":"Chronic resveratrol treatment ameliorates cell adhesion and mitigates the inflammatory phenotype in senescent human fibroblasts","volume":"68","author":"Pitozzi","year":"2013","journal-title":"J. Gerontol. - Ser. A Biol. Sci. Med. Sci."},{"key":"10.1016\/j.mad.2022.111675_bib152","doi-asserted-by":"crossref","first-page":"300","DOI":"10.3934\/molsci.2016.3.300","article-title":"Oxidative stress, cellular senescence and ageing","volume":"3","author":"Pole","year":"2016","journal-title":"AIMS Mol. Sci."},{"issue":"12","key":"10.1016\/j.mad.2022.111675_bib153","doi-asserted-by":"crossref","first-page":"2402","DOI":"10.4161\/cc.20882","article-title":"Suppression of replicative senescence by rapamycin in rodent embryonic cells","volume":"11","author":"Pospelova","year":"2012","journal-title":"Cell Cycle."},{"key":"10.1016\/j.mad.2022.111675_bib154","doi-asserted-by":"crossref","first-page":"106639","DOI":"10.18632\/oncotarget.22543","article-title":"BTK blocks the inhibitory effects of MDM2 on p53 activity","volume":"8","author":"Rada","year":"2017","journal-title":"Oncotarget"},{"key":"10.1016\/j.mad.2022.111675_bib155","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1016\/j.stem.2019.08.013","article-title":"Loss of SATB1 induces p21-dependent cellular senescence in post-mitotic dopaminergic neurons","volume":"25","author":"Riessland","year":"2019","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.mad.2022.111675_bib156","first-page":"2015","article-title":"Intracellular oxidant activity, antioxidant enzyme defense system, and cell senescence in fibroblasts with trisomy 21","author":"Rodr\u00edguez-Sureda","year":"2015","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.mad.2022.111675_bib157","doi-asserted-by":"crossref","first-page":"2356","DOI":"10.1038\/onc.2010.611","article-title":"Activation of nuclear factor-kappa B signalling promotes cellular senescence","volume":"30","author":"Rovillain","year":"2011","journal-title":"Oncogene"},{"key":"10.1016\/j.mad.2022.111675_bib158","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.bbi.2018.05.008","article-title":"Anti-IL17 treatment ameliorates Down syndrome phenotypes in mice","volume":"73","author":"Rueda","year":"2018","journal-title":"Brain. Behav. Immun."},{"key":"10.1016\/j.mad.2022.111675_bib159","series-title":"Neuropharmacology","article-title":"The flavonoid quercetin ameliorates Alzheimer\u2019s disease pathology and protects cognitive and emotional function in aged triple transgenic Alzheimer\u2019s disease model mice","author":"Sabogal-Gu\u00e1queta","year":"2015"},{"key":"10.1016\/j.mad.2022.111675_bib160","article-title":"Cellular senescence and Alzheimer disease: the egg and the chicken scenario","author":"Saez-Atienzar","year":"2020","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.mad.2022.111675_bib161","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/life11030229","article-title":"The cellular senescence stress response in post-mitotic brain cells: Cell survival at the expense of tissue degeneration","volume":"11","author":"Sah","year":"2021","journal-title":"Life"},{"key":"10.1016\/j.mad.2022.111675_bib162","doi-asserted-by":"crossref","first-page":"7101","DOI":"10.4049\/jimmunol.179.10.7101","article-title":"MAPK p38 regulates transcriptional activity of NF-\u03baB in primary human astrocytes via acetylation of p65","volume":"179","author":"Saha","year":"2007","journal-title":"J. Immunol."},{"key":"10.1016\/j.mad.2022.111675_bib163","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fimmu.2021.692321","article-title":"Accumulation of senescent neural cells in murine lupus with depression-like behavior","volume":"12","author":"Saito","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.mad.2022.111675_bib164","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.arr.2007.09.002","article-title":"Activation of innate immunity system during aging: NF-kB signaling is the molecular culprit of inflamm-aging","volume":"7","author":"Salminen","year":"2008","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.mad.2022.111675_bib165","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1016\/j.cellsig.2011.12.006","article-title":"Emerging role of NF-\u03baB signaling in the induction of senescence-associated secretory phenotype (SASP)","volume":"24","author":"Salminen","year":"2012","journal-title":"Cell. Signal."},{"key":"10.1016\/j.mad.2022.111675_bib166","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1007\/s00418-021-01992-z","article-title":"Senescence and associated blood\u2013brain barrier alterations in vitro","volume":"156","author":"Salvador","year":"2021","journal-title":"Histochem. Cell Biol."},{"key":"10.1016\/j.mad.2022.111675_bib167","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1016\/j.tcb.2018.03.003","article-title":"Cellular senescence in postmitotic cells: beyond growth arrest","volume":"28","author":"Sapieha","year":"2018","journal-title":"Trends Cell Biol."},{"key":"10.1016\/j.mad.2022.111675_bib168","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/cells8111446","article-title":"Dissecting aging and senescence-current concepts and open lessons","volume":"8","author":"Schmeer","year":"2019","journal-title":"Cells"},{"key":"10.1016\/j.mad.2022.111675_bib169","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1038\/nrc3960","article-title":"Forging a signature of in vivo senescence","volume":"15","author":"Sharpless","year":"2015","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.mad.2022.111675_bib170","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fnmol.2015.00077","article-title":"NF-kappaB signaling pathways in neurological inflammation: a mini review","volume":"8","author":"Shih","year":"2015","journal-title":"Front. Mol. Neurosci."},{"key":"10.1016\/j.mad.2022.111675_bib171","doi-asserted-by":"crossref","first-page":"2451","DOI":"10.1523\/JNEUROSCI.22-07-02451.2002","article-title":"The age-related decrease in CNS remyelination efficiency is attributable to an impairment of both oligodendrocyte progenitor recruitment and differentiation","volume":"22","author":"Sim","year":"2002","journal-title":"J. Neurosci."},{"key":"10.1016\/j.mad.2022.111675_bib172","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1007\/s10522-020-09900-z","article-title":"Spermidine, a caloric restriction mimetic, provides neuroprotection against normal and d-galactose-induced oxidative stress and apoptosis through activation of autophagy in male rats during aging","volume":"22","author":"Singh","year":"2021","journal-title":"Biogerontology"},{"key":"10.1016\/j.mad.2022.111675_bib173","first-page":"9","article-title":"Immune clearance of senescent cells to combat ageing and chronic diseases","author":"Song","year":"2020","journal-title":"Cells"},{"key":"10.1016\/j.mad.2022.111675_bib174","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1016\/j.tibs.2020.03.008","article-title":"Senescent cells: emerging targets for human aging and age-related diseases","volume":"45","author":"Song","year":"2020","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/j.mad.2022.111675_bib175","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.exger.2006.06.002","article-title":"The molecular basis of the prevention of Alzheimer\u2019s disease through healthy nutrition","volume":"42","author":"Steele","year":"2007","journal-title":"Exp Gerontol."},{"key":"10.1016\/j.mad.2022.111675_bib176","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.neurobiolaging.2018.10.007","article-title":"Phenotypic and functional differences between senescent and aged murine microglia","volume":"74","author":"Stojiljkovic","year":"2019","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.mad.2022.111675_bib177","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1016\/j.cell.2013.02.054","article-title":"The adaptor MAVS promotes NLRP3 mitochondrial localization and inflammasome activation","volume":"153","author":"Subramanian","year":"2013","journal-title":"Cell"},{"key":"10.1016\/j.mad.2022.111675_bib178","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.bbrc.2020.12.086","article-title":"Normal aging induces PD-1-enriched exhausted microglia and A1-like reactive astrocytes in the hypothalamus","volume":"541","author":"Suda","year":"2021","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.mad.2022.111675_bib179","first-page":"2018","article-title":"Matrine attenuates D-galactose-induced aging-related behavior in mice via inhibition of cellular senescence and oxidative stress","author":"Sun","year":"2018","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.mad.2022.111675_bib180","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1196\/annals.1361.066","article-title":"Premature immunosenescence in rheumatoid arthritis and multiple sclerosis patients","volume":"1051","author":"Thewissen","year":"2005","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.mad.2022.111675_bib181","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1038\/35041682","article-title":"Why do we age?","volume":"408","author":"Thomas","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.mad.2022.111675_bib182","first-page":"20","article-title":"TGF-\u03b2 signaling in cellular senescence and aging-related pathology","author":"Tominaga","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.mad.2022.111675_bib183","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1016\/S0531-5565(00)00180-7","article-title":"Cellular and molecular mechanisms of stress-induced premature senescence (SIPS) of human diploid fibroblasts and melanocytes","volume":"35","author":"Toussaint","year":"2000","journal-title":"Exp. Gerontol."},{"key":"10.1016\/j.mad.2022.111675_bib184","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41467-019-12888-x","article-title":"Identification and characterization of cardiac glycosides as senolytic compounds","volume":"10","author":"Triana-Mart\u00ednez","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.mad.2022.111675_bib185","first-page":"10","article-title":"Accumulation of dysfunctional SOD1 protein in Parkinson\u2019s disease is not associated with mutations in the SOD1 gene","author":"Trist","year":"2017","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.mad.2022.111675_bib186","first-page":"1","article-title":"Oxidative stress in the aging substantia nigra and the etiology of Parkinson\u2019s disease","author":"Trist","year":"2019","journal-title":"Aging Cell."},{"key":"10.1016\/j.mad.2022.111675_bib187","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.mad.2016.05.006","article-title":"DNA damage in the oligodendrocyte lineage and its role in brain aging","volume":"161","author":"Tse","year":"2017","journal-title":"Mech. Ageing Dev."},{"key":"10.1016\/j.mad.2022.111675_bib188","doi-asserted-by":"crossref","first-page":"5100","DOI":"10.1038\/sj.onc.1204665","article-title":"Activation of p53 transcriptional activity requires ATM\u2019s kinase domain and multiple N-terminal serine residues of p53","volume":"20","author":"Turenne","year":"2001","journal-title":"Oncogene"},{"key":"10.1016\/j.mad.2022.111675_bib189","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1038\/ncb2795","article-title":"Functional interplay between the DNA-damage-response kinase ATM and ARF tumour suppressor protein in human cancer","volume":"15","author":"Velimezi","year":"2013","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.mad.2022.111675_bib190","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1093\/emboj\/cdg139","article-title":"Transcriptional activation of the NF-\u03baB p65 subunit by mitogen- and stress-activated protein kinase-1 (MSK1)","volume":"22","author":"Vermeulen","year":"2003","journal-title":"EMBO J."},{"key":"10.1016\/j.mad.2022.111675_bib191","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1089\/ars.2020.8048","article-title":"Senescence in post-mitotic cells: a driver of aging?","volume":"34","author":"Von Zglinicki","year":"2021","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.mad.2022.111675_bib192","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1016\/j.trecan.2020.05.004","article-title":"Senescent cells in cancer therapy: friends or foes?","volume":"6","author":"Wang","year":"2020","journal-title":"Trends Cancer"},{"key":"10.1016\/j.mad.2022.111675_bib193","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1007\/s40520-015-0484-3","article-title":"p15INK4b regulates cell cycle signaling in hippocampal astrocytes of aged rats","volume":"28","author":"Wang","year":"2016","journal-title":"Aging Clin. Exp. Res."},{"key":"10.1016\/j.mad.2022.111675_bib194","first-page":"171","author":"Wang","year":"2002","journal-title":"Inhib. Cyclin-Depend. Kinases Improv. CA1 Neuron Surviv. Behav. Perform. Glob. Ischemia Rat."},{"key":"10.1016\/j.mad.2022.111675_bib195","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.pbb.2010.12.006","article-title":"Inhibiting NF-\u03baB activation and ROS production are involved in the mechanism of silibinin\u2019s protection against D-galactose-induced senescence","volume":"98","author":"Wang","year":"2011","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.mad.2022.111675_bib196","doi-asserted-by":"crossref","first-page":"3389","DOI":"10.1128\/MCB.22.10.3389-3403.2002","article-title":"Sequential activation\u00a0Dof the MEK-extracellular signal-regulated kinase and MKK3\/6-p38 mitogen-activated protein kinase pathways mediates oncogenic ras -induced premature senescence","volume":"22","author":"Wang","year":"2002","journal-title":"Mol. Cell. Biol."},{"issue":"11","key":"10.1016\/j.mad.2022.111675_bib197","doi-asserted-by":"crossref","first-page":"2915","DOI":"10.18632\/aging.101100","article-title":"Discovery of piperlongumine as a potential novel lead for the development of senolytic agents","volume":"8","author":"Wang","year":"2016","journal-title":"Aging (Albany NY)."},{"key":"10.1016\/j.mad.2022.111675_bib198","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1042\/BST20150014","article-title":"Dissecting molecular cross-talk between Nrf2 and NF-\u03baB response pathways","volume":"43","author":"Wardyn","year":"2015","journal-title":"Biochem. Soc. Trans."},{"key":"10.1016\/j.mad.2022.111675_bib199","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1007\/s12603-010-0275-7","article-title":"Study of telomere length and different markers of oxidative stress in patients with Parkinson\u2019s disease","volume":"15","author":"Watfa","year":"2011","journal-title":"J Nutr Health Aging."},{"key":"10.1016\/j.mad.2022.111675_bib200","doi-asserted-by":"crossref","first-page":"1835","DOI":"10.4103\/0366-6999.186646","article-title":"Amyloid \u03b2 protein aggravates neuronal senescence and cognitive deficits in 5XFAD mouse model of Alzheimer\u2019s disease","volume":"129","author":"Wei","year":"2016","journal-title":"Chin. Med. J."},{"key":"10.1016\/j.mad.2022.111675_bib201","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/cells8121546","article-title":"Amitosenescence and pseudomitosenescence: putative new players in the aging process","volume":"8","author":"Wengerodt","year":"2019","journal-title":"Cells"},{"key":"10.1016\/j.mad.2022.111675_bib202","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-020-57663-x","article-title":"Astrocyte support for oligodendrocyte differentiation can be conveyed via extracellular vesicles but diminishes with age","volume":"10","author":"Willis","year":"2020","journal-title":"Sci. Rep."},{"key":"10.1016\/j.mad.2022.111675_bib203","series-title":"International Review of Neurobiology","doi-asserted-by":"crossref","DOI":"10.1016\/bs.irn.2020.03.019","article-title":"Cellular senescence in aging and age-related diseases: Implications for neurodegenerative diseases","author":"Wissler Gerdes","year":"2020"},{"issue":"46","key":"10.1016\/j.mad.2022.111675_bib204","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.1515386112","article-title":"JAK inhibition alleviates the cellular senescence-associated secretory phenotype and frailty in old age","volume":"112","author":"Xu","year":"2015","journal-title":"Proc Natl Acad Sci U S A."},{"key":"10.1016\/j.mad.2022.111675_bib205","doi-asserted-by":"crossref","first-page":"1246","DOI":"10.1038\/s41591-018-0092-9","article-title":"Senolytics improve physical function and increase lifespan in old age","volume":"24","author":"Xu","year":"2018","journal-title":"Nat. Med."},{"key":"10.1016\/j.mad.2022.111675_bib206","doi-asserted-by":"crossref","first-page":"6401","DOI":"10.18632\/aging.103035","article-title":"Spermidine and spermine delay brain aging by inducing autophagy in SAMP8 mice","volume":"12","author":"Xu","year":"2020","journal-title":"Aging"},{"key":"10.1016\/j.mad.2022.111675_bib207","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.1161\/STROKEAHA.115.010835","article-title":"Vascular cell senescence contributes to blood-brain barrier breakdown","volume":"47","author":"Yamazaki","year":"2016","journal-title":"Stroke"},{"key":"10.1016\/j.mad.2022.111675_bib208","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1016\/j.exger.2005.07.011","article-title":"The limitations and validities of senescence associated-\u03b2- galactosidase activity as an aging marker for human foreskin fibroblast Hs68 cells","volume":"40","author":"Yang","year":"2005","journal-title":"Exp. Gerontol."},{"key":"10.1016\/j.mad.2022.111675_bib209","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1111\/acel.12594","article-title":"Age-related decline in BubR1 impairs adult hippocampal neurogenesis","volume":"16","author":"Yang","year":"2017","journal-title":"Aging Cell"},{"key":"10.1016\/j.mad.2022.111675_bib210","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1101\/gad.519709","article-title":"Autophagy mediates the mitotic senescence transition","volume":"23","author":"Young","year":"2009","journal-title":"Genes Dev."},{"key":"10.1016\/j.mad.2022.111675_bib211","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.ebiom.2018.09.015","article-title":"Fisetin is a senotherapeutic that extends health and lifespan","volume":"36","author":"Yousefzadeh","year":"2018","journal-title":"EBioMedicine"},{"key":"10.1016\/j.mad.2022.111675_bib212","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/acel.13094","article-title":"Tissue specificity of senescent cell accumulation during physiologic and accelerated aging of mice","volume":"19","author":"Yousefzadeh","year":"2020","journal-title":"Aging Cell"},{"issue":"4","key":"10.1016\/j.mad.2022.111675_bib213","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/j.biopha.2008.01.017","article-title":"Glutathione and Parkinson\u2019s disease: is this the elephant in the room?","volume":"62","author":"Zeevalk","year":"2008","journal-title":"Biomed Pharmacother."},{"key":"10.1016\/j.mad.2022.111675_bib214","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13578-020-00391-6","article-title":"Alternative lengthening of telomeres: from molecular mechanisms to therapeutic outlooks","volume":"10","author":"Zhang","year":"2020","journal-title":"Cell Biosci."},{"key":"10.1016\/j.mad.2022.111675_bib215","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1038\/s41593-019-0372-9","article-title":"Senolytic therapy alleviates A\u03b2-associated oligodendrocyte progenitor cell senescence and cognitive deficits in an Alzheimer\u2019s disease model","volume":"22","author":"Zhang","year":"2019","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.mad.2022.111675_bib216","first-page":"1","article-title":"Piperlongumine inhibits lung tumor growth via inhibition of nuclear factor kappa B signaling pathway","author":"Zheng","year":"2016","journal-title":"Nat. Publ. Gr."},{"key":"10.1016\/j.mad.2022.111675_bib217","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1111\/acel.12344","article-title":"The achilles\u2019 heel of senescent cells: from transcriptome to senolytic drugs","volume":"14","author":"Zhu","year":"2015","journal-title":"Aging Cell"},{"key":"10.1016\/j.mad.2022.111675_bib218","doi-asserted-by":"crossref","first-page":"1","DOI":"10.18632\/aging.101202","article-title":"New agents that target senescent cells: the flavone, fisetin, and the BCL \u2010 X L inhibitors, A1331852 and A1155463","volume":"9","author":"Zhu","year":"2017","journal-title":"Aging"},{"key":"10.1016\/j.mad.2022.111675_bib219","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1101\/gad.1550307","article-title":"Single- and double-stranded DNA: building a trigger of ATR-mediated DNA damage response","volume":"21","author":"Zou","year":"2007","journal-title":"Genes Dev."}],"container-title":["Mechanisms of Ageing and Development"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0047637422000574?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0047637422000574?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T17:49:12Z","timestamp":1758649752000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0047637422000574"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6]]},"references-count":219,"alternative-id":["S0047637422000574"],"URL":"https:\/\/doi.org\/10.1016\/j.mad.2022.111675","relation":{},"ISSN":["0047-6374"],"issn-type":[{"value":"0047-6374","type":"print"}],"subject":[],"published":{"date-parts":[[2022,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Cellular senescence in the aging brain: A promising target for neurodegenerative diseases","name":"articletitle","label":"Article Title"},{"value":"Mechanisms of Ageing and Development","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mad.2022.111675","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"111675"}}