{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T22:03:08Z","timestamp":1790373788731,"version":"4.1.0"},"reference-count":41,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Mechanisms of Ageing and Development"],"published-print":{"date-parts":[[2022,10]]},"DOI":"10.1016\/j.mad.2022.111714","type":"journal-article","created":{"date-parts":[[2022,8,2]],"date-time":"2022-08-02T20:55:29Z","timestamp":1659473729000},"page":"111714","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":28,"special_numbering":"C","title":["Cardioprotection of Klotho against myocardial infarction-induced heart failure through inducing autophagy"],"prefix":"10.1016","volume":"207","author":[{"given":"Kai","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongming","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yansong","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianling","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Hong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yinzhang","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lijun","family":"Qian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Di","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.mad.2022.111714_bib1","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2018.11.025","article-title":"Allicin attenuates pathological cardiac hypertrophy by inhibiting autophagy via activation of PI3K\/Akt\/mTOR and MAPK\/ERK\/mTOR signaling pathways","volume":"58","author":"Ba","year":"2019","journal-title":"Phytomedicine"},{"key":"10.1016\/j.mad.2022.111714_bib2","first-page":"1","article-title":"ISL1 cardiovascular progenitor cells for cardiac repair after myocardial infarction","author":"Bartulos","year":"2016","journal-title":"JCI Insight"},{"key":"10.1016\/j.mad.2022.111714_bib3","doi-asserted-by":"crossref","first-page":"1615","DOI":"10.1007\/s00109-019-01841-6","article-title":"Autophagy plays a critical role in Klotho gene deficiency-induced arterial stiffening and hypertension","volume":"97","author":"Chen","year":"2019","journal-title":"J. Mol. Med."},{"key":"10.1016\/j.mad.2022.111714_bib4","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2021.102173","article-title":"Estrogen inhibits renal Na-Pi Co-transporters and improves klotho deficiency-induced acute heart failure","volume":"47","author":"Chen","year":"2021","journal-title":"Redox Biol."},{"key":"10.1016\/j.mad.2022.111714_bib5","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1161\/CIRCRESAHA.120.317348","article-title":"Klotho deficiency causes heart aging via impairing the Nrf2-GR pathway","volume":"128","author":"Chen","year":"2021","journal-title":"Circ. Res."},{"key":"10.1016\/j.mad.2022.111714_bib6","doi-asserted-by":"crossref","first-page":"1826","DOI":"10.1080\/21655979.2021.1925008","article-title":"Ivabradine protects rats against myocardial infarction through reinforcing autophagy via inhibiting PI3K\/AKT\/mTOR\/p70S6K pathway","volume":"12","author":"Dai","year":"2021","journal-title":"Bioengineered"},{"key":"10.1016\/j.mad.2022.111714_bib7","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2019.172549","article-title":"Klotho inhibits angiotensin II-induced cardiac hypertrophy, fibrosis, and dysfunction in mice through suppression of transforming growth factor-\u03b21 signaling pathway","volume":"859","author":"Ding","year":"2019","journal-title":"Eur. J. Pharm."},{"key":"10.1016\/j.mad.2022.111714_bib8","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1038\/nrcardio.2014.28","article-title":"The inflammatory response in myocardial injury, repair, and remodelling","volume":"11","author":"Frangogiannis","year":"2014","journal-title":"Nat. Rev. Cardiol."},{"key":"10.1016\/j.mad.2022.111714_bib9","first-page":"195","article-title":"Rapamycin regulates the balance between cardiomyocyte apoptosis and autophagy in chronic heart failure by inhibiting mTOR signaling","volume":"45","author":"Gao","year":"2020","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.mad.2022.111714_bib10","article-title":"Loss of functional SCO2 attenuates oxidative stress in diabetic kidney disease","author":"Gujarati","year":"2021","journal-title":"Diabetes"},{"key":"10.1016\/j.mad.2022.111714_bib11","first-page":"2065","article-title":"Redd1 protects against post\u2011infarction cardiac dysfunction by targeting apoptosis and autophagy","volume":"44","author":"Huang","year":"2019","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.mad.2022.111714_bib12","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1002\/ehf2.13144","article-title":"Heart failure after myocardial infarction: incidence and predictors","volume":"8","author":"Jen\u010da","year":"2021","journal-title":"ESC Heart Fail."},{"key":"10.1016\/j.mad.2022.111714_bib13","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1016\/j.recesp.2011.10.027","article-title":"Heart failure in acute myocardial infarction: a comparison between patients with or without heart failure criteria from the FAST-MI registry","volume":"65","author":"Juilli\u00e8re","year":"2012","journal-title":"Rev. Esp. Cardiol."},{"key":"10.1016\/j.mad.2022.111714_bib14","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1161\/HYPERTENSIONAHA.120.16635","article-title":"Role of Klotho in the development of essential hypertension","volume":"77","author":"Kanbay","year":"2021","journal-title":"Hypertension"},{"key":"10.1016\/j.mad.2022.111714_bib15","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1002\/jnr.23204","article-title":"In vitro ischemia suppresses hypoxic induction of hypoxia-inducible factor-1\u03b1 by inhibition of synthesis and not enhanced degradation","volume":"91","author":"Karuppagounder","year":"2013","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.mad.2022.111714_bib16","doi-asserted-by":"crossref","first-page":"F772","DOI":"10.1152\/ajprenal.00504.2019","article-title":"Beclin 1\/Bcl-2 complex-dependent autophagy activity modulates renal susceptibility to ischemia-reperfusion injury and mediates renoprotection by Klotho","volume":"318","author":"Li","year":"2020","journal-title":"Am. J. Physiol. Ren. Physiol."},{"key":"10.1016\/j.mad.2022.111714_bib17","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1007\/s00395-020-0790-6","article-title":"CARD9 promotes autophagy in cardiomyocytes in myocardial ischemia\/reperfusion injury via interacting with Rubicon directly","volume":"115","author":"Li","year":"2020","journal-title":"Basic Res. Cardiol."},{"key":"10.1016\/j.mad.2022.111714_bib18","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1186\/s12935-020-1137-y","article-title":"Ubiquitin-specific peptide 22 acts as an oncogene in gastric cancer in a son of sevenless 1-dependent manner","volume":"20","author":"Lim","year":"2020","journal-title":"Cancer Cell Int."},{"key":"10.1016\/j.mad.2022.111714_bib19","doi-asserted-by":"crossref","first-page":"1923","DOI":"10.7150\/ijbs.27022","article-title":"Saikosaponin a protects from pressure overload-induced cardiac fibrosis via inhibiting fibroblast activation or endothelial cell EndMT","volume":"14","author":"Liu","year":"2018","journal-title":"Int. J. Biol. Sci."},{"key":"10.1016\/j.mad.2022.111714_bib20","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1111\/apha.12793","article-title":"Beneficial effects of renal denervation on cardiac angiogenesis in rats with prolonged pressure overload","volume":"220","author":"Lu","year":"2017","journal-title":"Acta Physiol."},{"key":"10.1016\/j.mad.2022.111714_bib21","first-page":"2033","article-title":"Sirt1 promotes autophagy and inhibits apoptosis to protect cardiomyocytes from hypoxic stress","volume":"43","author":"Luo","year":"2019","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.mad.2022.111714_bib22","doi-asserted-by":"crossref","DOI":"10.3390\/cells10112861","article-title":"A-kinase anchoring protein 2 promotes protection against myocardial infarction","volume":"10","author":"Maric","year":"2021","journal-title":"Cells"},{"key":"10.1016\/j.mad.2022.111714_bib23","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1136\/heartjnl-2013-304746","article-title":"Reduced Klotho is associated with the presence and severity of coronary artery disease","volume":"100","author":"Navarro-Gonz\u00e1lez","year":"2014","journal-title":"Heart"},{"key":"10.1016\/j.mad.2022.111714_bib24","doi-asserted-by":"crossref","DOI":"10.1042\/BSR20150278","article-title":"Expression signature of lncRNAs and their potential roles in cardiac fibrosis of post-infarct mice","volume":"36","author":"Qu","year":"2016","journal-title":"Biosci. Rep."},{"key":"10.1016\/j.mad.2022.111714_bib25","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1146\/annurev-physiol-021317-121427","article-title":"The role of autophagy in the heart","volume":"80","author":"Sciarretta","year":"2018","journal-title":"Annu Rev. Physiol."},{"key":"10.1016\/j.mad.2022.111714_bib26","doi-asserted-by":"crossref","first-page":"1596","DOI":"10.1111\/j.1532-5415.2011.03558.x","article-title":"Plasma klotho and cardiovascular disease in adults","volume":"59","author":"Semba","year":"2011","journal-title":"J. Am. Geriatr. Soc."},{"key":"10.1016\/j.mad.2022.111714_bib27","first-page":"5","article-title":"Heart failure complicating acute myocardial infarction; burden and timing of occurrence: a nation-wide analysis including 86 771 patients from the cardiovascular disease in Norway (CVDNOR) project","author":"Sulo","year":"2016","journal-title":"J. Am. Heart Assoc."},{"key":"10.1016\/j.mad.2022.111714_bib28","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2021.111287","article-title":"Cardioprotection of Panax notoginseng saponins against acute myocardial infarction and heart failure through inducing autophagy","volume":"136","author":"Wang","year":"2021","journal-title":"Biomed. Pharm."},{"key":"10.1016\/j.mad.2022.111714_bib29","article-title":"Dapagliflozin improves cardiac function, remodeling, myocardial apoptosis, and inflammatory cytokines in mice with myocardial infarction","author":"Wang","year":"2021","journal-title":"J. Cardiovasc. Transl. Res."},{"key":"10.1016\/j.mad.2022.111714_bib30","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1002\/cbin.11495","article-title":"Autophagy participates in the protection role of 1,25-dihydroxyvitamin D3 in acute myocardial infarction via PI3K\/AKT\/mTOR pathway","volume":"45","author":"Wei","year":"2021","journal-title":"Cell Biol. Int."},{"key":"10.1016\/j.mad.2022.111714_bib31","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1002\/med.21733","article-title":"Autophagy and cardiac diseases: therapeutic potential of natural products","volume":"41","author":"Wu","year":"2021","journal-title":"Med. Res. Rev."},{"key":"10.1016\/j.mad.2022.111714_bib32","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1016\/j.bbrc.2020.11.061","article-title":"Klotho ameliorates diabetic nephropathy by activating Nrf2 signaling pathway in podocytes","volume":"534","author":"Xing","year":"2021","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.mad.2022.111714_bib33","doi-asserted-by":"crossref","first-page":"52","DOI":"10.3892\/etm.2020.9484","article-title":"Klotho gene improves oxidative stress injury after myocardial infarction","volume":"21","author":"Xu","year":"2021","journal-title":"Exp. Ther. Med."},{"key":"10.1016\/j.mad.2022.111714_bib34","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1038\/cr.2013.154","article-title":"You are what you eat: multifaceted functions of autophagy during C. elegans development","volume":"24","author":"Yang","year":"2014","journal-title":"Cell Res."},{"key":"10.1016\/j.mad.2022.111714_bib35","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2021.114187","article-title":"The role and mechanism of hyperoside against myocardial infarction in mice by regulating autophagy via NLRP1 inflammation pathway","volume":"276","author":"Yang","year":"2021","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.mad.2022.111714_bib36","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2020.113915","article-title":"Necroptosis mediated by impaired autophagy flux contributes to adverse ventricular remodeling after myocardial infarction","volume":"175","author":"Zhang","year":"2020","journal-title":"Biochem. Pharm."},{"key":"10.1016\/j.mad.2022.111714_bib37","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2019.108599","article-title":"Tanshinone IIA protects against heart failure post-myocardial infarction via AMPKs\/mTOR-dependent autophagy pathway","volume":"112","author":"Zhang","year":"2019","journal-title":"Biomed. Pharm."},{"key":"10.1016\/j.mad.2022.111714_bib38","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2021.108046","article-title":"Selective inhibition of NLRP3 inflammasome reverses pressure overload-induced pathological cardiac remodeling by attenuating hypertrophy, fibrosis, and inflammation","volume":"99","author":"Zhao","year":"2021","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.mad.2022.111714_bib39","doi-asserted-by":"crossref","first-page":"2104","DOI":"10.1038\/s41598-018-20561-4","article-title":"MiR-26a-5p regulates cardiac fibroblasts collagen expression by targeting ULK1","volume":"8","author":"Zheng","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.mad.2022.111714_bib40","doi-asserted-by":"crossref","DOI":"10.1111\/cpr.12739","article-title":"Tanshinone I attenuates the malignant biological properties of ovarian cancer by inducing apoptosis and autophagy via the inactivation of PI3K\/AKT\/mTOR pathway","volume":"53","author":"Zhou","year":"2020","journal-title":"Cell Prolif."},{"key":"10.1016\/j.mad.2022.111714_bib41","doi-asserted-by":"crossref","DOI":"10.1016\/j.mad.2021.111442","article-title":"Klotho attenuated Doxorubicin-induced cardiomyopathy by alleviating Dynamin-related protein 1 - mediated mitochondrial dysfunction","volume":"195","author":"Zhuang","year":"2021","journal-title":"Mech. Ageing Dev."}],"container-title":["Mechanisms of Ageing and Development"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0047637422000963?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0047637422000963?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T17:47:20Z","timestamp":1758649640000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0047637422000963"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10]]},"references-count":41,"alternative-id":["S0047637422000963"],"URL":"https:\/\/doi.org\/10.1016\/j.mad.2022.111714","relation":{},"ISSN":["0047-6374"],"issn-type":[{"value":"0047-6374","type":"print"}],"subject":[],"published":{"date-parts":[[2022,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Cardioprotection of Klotho against myocardial infarction-induced heart failure through inducing autophagy","name":"articletitle","label":"Article Title"},{"value":"Mechanisms of Ageing and Development","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mad.2022.111714","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"111714"}}